16 completed, 3 recruiting, 3 terminated, 2 unknown. 11 Not applicable, 11 Phase 4, 1 Early Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Completed 7, Recruiting 3, Active not recruiting 1 |
| Phase 4 | 11 | Completed 7, Terminated 3, Unknown 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow enamel matrix proteins: new trials by email Literature Review of enamel matrix proteins trials Research Report on enamel matrix proteins
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of Enamel Matrix Derivative in Immediate Dental Implants in the Mandibular Molar Region Enamel Matrix Derivative (Emdogain), Immediate Dental Implant Placement - Tooth Loss | Not applicable | Recruiting | Mansoura University | 24 | 2026-09-11 | 2026-09-16 |
| Regenerative Gel (Emdogain®) for Healing After Wisdom Tooth Extraction Enamel Matrix Derivative (Emdogain®) - Alveolar Bone Loss, Periodontal Pocket | Not applicable | Recruiting | Aristotle University Of Thessaloniki | 70 | 2026-03-09 | 2026-07-22 |
| Biologicals in Management of Intra-Bony Defects Minimally invasive surgical treatment of the intra-bony defects, Use of the xenograft Bio-Oss® Collagen during the surgery, Use of enamel matrix derivative (Emdogain®) - Intra-bony Pockets, Periodontitis | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 30 | 2025-08-08 | 2026-03-17 |
| Comparison Between Emdogain and Amniotic Membrane as a Scaffold in Endodontic Regeneration of Immature Anterior Teeth Regenerative endodontic treatment with conventional blood clot technique., regenerative endodontic treatment with emdogain., regenerative endodontic treatment with amniotic membrane - Non-vital Immature Anterior Teeth | Not applicable | Active not recruiting | Al-Azhar University | 39 | 2025-03-01 | 2025-11-26 |
| Emdogain Adjunctive to Autotransplantation Emdogain (EMD) - test, Sham group - Autotransplantation, Emdogain | Phase 4 | Unknown | Universidad Complutense de Madrid | 20 | 2024-03-12 | 2024-05-09 |
| Effectiveness of Hyaluronic Acid (hyaDENT BG® Gel) Compared With Enamel Matrix Proteins (Emdogain®) in the Treatment of Angular Bone Defects in Combination With a Xenograft (Bio-Oss Collagen®) Bio-Oss Collagen + HyaDent BG, Bio-Oss Collagen + Emdogain - Periodontitis, Intrabony Periodontal Defect | Not applicable | Completed | Medical University of Sofia | 17 | 2024-03-12 | 2025-11-17 |
| Root Coverage Using ADM and Coronally Positioned Tunnel With or Without Enamel Matrix Derivative Regenerative tissue matrix and enamel matrix derivative, Regenerative tissue matrix - Recession, Gingival | Phase 4 | Completed | University of Louisville | 24 | 2022-10-06 | 2026-02-10 |
| The Flapless Approach in Periodontal Regeneration Flapless with Enamel Matrix Derivatives (EMD), Flapless without Enamel Matrix Derivatives (EMD) - Periodontitis, Adult, Intrabony Periodontal Defect | Not applicable | Completed | University of Turin, Italy | 46 | 2022-09-01 | 2023-12-19 |
| Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alone and Combined With Enamel Matrix Proteins and Ox-derived Bone Graft in the Treatment of Single Bone Defects Between Teeth. modified minimally invasive surgical technique, modified minimally invasive surgical technique plus emdogain, modified minimally invasive surgical technique plus emdogain and xenograft - Periodontal Diseases, Periodontal Bone Loss | Not applicable | Completed | Rungta College of Dental Sciences and Research | 45 | 2022-03-01 | 2025-12-30 |
| PRF Versus Emdogain for Class II Furcation Defects of Mandibular Molars Platelet rich fibrin, Emdogain - Peridontal Disease, Furcation Defects | Not applicable | Completed | Medical University of Sofia | 21 | 2021-12-02 | 2026-09-25 |
| Comparison of Clinical and Radiographic Parameters in the Application of Cross-linked Hyaluronic Acid 1.8% and Enamel Matrix Derivative in Periodontal Regeneration. Cross-Linked Hyaluronate Gel Prefilled Syringe 30 MG/3ML, Enamel Matrix Proteins (Active comparator group) - Chronic Periodontitis, Periodontal Bone Loss | Phase 4 | Completed | Andres Lopez Roldan | 53 | 2020-03-01 | 2026-08-03 |
| Mandibular Furcation III Regeneration (FURC-III-REGEN) Biphasic calcium phosphate (Straumann Bone Ceramic) + collagen membrane (Straumann Jason Membrane), Biphasic calcium phosphate (Straumann Bone Ceramic) + enamel matrix proteins (Straumann Emdogain) - Furcation Defects, Periodontal Diseases | Phase 4 | Terminated | University of Oslo | 5 | 2019-10-15 | 2023-11-30 |
| Mandibular Furcation II Regeneration Biphasic calcium phosphate (Straumann Bone Ceramic) + collagen membrane (Straumann Jason Membrane), Biphasic calcium phosphate (Straumann Bone Ceramic) + enamel matrix proteins (Straumann Emdogain) - Furcation Defects, Periodontal Diseases | Phase 4 | Terminated | University of Oslo | 5 | 2019-10-15 | 2023-11-30 |
| Collagen Matrix With and Without Enamel Matrix Derivative enamel matrix derivative, Porcine collagen matrix - Gingival Recession | Unknown | Walter Reed National Military Medical Center | 30 | 2019-01-01 | 2019-07-01 | |
| Effect of Enamel Matrix Proteins on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients Enamel Matrix Proteins Derivative, Saline - Periodontal Bone Loss | Early Phase 1 | Completed | University of Nebraska | 50 | 2017-02-01 | 2023-12-01 |
| Emdogain Implementation With Transcrestal Sinus Lifting and Dental Implant Placement Enamel Matrix Protein - Osseointegration Failure of Dental Implant, Bone Density Increased | Phase 4 | Completed | T.C. Dumlupınar Üniversitesi | 24 | 2017-01-01 | 2022-08-18 |
| Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis Enamel Matrix Proteins, Open Flap Debridement - Aggressive Periodontitis | Phase 4 | Completed | University of Campinas, Brazil | 45 | 2016-02-01 | 2018-10-11 |
| Emdogain Minimally Invasive Surgical Technique Scaling and root planing, Scaling and root planing without Emdogain, Emdogain application - Periodontitis | Not applicable | Completed | Institut Straumann AG | 51 | 2015-10-01 | 2019-10-17 |
| The Effect of Enamel Matrix Derivatives on Root Coverage Esthetic Score enamel matrix derivatives - Gingival Recession, Periodontal Diseases | Not applicable | Completed | Yuzuncu Yil University | 19 | 2015-01-01 | 2017-06-23 |
| EMD and/or Bone Substitute for the Treatment of Class II Furcations EMD, βTCP/HA, Flap access surgery - Periodontal Disease | Phase 4 | Completed | University of Campinas, Brazil | 41 | 2013-03-01 | 2017-03-20 |
Showing 20 of 25. Sign in to see all of them.
Periodontal Diseases (7) · Periodontitis (6) · Alveolar Bone Loss (5) · Gingival Recession (5) · Chronic Periodontitis (3) · Furcation Defects (3) · Aggressive Periodontitis (1) · Bacterial Infections (1) · Infections (1) · Inflammation (1) · Mouth Diseases (1) · Osteosclerosis (1) · Peri-Implantitis (1) · Periodontal Pocket (1) · Tooth Loss (1)
Medical University of Sofia (2) · University of Campinas, Brazil (2) · University of Oslo (2) · University of Sao Paulo (2) · Al-Azhar University (1) · Andres Lopez Roldan (1) · Aristotle University Of Thessaloniki (1) · Catrine Isehed (1) · Institut Straumann AG (1) · Mansoura University (1) · Peter Eickholz (1) · Rungta College of Dental Sciences and Research (1) · T.C. Dumlupınar Üniversitesi (1) · Tabriz University (1) · Universidad Complutense de Madrid (1)
Brazil (4) · United States (4) · Bulgaria (2) · Egypt (2) · Germany (2) · Norway (2) · Spain (2) · Belgium (1) · Canada (1) · Greece (1) · India (1) · Iran (1) · Italy (1) · Sweden (1) · Turkey (Türkiye) (1)
Amy Killeen, DDS, MS (1) · Ana Castro, Professor (1) · Arthur B Novaes, Professor (1) · Bindu Dukka, BDS, MSD, MPH (1) · Deniz Ozbay, DDS PhD (1) · Enilson A Sallum, PhD (1) · Francisco Alpiste Illueca (1) · Jennifer H Doobrow, DMD (1) · Luiz Antonio PA Lima, Associate (1) · Pamela K McClain, DDS (1) · Pernilla Lundberg, Assoc. Prof (1) · Peter Eickholz, Prof Dr (1)
PMID 17710290, PMID 19254123, PMID 19968743, PMID 20165744, PMID 22385260, PMID 24059744, PMID 25475143, PMID 26094684, PMID 32299097, PMID 38859627, PMID 40106008