196 completed, 27 unknown, 12 withdrawn, 11 not yet recruiting. 76 Phase 2, 56 Phase 3, 51 Phase 1, 51 Phase 4, 50 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Controlled Study, Performed to Evaluate the Safety and Efficacy of EscharEx and Its Placebo (Gel Vehicle) Compared to Non-surgical Standard of Care in Participants With Venous Leg Ulcers (VLU) EscharEx (EX-03), Placebo (Gel vehicle), Non-surgical standard of care (NSSOC) - Venus Leg Ulcers | Phase 2 | Not yet recruiting | MediWound Ltd | 45 | 2027-01-10 | 2026-10-16 |
| Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies | Phase 4 | Not yet recruiting | Wah Medical college , POF hospital | 80 | 2026-12-01 | 2026-09-02 |
| Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial Acne Clascoterone 1% cream, Clindamycin 1% lotion, Adapalene 0.1%/benzoyl peroxide 2.5% gel - Acne Vulgaris | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 118 | 2026-11-01 | 2026-10-19 |
| Hormone thERapy Effects on BRAin-HEART Health During the Menopausal Transition Transdermal estradiol, Standard of care - non hormonal - Menopause, Perimenopause | Phase 4 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2026-11-01 | 2026-07-29 |
| Phase 2 Efficacy and Safety of PP405 in Adult Females With Androgenetic Alopecia PP405 0.05% Topical Gel, Vehicle Topical Gel - Androgenetic Alopecia | Phase 2 | Not yet recruiting | Pelage Pharmaceuticals, Inc. | 200 | 2026-11-01 | 2026-10-30 |
| Phase 2/3 Efficacy and Safety of PP405 in Adult Males PP405 0.05% Topical Gel, Vehicle Topical Gel - Androgenetic Alopecia | Phase 2 / Phase 3 | Recruiting | Pelage Pharmaceuticals, Inc. | 600 | 2026-09-21 | 2026-10-28 |
| Radiofrequency Treatment Versus Topical Therapy for Facial Acne Vulgaris Adapalene 0.1% and Benzoyl Peroxide 2.5% gel, Sequential Radiofrequency Treatment - Acne Vulgaris | Not applicable | Recruiting | Jeisys Medical Inc | 60 | 2026-09-15 | 2026-09-04 |
| Photodynamic Therapy For Onychomycosis ALA 10% gel, PDT, Urea - Onychomycosis of Toenail | Phase 1 | Active not recruiting | The University of Texas Health Science Center, Houston | 5 | 2026-08-10 | 2026-10-06 |
| An Open Label, Single Treatment, Single Arm, Multiple Dose Phase-2 Study to Evaluate the Pharmacokinetics, Safety, and Clinical Performance of EscharEx (EX-03) in Participants With Venous Leg Ulcers EX-03 - Venous Leg Ulcer (VLU) | Phase 2 | Not yet recruiting | MediWound Ltd | 20 | 2026-08-01 | 2026-07-09 |
| Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus Muscle Biopsy, Jell-O with Amino acids, Dextrose - Type 1 Diabetes | Not applicable | Withdrawn | Mayo Clinic | 2026-06-01 | 2026-08-05 | |
| Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars. Concentrated Growth Factor (CGF) Gel - Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy | Not applicable | Not yet recruiting | Cairo University | 10 | 2026-05-01 | 2026-04-09 |
| Topical 5% Spironolactone Gel Versus 0.1% Adapalene Gel for Acne Vulgaris: A Randomized Split-Face Study Spironolactone 5% Topical Gel, Adapalene 0.1% Topical Gel - Acne Vulgaris | Phase 2 | Not yet recruiting | Assiut University | 40 | 2026-04-01 | 2026-03-17 |
| Topical Methotrexate vs Minoxidil for Localized Alopecia Areata Methotrexate 1% Topical Gel, Minoxidil 5% Topical Spray - Alopecia Areata | Phase 4 | Not yet recruiting | Jinnah Postgraduate Medical Centre | 268 | 2026-03-15 | 2026-03-10 |
| Assessment of Skin Lesions Using a Tissue Oxygen Imager Based on Protoporphyrin IX (PPIX) Fluorescence. This is an Open-label, Non-randomized, Feasibility Study That Includes a One-time Application of an FDA Approved Medication Followed by Local Imaging for Benign Skin Growth and Lesions Clinically Ameluz 10% Topical Gel, Protoporphyrin IX - Non-Melanoma Skin Cancer (NMSC), Benign Skin Growth | Recruiting | Dartmouth-Hitchcock Medical Center | 125 | 2025-11-14 | 2026-02-06 | |
| The Use of Ultrasound to Assess the Airway Anatomy Regarding Pharyngeal Seal and Its Protective Role Throw a Chemical Test for Three Supraglottic Devices (ProSeal LMA, I-gel, and I-gel Plus) evaluate the sealing quality (ProSeal LMA)using ultrasonography and a biochemical non invasive test to evaluate regurgitation, evaluate the sealing quality of SGA device ( i-gel)using ultrasonography and a biochemical test for assessment of regurgitation, evaluate the sealing quality of SGA device ( i-gel plus )using ultrasonography and a biochemical test for assessment of regurgitation - Combining Ultrasound Assessment of Sealing Quality With Chemical Monitoring , May Provide Valuable Insights to Compare Effectiveness of Different SAD | Not applicable | Active not recruiting | Ain Shams University | 105 | 2025-11-12 | 2026-06-11 |
| Chlorhexidine Gel After Third Molar Surgery Chlorhexidine 0.2% Gel - Postoperative Wound Healing | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 25 | 2025-10-01 | 2026-10-27 |
| Home-Based Quadriceps Isometric Exercise for Knee Osteoarthritis Pain Placebo Topical Gel, Cannabidiol (CBD) Topical Gel, Arnica montana Topical Gel - Older Adults (60 - 85 Years Old), OA Knee | Not applicable | Completed | Universidad del Valle de México, Campus Cuernavaca | 50 | 2025-09-01 | 2026-03-03 |
| Topical Capsaicin Versus Diclofenac for Chronic Temporomandibular Joint-Related Pain Capsaicin Topical Cream, Diclofenac 1% Topical - Temporomandibular Disorders (TMD), Temporomandibular Pain | Not applicable | Completed | Istanbul University | 50 | 2025-08-28 | 2026-07-01 |
| Effect of an Experimental Cannabidiol Gel on Tooth Sensitivity Potassium nitrate and sodium fluoride, Cannabidiol (CBD) Gel, Natrosol 4% Gel - Dentin Sensitivity | Phase 1 | Not yet recruiting | Universidade Federal do Para | 75 | 2025-07-25 | 2025-06-18 |
| Comparative Efficacy of Resveratrol 1 % Gel and Trichloroacetic Acid 20% in Treatment of Melasma: A Split-face Study resveratrol 1 % gel, TCA20% - Melasma | Not applicable | Not yet recruiting | Assiut University | 41 | 2025-07-22 | 2025-07-11 |
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Acne Vulgaris (64) · Keratosis, Actinic (12) · Pain (11) · Rosacea (11) · Varicose Ulcer (6) · Wounds and Injuries (5) · Alopecia (4) · Hypogonadism (4) · Osteoarthritis, Knee (4) · Agnosia (3) · Condylomata Acuminata (3) · Dentin Sensitivity (3) · Erythema (3) · Fatigue (3) · Head and Neck Neoplasms (3)
Galderma R&D (19) · Peplin (9) · GlaxoSmithKline (7) · Allergan (6) · CONRAD (6) · LEO Pharma (6) · MediWound Ltd (6) · Assiut University (4) · Maruho Co., Ltd. (4) · Novan, Inc. (4) · Stiefel, a GSK Company (4) · University of Washington (4) · Actavis Mid-Atlantic LLC (3) · Mayo Clinic (3) · Novartis (3)
United States (137) · Canada (20) · Germany (17) · Egypt (14) · Brazil (11) · Italy (9) · France (8) · India (8) · Poland (8) · Australia (7) · Spain (7) · Belize (6) · Israel (5) · Japan (4) · Puerto Rico (4)
Ronald W Gottschalk, MD (5) · Michael Graeber, MD (4) · Joyce Rico, MD (3) · Michael Graeber, M.D. (3) · Stephanie T Page, MD, PhD (3) · Alur S. Kumar, MD (2) · Anilkumar Malik, MD (2) · Bela J. Shah, MD (2) · Benoit Girard, MD (2) · Christina Weng (2) · Hemanji R. Jerajani, MD (2) · Ian McGowan, MD, PhD, FRCP (2)
PMID 22417254, PMID 24765228, PMID 31755993, PMID 41869811, PMID 11488820, PMID 12095065, PMID 12553848, PMID 12839559, PMID 15087400, PMID 15117561, PMID 15297079, PMID 15483476, PMID 16340529, PMID 16873800, PMID 17056383, PMID 17061223, PMID 17342504, PMID 17620596, PMID 17891002, PMID 18249468, PMID 18454257, PMID 18456072, PMID 18472984, PMID 18812132, PMID 18996225, PMID 19205490, PMID 19226355, PMID 19305337, PMID 19357135, PMID 19376456, PMID 19439902, PMID 19546218, PMID 19746769, PMID 19845233, PMID 19888035, PMID 19898665, PMID 20175433, PMID 20213916, PMID 20443719, PMID 20546215, PMID 20592293, PMID 21102369, PMID 21177791, PMID 21178659, PMID 21310307, PMID 21357346, PMID 21489572, PMID 21607190, PMID 21636735, PMID 21697501
U01AI068633 (2), U19AI082637 (2), U19AI101961 (2), 2009 (1), 2015 (1), 2023 (1), 5UM1AI068633 (1), K23AG027238 (1), P30CA012197 (1), R01AG037603 (1), R01CA237607 (1), U01AG014369 (1), UL1TR001082 (1)