440 completed, 146 unknown, 73 recruiting, 35 not yet recruiting. 531 Not applicable, 108 Phase 2, 58 Phase 3, 43 Phase 4, 40 Phase 1.
Follow Probiotics: new trials by email Literature Review of Probiotics trials Research Report on Probiotics
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Real-world Study of Gastrointestinal Health and Mental Wellness in U.S. Adults Following 12 Weeks of Probiotic Supplementation. Probiotic - Healthy Adults Reporting Recurrent Gastrointestinal Symptoms | Not applicable | Not yet recruiting | Novonesis | 300 | 2027-01-01 | 2026-09-30 |
| Genitourinary Study of Fostering Lactobacillus to Optimize the Microbiome in Women's Health (GUD-FLORA) Lactobacillus crispatus probiotic - Recurrent UTIs | Phase 1 | Withdrawn | Duke University | 2026-12-01 | 2026-08-28 | |
| R-2487 in Patients With Sjogren's Syndrome (SS) R-2487 - Sjogren's Syndrome, Sjögren | Phase 1 | Not yet recruiting | Rise Therapeutics LLC | 36 | 2026-11-01 | 2026-09-28 |
| A Study to Investigate the Effect of Probiotics (Limosilactobacillus Reuteri DSM 17938 and Limosilactobacillus Reuteri DSM 33633) on Symptoms of Viral Upper Respiratory Tract Infections in Children Probiotics (L. reuteri DSM 17938 and L. reuteri DSM 33633), Placebo - Virus Diseases in Children | Not applicable | Recruiting | Milosevits Gergely | 194 | 2026-10-19 | 2026-10-22 |
| Effect of Limosilactobacillus Reuteri on Social Deficits in Children With Autistic Spectrum Disorder Probiotics, Placebo - Autism Spectrum Disorder | Not applicable | Not yet recruiting | BioGaia AB | 200 | 2026-10-15 | 2026-09-30 |
| Effects of Synbiotic Supplementation on Gastrointestinal Symptoms, Appetite, and Nutritional Recovery in Patients After Autologous Bone Marrow Transplant Tri-component Synbiotic Supplement - Hematologic Neoplasms, Gastrointestinal Symptoms | Not applicable | Not yet recruiting | Alexandria University | 40 | 2026-10-01 | 2026-10-01 |
| The Gut - PRO Study Probiotic, Placebo - Alzheimer Disease | Phase 1 | Recruiting | University of Wisconsin, Madison | 40 | 2026-10-01 | 2026-09-29 |
| Effects of Probiotics on Skin Health in Healthy Women Probiotics, Placebo - Skin Aging, Dry Skin | Not applicable | Not yet recruiting | Probi AB | 140 | 2026-10-01 | 2026-10-21 |
| Probiotics for Sustained Health Probiotic, Placebo - Upper Respiratory Tract Infection (URTI) | Not applicable | Not yet recruiting | BioGaia AB | 70 | 2026-09-25 | 2026-09-24 |
| CASCADE 2002: PROTECT Study, "PRObiotics to TrEat Anal preCancer Trial EXE-346 Probiotic, Placebo, Usual Care High Resolution Anoscopy (HRA) - HSIL, High Grade Squamous Intraepithelial Lesion, HPV-Related Squamous Cell Carcinoma | Phase 2 | Recruiting | University of California, San Francisco | 90 | 2026-09-04 | 2026-09-15 |
| Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic Inflammation Probiotics, Placebo - Acne Vulgaris | Not applicable | Not yet recruiting | Foundation University Islamabad | 64 | 2026-09-01 | 2026-04-20 |
| Probiotic Research for Mental Health in Adult Volunteers Probiotic, Placebo - Healthy Adult Participants | Not applicable | Not yet recruiting | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | 60 | 2026-09-01 | 2026-08-07 |
| Effect of a Probiotic or Postbiotic on Gut Microbiome During Antibiotic Treatment Probiotic, Postbiotic, Placebo - Microbiome | Not applicable | Recruiting | The Archer-Daniels-Midland Company | 126 | 2026-08-27 | 2026-10-28 |
| Effects of Probiotic Supplementation on Gut Health, Immune Response, and Well-Being Probiotic capsules, Placebo - Gut Microbiome, Immune Responses | Not applicable | Recruiting | Orthomol Pharmazeutische Vertiebs GmbH | 50 | 2026-08-13 | 2026-08-21 |
| Probiotic Intervention for Digestive Health in Obese Patients Initiating GLP-RA Treatment Probiotics (Natural product), Placebo - Obesity &Amp; Overweight, Digestive Disorders | Not applicable | Recruiting | Hospices Civils de Lyon | 50 | 2026-08-05 | 2026-08-19 |
| Povidone Iodine for Caries Prevention Povidone Iodine 5% Soln,Top,Kit, Probiotics, Placebo - Dental Caries | Phase 3 | Not yet recruiting | Jeffrey A. Banas | 174 | 2026-08-03 | 2026-08-03 |
| Adults With Constipation Probiotics, Placebo - Constipation | Not applicable | Recruiting | Wecare Probiotics Co., Ltd. | 70 | 2026-07-24 | 2026-08-28 |
| Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel Placebo, Probiotic - Healthy | Phase 2 | Not yet recruiting | Min-Tze LIONG | 60 | 2026-07-01 | 2026-07-09 |
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| Probiotics for Depressive Symptomatology and Neural Activity. Ecologic® Barrier, Placebo powder - Mild-to-moderate Depression, Neural Activity | Not applicable | Not yet recruiting | University of Reading | 76 | 2026-07-01 | 2026-06-25 |
Showing 20 of 772. Sign in to see all of them.
Obesity (55) · Diarrhea (32) · Irritable Bowel Syndrome (25) · Constipation (21) · Inflammation (17) · Overweight (17) · Respiratory Tract Infections (15) · Anxiety Disorders (13) · COVID-19 (13) · Infections (13) · Depression (12) · Diabetes Mellitus, Type 2 (12) · Premature Birth (12) · Insulin Resistance (11) · Non-alcoholic Fatty Liver Disease (11)
Wecare Probiotics Co., Ltd. (42) · Probi AB (15) · Min-Tze LIONG (13) · AB Biotics, SA (10) · The Archer-Daniels-Midland Company (10) · Lallemand Health Solutions (9) · University of Copenhagen (9) · Société des Produits Nestlé (SPN) (8) · Danisco (7) · Lund University (7) · Ain Shams University (6) · Chung Shan Medical University (6) · Shanghai 10th People's Hospital (6) · BioGaia AB (5) · Chr Hansen (5)
China (108) · United States (94) · Spain (46) · Taiwan (38) · Canada (33) · Italy (31) · Sweden (29) · Brazil (27) · Malaysia (26) · United Kingdom (20) · Denmark (18) · India (18) · Poland (18) · Egypt (16) · Mexico (16)
Huanlong Qin (4) · Bobbi Langkamp-Henken, PhD (3) · Erik Rein-Hedin, MD (3) · Ai Zhou, Ph.D. (2) · Aleksandra M Cichonska, PhD (2) · Andreas Munk Petersen, MD, PhD, DMSc (2) · Anna Lyra, PhD (2) · Arthur Ouwehand, PhD (2) · Bo Jacobsson, Professor (2) · Bobbi Langkamp-Henken, Ph.D. (2) · Carles Lerin, PhD (2) · Ciro Costagliola, Full Professor (2) · Daniel Agardh, PhD (2) · Dr Lynette Shek, Consultant (2)
PMID 37870148, PMID 39470206, PMID 11297958, PMID 11921380, PMID 16187156, PMID 18281199, PMID 19285652, PMID 20980489, PMID 21821542, PMID 21873895, PMID 21945174, PMID 22836031, PMID 22916296, PMID 24034345, PMID 24848255, PMID 25894405, PMID 26427036, PMID 26706022, PMID 27288567, PMID 27698616, PMID 28239408, PMID 28923425, PMID 29731182, PMID 31125783, PMID 33870484, PMID 36149331, PMID 10831441, PMID 11069570, PMID 11256233, PMID 11401877, PMID 11468003, PMID 11606029, PMID 11799281, PMID 12500206, PMID 12500425, PMID 12612204, PMID 12788576, PMID 12848475, PMID 14121956, PMID 14657823, PMID 14679449, PMID 14762403, PMID 15379842, PMID 15747716, PMID 15914321, PMID 15942443, PMID 16157765, PMID 16172836, PMID 16197582, PMID 16317068
2019 (2), 2015 (1), 2023 (1), 2025 (1), K23AA029198 (1), R01HD095158 (1), R01HL080074 (1), R01NR005337 (1), R03AG040669 (1), R61AG088913 (1), U01AA021893 (1), U24CA275417 (1), UL1TR003096-03 (1)