8 completed, 1 enrolling by invitation, 1 terminated. 2 Not applicable, 2 Phase 4, 1 Early Phase 1, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 4 | 2 | Completed 2 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Post Operative Cognitive Dysfunction: new trials by email Literature Review of Post Operative Cognitive Dysfunction trials Research Report on Post Operative Cognitive Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Eye Movements to Predict Post-Operative Delirium Post Operative Delerium, Post Operative Cognitive Dysfunction | Enrolling by invitation | University of Chile | 40 | 2026-08-06 | 2026-09-08 | |
| Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft. intranasal saline group, intranasal insulin, Intranasal dexmedetomidine - Post Operative Cognitive Dysfunction | Early Phase 1 | Completed | Minia University | 150 | 2024-12-27 | 2026-08-25 |
| Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery Elective Orthopedic Surgery - Post Operative Cognitive Dysfunction | Completed | HealthPartners Institute | 47 | 2020-01-06 | 2024-04-19 | |
| Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients methylcobalamin, Folic Acid, Placebo for methylcobalamin - Post Operative Cognitive Dysfunction | Not applicable | Terminated | Xijing Hospital | 40 | 2019-01-10 | 2021-08-04 |
| Ketamine and Postoperative Cognitive Dysfunction Ketamine, Placebo - Post Operative Cognitive Dysfunction | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 307 | 2017-03-20 | 2019-09-10 |
| Reversal of General Anesthesia With Methylphenidate Methylphenidate, Saline - Post Operative Cognitive Dysfunction, Emergence From Anesthesia | Phase 1 / Phase 2 | Completed | Massachusetts General Hospital | 32 | 2014-11-01 | 2019-08-22 |
| Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care Total intravenous anesthesia with propofol, General anesthesia with isoflurane - Alzheimers Disease, Postoperative Delirium | Phase 4 | Completed | Duke University | 191 | 2013-11-01 | 2023-03-22 |
| Effect of Preoperative Hospitalization Duration on Post-operative Cognitive Dysfunction Mini Mental and Modified Mini Mental Test - Post Operative Cognitive Dysfunction | Completed | Burcu Ozalp Horsanali | 64 | 2013-11-01 | 2017-09-25 | |
| Sugammadex and Cognitive Function Sugammadex, Neostigmine/atropine - Post Operative Cognitive Dysfunction | Not applicable | Completed | Attikon Hospital | 160 | 2010-09-01 | 2020-04-13 |
| Elder Surgery - Functional Recovery Following Beta Blockade Atenolol - Post Operative Cognitive Dysfunction | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 359 | 2002-09-01 | 2016-03-16 |
Cognitive Dysfunction (2) · Delirium (2) · Emergence Delirium (2) · Alzheimer Disease (1)
Mental Disorders (4) · Neurocognitive Disorders (4) · Confusion (3) · Nervous System Diseases (3) · Neurobehavioral Manifestations (3) · Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Cognition Disorders (2) · Pathologic Processes (2) · Postoperative Complications (2) · Brain Diseases (1) · Central Nervous System Diseases (1) · Delirium (1) · Dementia (1)
Anesthesia, General (1) · Atenolol (1) · Atropine (1) · Folic Acid (1) · Isoflurane (1) · Ketamine (1) · Methylphenidate (1) · Neostigmine (1) · Propofol (1) · Saline Solution (1) · Sodium Chloride (1) · Sugammadex (1) · Vitamin B 12 (1) · mecobalamin (1)
Assistance Publique - Hôpitaux de Paris (1) · Attikon Hospital (1) · Burcu Ozalp Horsanali (1) · Duke University (1) · HealthPartners Institute (1) · Icahn School of Medicine at Mount Sinai (1) · Massachusetts General Hospital (1) · Minia University (1) · University of Chile (1) · Xijing Hospital (1)
United States (4) · Chile (1) · China (1) · Egypt (1) · France (1) · Greece (1)
Franck Verdonk, MD, PhD (1) · Ivan Plaza-Rosales, PhD (1) · Jefrey H. Silverstein, MD (1) · Lize Xiong, M.D., Ph.D. (1) · Michael H Rosenbloom, MD (1) · Miles Berger, MD, PhD (1)
PMID 35104057, PMID 37271721, PMID 38710325
2016 (1)