46 completed, 3 unknown, 1 terminated. 27 Phase 3, 12 Phase 4, 9 Not applicable, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 27 | Completed 26, Unknown 1 |
| Phase 4 | 12 | Completed 9, Unknown 2, Terminated 1 |
| Not applicable | 9 | Completed 9 |
| Phase 2 | 1 | Completed 1 |
Follow Triclosan: new trials by email Literature Review of Triclosan trials Research Report on Triclosan
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparison Between the Effect of Triclosan Toothpaste and Chlorhexidine Mouthwash on Gingival Health in a Group of Fixed Orthodontic Patients: A Randomized Controlled Clinical Trial Triclosan 0.3% toothpaste, sodium fluoride 0.24% toothpaste, Chlorhexidine 0.2% mouthwash - Gingival Inflammation | Phase 4 | Completed | University of Science and Technology, Yemen | 60 | 2026-02-14 | 2026-09-11 |
| Study to Evaluate the Safety of Sebryl® and Sebryl Plus® in Seborrheic Dermatitis and Psoriasis of Scalp Allantoin/ Coal Tar/ Clioquinol, Allantoin/ Coal Tar/ Clioquinol/ Triclosan - Seborrheic Dermatitis, Psoriasis of Scalp | Completed | Laboratorios Silanes S.A. de C.V. | 90 | 2021-11-29 | 2022-04-13 | |
| Pre-surgical Antisepsis of Hands After Washing With Triclosan 0.5% Compared to Propan-1-ol 60% Triclosan 0.5 % Topical Solution, propanolol - Antisepsis | Phase 4 | Completed | Centro Ortopedico y Quirurgico del Pie | 24 | 2020-10-01 | 2020-11-02 |
| Triclosan-antibacterial Sutures Efficacy on the Incidence of Surgical Site Infection in Clean-contaminated Wounds coated vicryl plus, Vicryl - Surgical Site Infection, Surgical Wound | Phase 4 | Unknown | ClinAmygate | 430 | 2020-02-05 | 2023-09-06 |
| Triclosan-antibacterial Sutures Impact on the Incidence of Surgical Site Infection in Laparoscopic Surgeries. Coated Vicryl plus, Coated vicryl - Laparoscopic Surgery, Surgical Wound | Phase 4 | Completed | ClinAmygate | 912 | 2020-02-05 | 2022-05-11 |
| Antibacterial-coated Sutures at Time of Cesarean Vicryl-plus, monocryl-plus, PDS-plus (Triclosan-coated Sutures), Vicryl, monocryl, PDS (not coated with triclosan) - Surgical Site Infection, Surgical Wound Infection | Phase 4 | Terminated | The University of Texas Medical Branch, Galveston | 1169 | 2018-01-09 | 2026-06-22 |
| Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families. Triclosan, Placebo - Generalized Aggressive Periodontitis | Phase 4 | Completed | University of Campinas, Brazil | 40 | 2016-01-30 | 2018-10-02 |
| The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash, stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash, fluoride toothpaste + fluoride Mouthwash - Dental Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 120 | 2014-07-01 | 2015-08-17 |
| Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 179 | 2014-06-01 | 2016-03-30 |
| The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste - Dental Plaque, Gingivitis | Phase 4 | Completed | Colgate Palmolive | 129 | 2014-06-01 | 2016-03-30 |
| Triclosan Toothpaste as a Preventive Strategy of Mucositis in Smokers Placebo toothpaste, triclosan/copolymer/fluoride toothpaste - Dental Implants, Cigarette Smoking | Not applicable | Completed | Paulista University | 26 | 2013-07-01 | 2017-08-07 |
| Impact of a Triclosan-containing Toothpaste During the Progression of Experimental Peri-implant Mucositis Placebo toothpaste, triclosan/copolymer/fluoride toothpaste - Biological Markers; Dental Implants; Cytokines; Triclosan; Toothpastes; Peri-Implantitis; Microbiology | Not applicable | Completed | Paulista University | 22 | 2013-06-01 | 2017-05-09 |
| Efficacy of a Triclosan Formulation to Control the Initial Subgingival Biofilm Formation Test - Using of a suspension containing Triclosan, Control - Using of a suspension without Triclosan - Dental Plaque | Not applicable | Completed | Federal University of Rio Grande do Sul | 28 | 2013-05-01 | 2014-07-16 |
| Study of the Anti-Inflammatory Effects of Colgate Total® During an Experimental Gingivitis Model Toothpaste without triclosan, Triclosan - Gingivitis | Not applicable | Completed | University of Michigan | 32 | 2013-03-01 | 2016-01-13 |
| Residual Effect of Chlorhexidine-alcohol Compared to Triclosan-alcohol Bacterial culture of the prepared skin's areas with two antiseptics and two controls, Preparing skin's areas to be tested with two antiseptics and two controls - Infectious Diseases | Phase 3 | Completed | Universidad de Guanajuato | 135 | 2013-01-01 | 2014-07-02 |
| Effectiveness of Triclosan Coated Sutures in Preventing Leg Wound Infection After Coronary Artery Bypass Surgery Triclosan, Conventional non-coated surgical sutures - Complication of Coronary Artery Bypass Graft, Surgical Wound Infection | Phase 4 | Unknown | Rambam Health Care Campus | 410 | 2011-10-01 | 2011-10-24 |
| Triclosan, Triclocarban, and the Microbiota triclosan/triclocarban-containing personal care products - Triclosan Effects on Microbial Flora | Not applicable | Completed | Stanford University | 20 | 2011-07-01 | 2021-03-17 |
| Clinical Efficacy of the Drug Ster® Compared With Predfort® in Control of Postoperative Inflammation in Cataract Surgery Ster, Pred Fort - Inflammation, Cataract Surgery | Phase 3 | Completed | Azidus Brasil | 106 | 2011-01-01 | 2022-11-02 |
| Triclosan Toothpaste in the Maintenance Phase of Peri-implantitis Treatment. Surgical anti-infective therapy, Periodontal treatment, Oral Hygiene Instruction - Peri-Implantitis, Periodontal Diseases | Phase 3 | Completed | University of Guarulhos | 102 | 2010-06-01 | 2017-06-19 |
| A Study of Different Use Regimens Using Two Acne Treatments benzoyl peroxide wash, Tretinoin gel - Acne Vulgaris | Phase 4 | Completed | Bausch Health Americas, Inc. | 247 | 2009-02-01 | 2012-02-15 |
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Dental Plaque (14) · Gingivitis (8) · Gingival Diseases (6) · Surgical Wound Infection (4) · Periodontal Diseases (3) · Staphylococcal Infections (3) · Inflammation (2) · Peri-Implantitis (2) · Periodontitis (2) · Surgical Wound (2) · Acne Vulgaris (1) · Cataract (1) · Cellulitis (1) · Cigarette Smoking (1) · Communicable Diseases (1)
Colgate Palmolive (29) · ClinAmygate (2) · Paulista University (2) · Ann & Robert H Lurie Children's Hospital of Chicago (1) · Azidus Brasil (1) · Bausch Health Americas, Inc. (1) · Centro Ortopedico y Quirurgico del Pie (1) · Federal University of Rio Grande do Sul (1) · Henry M. Jackson Foundation for the Advancement of Military Medicine (1) · Laboratorios Silanes S.A. de C.V. (1) · Natividad Medical Center (1) · Rambam Health Care Campus (1) · Stanford University (1) · The University of Texas Medical Branch, Galveston (1) · Universidad de Guanajuato (1)
United States (27) · Brazil (5) · Australia (2) · Egypt (2) · Israel (2) · Mexico (2) · Spain (2) · India (1) · Italy (1) · Puerto Rico (1) · Switzerland (1) · Thailand (1) · Yemen (1)
Patricia Corby, DDS (3) · Emad R Issak, Diploma (2) · Gregory Seymour, BDS (2) · Yanfang Ren, DDS (2) · Allen Radner, M.D. (1) · Ana Rossi, MD (1) · Augusto E Boneta, DDS (1) · Augusto Elias, DDS (1) · Benjamin Bush, M.D. (1) · Bernal Stewart (1) · Daniel Fine, DDS (1) · David Paquette, DMD (1) · Denis Kinane, BDS (1) · Gregory Seymour, BDS, PhD (1) · Janet Kinney, MS (1)
PMID 31481559, PMID 10477976, PMID 19711612, PMID 20677537, PMID 20831669, PMID 21269037, PMID 22033452, PMID 24310847, PMID 26018036, PMID 26380335, PMID 26820239, PMID 30328176, PMID 31907625, PMID 34933701, PMID 9442423