91 completed, 17 unknown, 4 not yet recruiting, 3 recruiting. 122 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 122 | Completed 91, Unknown 17, Not yet recruiting 4, Recruiting 3, Terminated 3, Withdrawn 2, Active not recruiting 1, Enrolling by invitation 1 |
Follow Periodontitis: new trials by email Literature Review of Periodontitis trials Research Report on Periodontitis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial. Doxycycline and Atorvastatin loaded Chitosan nanoparticles local drug - Chronic Periodontitis | Phase 4 | Not yet recruiting | Fayoum University | 80 | 2026-06-01 | 2026-06-08 |
| This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%) - Periodontitis, Smokers | Phase 4 | Recruiting | Military Hospital of Tunis | 50 | 2026-05-25 | 2026-07-16 |
| Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy Amphion® Mouthwash, Placebo Mouthwash - Periodontitis, Mouthwash | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2026-03-01 | 2026-02-11 |
| Calcium Hydroxide Versus Triple Antibiotic Paste for Pain After Root Canal Treatment Calcium Hydroxide (CH), Triple Antibiotic Paste - Apical Periodontitis, Pulp Necrosis | Phase 4 | Completed | Rehman Medical Institute - RMI | 138 | 2026-02-01 | 2026-11-06 |
| "Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy" Non surgical root surface debridement in one stage without receiving Ibuprofen, Non surgical root surface debridement in one stage with receiving Ibuprofen - Periodontitis | Phase 4 | Recruiting | University of Baghdad | 30 | 2025-12-01 | 2026-03-09 |
| Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis Melatonin-Loaded Injectable Platelet-Rich Fibrin, injectible platelet rich fibrin (i-PRF ), scaling and root planning - Periodontitis Stage II | Phase 4 | Completed | Al-Azhar University | 30 | 2025-11-01 | 2026-11-09 |
| Effect of Different Sealers and Activation Methods on Pain Root Canal Sealants - Chronic Apical Periodontitis | Phase 4 | Not yet recruiting | TC Erciyes University | 80 | 2025-03-01 | 2025-03-05 |
| Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis Platelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder - Alveolar Bone Loss Associated Chronic Periodontitis | Phase 4 | Active not recruiting | Bahria University | 120 | 2025-01-22 | 2025-03-04 |
| Effect of Two Different Irrigation Protocols and Activation Techniques on Postoperative Pain in Single-visit Endodontic Retreatment: Prospective Randomized Clinical Trial root canal irrigation - Apical Periodontitis | Phase 4 | Recruiting | TC Erciyes University | 100 | 2025-01-01 | 2026-05-20 |
| Melatonin Gel as an Adjuvant in the Surgical Management of Intrabony Defects Melatonin gel mixed with xenograft, Xenograft - Periodontal Disease, AVDC Stage 3 | Phase 4 | Completed | Ain Shams University | 20 | 2025-01-01 | 2025-08-29 |
| Periapical Healing in Response to Endodontically Treated Teeth With Different Sealing Cement Zinc-Oxide Eugenol Sealer, AH-Plus Epoxy Resin Sealer, Bio-C Sealer - Apical Periodontitis | Phase 4 | Unknown | Institucion Universitaria Colegios de Colombia | 72 | 2023-08-01 | 2024-07-09 |
| Evaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodontal Disease placebo gel, herbal drug - Periodontal Diseases | Phase 4 | Completed | Rungta College of Dental Sciences and Research | 50 | 2023-05-30 | 2025-08-22 |
| Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis Oral biological antimicrobial gel, minocycline hydrochloride ointment, SRP - Periodontitis | Phase 4 | Completed | Beijing Stomatological Hospital, Capital Medical University | 51 | 2022-09-05 | 2024-04-30 |
| Non-surgical Step 3 Periodontal Treatment With/Without Adjunctive Protocol - Pilot RCT. subgingival instrumentation plus Perisolv / hyaDent BG, subgingival instrumentation - Periodontal Pocket | Phase 4 | Completed | University of Witten/Herdecke | 52 | 2022-08-01 | 2024-05-31 |
| ''Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Periodontitis Hyaluronic acid, non surgical periodontal therapy - Periodontitis | Phase 4 | Completed | Ehab Haider Hassan El-emam | 28 | 2022-05-02 | 2023-04-28 |
| Advanced Platelet-rich Fibrin Combined With Open Debridement in Management of Suprabony Periodontal Defects advanced PRF - Periodontitis, Adult | Phase 4 | Completed | October University for Modern Sciences and Arts | 30 | 2021-11-21 | 2023-03-27 |
| Indocyanine-green Mediated Photosensitizer VS Aloe Vera Gel: Adjunct Therapy to Scaling and Root Planing in Patients With Chronic Periodontitis Plant extract - Periodontitis, Periodontal Inflammation | Phase 4 | Completed | Riyadh Elm University | 150 | 2021-09-07 | 2023-09-13 |
| Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy Lepidium Sativum, Simvastatin - Periodontitis | Phase 4 | Completed | Ain Shams University | 30 | 2021-09-01 | 2022-12-20 |
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Chronic Periodontitis (50) · Periodontal Diseases (14) · Periapical Periodontitis (9) · Periodontal Pocket (8) · Aggressive Periodontitis (7) · Diabetes Mellitus (6) · Dental Plaque (4) · Alveolar Bone Loss (3) · Dental Pulp Necrosis (3) · Gingivitis (3) · Periapical Abscess (3) · Bacteremia (2) · Bone Diseases, Metabolic (2) · Dental Pulp Diseases (2)
Mouth Diseases (122) · Stomatognathic Diseases (122) · Periodontal Diseases (108) · Pathological Conditions, Signs and Symptoms (58) · Pathologic Processes (57) · Disease Attributes (51) · Chronic Disease (50) · Jaw Diseases (12) · Periapical Diseases (12) · Tooth Diseases (12) · Nutritional and Metabolic Diseases (11) · Metabolic Diseases (10) · Musculoskeletal Diseases (10) · Bone Diseases (8)
Tooth Exfoliation (18) · Root Planing (14) · Metronidazole (10) · Amoxicillin (9) · Chlorhexidine (6) · Moxifloxacin (4) · Oils, Volatile (4) · Photochemotherapy (4) · Gels (3) · Minocycline (3) · Simvastatin (3) · enamel matrix proteins (3) · proliferation regulatory factors, human urine (3) · Ciprofloxacin (2) · Doxycycline (2)
Tatyasaheb Kore Dental College (7) · Ain Shams University (5) · University of Sao Paulo (5) · University of Guarulhos (4) · University of Santiago de Compostela (4) · University of Taubate (4) · Facultad Nacional de Salud Publica (3) · Ondine Research Laboratories (3) · Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre (3) · University of Campinas, Brazil (3) · Al-Azhar University (2) · Dr. D. Y. Patil Dental College & Hospital (2) · Ondokuz Mayıs University (2) · TC Erciyes University (2) · University of Oslo (2)
Brazil (15) · India (11) · Egypt (9) · Spain (7) · Germany (6) · United States (6) · Turkey (Türkiye) (5) · Colombia (4) · Pakistan (3) · Saudi Arabia (3) · Canada (2) · China (2) · France (2) · Italy (2) · Malaysia (2)
Ahmed Y Gamal, Professor (2) · Girish D Deore, BDS (2) · Jose R Cortelli, PhD (2) · Ahmed Y Gamal, professor (1) · Alpiste Illueca Francisco, Professor (1) · Andrea Mombelli, Dr.med.dent. (1) · Anne Merete Aass, Professor (1) · Archana Singh, MDS (1) · Bahar Kuru, Prof. Dr. (1) · Basak Dogan, Prof. Dr. (1) · Bekir Karabucak, DMD, MS (1)
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