142 completed, 21 unknown, 11 terminated, 10 recruiting. 68 Not applicable, 45 Phase 4, 40 Phase 3, 30 Phase 2, 14 Phase 1.
Follow chlorhexidine gluconate: new trials by email Literature Review of chlorhexidine gluconate trials Research Report on chlorhexidine gluconate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO) 2% intranasal mupirocin ointment, 4% chlorhexidine gluconate body cleanser - Sarcoma,Soft Tissue | Phase 2 | Not yet recruiting | Adam Olson | 31 | 2026-09-30 | 2026-02-09 |
| A Comparative Study of the Antibacterial Effects of Two Preoperative Hair Removal Methods in Male Patients With Urethral Stricture Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG). - Urethral Stricture | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 40 | 2026-04-01 | 2026-04-02 |
| Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-Growth Resveratrol-Based Mouthwash, Chlorhexidine Gluconate 0.12 % Mouthwash, Placebo mouthwash - Mouthwash, Chlorhexidine | Phase 3 | Not yet recruiting | University of Baghdad | 20 | 2026-03-01 | 2026-02-06 |
| Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental Implants Laser Photodynamic Therapy (PDT), GalvoSurge Electrolytic Cleaning, 0.2% Chlorhexidine Gluconate - Periimplant Diseases, Dental Implant Failure | Not applicable | Recruiting | University of Zagreb | 90 | 2026-03-01 | 2026-10-02 |
| The Impact of Irrisept in Reducing Urinary Tract Infection During Urethral Catheter Removal. 0.05% Chlorhexidine Gluconate, Normal Saline - Urinary Tract Infection, Antibiotic | Not applicable | Recruiting | Ohio State University | 300 | 2026-01-01 | 2026-07-31 |
| Ulcer Plants: Highly Accessible Plant Antiseptics for Use in Remote Areas of PNG - Second Trial Ficus septica exudate, Active Comparator: Savlon antiseptic cream (cetrimide with chlorhexidine digluconate) - Cutaneous Ulcer Disease, Skin Sores | Phase 2 | Active not recruiting | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 222 | 2025-11-03 | 2026-07-16 |
| The Effect of Different Types of Mouthwash on Extraction Sockets' Healing Chlorhexidine Gluconate, Bone Bioactive Liquid, Hyaluronic Acid mouthwash - Extraction Socket Healing, Quality of Life | Phase 4 | Recruiting | University of Jordan | 100 | 2025-08-10 | 2026-05-07 |
| Comparison of Frequency of Calcium Hydroxide Mixed With 0.2% Chlorhexidine Versus Saline as Intracanal Medicament in Periapical Periodontitis-A Randomized Controlled Trial Calcium Hydroxide + Normal Saline, Calcium Hydroxide + 0.2% Chlorhexidine Digluconate - Periapical Periodontitis | Not applicable | Active not recruiting | Aqsa Afzal | 80 | 2025-07-15 | 2025-11-26 |
| Topical Chlorhexidine and Metronidazole Gels for Gingival Inflammation Chlorhexidine Gluconate Gel 1%, Chlorhexidine Gluconate 0.5% + Metronidazole 1.5% Gel, Placebo Gel - Plaque Induced Gingivitis | Not applicable | Completed | H.P. Government Dental College and Hospital Shimla | 120 | 2025-05-16 | 2026-08-21 |
| Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar Extraction Chlorhexidine Gluconate 0.12% Mouthwash, Tea Tree Oil mouthwash - Postoperative Pain, Postoperative Complications | Not applicable | Recruiting | Harran University | 54 | 2025-04-15 | 2025-09-18 |
| Essential Oil Mouthwash - Oral Hygiene Essential oil mouthwash, Chlorhexidine gluconate alcohol-free mouthwash, Povidone-iodine alcohol-free mouthwash - Oral Hygiene, Oral Health, Dental Plaque | Not applicable | Completed | China Medical University, Taiwan | 150 | 2025-04-12 | 2026-10-21 |
| Development and Evaluation of a ChlorHexidine Gluconate bAthing pRotocol for Healthcare Settings in Low- and Middle-income Countries Chlorhexidine Gluconate (CHG) - Multidrug Resistant Bacterial Infection | Not applicable | Terminated | University of Pennsylvania | 19 | 2025-02-19 | 2025-07-03 |
| The Effect of an Suction Toothbrush on the Development of Ventilator-Associated Pneumonia Suction tootbrush and distiled water, suction tootbrush and .12% chlorhexidine gluconate, Oral care sponge and with 15 ml of 0.12% chlorhexidine gluconate oral solution - Infection, Intensive Care (ICU) | Not applicable | Completed | Koç University | 111 | 2025-02-01 | 2026-04-23 |
| Ulcer Plants: Highly Accessible Plant Antiseptics for Use in Remote Areas of PNG Ficus septica exudate (antiseptic plant exudates), Pterocarpus indicus exudate, Curcuma longa aqueous extract - Cutaneous Ulcer Disease, Skin Sores | Phase 2 | Completed | Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia | 370 | 2024-10-04 | 2024-11-29 |
| A Stratified, Multi-ARm, muLti-site Randomised Platform Trial Aiming to Reduce the INcidence of Post-operative SSI Chlorhexidine Gluconate 2.0% to 4.0% (e.g. Hibiscrub) preoperative shower, Intraoperative wound wash (e.g. Granudacyn), DACC surgical wound dressing (e.g. Leukomed Sorbact) - Surgical Site Infection | Not applicable | Unknown | University of Birmingham | 10092 | 2024-09-01 | 2024-06-20 |
| Optimizing Infection Prophylaxis Prior to Shoulder Surgery Chlorhexidine Gluconate - Arthroplasty Shoulder, Periprosthetic Joint Infection | Not applicable | Recruiting | University of Washington | 40 | 2024-08-31 | 2024-12-05 |
| The Effect of Number of Showers With 4% Chlorhexidine Gluconate on Prevention of Surgical Site Infections 1 shower with 4% chlorhexidine gluconate, 2 shower with 4% chlorhexidine gluconate - Surgical Site Infections, Lumbar Disc Herniation | Not applicable | Active not recruiting | Çanakkale Onsekiz Mart University | 86 | 2024-07-01 | 2025-09-17 |
| Infection Prophylaxis in Total Joint Replacement Chlorhexidine Gluconate, Vancomycin Hydrochloride, Povidone-Iodine - Periprosthetic Joint Infection | Phase 3 | Recruiting | Hamilton Health Sciences Corporation | 21006 | 2024-05-07 | 2026-05-22 |
| Investigating the Effect of Chlorine Dioxide and Chlorhexidine Mouthwash on Bad Breath Chlorine dioxide mouthwash, Chlorhexidine mouthwash - Halitosis | Not applicable | Enrolling by invitation | Semmelweis University | 60 | 2024-04-18 | 2025-08-05 |
| Staph Intervention for Effective Local Defense Mupirocin + Nozin + chlorhexidine gluconate, Education + Household supplies - Staphylococcus Aureus Infection | Phase 4 | Completed | Johns Hopkins Bloomberg School of Public Health | 78 | 2024-04-01 | 2026-06-12 |
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Surgical Wound Infection (24) · Infections (12) · Staphylococcal Infections (10) · Dental Caries (7) · Dental Plaque (7) · Gingivitis (7) · Cross Infection (6) · Pneumonia, Ventilator-Associated (6) · Staphylococcal Skin Infections (5) · COVID-19 (4) · Periodontitis (4) · Abscess (3) · Communicable Diseases (3) · Mucositis (3) · Periodontal Diseases (3)
Medline Industries (8) · Zurex Pharma, Inc. (7) · Solventum US LLC (6) · Cairo University (5) · C. R. Bard (4) · Colgate Palmolive (4) · Johns Hopkins University (3) · King Abdulaziz University (3) · Molnlycke Health Care AB (3) · Universidad de Guanajuato (3) · University of California, San Francisco (3) · Washington University School of Medicine (3) · Augusta University (2) · Boston University (2) · Columbia University (2)
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Bruno CV Gurgel, Doctor (2) · Daryl S Paulsen, PhD (2) · David A Kaufman, MD (2) · Davidson H Hamer, MD (2) · Esther Campbell (2) · M. Hamid Bashir, MD (2) · Ronaldo B Santana, DDS,MScD,DSc (2) · Rozalia Olsavszky, MD (2) · Aaron Milstone, MD, MHS (1) · Adam M Olson, MD (1) · Afnan M Saber, MSc (1) · Ahmad Hamdan, Ph.D. in Periodontics (1) · Ahmed Yousif (1) · Alejandro E Macias, M. D. (1) · Alejandro Mira, PhD (1)
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R01CA163394 (1), R21DE020916 (1), S06GM142120 (1), U10CA095861 (1), UG1CA189955 (1), UG1EY028518 (1)