129 completed, 26 unknown, 15 terminated, 8 recruiting. 75 Not applicable, 55 Phase 2, 39 Phase 3, 20 Phase 4, 17 Phase 1.
Follow Vitamin B 12: new trials by email Literature Review of Vitamin B 12 trials Research Report on Vitamin B 12
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only - Hypovitaminosis b 12 | Phase 3 | Not yet recruiting | Tanta University | 23 | 2026-12-30 | 2025-05-13 |
| Vitamin B12 Absorption Study Ampli-B, Vitamin B12 - Healthy Volunteers | Phase 4 | Completed | RDC Clinical Pty Ltd | 12 | 2026-07-20 | 2026-09-09 |
| Effect of EGCG, Folic Acid, Vitamin B12 and Hyaluronic Acid on HPV DNA Integration Epigallocatechin gallate (EGCG), Folic Acid (FA), Vitamin B12 (B12), and Hyaluronic Acid (HA) - HPV Infection, HPV Integration | Not applicable | Not yet recruiting | IRCCS San Raffaele | 42 | 2026-07-01 | 2026-07-13 |
| Oral Versus Intravenous Vitamin B12 Replacement in Hemodialysis Patients Mecobalamin IV Injection, Mecobalamin Tablets - Vitamin B12 Deficiency, Renal Failure , Chronic | Not applicable | Completed | Jinnah Hospital | 60 | 2026-02-22 | 2026-08-24 |
| Effects of Vitamin B12 and Natural Orange Extract, and Their Combination on Physical and Mental Performance Vitamin B 12, Natural orange extract, Vitamina B12 + natural orange extract - Vitamin b12, Supplementation During Endurance Performance | Not applicable | Enrolling by invitation | Francisco Javier Martínez Noguera | 20 | 2025-12-01 | 2026-01-14 |
| Effectiveness of Vitamin b12 Versus Kenalog on Traumatic Ulcer Associated With Orthodontic Treatment cyanocobalamin, triamcinolone acetonide - Mouth Ulcer | Not applicable | Completed | Hawraa Ali Abdullah | 82 | 2025-08-19 | 2026-03-03 |
| Combination Gerotherapeutic Interventions for Healthspan Improvement Rapamycin, Naltrexone, Metformin - Healthspan Improvement, Aging | Phase 3 | Active not recruiting | AgelessRx | 30 | 2025-07-23 | 2026-03-16 |
| Comparative Study of Combination Treatment of Bionerv E+ Versus Vitamin B Complex in Treatment of Diabetic Polyneuropathy in Type 2 Diabetic Patients and Its Effect on Wound Healing Alpha-Lipoic Acid, Vitamin B1, Vitamin B6, Vitamin B12, Vitamin E, Vitamin B1, Vitamin B6, Vitamin B12 - Diabetic Foot Ulcer (DFU), Diabetic Symmetrical Polyneuropathy | Not applicable | Recruiting | BREGO Life Sciences | 100 | 2025-07-22 | 2026-10-16 |
| ICOPE INTENSE-K Pilot Study ICOPE intense intervention, Ketone Ester (KE) supplementation, Placebo - Ageing | Not applicable | Recruiting | University Hospital, Toulouse | 40 | 2025-07-09 | 2025-07-23 |
| A Study to See if a Combination of Vitamins That is Injected Into a Muscle is as Good and Safe as a Vitamin That is Taken by Mouth Vitamin B12, Vitamin B6, Folic acid, Vitamin B12 (Cyanocobalamin) - Vitamin B12 Deficiency | Phase 4 | Completed | Medice Arzneimittel Pütter GmbH & Co KG | 46 | 2025-04-16 | 2026-09-04 |
| Study of Vitamin B12 Metabolism in Children With Sickle Cell Disease Exposed to MEOPA Vitamin B12 - Sickle Cells Patients | Recruiting | CHU de Reims | 29 | 2024-11-27 | 2025-12-10 | |
| Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Moderate Neurocognitive Impairment (Dementia) Secretome injection, Vitamin B12 Injection - Dementia, Moderate Dementia | Phase 1 | Unknown | Baermed | 54 | 2024-10-15 | 2024-10-09 |
| THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMES Vitamin B12 - Premature Ejaculation | Completed | OZGUR EKICI | 54 | 2024-10-01 | 2025-06-25 | |
| The Effect of Natural Molecules on HPV Infection EGCG, FA, HA, B12 - HPV (Human Papillomavirus)-associated | Not applicable | Completed | AGUNCO Obstetrics and Gynecology Centre | 106 | 2024-08-01 | 2025-03-19 |
| Effect of a New Formulation of Vitamin B12 on Physical and Mental Vitamin B12 (B12), PLACEBO (PLA) - Performance Enhancing Product Use | Not applicable | Recruiting | Francisco Javier Martínez Noguera | 18 | 2024-07-01 | 2024-10-15 |
| Needle-Free Subcutaneous Injector and Conventional Intramuscular Injection of Mecobalamin in Diabetes Peripheral Neuropathy needle-free subcutaneous injector for Mecbl, intramuscular injection of Mecbl - Diabetic Peripheral Neuropathy | Not applicable | Unknown | Peking University Third Hospital | 30 | 2024-05-30 | 2024-05-06 |
| Efficacy and Safety of Etoricoxib/Cyanocobalamin Versus Etoricoxib for Acute Low Back Pain Etoricoxib + Cyanocobalamin fixed dose, Etoricoxib fixed dose - Acute Low-back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 190 | 2024-04-26 | 2024-11-27 |
| Assessing the Efficacy of Different Carrier Systems in Oral Vitamin B12 Supplementation Vit B12 - Vitamin B 12 Deficiency | Not applicable | Completed | Liaquat University of Medical & Health Sciences | 70 | 2024-04-12 | 2024-07-18 |
| Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's Disease Folic Acid 1 MG, Vitamin B6 25 MG, Vitamin B12 - Parkinson&Amp;#39;s Disease | Not applicable | Recruiting | Oregon Health and Science University | 150 | 2024-03-05 | 2025-01-13 |
| Effects of Lactoferrin-enriched Whey on Iron Status in Females Lactoferrin, iron and B12 in Whey Protein, Lactoferrin, Iron and B12 in Rice Protein, Lactoferrin, Iron and B12 in Maltrodextrin - Serum Ferritin | Not applicable | Unknown | Utah State University | 82 | 2024-03-01 | 2025-01-28 |
Showing 20 of 190. Sign in to see all of them.
Vitamin B 12 Deficiency (20) · Carcinoma, Non-Small-Cell Lung (12) · Anemia (10) · Recurrence (8) · Stroke (7) · Cardiovascular Diseases (6) · Lung Neoplasms (6) · Neoplasm Metastasis (5) · Autistic Disorder (4) · Breast Neoplasms (4) · Lymphoma, T-Cell, Peripheral (4) · Myocardial Infarction (4) · Schizophrenia (4) · Cognitive Dysfunction (3) · Depression (3)
Acrotech Biopharma Inc. (6) · University of Aarhus (4) · Eli Lilly and Company (3) · Haukeland University Hospital (3) · Massachusetts General Hospital (3) · Universität des Saarlandes (3) · AGUNCO Obstetrics and Gynecology Centre (2) · Arkansas Children's Hospital Research Institute (2) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (2) · Brigham and Women's Hospital (2) · Centre For International Health (2) · Chinese University of Hong Kong (2) · Emisphere Technologies, Inc. (2) · Francisco Javier Martínez Noguera (2) · Fundação Educacional Serra dos Órgãos (2)
United States (53) · Italy (16) · China (12) · India (10) · Brazil (9) · France (8) · Germany (8) · Australia (7) · Pakistan (6) · Spain (6) · United Kingdom (6) · Canada (5) · Mexico (5) · Netherlands (5) · Norway (5)
Rima Obeid, PhD (3) · Eva M Lonn, MD MSc FRCPC FACC (2) · Garry Weems, PharmD (2) · Michael Saunders, MD (2) · Per Magne Ueland, M.D., Ph.D. (2) · Tor A Strand, MD/PhD (2) · Zeina Nahleh, MD (2) · Absalon D Gutierrez, MD (1) · Adauto Castelo, PhD (1) · Adelfia Urenda-Quezada, MD (1) · Afifa Siddique, MBBS (1) · Alan Ho, MD, PhD (1)
PMID 18940900, PMID 19056591, PMID 24025626, PMID 29472265, PMID 31005968, PMID 37465924, PMID 38642841, PMID 10069782, PMID 10367822, PMID 10529901, PMID 10793599, PMID 10946791, PMID 11001674, PMID 11339434, PMID 11844814, PMID 12324494, PMID 12507972, PMID 1447744, PMID 14699020, PMID 15117425, PMID 15321804, PMID 15910853, PMID 16208639, PMID 16531613, PMID 16531614, PMID 16543037, PMID 16613998, PMID 16849761, PMID 16960155, PMID 17315026, PMID 17470822, PMID 17645592, PMID 17954810, PMID 18003666, PMID 18070815, PMID 18510727, PMID 18620104, PMID 18705976, PMID 18714059, PMID 18809959, PMID 18854539, PMID 19118243, PMID 19124628, PMID 19125808, PMID 19228852, PMID 19277125, PMID 19549699, PMID 19605506, PMID 19687335, PMID 19901100
2008 (2), 2015 (2), 2018 (1), M01RR000082 (1), P42ES010349 (1), P60AR047782 (1), R01AG017160 (1), R01MH070831 (1), R21AT002571 (1), R21CA107277 (1), R21DK122234 (1), U10CA180888 (1)