146 completed, 35 unknown, 28 recruiting, 11 terminated. 173 Not applicable, 14 Phase 2, 12 Phase 4, 8 Phase 3, 7 Phase 1.
Follow Postpartum Depression: new trials by email Literature Review of Postpartum Depression trials Research Report on Postpartum Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Whole-Body Hyperthermia for Mood and Anxiety Disorders Whole-Body Hyperthermia, fMRI - Postpartum Depression, Mood Disorders | Not applicable | Not yet recruiting | Weill Medical College of Cornell University | 240 | 2028-06-01 | 2026-06-23 |
| POSH-Ex: Physiotherapist-Led Telerehabilitation Exercise Programme for Postpartum Sexual Health POSH-Ex (Postpartum Sexual Health Exercise) - Postpartum Sexual Dysfunction, Postpartum Depression | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 84 | 2026-09-01 | 2026-08-05 |
| Implementation of a Clinical Decision Support Tool for Postpartum Depression Clinical Decision Support Tool - Postpartum Depression | Not applicable | Recruiting | Weill Medical College of Cornell University | 160 | 2026-07-01 | 2026-07-30 |
| Midwife-Led Digital Follow-Up After Cesarean Section Midwife-Led Digital Follow-Up Program - Postpartum Depression, Breastfeeding | Not applicable | Recruiting | Inonu University | 104 | 2026-06-15 | 2026-09-14 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| A Descriptive Study of the Correlation Between Postpartum Depression and Body Image Dissatisfaction, Self-objectification, and Social Media Appearance Comparison Postpartum Depression | Not yet recruiting | Sun Yat-sen University | 385 | 2026-04-28 | 2026-05-22 | |
| Efficacy of Yoga-Based Intervention in Improving Mother-Child Bonding in Maternal Depression Add-on Yoga Intervention, Treatment as Usual(Medication Based) - Perinatal Depression, Postpartum Depression | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 52 | 2026-04-15 | 2026-04-07 |
| Psychological Empowerment Program in Preventing Postpartum Depression Among Pregnant Women Psychological Empowerment Program - Postpartum Depression | Not applicable | Active not recruiting | Miranie Safaringga | 92 | 2026-03-10 | 2026-06-09 |
| The Effect of Art-Based Mandala Coloring Activity on Postpartum Anxiety and Postpartum Depression Mandala Coloring Activity - Postpartum Depression, Postpartum Anxiety | Not applicable | Not yet recruiting | Afyonkarahisar Health Sciences University | 60 | 2026-01-15 | 2026-01-07 |
| Effect of Listening to Surah Al-Inshirah (The Opening-Up of the Heart) After Cesarean Birth on Postpartum Outcomes Listening to Surah Al-Inshirah - Postpartum Depression, Maternal-Fetal Relations | Not applicable | Enrolling by invitation | Selcuk University | 172 | 2026-01-01 | 2026-03-05 |
| A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone Zuranolone - Postpartum Depression | Recruiting | Biogen | 300 | 2025-12-22 | 2026-09-08 | |
| Postpartum 1-Day CBT Pilot Study (Türkiye) One-Day Online CBT-Based Workshop - Postpartum Depression | Not applicable | Not yet recruiting | Marmara University | 60 | 2025-12-01 | 2025-12-05 |
| The Effect of Psychodramatic Role-Playing on Postpartum Depression, Self-Efficacy, and Perceived Social Support Psychodramatic Role-Playing Childbirth Education, Standard Childbirth Education - Postpartum Depression, Maternal Self-Efficacy | Not applicable | Completed | Istanbul University - Cerrahpasa | 57 | 2025-10-31 | 2026-04-02 |
| The Perinatal Synergistic Multi-component Intervention to alLeviate dEpressive Symptoms. A Case Series interpersonal psychotherapy (IPT), Ketamine - Postpartum Depression | Phase 2 / Phase 3 | Withdrawn | Washington University School of Medicine | 2025-10-15 | 2025-10-29 | |
| Psychoeducational Intervention to Reduce Depressive Symptoms and Strengthen Mother-Infant Bonding the psychoeducation intervention program, routine care - Postpartum Depression, Psychoeducation | Not applicable | Completed | Yasemin Ozhuner | 88 | 2025-07-02 | 2026-01-07 |
| Prevention of Postpartum Depression: A Pilot Placebo-controlled Trial of Trazodone Trazodone, Placebo - Postpartum Depression | Phase 1 | Withdrawn | Verinder Sharma | 2025-04-17 | 2025-04-04 | |
| Ketamine Pharmacokinetics and Pharmacodynamics for Postpartum Depression and Pain After Cesarean Delivery Ketamine (Ketalar) - Pain, Postpartum Depression | Phase 1 | Recruiting | University of Utah | 50 | 2025-03-28 | 2026-10-02 |
| Prenatal Yoga to Prevent Postpartum Depression Prenatal Yoga to Prevent Postpartum Depression (PRY-D) intervention, Treatment as Usual (TAU) - Postpartum Depression | Not applicable | Completed | Henry Ford Health System | 62 | 2025-02-26 | 2026-08-03 |
| Improving Maternal Sleep and Mental Health Smart Bassinet, HALO - Postpartum Depression, Postpartum Anxiety | Not applicable | Recruiting | University of Colorado, Colorado Springs | 342 | 2025-01-15 | 2025-02-10 |
| Sleep, Oxytocin and Reward Processing in Women in the Postpartum Phase Postpartum Depression | Not yet recruiting | International Research Training Group 2804 | 100 | 2025-01-01 | 2024-12-02 |
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Depression, Postpartum (249) · Depression (41) · Anxiety Disorders (16) · Breast Feeding (15) · Depressive Disorder, Major (13) · Premature Birth (10) · Motor Activity (8) · Psychological Well-Being (7) · Puerperal Disorders (5) · Fatigue (4) · Mood Disorders (4) · Pain, Postoperative (4) · Postpartum Hemorrhage (4) · Bipolar Disorder (3) · COVID-19 (3)
Female Urogenital Diseases and Pregnancy Complications (249) · Pregnancy Complications (249) · Urogenital Diseases (249) · Depressive Disorder (247) · Mental Disorders (247) · Mood Disorders (245) · Puerperal Disorders (244) · Behavior (74) · Behavioral Symptoms (42) · Pathological Conditions, Signs and Symptoms (27) · Signs and Symptoms (20) · Feeding Behavior (15) · Obstetric Labor Complications (15) · Pathologic Processes (12) · Neurologic Manifestations (10)
Cognitive Behavioral Therapy (9) · brexanolone (7) · Esketamine (6) · Ketamine (6) · Saline Solution (6) · Therapeutics (6) · Estradiol (4) · Sodium Chloride (4) · Escitalopram (3) · Exercise (3) · Psychiatric Status Rating Scales (3) · Quetiapine Fumarate (3) · Control Groups (2) · Injections (2) · Kangaroo-Mother Care Method (2)
McMaster University (14) · Northwestern University (8) · Peking University First Hospital (5) · Supernus Pharmaceuticals, Inc. (5) · University of North Carolina, Chapel Hill (4) · University of Pennsylvania (4) · Washington University School of Medicine (4) · Weill Medical College of Cornell University (4) · Children's Hospital of Philadelphia (3) · Istanbul University - Cerrahpasa (3) · Johns Hopkins University (3) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (3) · National Institute of Mental Health (NIMH) (3) · Rhode Island Hospital (3) · University of California, San Francisco (3)
United States (109) · Canada (33) · Turkey (Türkiye) (29) · China (10) · Israel (5) · France (4) · Denmark (3) · Spain (3) · United Kingdom (3) · Australia (2) · Egypt (2) · Germany (2) · Indonesia (2) · Italy (2) · Malaysia (2)
Ryan Van Lieshout, MD, PhD (6) · Darius Tandon, PhD (4) · Dong-Xin Wang, MD, PhD (4) · Peter J Schmidt, M.D. (3) · Beth A Lewis, PhD (2) · Helen Colquhoun, MD (2) · Katherine M Sharkey, MD, PhD (2) · Linda H Chaudron, MD, MS (2) · Rheanna Platt, MD (2) · Rhonda Boyd, PhD (2) · Ryan J Van Lieshout, MD, PhD (2) · Scott Stuart, MD (2) · Shaila Misri, MD (2) · Sherryl Goodman, PhD (2) · Sona Dimidjian, PhD (2)
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R21MD011320 (2), R34MH083866 (2), 2023 (1), F32MH077371 (1), K23HD065872 (1), K23MH090245 (1), K23MH118431 (1), P20GM152304 (1), P60MD000270 (1), R01HD097215 (1), R01MD016029 (1), R01MD016037 (1), R01MH084931 (1), R01MH093342 (1), R01MH096748 (1)