17 completed, 7 not yet recruiting, 6 unknown, 4 recruiting. 13 Not applicable, 10 Phase 3, 9 Phase 2, 6 Phase 4, 3 Phase 1.
Follow mecobalamin: new trials by email Literature Review of mecobalamin trials Research Report on mecobalamin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| DV Plus Toripalimab With Cetirizine and Mecobalamin Pretreatment in Patients With Locally Advanced Unresectable or Metastatic Bladder Cancer Disitamab Vedotin, Toripalimab, Cetirizine - Bladder Cancer | Phase 1 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 20 | 2027-01-01 | 2026-10-01 |
| Clinical Study of Zuogui Jiangtang Shuluo Formula in Treating Diabetic Peripheral Neuropathy Zuogui Jiangtang Shuluo Formula, Mecobalamin - Diabetic Peripheral Neuropathy (DPN) | Not applicable | Not yet recruiting | The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine | 74 | 2026-08-15 | 2026-08-18 |
| Study of Wenyang Tongbi Formula in the Treatment of Chemotherapy-Induced Polyneuropathy Wenyang Tongbi Granules and Placebo mecobalamin, Mecobalamin with placebo Wenyang Tongbi Granules - Chemotherapy-induced Peripheral Neuropathy | Early Phase 1 | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 144 | 2026-07-01 | 2026-06-04 |
| Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy Mecobalamin - Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy, Chemotherapy-induced | Phase 3 | Recruiting | Qinghai Red Cross Hospital | 326 | 2026-02-24 | 2026-04-30 |
| Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patients Mecobalamin IV Injection, Mecobalamin Tablets - Vitamin B12 Deficiency, Renal Failure , Chronic | Not applicable | Completed | Jinnah Hospital | 60 | 2026-02-22 | 2026-08-24 |
| Hand and Foot Bath for Taxane-Induced Peripheral Neurotoxicity Traditional Chinese medicine (TCM) hand and foot baths, Methylcobalamin (methylB12) - Breast Cancer | Phase 4 | Not yet recruiting | Peking University Cancer Hospital & Institute | 78 | 2026-02-01 | 2026-01-20 |
| Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling hypoglycemic treatment, Tangshen'an Granules, Ginkgo Leaf Tablets - Diabetes Mellitus, Diabetic Retinopathy | Phase 2 | Not yet recruiting | Hejiang Ye | 160 | 2026-01-01 | 2025-09-26 |
| Mecobalamin in Promoting Recurrent Laryngeal Nerve Function Recovery After Thyroid Surgery Mecobalamin, placebo - Patients Undergoing Open Thyroid Surgery | Phase 3 | Not yet recruiting | West China Hospital | 528 | 2025-12-01 | 2025-12-10 |
| Bioequivalence Study of WP205 in Healthy Participants Methylcobalamin Injection(WP205), Methylcobalamin for Injection - Therapeutic Equivalency, Healthy | Phase 1 | Completed | Wanbangde Pharmaceutical Group Co., LTD | 20 | 2025-10-29 | 2026-08-24 |
| Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker Evaluation Acupuncture, Sham, Valacyclovir, pregabalin and mecobalamin - Acute Herpes Zoster | Not applicable | Recruiting | Dexiong Han | 228 | 2025-09-01 | 2026-06-16 |
| Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion Treatment Anti-VEGF drug, Mecobalamin 5 MG, Placebo - Retinal Vein Occlusion (RVO) | Phase 4 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 120 | 2025-08-01 | 2026-02-27 |
| Combination Gerotherapeutic Interventions for Healthspan Improvement Rapamycin, Naltrexone, Metformin - Healthspan Improvement, Aging | Phase 3 | Active not recruiting | AgelessRx | 30 | 2025-07-23 | 2026-03-16 |
| Electroacupuncture for PHN: Efficacy and Biomarker Evaluation in a Multicenter, Randomized, Sham-Controlled Trial Protocol Electroacupuncture (Hans-100A, Nanjing Jisheng Medical Technology, China), Pharmacotherapy：① Pregabalin ( Lyrica™ ，Pfizer Inc. America) ② Methylcobalamin ( Mecobalamin tablets， Weicai (China) Pharmaceutical Co., Ltd， China）, Streitberger Placebo Needle Set ( Asiamed ) - Postherpetic Neuralgia ( PHN ) | Not applicable | Not yet recruiting | Dexiong Han | 207 | 2025-07-01 | 2025-07-09 |
| Mecobalamin Combined With Ceftriaxone Sodium in the Treatment of Sepsis Liver Injury Mecobalamin, Ceftriaxone Sodium, Saline - Sepsis, Liver Dysfunction | Phase 4 | Unknown | Sichuan Provincial People's Hospital | 40 | 2024-01-15 | 2024-01-24 |
| Effect of Methylcobalamin and Cyanocobalamin Consumption on Vitamin B12 Nutritional Status Methylcobalamin, Cyanocobalamin group, Control group - Vitamin B12 Nutritional Deficiency | Not applicable | Recruiting | Fundació Eurecat | 54 | 2023-09-09 | 2024-10-30 |
| Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated With Elevated Serum Homocysteine in Hemodialysis Patients. L-Methyl Folate and methylcobalamine - End Stage Renal Disease, Hypertension, Renal | Phase 4 | Completed | Alexandria University | 51 | 2023-04-01 | 2025-01-13 |
| Effect of Ultrasound-guided Stellate Ganglion Block Combined With Facial Nerve and Glossopharyngeal Nerve Block on the Treatment of Sudden Deafness Stellate ganglion block, Facial and glossopharyngeal nerve blocks, Mecobalamin Tablets - Sudden Deafness | Not applicable | Unknown | Zhuan Zhang | 90 | 2022-11-14 | 2022-11-21 |
| Combination Therapy of Different Antidepressants With Dietary Supplements L-methylfolate, Vitamin B12, magnesium - Depression | Not applicable | Completed | Riphah International University | 88 | 2022-10-05 | 2023-09-11 |
| The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome Mecobalamin 5 MG Disintegrating Oral Tablet, placebo - Hand-foot Syndrome | Phase 3 | Active not recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 234 | 2022-01-01 | 2026-02-02 |
| Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients Epalrestat,Mecobalamin, Mecobalamin - Diabetes | Phase 4 | Unknown | Xiangya Hospital of Central South University | 72 | 2022-01-01 | 2022-01-11 |
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Amyotrophic Lateral Sclerosis (3) · Autistic Disorder (3) · Vitamin B 12 Deficiency (3) · Breast Neoplasms (2) · Diabetes Mellitus (2) · Muscular Atrophy (2) · Behavior (1) · Cardiovascular Diseases (1) · Child Development Disorders, Pervasive (1) · Chronic Pain (1) · Cognitive Dysfunction (1) · Depression (1) · Diabetes Mellitus, Type 2 (1) · Diabetic Neuropathies (1) · Diabetic Retinopathy (1)
Eisai Co., Ltd. (4) · Dexiong Han (2) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (2) · University of California, San Francisco (2) · Zhuan Zhang (2) · AgelessRx (1) · Alexandria University (1) · Arkansas Children's Hospital Research Institute (1) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (1) · Carolina Musculoskeletal Institute (1) · First Affiliated Hospital of Chongqing Medical University (1) · Fundació Eurecat (1) · Hejiang Ye (1) · Jinnah Hospital (1) · Liaoning University of Traditional Chinese Medicine (1)
China (18) · United States (5) · Japan (3) · Pakistan (2) · Egypt (1) · South Korea (1) · Spain (1) · Sweden (1) · United Kingdom (1)
Kazunori Saeki (2) · Afifa Siddique, MBBS (1) · Amalia A Tsiami, PhD (1) · Antoni Caimari, PhD (1) · Carina Elmqvist, Ass prof (1) · Chang Gong (1) · Chun Pan, ph.D (1) · David C Chappell, PhD (1) · Hanan M El-gowelli, PhD (1) · Hesham A Elghoneimy, PhD (1) · Jenell Decker, MD (1) · Juan Huang (1) · Lize Xiong, M.D., Ph.D. (1) · Mohamed S Salem, PharmD (1)
PMID 25982504, PMID 40935571, PMID 10219748, PMID 11562419, PMID 12454521, PMID 15385656, PMID 18587236, PMID 19056591, PMID 23817134, PMID 26300733, PMID 26889605, PMID 30578206, PMID 30636701, PMID 34282267, PMID 35532908, PMID 36997252, PMID 39192360, PMID 39844190, PMID 41199896, PMID 41475066, PMID 41580678, PMID 42283837, PMID 42486517, PMID 9843082