180 completed, 37 unknown, 9 recruiting, 8 not yet recruiting. 254 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 254 | Completed 180, Unknown 37, Recruiting 9, Not yet recruiting 8, Terminated 7, Active not recruiting 6, Withdrawn 4, Enrolling by invitation 3 |
Follow Periodontal Diseases: new trials by email Literature Review of Periodontal Diseases trials Research Report on Periodontal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Endodontic Microsurgery Platelet rich fibrin - Apical Periodontitis | Phase 4 | Not yet recruiting | Mark Schachman | 20 | 2026-10-01 | 2026-07-29 |
| Oral Hygiene Assistance Training Program Stannous Fluoride Toothpaste (SnF), sodium fluoride 5000 ppm, cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash - Elderly, Periodontal Disease | Phase 4 | Not yet recruiting | Colgate Palmolive | 500 | 2026-09-20 | 2026-09-08 |
| Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses. Stannous Fluoride Toothpaste (SnF) - Gingival Inflammation | Phase 4 | Not yet recruiting | Colgate Palmolive | 20 | 2026-09-01 | 2026-09-03 |
| Nanozymes in Endodontics Nanozyme treatment, Control (Standard treatment) - Apical Periodontitis, Endodontic Disease | Phase 4 | Enrolling by invitation | University of Pennsylvania | 72 | 2026-08-24 | 2026-10-13 |
| Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis. A Randomized Controlled Clinical Trial. Doxycycline and Atorvastatin loaded Chitosan nanoparticles local drug - Chronic Periodontitis | Phase 4 | Not yet recruiting | Fayoum University | 80 | 2026-06-01 | 2026-06-08 |
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With Diabetes Diabetes Oral Health Program, Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash - Diabetes Type 2, Periodontal Disease | Phase 4 | Enrolling by invitation | Colgate Palmolive | 10000 | 2026-05-26 | 2026-09-03 |
| This a Clinical Trial to Evaluate the Efficacy of I-PRF, Povidone-Iodine and Laser as Adjuncts to Non-surgical Periodontal Treatment in Smokers and Non-Smokers Periodontitis Patients Injectable Platelet-Rich Fibrin (I-PRF), Diode Laser Activation, Povidone-Iodine Irrigation (1%) - Periodontitis, Smokers | Phase 4 | Recruiting | Military Hospital of Tunis | 50 | 2026-05-25 | 2026-07-16 |
| Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High Gingivitis sodium monofluorophosphate toothpaste - Gingivitis, Plaque | Phase 4 | Recruiting | Colgate Palmolive | 100 | 2026-04-20 | 2026-05-29 |
| Evaluation of the Anti-plaque Effect of a Bioflavonoid-based Antiseptic Mouthwash Bioflavonoid mouthwash, Chlorhexidine 0.12% mouthwash - Gingival Inflammation, Dental Plaque Accumulation | Phase 4 | Completed | University of Barcelona | 24 | 2026-03-02 | 2026-09-17 |
| Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy Amphion® Mouthwash, Placebo Mouthwash - Periodontitis, Mouthwash | Phase 4 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2026-03-01 | 2026-02-11 |
| Comparison Between the Effect of Triclosan Toothpaste and Chlorhexidine Mouthwash on Gingival Health in a Group of Fixed Orthodontic Patients: A Randomized Controlled Clinical Trial Triclosan 0.3% toothpaste, sodium fluoride 0.24% toothpaste, Chlorhexidine 0.2% mouthwash - Gingival Inflammation | Phase 4 | Completed | University of Science and Technology, Yemen | 60 | 2026-02-14 | 2026-09-11 |
| 6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health Test Mouthrinse, Control Mouthrinse - Gingivitis, Dental Plaque Accumulation | Phase 4 | Recruiting | Colgate Palmolive | 90 | 2026-01-28 | 2026-02-17 |
| Clinical Performance of Nobel N1 System Nobel N1 implant - Tooth Loss, Dental Implant | Phase 4 | Recruiting | Louisiana State University Health Sciences Center in New Orleans | 50 | 2025-12-15 | 2026-08-27 |
| "Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy" Non surgical root surface debridement in one stage without receiving Ibuprofen, Non surgical root surface debridement in one stage with receiving Ibuprofen - Periodontitis | Phase 4 | Recruiting | University of Baghdad | 30 | 2025-12-01 | 2026-03-09 |
| Adjunctive Topical Melatonin Gel in Non-Surgical Periodontal Therapy for Periodontitis Topical 5% Melatonin Gel, Placebo - Periodontal Disease, Melatonin | Phase 4 | Completed | Liaquat College of Medicine and Dentistry | 30 | 2025-11-03 | 2026-05-26 |
| Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis Melatonin-Loaded Injectable Platelet-Rich Fibrin, injectible platelet rich fibrin (i-PRF ) - Periodontitis Stage II | Phase 4 | Enrolling by invitation | Al-Azhar University | 60 | 2025-11-01 | 2026-01-05 |
| Assessing Gingivitis and Plaque From a Marketed Toothpaste Stannous Fluoride Dentifrice, Test Stannous Fluoride Dentifrice, Sodium monofluorophosphate dentifrice - Gingivitis | Phase 4 | Active not recruiting | Procter and Gamble | 120 | 2025-08-30 | 2025-09-23 |
| Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and Gingivitis Mouthwash, Floss, Toothbrush - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 228 | 2025-07-07 | 2025-10-30 |
| Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF Coronally Advanced Tunel + ADM (Novomatrix®), Coronally Advanced Tunel + ADM (Novomatrix®) + L-PRF - Gingival Recession, Gingival Recession, Localized | Phase 4 | Not yet recruiting | Andres Matteo Pascual La Rocca | 44 | 2025-04-01 | 2025-01-28 |
| Effect of Different Sealers and Activation Methods on Pain Root Canal Sealants - Chronic Apical Periodontitis | Phase 4 | Not yet recruiting | TC Erciyes University | 80 | 2025-03-01 | 2025-03-05 |
Showing 20 of 254. Sign in to see all of them.
Periodontitis (65) · Chronic Periodontitis (50) · Gingivitis (48) · Gingival Recession (27) · Peri-Implantitis (17) · Dental Plaque (12) · Alveolar Bone Loss (10) · Diabetes Mellitus (8) · Periapical Periodontitis (8) · Periodontal Pocket (8) · Aggressive Periodontitis (7) · Tooth Loss (7) · Dental Caries (5) · Bone Diseases, Metabolic (4)
Stomatognathic Diseases (254) · Mouth Diseases (253) · Gingival Diseases (78) · Pathological Conditions, Signs and Symptoms (73) · Pathologic Processes (64) · Periodontitis (56) · Infections (53) · Disease Attributes (52) · Chronic Disease (50) · Periodontal Atrophy (40) · Tooth Diseases (33) · Musculoskeletal Diseases (20) · Bone Diseases (17) · Nutritional and Metabolic Diseases (17)
Tooth Exfoliation (17) · Chlorhexidine (15) · Metronidazole (14) · Root Planing (14) · Amoxicillin (13) · enamel matrix proteins (8) · Alloderm (6) · Mouthwashes (6) · Oils, Volatile (6) · Cetylpyridinium (5) · Ethanol (5) · Triclosan (5) · chlorhexidine gluconate (5) · hydrated silica gel-based toothpaste (5) · Doxycycline (4)
Colgate Palmolive (14) · Tatyasaheb Kore Dental College (8) · University of Campinas, Brazil (8) · University of Sao Paulo (8) · University of Oslo (7) · Ain Shams University (6) · University of Taubate (6) · Procter and Gamble (5) · University of Santiago de Compostela (5) · University of Guarulhos (4) · Cairo University (3) · Dr. D. Y. Patil Dental College & Hospital (3) · Facultad Nacional de Salud Publica (3) · GlaxoSmithKline (3) · Krishnadevaraya College of Dental Sciences & Hospital (3)
United States (36) · Brazil (28) · India (16) · Spain (15) · Egypt (14) · Germany (11) · Italy (11) · Turkey (Türkiye) (9) · Canada (6) · Norway (6) · Switzerland (6) · United Kingdom (6) · Colombia (5) · Pakistan (5) · Saudi Arabia (4)
Enilson A Sallum, PhD (5) · Ahmed Y Gamal, Professor (2) · Chhaju Ram Goyal, DDS (2) · Daniele Cardaropoli, DDS (2) · Girish D Deore, BDS (2) · Gustavo Avila-Ortiz, DDS, MS, PhD (2) · Hans R Preus, PhD (2) · Jose R Cortelli, PhD (2) · Michael Lynch, DMD, PhD (2) · Ronaldo B Santana, DDS,MScD,DSc (2) · Aaron Biesbrock, DMD, PhD (1) · Abdullah AlAlwani, DDS (1) · Ahmed Khalil, professor (1) · Ahmed Y Gamal, professor (1)
PMID 33197289, PMID 16018754, PMID 19968743, PMID 25981528, PMID 26285807, PMID 34790237, PMID 5237684, PMID 10328647, PMID 11276867, PMID 11514795, PMID 11516756, PMID 11702237, PMID 11737510, PMID 11989392, PMID 12622859, PMID 12666710, PMID 12787214, PMID 1298430, PMID 14121956, PMID 14296927, PMID 14489483, PMID 14710766, PMID 14742657, PMID 15341352, PMID 15455740, PMID 15655026, PMID 15703760, PMID 15766375, PMID 16460251, PMID 16553634, PMID 17068477, PMID 17355365, PMID 18269662, PMID 18622483, PMID 18724841, PMID 18724858, PMID 18771373, PMID 19254123, PMID 19538334, PMID 19678861, PMID 19722800, PMID 20151809, PMID 20350159, PMID 20383102, PMID 20447259, PMID 20507380, PMID 20618550, PMID 20881341, PMID 21261673, PMID 21323710
2015 (2), P20RR017696 (1)