358 completed, 71 unknown, 39 terminated, 21 withdrawn. 135 Phase 3, 118 Phase 4, 108 Phase 2, 97 Phase 1, 72 Not applicable.
Follow this drug Literature Review of Simvastatin trials Research Report on Simvastatin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab - Gastroesophageal Adenocarcinoma | Phase 2 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 184 | 2027-01-01 | 2026-07-10 |
| Aggressive Lipid Lowering Therapy in ICI-Treated Melanoma Statins (atorvastatin, rosuvastatin, simvastatin, or pravastatin), +/- ezetimibe, +/- PCSK9 inhibitor (alirocumab, evolocumab, inclisiran) - Melanoma | Not applicable | Recruiting | University of Colorado, Denver | 40 | 2026-12-31 | 2026-08-07 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent Glioma Valproic Acid (VPA), Irinotecan, Simvastatin - Glioblastoma, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Recruiting | Inova Health Care Services | 52 | 2026-09-04 | 2026-09-21 |
| Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure Simvastatin, Baricitinib - ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure | Phase 2 | Not yet recruiting | University of Colorado, Denver | 300 | 2026-09-01 | 2026-10-08 |
| Topical 2% Simvastatin for Xanthelasma Palpebrarum Topical Simvastatin 2% Cream, Vehicle cream - Xanthelasma Palpebrarum | Phase 2 | Not yet recruiting | Klira Skin | 30 | 2026-08-01 | 2026-06-23 |
| New Topical Treatment in Patchy Alopecia Areata topical metformin 30% ointment, Topical Simvastatin 2% ointment, Topical betamethasone valerate 0.1% ointment - Alopecia Areata | Not applicable | Not yet recruiting | Sohag University | 60 | 2026-06-28 | 2026-07-10 |
| Simvastatin Efficacy in ARID1A Mutated Advanced gastroESophageal Carcinoma Treated With Immunotherapy standard nivolumab and oxaliplatin- based chemotherapy, simvastatin in combination with standard nivolumab and oxaliplatin-based chemotherapy - Advanced or Metastatic Gastrooesophageal Carcinoma | Phase 2 | Recruiting | National Cancer Institute, Naples | 84 | 2026-03-13 | 2026-04-14 |
| Effects of Selected Statins on Blood Glucose Levels in Healthy Volunteers Simvastatin (10mg, 20mg, 40mg), Rosuvastatin (5mg, 20mg, 40mg), Atorvastatin (10mg, 20mg, 40mg) - Diabete Mellitus, Lipid Profile | Phase 1 | Not yet recruiting | Shaheed Benazir Bhutto University Sheringal Dir Upper | 100 | 2026-03-01 | 2026-01-30 |
| [Effects of Selected Statins on Cardiovascular Parameters in Healthy Volunteers] Rosuvastatin (5mg, 20mg, 40mg), Atorvastatin (10mg, 20mg, 40mg), Simvastatin (10mg, 20mg, 40m - Lipid Profile,Blood Pressure | Phase 1 | Not yet recruiting | Shaheed Benazir Bhutto University Sheringal Dir Upper | 100 | 2026-03-01 | 2026-02-05 |
| Adebrelimab Combined With Gemcitabine, Cisplatin, and Simvastatin for Advanced Biliary Tract Cancer Adebrelimab, Gemcitabine + Cisplatin, Simvastatin 20mg - Advanced Biliary Tract Carcinoma | Phase 1 / Phase 2 | Recruiting | Tongji Hospital | 29 | 2026-01-30 | 2026-03-23 |
| Antimicrobial and Anti-inflammatory Effects of Simvastatin as an Intracanal Medication Simvastatin as an intracanal medication - Endodontically Retard Teeth, Periapical Radiolucency | Not applicable | Recruiting | Hadeer Maher Mostafa Mohamed | 54 | 2025-08-10 | 2025-12-01 |
| Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and Survival Simvastatin 20mg, Carvedilol 3.125 mg - Decompensated Cirrhosis, Cirrhotic Cardiomyopathy | Not applicable | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 260 | 2025-06-10 | 2025-06-08 |
| Alveolar Ridge Splitting With Simvastatin/PRF Composite and Simultaneous Implant Placement Alveolar Ridge Splitting with Simultaneous Implant Placement, Xenogeneic Bone Graft, Platelet-Rich Fibrin (PRF) - Alveolar Ridge Atrophy, Tooth Loss | Not applicable | Completed | Maruwan Ali Alteer | 21 | 2025-06-02 | 2026-07-09 |
| Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract Cancer Envafolimab + Gemcitabine + Cisplatin + Simvastatin - Biliary Tract Cancer, Advanced Cancer | Phase 2 | Not yet recruiting | Tongji Hospital | 62 | 2025-06-01 | 2025-06-04 |
| A Study to Investigate the Effect of AZD5004 on Rosuvastatin, Atorvastatin, Simvastatin, Repaglinide and the Effect of Erythromycin on AZD5004 in Healthy Participants AZD5004, Rosuvastatin, Erythromycin - Healthy Participants | Phase 1 | Completed | AstraZeneca | 49 | 2025-05-06 | 2025-10-10 |
| Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russia Atorvastatin, Simvastatin, Rozuvastatin - Atherosclerotic Cardiovascular Disease | Recruiting | Novartis Pharmaceuticals | 2382 | 2025-04-15 | 2025-08-03 | |
| Randomized Comparison of Morning Versus Bedtime Administration of Statins: A Cardiovascular Circadian Chronotherapy (C3) Trial Statin in the evening (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin in the morning (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin) - Cardiovascular Diseases (CVD), Drug Effect | Phase 4 | Not yet recruiting | Tor Biering-Sørensen | 42000 | 2025-02-28 | 2025-03-04 |
| StAtins in Frail OldEr Patients with Ischemic Stroke or Transient Ischemic Attack - the Randomized Controlled Trial Statin (atorvastatin, fluvastatin, pravastatin, rosuvastatin or simvastatin) - Ischemic Stroke, Transient Ischemic Attack | Phase 4 | Not yet recruiting | Prof. dr. Nathalie van der Velde | 612 | 2025-02-01 | 2025-01-21 |
| Topic Simvastatin for Bone Regeneration Simvastatin, Simvastatin 10 mg, Simvastatin Placebo - Dimensional Changes, Bone Density | Early Phase 1 | Recruiting | Universidad de Granada | 90 | 2025-01-07 | 2025-06-22 |
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PMID 38018702, PMID 21518985, PMID 37462232, PMID 24794878, PMID 26708287, PMID 18765432, PMID 18783301, PMID 19208350, PMID 20587587, PMID 20663203, PMID 21401833, PMID 22500948, PMID 25084698, PMID 25172198, PMID 25216871, PMID 25245415, PMID 27289122, PMID 29301785, PMID 32905623, PMID 33654016, PMID 34134520, PMID 35031587, PMID 36398903, PMID 10205010, PMID 10334539, PMID 11723015, PMID 11876689, PMID 12034651, PMID 12467231, PMID 14988829, PMID 15477398, PMID 15646894, PMID 16061117, PMID 16170339, PMID 16287954, PMID 16306522, PMID 16514303, PMID 16572283, PMID 16580386, PMID 16749654, PMID 16843192, PMID 16844920, PMID 16893434, PMID 17105841, PMID 17183151, PMID 17418291, PMID 17761367, PMID 17763406, PMID 17804683, PMID 17931979
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