6 completed, 2 unknown, 1 active not recruiting, 1 not yet recruiting. 12 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 12 | Completed 6, Unknown 2, Active not recruiting 1, Not yet recruiting 1, Terminated 1, Withdrawn 1 |
Follow Postpartum Depression: new trials by email Literature Review of Postpartum Depression trials Research Report on Postpartum Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| Effect of Low-dose Esketamine on Maternal Depression at 3 Years After Childbirth Esketamine, Placebo - Prenatal Depression, Ketamine | Phase 4 | Active not recruiting | Peking University First Hospital | 364 | 2023-09-09 | 2024-12-05 |
| Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in Parturients Esketamine, Sufentanil - Postpartum Depression | Phase 4 | Unknown | Women's Hospital School Of Medicine Zhejiang University | 364 | 2023-05-01 | 2024-08-20 |
| Effects of Esketamine on Postpartum Depression Esketamine is not added, Esketamine 0.2mg/kg, Esketamine 0.4mg/kg - Postpartum Depression | Phase 4 | Unknown | Qinghai University | 500 | 2022-02-20 | 2022-02-08 |
| A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting ZULRESSO® - Postpartum Depression | Phase 4 | Completed | Supernus Pharmaceuticals, Inc. | 52 | 2021-10-08 | 2025-09-15 |
| A Study to Evaluate Multimodal Neuroimaging Parameters in Women With Postpartum Depression Who Are Receiving ZULRESSO™ (Brexanolone) Brexanolone - Postpartum Depression | Phase 4 | Withdrawn | Sage Therapeutics | 2020-02-01 | 2020-08-18 | |
| Neuraxial Preservative Free Morphine for Normal Spontaneous Vaginal Delivery Preservative Free Morphine, Saline - Postpartum Pain, Postpartum Depression | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 160 | 2019-10-19 | 2024-08-14 |
| Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries Epidural saline + IV saline, Epidural morphine 3 mg + IV saline, Epidural morphine 3 mg + IV ketamine 0.3 mg/kg - Pain, Postpartum Depression | Phase 4 | Completed | Northwestern University | 67 | 2018-06-27 | 2026-04-24 |
| Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression Ketamine, Placebo - Perinatal Depression, Ketamine | Phase 4 | Completed | Peking University First Hospital | 64 | 2017-11-23 | 2021-12-13 |
| Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Depot medroxyprogesterone acetate - Contraception, Postpartum Depression | Phase 4 | Completed | Beatrice Chen | 184 | 2011-11-01 | 2018-08-31 |
| Escitalopram (Lexapro) for the Treatment of Postpartum Depression Escitalopram - Postpartum Depression | Phase 4 | Completed | Massachusetts General Hospital | 7 | 2009-01-01 | 2014-08-06 |
| Postpartum Depression: Transdermal Estradiol Versus Sertraline Transdermal Estradiol, Sertraline, Placebo - Postpartum Depression | Phase 4 | Terminated | Northwestern University | 85 | 2008-08-01 | 2019-09-10 |
Depression, Postpartum (12) · Anxiety Disorders (1) · Breast Feeding (1) · Depression (1) · Pain (1)
Depressive Disorder (12) · Female Urogenital Diseases and Pregnancy Complications (12) · Mental Disorders (12) · Mood Disorders (12) · Pregnancy Complications (12) · Puerperal Disorders (12) · Urogenital Diseases (12) · Behavior (2) · Behavioral Symptoms (1) · Feeding Behavior (1) · Neurologic Manifestations (1) · Pathological Conditions, Signs and Symptoms (1) · Signs and Symptoms (1)
Esketamine (3) · Saline Solution (3) · Sodium Chloride (3) · Ketamine (2) · brexanolone (2) · Escitalopram (1) · Estradiol (1) · Medroxyprogesterone Acetate (1) · N,N-dimethyl-4-anisidine (1) · Pregnanolone (1) · Sertraline (1) · Sufentanil (1)
Peking University First Hospital (3) · Northwestern University (2) · Beatrice Chen (1) · Icahn School of Medicine at Mount Sinai (1) · Massachusetts General Hospital (1) · Qinghai University (1) · Sage Therapeutics (1) · Supernus Pharmaceuticals, Inc. (1) · Women's Hospital School Of Medicine Zhejiang University (1)
United States (6) · China (4)
Dong-Xin Wang, MD, PhD (2) · Daniel Katz, MD (1) · Dong-Xin Wang, MD,PhD (1) · Feyce Peralta, MD (1) · Katherine L Wisner, MD, MS (1) · Marlene P Freeman, MD (1) · Wang Xuejun, director (1) · Weiguo Lyv, Dr (1)
PMID 22283499, PMID 23394227, PMID 33078388, PMID 36570810, PMID 39626074