1503 completed, 348 unknown, 162 recruiting, 97 terminated. 735 Not applicable, 291 Phase 3, 272 Phase 4, 244 Phase 2, 161 Phase 1.
Follow Bone Diseases, Metabolic: new trials by email Literature Review of Bone Diseases, Metabolic trials Research Report on Bone Diseases, Metabolic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD Romosozumab, Zoledronic Acid 5 MG in 5 ML Injection, Calcium 500 mg and Vitamin D3 800 IU - Osteoporosis in Post-menopausal Women | Phase 4 | Not yet recruiting | Sahlgrenska University Hospital | 216 | 2027-01-11 | 2026-08-19 |
| Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes | Recruiting | Bettina Mittendorfer | 100 | 2027-01-01 | 2026-05-07 | |
| Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis Exercise training - Osteopenia, Osteoporosis | Not applicable | Withdrawn | University of Alabama at Birmingham | 2026-12-01 | 2026-07-01 | |
| Time-Restricted Eating and Exercise for Bone Health Time-restricted eating combined with resistance exercise (TRE+Ex), Habitual eating pattern combined with resistance exercise (HE+Ex) - Osteopenia | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 24 | 2026-11-01 | 2026-09-17 |
| Study of TST002 Injection in Postmenopausal Women With Osteoporosis or Low Bone Mass Denosumab, Placebo - Postmenopausal Osteoporosis, Low Bone Mass | Phase 2 | Not yet recruiting | Transcenta Therapeutics (Hangzhou) Co., Ltd. | 110 | 2026-10-31 | 2026-09-11 |
| Osteoporosis & Renal Disease: Research in Primary Health Care Services Fracture risk assessment tool (FRAX), Dual-Energy X-ray Absorptiometry (DXA) - Osteoporosis, Chronic Kidney Disease Mineral and Bone Disorder | Not yet recruiting | Universidade do Porto | 622 | 2026-10-01 | 2026-09-30 | |
| Controlled Reduction of AO Spine B3 Fractures in Ankylosing Spinal Disorders Using an Inflatable Positioning Device: Technical Note and Retrospective Single-centre Case Series Spine Fracture, Osteoporosis | Not yet recruiting | Diakonie-Klinikum Stuttgart | 23 | 2026-09-20 | 2026-09-29 | |
| Comparison of Induced Membrane Technique With Vascularized Fibula Flap for Pediatric Limb Reconstruction limb reconstruction - Bone Loss, Microsurgery | Not yet recruiting | Central Hospital, Nancy, France | 140 | 2026-09-15 | 2026-09-17 | |
| Bone and Muscle Oxygenation in Military Test Pilots Supervised Resistance and Core Stabilization Exercise Program - Low Bone Mineral Density, Muscle Oxygenation | Not applicable | Not yet recruiting | Emine Merve Ersever | 10 | 2026-09-15 | 2026-08-26 |
| Access to Probing and Peri-implant Diseases Peri-implant probing - Peri-implantitis, Peri-implant Bone Loss | Recruiting | Arrow Development | 281 | 2026-09-01 | 2026-10-13 | |
| Calcium-Rich Food Versus Calcium Carbonate for Bone Health 500 mg calcium from milk-derived minerals, Calcium Carbonate 500 MG - Osteopenia, Osteoporosis | Not applicable | Not yet recruiting | Cornell University | 217 | 2026-09-01 | 2026-08-13 |
| Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 Years Romosozumab, Denosumab - Glucocorticoid-Associated Osteopenia and Osteoporosis | Phase 4 | Not yet recruiting | Tuen Mun Hospital | 54 | 2026-09-01 | 2026-08-12 |
| Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women Full-Spectrum Cannabis Extract 5:1 (CBD:THC) - Chronic Pain, Fibromyalgia | Phase 2 | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 80 | 2026-09-01 | 2026-08-26 |
| Post-osteoporotic Fracture Exercise Program Exercise Program - Osteoporosis, Osteoporotic Fracture | Not applicable | Not yet recruiting | Western University, Canada | 100 | 2026-09-01 | 2026-08-20 |
| Effects of Sensorimotor Balance Training vs Digitally Augmented Core Stabilization in Women With Osteoporosis Sensorimotor-Based Balance Training, Digitally Augmented Core Stabilization - Postmenopausal Osteoporosis | Not applicable | Not yet recruiting | Riphah International University | 40 | 2026-09-01 | 2026-10-15 |
| EFFECTIVENESS AND CLINICAL OPTIMIZATION OF A STANDARDIZED PHYSIOTHERAPY EXERCISE PROGRAM TARGETING BALANCE-POSTURE INTERACTION AND FALL RISK IN OSTEOPOROSIS: A RANDOMIZED CONTROLLED TRIAL Structured Physiotherapy Exercise Program - Osteoporosis, Risk of Falls | Not applicable | Not yet recruiting | Alma Mater Europaea - Slovenia | 88 | 2026-09-01 | 2026-08-13 |
| Release Kinetics of rhBMP-2 Using E-PRF as an Autologous Carrier: An In Vitro Analysis E-PRF/rhBMP-2 (similar ratios), E-PRF/ACS/rhBMP-2, rhBMP-2/E-PRF - Bone Loss | Withdrawn | University of Alabama at Birmingham | 2026-09-01 | 2026-09-30 | ||
| Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis intra-oral 3D optical impression - Osteogenesis Imperfecta, Rare Bone Disorders | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 240 | 2026-09-01 | 2026-06-24 |
| Effect of Postural Correction Exercises on Pelvic Floor Dysfunction in Postmenopausal Osteoporotic Women Estrogen replacement therapy, General advice, Postural correction exercise program - Osteoporosis, Postmenopausal | Not applicable | Not yet recruiting | Cairo University | 60 | 2026-09-01 | 2026-09-08 |
| The Relationship Between Lipedema and Osteoporosis DXA - Lipedema, Osteoporosis | Not yet recruiting | Fatih Sultan Mehmet Training and Research Hospital | 120 | 2026-08-20 | 2026-08-21 |
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Osteoporosis (1553) · Osteoporosis, Postmenopausal (330) · Fractures, Bone (138) · Sarcopenia (75) · Chronic Kidney Disease-Mineral and Bone Disorder (73) · Motor Activity (73) · Diabetes Mellitus (55) · Breast Neoplasms (53) · Osteoporotic Fractures (53) · Hip Fractures (52) · Renal Insufficiency, Chronic (51) · Obesity (50) · Bone Diseases (49) · Familial Hypophosphatemic Rickets (49)
Nutritional and Metabolic Diseases (2334) · Metabolic Diseases (2326) · Musculoskeletal Diseases (2314) · Bone Diseases (2286) · Pathological Conditions, Signs and Symptoms (415) · Wounds and Injuries (307) · Nutrition Disorders (264) · Urogenital Diseases (252) · Endocrine System Diseases (234) · Pathologic Processes (221) · Signs and Symptoms (221) · Nervous System Diseases (212) · Deficiency Diseases (210) · Avitaminosis (208)
Denosumab (120) · Alendronate (114) · Teriparatide (108) · Zoledronic Acid (103) · Cholecalciferol (88) · Vitamin D (83) · Calcium (73) · Risedronic Acid (72) · Exercise (48) · Absorptiometry, Photon (44) · Calcium Carbonate (42) · Ibandronic Acid (42) · romosozumab (33) · Resistance Training (28) · Raloxifene Hydrochloride (26)
Amgen (49) · Eli Lilly and Company (45) · National Taiwan University Hospital (33) · Cairo University (30) · Massachusetts General Hospital (30) · GlaxoSmithKline (24) · Hoffmann-La Roche (24) · Merck Sharp & Dohme LLC (24) · Novartis Pharmaceuticals (23) · University of Aarhus (22) · Organon and Co (19) · University of Alabama at Birmingham (18) · Columbia University (16) · Mayo Clinic (16) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (15)
United States (714) · Canada (163) · France (147) · China (122) · Denmark (119) · United Kingdom (99) · Germany (97) · Italy (95) · Turkey (Türkiye) (95) · Spain (87) · Egypt (76) · Taiwan (67) · Poland (61) · Japan (58) · South Korea (57)
Mustafa H Temel, M.D. (10) · Thomas J Schnitzer, MD, PhD (7) · Benjamin Leder, MD (5) · Connie M Weaver, PhD (5) · Ding-Cheng Chan, MD, PhD (5)
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