272 completed, 29 recruiting, 24 terminated, 20 withdrawn. 169 Not applicable, 72 Phase 2, 42 Phase 4, 36 Phase 1, 28 Phase 3.
Follow Nicotine Dependence: new trials by email Literature Review of Nicotine Dependence trials Research Report on Nicotine Dependence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Very Low Nicotine Content Cigarettes Among Adults Who Smoke Daily in South Korea SPECTRUM cigarettes - Cigarette Smoking, Nicotine Dependence | Not applicable | Not yet recruiting | Sung-il Cho | 300 | 2027-01-01 | 2026-08-10 |
| Effects of Psilocybin on Craving in Nicotine Dependence Psilocybin (drug) - Nicotine Dependence | Phase 2 | Not yet recruiting | University of British Columbia | 3 | 2027-01-01 | 2026-10-01 |
| Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information - Smoking Cessation, Cigarette Smoking | Not applicable | Not yet recruiting | University of Minnesota | 30 | 2026-11-10 | 2026-10-13 |
| Prevalence and Association of Dysfunctional Breathing With Nicotine Dependence and Physical Activity Among Young Smokers Observational evaluation. - Dysfunctional Breathing, Physical Activity | Not yet recruiting | Istinye University | 420 | 2026-09-30 | 2026-09-28 | |
| Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid QuitAid (pharmacist-delivered MTM), Nicotine Replacement Therapy (NRT) - Tobacco Use Cessation, Tobacco Use Disorder | Not applicable | Not yet recruiting | University of Virginia | 120 | 2026-09-01 | 2026-07-10 |
| Sex Differences in E-Cigarette Perception Nicotine Level 1 (0mg/ml), Nicotine Level 2 (36mg/ml), Nicotine Level 3 (59mg/ml) - Nicotine Dependence, E-cigarette Use | Not applicable | Recruiting | Yale University | 60 | 2026-07-30 | 2026-09-02 |
| Puff Topography and Sensory Effects Across IQOS Device Generations IQOS Iluma i with TEREA Tobacco Sticks, IQOS 2.4 with HEETS Tobacco Sticks - Nicotine Dependence, Tobacco Use | Not applicable | Recruiting | American University of Beirut Medical Center | 50 | 2026-07-27 | 2026-07-30 |
| Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - Nicotine Dependence, Transcranial Magnetic Stimulation | Phase 4 | Recruiting | Massachusetts General Hospital | 30 | 2026-07-02 | 2026-09-15 |
| A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users Smartphone app, Text Message, Survey Administration - Nicotine Dependence, Tobacco-Related Carcinoma | Not applicable | Recruiting | Fred Hutchinson Cancer Center | 1178 | 2026-05-20 | 2026-09-08 |
| Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use Oral Nicotine Pouch, Smoking Cue Reactivity Task - Nicotine Dependence | Not applicable | Recruiting | University of Southern California | 45 | 2026-04-30 | 2026-07-13 |
| Smart Olfaction App to Reduce Relapse Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition - Nicotine Dependence | Early Phase 1 | Recruiting | University of Houston | 132 | 2026-04-22 | 2026-07-08 |
| Social Media Support Groups for Adolescent Vaping Cessation Social Media Intervention - Vaping, Vaping Cessation | Not applicable | Recruiting | University of California, San Francisco | 60 | 2026-04-15 | 2026-07-17 |
| Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients Auricular acupressure, Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge), Sham Auricular Acupressure - Nicotine Dependence, Nicotine Withdrawal | Not applicable | Recruiting | Chiao-Chiao Liao | 60 | 2026-03-23 | 2026-04-13 |
| Understanding How Cigarette Direct Mail Marketing Influences Smoking Behaviors Among High and Low Socioeconomic Status Young Adult Smokers Exposure to smoking advertising with coupon, Exposure to smoking advertising without coupons, Exposure to non health related images - Nicotine Dependence | Not applicable | Withdrawn | National Institute on Minority Health and Health Disparities (NIMHD) | 2026-03-17 | 2026-03-18 | |
| Effect of Perioperative High-dose Transdermal Nicotine Patch on Pain Sensitivity Among Male Abstinent Tobacco Smokers Undergoing Thoracic Surgery: A Randomized Controlled Pilot Study Nicotine patch - Nicotine Dependence, Thoracic Diseases | Not applicable | Recruiting | Henan Provincial People's Hospital | 80 | 2025-11-30 | 2026-01-22 |
| TUBSIS 2.0 - Tobacco Use Behavioral Support and Intervention System TUBSIS 2.0 - Tobacco Use Disorder, Nicotine Dependence | Not applicable | Recruiting | University of Zurich | 406 | 2025-11-15 | 2026-05-05 |
| A Trial of Varenicline for E-cigarette Cessation Varenicline 1mg BID, Placebo - E-cigarette Use, Vaping | Phase 2 | Recruiting | Yale University | 326 | 2025-10-14 | 2025-12-17 |
| Effects of Cannabidiol on Stress and Nicotine Withdrawal Epidiolex - CBD, Stress | Phase 1 | Recruiting | Johns Hopkins University | 90 | 2025-08-25 | 2026-08-10 |
| Behavioral Intervention for Youth to Promote Vaping Cessation QuitVaping, This is Quitting (TIQ) - Vaping, Vaping Teens | Not applicable | Recruiting | Massachusetts General Hospital | 400 | 2025-06-18 | 2026-07-07 |
| Family and Peer Influences on Nicotine Dependence in Medical Students of South Punjab Nicotine Dependence, Tobacco Use Disorder | Completed | Nishtar Medical University | 366 | 2025-05-13 | 2025-08-14 |
Showing 20 of 378. Sign in to see all of them.
Tobacco Use Disorder (378) · Smoking (116) · Smoking Cessation (112) · Cigarette Smoking (52) · Vaping (40) · Tobacco Use (27) · Substance-Related Disorders (20) · Tobacco Smoking (20) · Behavior, Addictive (11) · Schizophrenia (11) · Tobacco Use Cessation (9) · Alcoholism (8) · Depression (7) · Marijuana Abuse (7) · Mental Disorders (6)
Chemically-Induced Disorders (378) · Mental Disorders (372) · Substance-Related Disorders (358) · Behavior (249) · Health Behavior (116) · Smoking (76) · Tobacco Use (55) · Tobacco Smoking (48) · Pathological Conditions, Signs and Symptoms (12) · Schizophrenia Spectrum and Other Psychotic Disorders (12) · Compulsive Behavior (11) · Impulsive Behavior (10) · Alcohol-Related Disorders (8) · Behavioral Symptoms (8) · Nervous System Diseases (8)
Nicotine (50) · Tobacco Use Cessation Devices (48) · Varenicline (47) · Bupropion (18) · Nicotine Replacement Therapy (15) · Electronic Nicotine Delivery Systems (13) · Behavior Therapy (9) · Counseling (8) · Exercise (8) · Nicotine Chewing Gum (8) · Sugars (8) · Tobacco Products (8) · Transcranial Magnetic Stimulation (8) · Cognitive Behavioral Therapy (7) · Motivational Interviewing (7)
Yale University (35) · National Institute on Drug Abuse (NIDA) (27) · Medical University of South Carolina (20) · University of Wisconsin, Madison (20) · Centre for Addiction and Mental Health (18) · Duke University (18) · University of Pennsylvania (16) · University of California, San Francisco (14) · Massachusetts General Hospital (13) · Mclean Hospital (12) · University of Minnesota (8) · Mayo Clinic (7) · Brown University (5) · Johns Hopkins University (5) · UConn Health (5)
United States (314) · Canada (19) · France (5) · Lebanon (3) · Switzerland (3) · Turkey (Türkiye) (3) · Indonesia (2) · Israel (2) · New Zealand (2) · Poland (2) · South Korea (2) · Austria (1) · Brazil (1) · China (1) · Cyprus (1)
Elliot Stein, Ph.D. (8) · James M Davis, MD (6) · Jed E Rose, Ph.D. (6) · Mehmet Sofuoglu, M.D.,Ph.D. (5) · Bernard Le Foll, MD, PhD (4) · Caryn Lerman, PhD (4) · Laurie Zawertailo, PhD (4) · Lisa Fucito, PhD (4) · Nancy K Mello, PhD (4) · Robert A Schnoll, PhD (4) · F. Joseph McClernon, Ph.D. (3) · Gideon St. Helen, PhD (3) · Megan E Piper, PhD (3) · Neal Benowitz, MD (3) · Stephen J Heishman, Ph.D. (3)
PMID 37142273, PMID 37230961, PMID 37335995, PMID 34611902, PMID 35420700, PMID 39868569, PMID 39101506, PMID 11420814, PMID 12745503, PMID 16499517, PMID 17141485, PMID 17587504, PMID 17984409, PMID 18842256, PMID 19204579, PMID 19648219, PMID 19733449, PMID 20056957, PMID 20124230, PMID 20207347, PMID 20236788, PMID 20395358, PMID 20542391, PMID 20590478, PMID 20716302, PMID 20934835, PMID 21221531, PMID 21471305, PMID 21504885, PMID 21652735, PMID 21723049, PMID 21762878, PMID 21846661, PMID 21885891, PMID 21989407, PMID 22007015, PMID 22119451, PMID 22154236, PMID 22172440, PMID 22209026, PMID 22352784, PMID 22370063, PMID 22496918, PMID 22540436, PMID 22695488, PMID 22713093, PMID 22766487, PMID 23117126, PMID 23265088, PMID 23422399
P50DA027840 (9), P50AA015632 (4), P50CA143188 (4), U54DA036151 (4), 271201400069C-0-0-1 (2), K01DA019446 (2), K23DA022471 (2), P50DA009241 (2), P50DA019706 (2), P50DA036151 (2), R01DA036486 (2), R01DA052583 (2), U01DA019378 (2), U01DA045519 (2), U54HL147127 (2)