178 completed, 38 unknown, 9 recruiting, 7 withdrawn. 109 Phase 4, 50 Not applicable, 40 Phase 3, 24 Phase 2, 8 Phase 1.
Follow Sugammadex: new trials by email Literature Review of Sugammadex trials Research Report on Sugammadex
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| REMIfentanil (2 vs. 4 mcg/kg) Facilitated Intubation Without Neuromuscular Blockade Versus Succinylcholine and Rocuronium With Sugammadex for Endotracheal Intubation in Spine Surgery Requiring Motor Evoked Potential Monitoring Low-Dose Remifentanil, High-Dose Remifentanil, Succinylcholine - Airway Management, Endotracheal Intubation | Phase 4 | Not yet recruiting | Mayo Clinic | 316 | 2026-09-01 | 2026-09-22 |
| The Effect of Neostigmine and Sugammadex on the Optic Nerve Sheath Diameter Sugammadex 2 mg/kg, Neostigmine + Atropine - Neuromuscular Blockade Reversal Agent | Phase 4 | Completed | Cukurova University | 86 | 2026-06-25 | 2026-10-21 |
| Venous Tourniquet vs. Arterial Tourniquet for Seizure Monitoring in ECT Device: Arterial Tourniquet, Device: Venous Tourniquet, Sugammadex - Major Depressive Disorder, Bipolar Disorder | Not applicable | Recruiting | Medipol University | 20 | 2026-04-20 | 2026-07-27 |
| A Dose-response Study to Determine the Right Dosage of Sugammadex as a Reversal Agent of Rocuronium in Infants Between 1 and 24 Months Old Sugammadex - Curarization, Postoperative Residual | Phase 4 | Not yet recruiting | University Hospital, Caen | 99 | 2026-03-30 | 2026-03-17 |
| Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery Neostigmine + Atropine, Sugammadex - Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus | Phase 3 | Not yet recruiting | Xijing Hospital | 560 | 2026-01-01 | 2025-12-09 |
| Impact of Sugammadex Versus Neostigmine on Early Postoperative Pulmonary Function Sugammadex, Neostigmine - Residual Neuromuscular Block | Not applicable | Recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 240 | 2025-12-30 | 2026-06-22 |
| Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery Sugammadex - Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery | Recruiting | Dr. Nguyen Thi Thu Hang | 80 | 2025-12-04 | 2026-09-01 | |
| Risk of Acute Complications With Rocuronium vs Cisatracurium in Patients With Chronic Kidney Disease Rocuronium, Cisatracurium, Sugammadex - Post Operative Pulmonary Complications, Neuromuscular Blockade | Phase 4 | Recruiting | The University of Texas Medical Branch, Galveston | 490 | 2025-08-26 | 2026-10-20 |
| Minimal Flow Anesthesia and Infection Risk Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG - Minimal Flow Anesthesia, General Anaesthesia | Not applicable | Completed | Ankara City Hospital Bilkent | 140 | 2025-08-01 | 2026-10-05 |
| Sugammadex-Induced Clenching During Neuromuscular Blockade Reversal Sugammadex 1 mg/kg Group, Sugammadex 2 mg/kg Group, Sugammadex 4 mg/kg Group - Neuromuscular Blockade Reversal Agent, Perioperative Complications | Not applicable | Recruiting | Wonkwang University Hospital | 240 | 2025-07-01 | 2026-07-07 |
| NMBA Reversal and Postoperative Urinary Retention Choice of reversal agent (sugammadex or neostigmine [with muscaranic antagonist]) - Neuromuscular Blocking Agents, Urinary Retention After Procedure | Active not recruiting | Beth Israel Deaconess Medical Center | 70000 | 2025-06-08 | 2026-01-23 | |
| Placental Transfer of Sugammadex in the Human Placental Perfusion Model Sugammadex - Pregnancy | Not applicable | Enrolling by invitation | Universitaire Ziekenhuizen KU Leuven | 16 | 2025-03-17 | 2026-01-09 |
| Sugammadex on Laparoscopic Bariatric Surgery Sugammadex, Neostigmine - Laparoscopic Bariatric Surgery, Sugammadex | Not applicable | Not yet recruiting | Shanxi Bethune Hospital | 60 | 2024-12-01 | 2024-11-07 |
| Recovery Times of Half Dose Sugammadex and Neostigmine for Rocuronium-induced Neuromuscular Blockade Sugammadex 1 mg/kg, Neostigmine + Atropine - Neuromuscular Blocking Agents, Reversal of Neuromuscular Blockade | Phase 1 / Phase 2 | Recruiting | Universitas Padjadjaran | 60 | 2024-11-05 | 2025-01-28 |
| Effectiveness on Smooth Extubation According to the Administration Time of Sugammadex sugammadex - Sugammadex, Extubation | Not applicable | Unknown | Ajou University School of Medicine | 66 | 2024-10-03 | 2024-07-25 |
| Sugammadex Dose Finding Under Two Years Old Sugammadex - Neuromuscular Blockade | Phase 2 | Unknown | Sang-Hwan Ji | 33 | 2024-09-15 | 2024-08-29 |
| Using Diaphragm Ultrasonography, Sugammadex Recovers Diaphragmatic Function More Effectively Than Neostigmine. sugammadex, Neostigmine - Perioperative Diaphragmatic Function | Phase 1 | Completed | Ain Shams University | 60 | 2024-08-26 | 2025-05-21 |
| Deep Versus Moderate Neuromuscular Blockade in Bariatric Surgery Deep neuromascular blockage, Moderate neuromascular blockage - Neuromuscular Blockade | Not applicable | Unknown | University Hospital of Patras | 50 | 2024-08-01 | 2024-08-14 |
| Sugammadex Vs Neostigmine in Reversing Neuromuscular Blocks in Outpatient ERCP. A Randomized, Double-Blinded Trial 2 mg/kg sugammadex, 0.07 mg/kg neostigmine - Neuromuscular Blocks | Phase 3 | Recruiting | The Cleveland Clinic | 80 | 2024-06-01 | 2025-12-15 |
| The Clinical Effect of Sugammadex Sodium (Domestic) for Antagonizing Neuromuscular Blockade After Thoracic Surgery SUGAMMADEX SODIUM 100 Mg in 1 mL, Neostigmine - Neuromuscular Blockade | Not applicable | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 80 | 2024-06-01 | 2025-02-17 |
Showing 20 of 243. Sign in to see all of them.
Delayed Emergence from Anesthesia (21) · Postoperative Complications (7) · Postoperative Nausea and Vomiting (5) · Emergence Delirium (4) · Obesity (4) · Obesity, Morbid (4) · Pain, Postoperative (4) · Sleep Apnea, Obstructive (4) · Renal Insufficiency (3) · Vomiting (3) · Arrhythmias, Cardiac (2) · Bradycardia (2) · Brain Neoplasms (2) · Critical Illness (2) · Hypersensitivity (2)
Merck Sharp & Dohme LLC (41) · Seoul National University Hospital (8) · Guangzhou General Hospital of Guangzhou Military Command (5) · Seoul National University Bundang Hospital (5) · Technical University of Munich (4) · University of Texas Southwestern Medical Center (4) · Yonsei University (4) · Ajou University School of Medicine (3) · Attikon Hospital (3) · Herlev Hospital (3) · Onze Lieve Vrouw Hospital (3) · Radboud University Medical Center (3) · The Cleveland Clinic (3) · West Virginia University (3) · Ain Shams University (2)
United States (46) · South Korea (27) · Turkey (Türkiye) (14) · China (13) · Belgium (12) · Denmark (10) · Germany (9) · Italy (9) · Netherlands (7) · Egypt (6) · Canada (5) · France (5) · Greece (5) · Taiwan (5) · Malaysia (4)
Tiffany Moon, MD (3) · Ah-Young Oh, MD.,Ph.D. (2) · Brandon M Togioka, MD (2) · Federico Piccioni, MD (2) · Manfred Blobner, MD (2) · Adam M Thaler, DO (1) · Ah Young Oh (1) · AhYoung Oh, M.D Ph. D (1) · Ahmed M Elshafie (1) · Alain F Kalmar, MD, PhD, MSc (1) · Albert Dahan, MD, PhD, Professor (1) · Alex Sia (1) · Alicja Bartkowska-Sniatkowska, MD PhD (1)
PMID 20683334, PMID 17307778, PMID 18385265, PMID 18946293, PMID 19194156, PMID 19387176, PMID 19713265, PMID 20876699, PMID 24240315, PMID 24809482, PMID 27871504, PMID 28399799, PMID 39773137, PMID 10793585, PMID 11339776, PMID 12456412, PMID 17156221, PMID 17264722, PMID 17312210, PMID 17667567, PMID 18648227, PMID 19455040, PMID 19512873, PMID 19933538, PMID 20007792, PMID 20234315, PMID 20375901, PMID 20442260, PMID 20523215, PMID 20601860, PMID 20809967, PMID 20885293, PMID 21239968, PMID 21709661, PMID 22476448, PMID 22608583, PMID 22698066, PMID 22732111, PMID 23452344, PMID 23461992, PMID 23599531, PMID 23851450, PMID 24186470, PMID 24305646, PMID 24427455, PMID 24639018, PMID 24686347, PMID 24710957, PMID 24740312, PMID 24833824
2017 (4), 2005 (3), 2009 (2), 2014 (2), 2004 (1), 2008 (1), 2019 (1), 2023 (1), 2025 (1), UL1TR002378 (1)