247 completed, 67 unknown, 23 recruiting, 23 terminated. 132 Not applicable, 100 Phase 2, 74 Phase 3, 60 Phase 4, 40 Phase 1.
Follow Folic Acid: new trials by email Literature Review of Folic Acid trials Research Report on Folic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Furosemide vs Placebo in Severe Preeclampsia Postpartum Furosemide, Folic Acid 5 MG - Severe Preeclampsia | Phase 2 | Not yet recruiting | Universidad Nacional Autonoma de Honduras | 186 | 2026-11-02 | 2026-11-05 |
| Safety and Efficacy of Folic Acid Combined With Atezolizumab and Bevacizumab as First-Line Therapy for Unresectable Hepatocellular Carcinoma Folic Acid, Atezolizumab & Bevacizumab - Unresectable Hepatocellular Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | West China Hospital | 78 | 2026-10-01 | 2026-09-23 |
| Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study Iron (60 mg)- folic acid (400 ug) [IFA], Multiple micronutrient supplement [MMS], Multiple micronutrient supplement Plus [MMS+] - Neurodevelopment Outcome, Linear Growth | Phase 3 | Recruiting | Johns Hopkins Bloomberg School of Public Health | 3000 | 2026-09-27 | 2026-10-09 |
| An RCT Study Between WHO and RCOG Based Practices Iron Polymaltose Complex with folic acid - Postpartum Anemia | Not applicable | Not yet recruiting | Sana Nadeem Qasir | 100 | 2026-09-01 | 2026-08-05 |
| Inositol and Metformin Administration in Mediterranean Diet and Low-Carbohydrate Diets in Women With PCOS Metformin, İnositol, Folic Acid - PCOS (Polycystic Ovary Syndrome), Insulin Resistance | Not applicable | Recruiting | Dicle University | 90 | 2026-08-13 | 2026-10-16 |
| Mitigate Immune-Mediated Loss of Therapeutic Response to Asfotase Alfa (STRENSIQ®) for Hypophosphatasia methotrexate, rituximab, bortezomib - Hypophosphatasia | Phase 4 | Withdrawn | Alexion Pharmaceuticals, Inc. | 2026-07-29 | 2025-12-18 | |
| Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA) - HPV Infection, HPV Integration | Not applicable | Not yet recruiting | IRCCS San Raffaele | 42 | 2026-07-01 | 2026-07-13 |
| Effect of a Food Intervention With a Prebiotic Alone or Combined With B-vitamins on Gut Microbiota Diversity, Inflammation and Mental Health Outcomes in Older Adults (GutFood) Inulin and B-vitamins, Inulin, Placebo - Biomarkers of B-vitamin Status and Gut Microbiome Composition | Not applicable | Recruiting | University of Ulster | 84 | 2026-05-18 | 2026-05-18 |
| Safety and Efficacy of Iron Prophylaxis With on Iron Homeostasis in Healthy Pregnant Women Iron plus folic acid, Folic acid - Iron Deficiency Anemia in Pregnancy, Iron Deficiency in Pregnancy | Not applicable | Recruiting | IBSA Farmaceutici Italia Srl | 162 | 2026-05-18 | 2026-10-20 |
| Folic Acid Salt Study (FISFA Zambia) Fortified Iodized Salt with Folic Acid (FISFA) - Folate Deficiency, Neural Tube Defects | Not applicable | Recruiting | University of Alabama at Birmingham | 250 | 2026-04-10 | 2026-06-29 |
| Effect of Aspirin and Folic Acid for Sudden Sensorineural Hearing Loss Aspirin + Acid folic, Placebo Aspirin + Placebo Acid folic - Sudden Sensorineural Hearing Loss | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 142 | 2026-04-01 | 2026-01-14 |
| Folate Treatment to Reduce Death Risk in the Year After Infection-Related Acute Kidney Injury Folic Acid 5 MG - Infection-Associated Acute Kidney Injury | Early Phase 1 | Not yet recruiting | The University of Hong Kong | 382 | 2026-04-01 | 2026-01-29 |
| The Impact of Myo-Inositol on Glycemic Control and Oxidative Stress in Gestational Diabetes Mellitus Myo-inositol 2 g + Folic acid 200 µg, Folic acid 200 µg, Insulin therapy - Gestational Diabetes Mellitus (GDM) | Not applicable | Recruiting | Medical University of Vienna | 40 | 2026-03-23 | 2026-07-06 |
| Efficacy of Alpha Lipoic Acid Combined With Myo-Inositol in Non-Diabetic PCOS Patients Myo-inositol, Folic Acid, Alpha Lipoic Acid - Poly Cystic Ovary Syndrome | Phase 3 | Recruiting | Beni-Suef University | 180 | 2026-03-10 | 2026-06-05 |
| Prospective Management of Plaque Instability With Statins and Extra Folic Acid Atorvastatin plus folic acid, Atorvastatin - Carotid Atherosclerotic Plaque | Phase 1 / Phase 2 | Recruiting | Ruijin Hospital | 180 | 2026-03-01 | 2026-07-02 |
| Myo-Inositol and Folic Acid for Improving Inflammation in Polycystic Ovary Syndrome myo-inositol 2000 gm + folic acid 200 mcg - Inflammation Biomarkers, Poly Cystic Ovary Syndrome | Not applicable | Active not recruiting | Khyber Medical University Peshawar | 50 | 2025-10-11 | 2026-09-15 |
| Growth Hormone and Dehydroepiandrosterone Role in Vitro Fertilization Somatropin (4IU for 1 month) plus, folic acid 400 mcg per day., DHEA plus folic acid 400mcg per day, control group - Infertility, Infertility (IVF Patients) | Phase 2 / Phase 3 | Recruiting | Beni-Suef University | 165 | 2025-10-10 | 2026-01-07 |
| Feasibility Test of Folic Acid on Acute Kidney Injury Folic Acid 5 MG - Acute Kidney Injury | Early Phase 1 | Not yet recruiting | The University of Hong Kong | 90 | 2025-10-01 | 2025-07-15 |
| ICOPE INTENSE-K Pilot Study ICOPE intense intervention, Ketone Ester (KE) supplementation, Placebo - Ageing | Not applicable | Recruiting | University Hospital, Toulouse | 40 | 2025-07-09 | 2025-07-23 |
| Effects of Folic Acid and Vitamin E on Hormones in Polycystic Ovary Syndrome Vitamin E 400, Folic Acid 5 Mg Oral Tablet - PCOS (Polycystic Ovary Syndrome) | Not applicable | Completed | Al-Mustansiriyah University | 207 | 2025-07-01 | 2026-07-23 |
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Arthritis, Rheumatoid (34) · Anemia (23) · Polycystic Ovary Syndrome (23) · Carcinoma, Non-Small-Cell Lung (14) · Anemia, Iron-Deficiency (11) · Colorectal Neoplasms (11) · Inflammation (10) · Diabetes, Gestational (9) · Lung Neoplasms (9) · Folic Acid Deficiency (8) · Hypertension (8) · Infertility (8) · Insulin Resistance (8) · Malnutrition (8) · Cardiovascular Diseases (7)
Acrotech Biopharma Inc. (6) · Genentech, Inc. (6) · AGUNCO Obstetrics and Gynecology Centre (5) · Ain Shams University (5) · Eli Lilly and Company (5) · Hoffmann-La Roche (5) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5) · Massachusetts General Hospital (5) · Shenzhen Ausa Pharmed Co.,Ltd (5) · University of Alabama at Birmingham (5) · University of British Columbia (5) · Amgen (4) · Centers for Disease Control and Prevention (4) · Emory University (4) · Harvard School of Public Health (HSPH) (4)
United States (80) · Italy (42) · China (36) · Canada (23) · United Kingdom (23) · Egypt (21) · Germany (19) · India (17) · Mexico (14) · Spain (14) · Brazil (13) · Bangladesh (12) · Netherlands (11) · Russia (11) · France (10)
Petra Verhoef, PhD (3) · A O Dosunmu, M.D. (2) · Berthold Koletzko, Prof. (2) · Fabio Ghezzi, M.D. (2) · Garry Weems, PharmD (2) · Lynn B Bailey, PhD (2)
PMID 25771069, PMID 21869730, PMID 22230384, PMID 22880024, PMID 29030456, PMID 22897803, PMID 26063325, PMID 27834686, PMID 30590411, PMID 31005968, PMID 34338114, PMID 34661903, PMID 35506389, PMID 36790138, PMID 36792333, PMID 37465924, PMID 38642841, PMID 39145520, PMID 41705996, PMID 10069782, PMID 10367822, PMID 10529901, PMID 10946791, PMID 11001674, PMID 11339434, PMID 11844814, PMID 11877368, PMID 12324494, PMID 12507972, PMID 12621133, PMID 1447744, PMID 14561807, PMID 14699020, PMID 15117425, PMID 15321804, PMID 15476202, PMID 15910853, PMID 16208639, PMID 16531613, PMID 16531614, PMID 16543037, PMID 16613998, PMID 16849761, PMID 16960155, PMID 17118406, PMID 17200216, PMID 17222700, PMID 17240287, PMID 17315026, PMID 17470822
2008 (4), 2009 (3), 2015 (3), 2014 (2), 2004 (1), 2005 (1), 2016 (1), 2023 (1), K23HL098744 (1), M01RR000052 (1), P30AG028740 (1), P30CA016056 (1), P42ES010349 (1), P60AR047782 (1), R01AG017160 (1)