Atropine: Clinical Trials

109 completed, 27 unknown, 11 recruiting, 8 active not recruiting. 47 Phase 4, 43 Not applicable, 31 Phase 3, 29 Phase 2, 19 Phase 1.

By phase and status

Phase	Trials	Status
Phase 4	47	Completed 30, Unknown 15, Recruiting 1, Withdrawn 1
Not applicable	43	Completed 25, Unknown 7, Recruiting 4, Active not recruiting 3, Terminated 3, Suspended 1
Phase 3	31	Completed 23, Not yet recruiting 2, Recruiting 2, Terminated 2, Active not recruiting 1, Withdrawn 1
Phase 2	29	Completed 17, Active not recruiting 4, Not yet recruiting 3, Recruiting 2, Unknown 2, Withdrawn 1
Phase 1	19	Completed 14, Withdrawn 2, Not yet recruiting 1, Recruiting 1, Unknown 1
Early Phase 1	7	Completed 3, Recruiting 2, Unknown 1, Withdrawn 1

Follow Atropine: new trials by email Literature Review of Atropine trials Research Report on Atropine

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study of Sacituzumab Govitecan With Atropine to Improve Tolerability in Advanced TNBC and HR+/HER2- Breast Cancer Sacituzumab Govitecan (SG), Atropine, G-CSF (Granulocyte colony-stimulating factor) - Breast Cancer, Advanced HR+/HER2- Breast Cancer	Phase 2	Not yet recruiting	MedSIR	30	2026-07-01	2026-01-28
A RCT of Spectacles With Aspherical Lenslets or 0.05% Atropine for Myopia Control Atropine, Spectacles with HAL, Placebo Eyedrops - Myopia	Phase 3	Recruiting	Jaeb Center for Health Research	348	2026-07-01	2026-11-02
The Effect of Neostigmine and Sugammadex on the Optic Nerve Sheath Diameter Sugammadex 2 mg/kg, Neostigmine + Atropine - Neuromuscular Blockade Reversal Agent	Phase 4	Completed	Cukurova University	86	2026-06-25	2026-10-21
Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System - Paroxysmal Atrial Fibrillation	Not applicable	Recruiting	China National Center for Cardiovascular Diseases	390	2026-06-01	2026-10-26
Delaying the Onset of Nearsightedness Until Treatment (DONUT) Clinical Trial Atropine Sulfate 0.05% Oph Soln, Placebo - Myopia	Phase 3	Recruiting	Ohio State University	664	2026-05-27	2026-09-21
Magnesium Sulphate With Atropine and Pralidoxime vs Standard Therapy Alone in Acute Organophosphate Poisoning Atropine plus pralidoxime, Atropine and pralidoxime with adjunctive MgSO4 - Organophosphate Poisoning	Not applicable	Recruiting	Muhammad Aamir Latif	38	2026-05-10	2026-08-20
PROTECT-Study: Prospective Research on Optimizing Atropine Concentration Escalation for Children's Myopia Prevention 0.01% Atropine - Pre-myopia	Phase 1 / Phase 2	Not yet recruiting	Tianjin Medical University Eye Hospital	233	2026-03-30	2026-03-04
APPRAISE: Assessment of Pain and Posterior Synechiae Reduction With Atropine, an Investigation of Post-Surgical Eyes Atropine 1% - Eye Disorders	Phase 4	Recruiting	University of California, San Francisco	62	2026-03-10	2026-07-31
Spinal Morphine and Atropine Added to General Anaesthesia for Nausea and Pain After Abdominal Laparoscopy Intrathecal bupivacaine, morphine and atropine, General anaesthesia, Multimodal analgesia and antiemetic prophylaxis - Postoperative Nausea and Vomiting, Postoperative Pain	Phase 4	Completed	Universitas Indonesia	63	2026-02-02	2026-10-01
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery Neostigmine + Atropine, Sugammadex - Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus	Phase 3	Not yet recruiting	Xijing Hospital	560	2026-01-01	2025-12-09
Emergence Agitation Neostigmine + Atropine, Sugamadex - Emergence Agitation, Nasal Surgery	Not applicable	Active not recruiting	Ain Shams University	486	2025-10-30	2025-11-28
Efficacy of Topical Atropine Eye Drops for Control of Myopia Progression Among Children Attending Mansoura University Ophthalmic Center Atropine 0.05% Eye drops, Placebo ophthalmic solution - Myopia	Phase 2 / Phase 3	Not yet recruiting	Mansoura University	45	2025-09-01	2025-09-09
Minimal Flow Anesthesia and Infection Risk Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG - Minimal Flow Anesthesia, General Anaesthesia	Not applicable	Completed	Ankara City Hospital Bilkent	140	2025-08-01	2026-10-05
The Effect of 0.01% Atropine Eye Drops on Axial Length and Refraction in Myopic Children Compared to a Control Group Atropine 0.01% eye drops - Focus on Axial Length	Phase 2	Recruiting	Liaquat National Hospital & Medical College	60	2025-07-13	2026-03-06
Atropine Alone vs Atropine Plus Bifocal Spectacles for Myopia Control in Children Atropine Sulfate 0.05% Ophthalmic Solution, Bifocal Spectacles - Myopia, Progressive Myopia	Not applicable	Completed	University of Faisalabad	210	2025-02-17	2026-05-29
A Study of SHJ002 Sterile Ophthalmic Solution for Myopia Control SHJ002, Atropine - Myopia, Progressive	Phase 2	Active not recruiting	Sunhawk Vision Biotech, Inc.	140	2025-01-22	2026-01-23
Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade Sugammadex 1 mg/kg, Neostigmine + Atropine - Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade	Phase 1 / Phase 2	Recruiting	Universitas Padjadjaran	60	2024-11-05	2025-01-28
Early Intervention for Premyopic Children MiyoSmart Spectacles, 0.01% atropine - Myopia, Preschool	Phase 2	Active not recruiting	National Yang Ming Chiao Tung University Hospital	240	2024-10-06	2025-06-12
Orthokeratology and 0.01% Atropine Sequential Treatment for Myopia Control Ortho-k lenses, 0.01% Atropine - Myopia	Not applicable	Active not recruiting	Zhongshan Ophthalmic Center, Sun Yat-sen University	112	2024-09-21	2026-08-18
Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial intravenous 50 mL of saline injection of 0.9% after umbilical cord clamping., Neostigmine 20μg/kg (Neostigmine Methylsulphate 0.5 mg, Amriya Pharm.Ind.) and atropine 0.01 mg/kg (diluted in 50 ml saline; 0.9% for 10 min) following umbilical cord clamping. - Acute Pain	Phase 4	Unknown	Minia University	180	2024-07-15	2024-07-16

Showing 20 of 170. Sign in to see all of them.

Conditions studied

Myopia (41)  ·  Amblyopia (9)  ·  Bradycardia (9)  ·  Myopia, Degenerative (5)  ·  Organophosphate Poisoning (5)  ·  Hypotension (3)  ·  Insulin Resistance (3)  ·  Pain (3)  ·  Refractive Errors (3)  ·  Arrhythmias, Cardiac (2)  ·  Breast Neoplasms (2)  ·  Heart Arrest (2)  ·  Hypoglycemia (2)  ·  Pain, Postoperative (2)  ·  Post-Dural Puncture Headache (2)

Sponsors

Jaeb Center for Health Research (9)  ·  Merck Sharp & Dohme LLC (6)  ·  Shanghai Eye Disease Prevention and Treatment Center (5)  ·  Ain Shams University (4)  ·  Assiut University (4)  ·  Seoul National University Hospital (4)  ·  Mansoura University (3)  ·  The Hong Kong Polytechnic University (3)  ·  B.P. Koirala Institute of Health Sciences (2)  ·  Baskent University (2)  ·  Beijing Tongren Hospital (2)  ·  Biomedical Advanced Research and Development Authority (2)  ·  Centre Hospitalier Intercommunal Creteil (2)  ·  Laboratorios Sophia S.A de C.V. (2)  ·  Medical University of Vienna (2)

Countries

United States (46)  ·  China (15)  ·  Egypt (14)  ·  South Korea (9)  ·  Taiwan (8)  ·  Turkey (Türkiye) (5)  ·  Austria (4)  ·  Denmark (4)  ·  France (4)  ·  Italy (4)  ·  Belgium (3)  ·  Canada (3)  ·  Germany (3)  ·  Hong Kong (3)  ·  Israel (3)

Top investigators

Andrea Cornini, MD (2)  ·  David K. Wallace, M.D. (2)  ·  Guido Fanelli, MD (2)  ·  Jianfeng Zhu (2)  ·  Marzieh Salehi, MD, MS (2)  ·  Mitchell M. Scheiman, O.D. (2)  ·  Richard W. Hertle, M.D. (2)  ·  Adriana Rodriguez, MD (1)  ·  Ahmed M Shaat, MD (1)  ·  Akcan Akkaya, MD. (1)  ·  Alain F Kalmar, MD, PhD (1)  ·  Alexandra Benavente-Perez, PhD (1)  ·  Alice P Chen, M.D. (1)  ·  Anand Chockalingam, MD (1)

Results publications

PMID 20451898, PMID 22108357, PMID 10048351, PMID 10793585, PMID 10861154, PMID 15522375, PMID 17307778, PMID 18385265, PMID 19018977, PMID 19028329, PMID 19064841, PMID 19139333, PMID 19541265, PMID 19934423, PMID 21746992, PMID 21907115, PMID 22476448, PMID 22633344, PMID 22678319, PMID 22698066, PMID 22748697, PMID 23603153, PMID 24247230, PMID 24465046, PMID 24789375, PMID 24809482, PMID 25187755, PMID 25208233, PMID 25727586, PMID 25762533, PMID 25794212, PMID 26136531, PMID 2615447, PMID 26254585, PMID 26492921, PMID 2676955, PMID 26817505, PMID 28178072, PMID 28403018, PMID 29467022, PMID 29621571, PMID 29715354, PMID 30881948, PMID 31046016, PMID 31356374, PMID 31653669, PMID 31684867, PMID 32091590, PMID 32616309, PMID 32874839

NIH funding

U10EY011751 (8), 2017 (3), 2018 (1), 2025 (1), R01DK105379 (1), UG1EY037201 (1), UG1EY037202 (1)