43 completed, 2 recruiting, 1 not yet recruiting, 1 terminated. 16 Phase 3, 15 Not applicable, 10 Phase 4, 4 Phase 2, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 16 | Completed 16 |
| Not applicable | 15 | Completed 11, Recruiting 2, Not yet recruiting 1, Unknown 1 |
| Phase 4 | 10 | Completed 10 |
| Phase 2 | 4 | Completed 3, Terminated 1 |
| Early Phase 1 | 1 | Completed 1 |
Follow this drug Literature Review of hydrated silica gel-based toothpaste trials Research Report on hydrated silica gel-based toothpaste
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Assess the Efficacy of an Experimental Mouthwash Used With a Marketed Whitening Toothpaste on Stain Build-up Whitening Toothpaste, Experimental Mouthwash, Regular Fluoride Toothpaste - Tooth Discoloration | Not applicable | Recruiting | HALEON | 360 | 2026-09-25 | 2026-10-07 |
| Evaluation of the Effect of the Toothpaste on Delicate Gums Gingivitis toothpaste, Regular toothpaste - Gingivitis | Not applicable | Recruiting | Lacer S.A. | 60 | 2026-03-24 | 2026-05-14 |
| Evaluation of the Whitening Effect in Subjects After Professional Tooth Cleaning Procedure Whitening toothpaste, Regular toothpaste - Tooth Color | Not applicable | Completed | Lacer S.A. | 56 | 2026-03-03 | 2026-08-26 |
| Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser - Gingivitis, Dental Plaque | Not applicable | Not yet recruiting | Riyadh Elm University | 21 | 2026-02-01 | 2026-01-08 |
| A Clinical Study to Evaluate the Efficacy of a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation Crest Cavity Protection Toothpaste, Experimental Mouthwash - Dental Plaque, Gingivitis | Not applicable | Completed | HALEON | 136 | 2025-04-21 | 2025-09-17 |
| A Clinical Study Assessing the Effects of a Marketed Dentifrice on Tooth Sensitivity While Undergoing Tooth Bleaching Test Dentifrice (Sensodyne Repair and Protect Original Mint), Positive Control Dentifrice (Sensodyne Fresh Mint), Reference Dentifrice (Crest Cavity Protection Regular) - Dentin Sensitivity | Phase 4 | Completed | HALEON | 90 | 2024-10-07 | 2025-12-15 |
| Clinical Study to Evaluate the Anti-sensitivity Efficacy of a Stannous Fluoride Toothpaste in a Population of Dentin Hypersensitivity Sufferers Stannous fluoride toothpaste, Crest cavity protection toothpaste - Dentin Sensitivity | Not applicable | Completed | HALEON | 111 | 2024-03-25 | 2025-06-24 |
| In Situ Comparison of the Remineralization Potential of Optimized Fluoride Dentifrice With Control Fluoride Dentifrice 0 ppm F (placebo, negative control), 1100 ppm F as sodium fluoride (positive control), 1100 ppm F as sodium fluoride Test Product - Caries | Phase 3 | Completed | Indiana University | 52 | 2023-10-02 | 2025-06-15 |
| Fluoride in Saliva After Use of Fluoride Toothpastes Followed by Fluoride Mouthrinses Crest Cavity Protection toothpaste, Crest Cavity Protection toothpaste followed by Act Mint Fluoride Rinse, Colgate PreviDent 5000+ toothpaste - Dental Caries | Early Phase 1 | Completed | University of Michigan | 20 | 2023-03-23 | 2026-03-12 |
| Anti-Inflammatory Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis Capitano zenzero toothpaste, Colgate total toothpaste - Gingivitis | Phase 3 | Completed | University of Baghdad | 80 | 2022-02-12 | 2023-05-22 |
| The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load Distilled Water, 1% Povidone Iodine (PVP-I), 1.5% Hydrogen Peroxide (H2O2) - SARS-CoV-2, COVID-19 | Phase 4 | Completed | King Abdulaziz University | 90 | 2021-01-03 | 2022-07-21 |
| The Effect of Toothpaste Containing Aloe Vera on Gingivitis aloe vera toothpaste, Colgate Total - Generalized Gingivitis | Phase 2 | Completed | Zainab J Abbas | 24 | 2020-03-13 | 2020-12-10 |
| The Influence of Preventive Regimens Containing Different Toothpastes on Caries Risk of High Risk Patients: A Randomized Clinical Trial dual Zinc plus Arginine based toothpaste (Colgate total), Zinc based toothpaste (Crest complete), Fluoride based toothpaste (Signal) - Prevention of Dental Caries | Not applicable | Unknown | Cairo University | 66 | 2019-10-01 | 2019-07-26 |
| Effect of Over-the-counter Toothpastes on Chemotherapy-induced Oral Mucositis Oral Defense Toothpaste, Crest Toothpaste, Magic Mouth Rinse - Mucositis, Neoplasms | Phase 2 | Terminated | Oral Defense, LLC | 1 | 2018-05-29 | 2019-02-06 |
| Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine - Saliva Altered, Oral Hygiene | Not applicable | Completed | Dr Meru S | 30 | 2018-05-28 | 2018-12-06 |
| Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Fruit Juice Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine - Saliva Altered, Oral Hygiene | Not applicable | Completed | Dr Meru S | 30 | 2018-04-25 | 2018-12-06 |
| A Pilot Study to Evaluate a Molecular Method for Plaque stannous fluoride toothpaste, cavity protection toothpaste - Plaque, Gingivitis | Not applicable | Completed | Procter and Gamble | 60 | 2015-08-01 | 2017-10-06 |
| A Pilot Study to Evaluate a Method for Plaque When Comparing Stannous Fluoride Toothpaste to a Regular Dentifrice stannous fluoride toothpaste, cavity protection toothpaste - Plaque, Gingivitis | Not applicable | Completed | Procter and Gamble | 60 | 2015-06-01 | 2017-10-06 |
| Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory Markers Triclosan Containing Toothpaste, Triclosan Free Toothpaste - Periodontal Disease, Systemic Inflammatory Markers | Phase 4 | Completed | Colgate Palmolive | 303 | 2015-06-01 | 2019-02-22 |
| Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars Fluoride Varnish, Control Group - Dental Caries | Phase 4 | Completed | Universidad Iberoamericana | 180 | 2015-03-01 | 2016-11-04 |
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Gingivitis (15) · Dental Plaque (13) · Gingival Diseases (4) · Dentin Sensitivity (3) · Periodontal Diseases (3) · Plaque, Amyloid (3) · Dental Caries (2) · Mucositis (2) · Periodontitis (2) · Tooth Discoloration (2) · Arthritis, Rheumatoid (1) · COVID-19 (1) · Coronavirus Infections (1) · Diabetes Mellitus, Type 2 (1) · Dry Socket (1)
Colgate Palmolive (22) · HALEON (4) · Dr Meru S (2) · Johnson & Johnson Consumer and Personal Products Worldwide (2) · Lacer S.A. (2) · Procter and Gamble (2) · University of Michigan (2) · Assistance Publique - Hôpitaux de Paris (1) · Cairo University (1) · Federal University of Paraíba (1) · Indiana University (1) · King Abdulaziz University (1) · Oral Defense, LLC (1) · Riyadh Elm University (1) · Universidad Iberoamericana (1)
United States (25) · India (3) · Spain (3) · Iraq (2) · Saudi Arabia (2) · Thailand (2) · Canada (1) · Dominican Republic (1) · Egypt (1) · France (1) · Israel (1) · Italy (1) · Puerto Rico (1) · Switzerland (1)
Meru S, MDS (2) · Michael Lynch, DMD, PhD (2) · Anderson Hara, DDS, PhD (1) · Arvind Chaudhry, MD,PhD (1) · Augusto E Boneta, DDS (1) · Daniel Fine, DDS (1) · David Paquette, DMD (1) · Domenick Zero, DDS, MS (1) · Dr. Faisal A Althobaiti, BDS (1) · Dr. Nancy M Ajwa, MSc (1) · Frank Lippert, PhD (1) · Gregory Seymour, BDS, PhD (1) · Janet Kinney, MS (1) · Jonathan Mann, MSc (1) · Joseph J Zambon, DDS (1)
PMID 11225528, PMID 11505791, PMID 16490989, PMID 17099299, PMID 20354090, PMID 23017003, PMID 23433693, PMID 23929644, PMID 26087570, PMID 26820239, PMID 29633177, PMID 30639191, PMID 31761015, PMID 32047895, PMID 32159775, PMID 32326426, PMID 32425001, PMID 32505069, PMID 32859459, PMID 33215159, PMID 41553854