183 completed, 54 unknown, 27 recruiting, 27 terminated. 309 Phase 3, 49 Phase 2.
Follow Myocardial Infarction: new trials by email Literature Review of Myocardial Infarction trials Research Report on Myocardial Infarction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cilostazol for Prevention of Recurrent Stroke Trial Cilostazol 100 mg Tablets, Placebo - Stroke Recurrence, Myocardial Infarction | Phase 3 | Not yet recruiting | Stanford University | 2000 | 2026-10-01 | 2026-10-26 |
| Randomized Evaluation of Istaroxime for Stabilization in Acute Heart Failure-Cardiogenic Shock istaroxime, placebo - Cardiogenic Shock | Phase 2 / Phase 3 | Recruiting | Seismic Pharmaceuticals Operations LLC | 600 | 2026-09-09 | 2026-09-23 |
| Lp(a) Lowering Study of Pelacarsen (TQJ230) in Patients in the US With Elevated Lp(a) and Recent ACS (STEMI/NSTEMI) - Lp(a)FRONTIERS PEARL Pelacarsen, Placebo - Acute Coronary Syndrome (ACS) | Phase 3 | Withdrawn | Novartis Pharmaceuticals | 2026-09-01 | 2026-10-14 | |
| Comparative Evaluation of Sustained meChanical AsPiration Thrombectomy and no Thrombus Modification for Pre-stent Thrombus bUrden Reduction in Patients With Acute Myocardial Infarction Study: the CAPTURE AMI Study Sustained thrombectomy, Percutaneous Coronary Intervention - STEMI - ST Elevation Myocardial Infarction | Phase 2 / Phase 3 | Recruiting | Oxford University Hospitals NHS Trust | 60 | 2026-07-08 | 2026-07-10 |
| Use of the Methoxyflurane as Pain-killer in the Prehospital Management of Acute Myocardial Infarction Methoxyflurane, Morphine - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 700 | 2026-06-01 | 2026-03-03 |
| An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230) Pelacarsen (TQJ230) - Cardiovascular Disease and Lipoprotein(a) | Phase 3 | Active not recruiting | Novartis Pharmaceuticals | 5700 | 2026-05-11 | 2026-10-14 |
| Prehospital Pulse-dose Glucocorticoid in Patients With ST-segment Elevation Myocardial Infarction 2 - The PULSE-MI 2 Trial Methylprednisolone 250 mg, NaCl (0,9%) - STEMI - ST Elevation Myocardial Infarction | Phase 3 | Recruiting | Thomas Engstrom | 5204 | 2026-04-20 | 2026-04-23 |
| Ivabradine in the Acute Management of Cardiogenic Shock Ivabradine 5mg Tab, Placebo Oral Tablet - Cardiogenic Shock Post Myocardial Infarction | Phase 3 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 200 | 2026-04-20 | 2026-07-20 |
| Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone Ticagrelor + placebo, Ticagrelor + aspirin - NSTEMI - Non-ST Segment Elevation MI, STEMI (ST Elevation MI) | Phase 3 | Recruiting | Montreal Heart Institute | 2570 | 2026-03-03 | 2026-03-10 |
| Aspirin Continuation or Interruption in Patients at Moderate Risk for Cardiovascular Events Undergoing Colonoscopy and/or Polypectomy Aspirin 80mg, Placebo Oral Tablet - Myocardial Infarction (MI), Cardiovascular Events | Phase 3 | Recruiting | Chinese University of Hong Kong | 2514 | 2026-02-10 | 2026-03-18 |
| Efficacy of Montelukast on STEMl Patients Montelukast, Placebo - Myocardial Infarction (MI) | Phase 3 | Recruiting | Shanghai Zhongshan Hospital | 512 | 2026-02-01 | 2026-01-13 |
| Inhibition of Late Sodium Current (INa) to Prevent Coronary MICROvascular Dysfunction in Patients Presenting With ST-Elevation Myocardial Infarction and Multivessel Disease: INaMICRON Study Ranolazine - STEMI (ST Elevation MI) | Phase 2 / Phase 3 | Recruiting | Federico II University | 100 | 2026-02-01 | 2026-03-11 |
| Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial) Dapagliflozin 10 MG Oral Tablet, Semaglutide (Rybelsus®) - Acute Myocardial Infarction With ST Elevation | Phase 3 | Recruiting | Instituto Mexicano del Seguro Social | 44 | 2025-12-30 | 2026-01-05 |
| Epicardial Cardiac Fat-CT (EPIC-CT) Dapagliflozin 10 MG Oral Tablet, Semaglutide (Rybelsus®) - STEMI - ST Elevation Myocardial Infarction, Epicardial Fat | Phase 3 | Recruiting | Instituto Mexicano del Seguro Social | 136 | 2025-12-30 | 2026-01-02 |
| A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, in People With a Heart Attack Ziltivekimab, Ziltivekimab Placebo - Myocardial Infarction | Phase 3 | Recruiting | Novo Nordisk A/S | 332 | 2025-12-18 | 2026-03-11 |
| DCB vs. DES in Young STEMI Patients: The DCB-STEMI Trial Drug coated balloon (Prevail; Medtronic Inc.), Drug eluting stent - STEMI (ST Elevation MI) | Phase 3 | Recruiting | National Institute of Cardiovascular Diseases, Pakistan | 496 | 2025-11-05 | 2025-11-14 |
| Evaluation of Efficacy and Safety of Early in Hospital Initiation of Inclisiran Treatment in Patients With Acute Coronary Syndromes Placebo, Inclisiran - Acute Coronary Syndrome | Phase 3 | Recruiting | Novartis Pharmaceuticals | 300 | 2025-10-03 | 2026-09-16 |
| Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation Inahled Isoflurane, Propofol, midazolam - Cardiogenic Shock, ECMO | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2025-09-15 | 2025-08-01 |
| OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events Olpasiran, Placebo - Cardiovascular Disease | Phase 3 | Recruiting | Amgen | 11000 | 2025-08-22 | 2026-08-21 |
| The Impact of Fexofenadine Hydrochloride on the Prognosis of Patients Post-Acute Myocardial Infarction Fexofenadine 60 Mg Oral Tablet, Placebo - Zhejiang University | Phase 3 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2804 | 2025-01-27 | 2026-08-07 |
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ST Elevation Myocardial Infarction (94) · Cardiovascular Diseases (58) · Acute Coronary Syndrome (42) · Heart Diseases (41) · Myocardial Ischemia (39) · Stroke (34) · Heart Failure (31) · Coronary Disease (28) · Angina, Unstable (26) · Non-ST Elevated Myocardial Infarction (23) · Coronary Artery Disease (22) · Shock, Cardiogenic (15) · Atherosclerosis (13) · Diabetes Mellitus (11)
Pathologic Processes (309) · Pathological Conditions, Signs and Symptoms (309) · Necrosis (308) · Infarction (307) · Vascular Diseases (307) · Ischemia (303) · Myocardial Ischemia (270) · Heart Diseases (268) · Cardiovascular Diseases (251) · Signs and Symptoms (47) · Central Nervous System Diseases (40) · Nervous System Diseases (40) · Brain Diseases (39) · Neurologic Manifestations (39)
Clopidogrel (18) · Aspirin (17) · Ticagrelor (16) · dapagliflozin (11) · Prasugrel Hydrochloride (9) · Enoxaparin (8) · Colchicine (7) · Heparin (7) · Rivaroxaban (7) · Standard of Care (7) · Tissue Plasminogen Activator (7) · Tenecteplase (6) · bivalirudin (6) · Atorvastatin (5) · Percutaneous Coronary Intervention (5)
National Heart, Lung, and Blood Institute (NHLBI) (20) · Assistance Publique - Hôpitaux de Paris (11) · Novartis Pharmaceuticals (8) · Boehringer Ingelheim (6) · The Medicines Company (5) · Collegium Medicum w Bydgoszczy (4) · GlaxoSmithKline (4) · Merck Sharp & Dohme LLC (4) · National Institute of Cardiovascular Diseases, Pakistan (4) · Population Health Research Institute (4) · Sanofi (4) · AstraZeneca (3) · Brigham and Women's Hospital (3) · Gennaro Sardella (3) · Karolinska Institutet (3)
United States (75) · France (57) · Canada (55) · Germany (46) · Italy (40) · Spain (37) · Poland (36) · United Kingdom (34) · Netherlands (31) · China (29) · Australia (28) · Belgium (28) · Brazil (28) · Sweden (28) · Hungary (27)
Ali Eskandari, MD (2) · Allan Barker (2) · David Richardson (2) · Deepak L. Bhatt, MD (2) · Eugene Braunwald (2) · Gary Wilner (2) · Hamid Gourabi, PhD (2) · Hossein Baharvand, PhD (2) · Hossein Vakili, M.D. (2) · J. McNamara (2) · James Schoenberger (2) · James Willerson (2)
PMID 35224730, PMID 34932836, PMID 41114449, PMID 20189026, PMID 23174632, PMID 24561145, PMID 25572507, PMID 26089177, PMID 26198286, PMID 27160944, PMID 27165710, PMID 27287251, PMID 28304242, PMID 29685591, PMID 29716940, PMID 29910052, PMID 31733140, PMID 35277540, PMID 36302586, PMID 10811917, PMID 11239408, PMID 11786451, PMID 12324494, PMID 12460865, PMID 12507972, PMID 14578255, PMID 14699020, PMID 15007111, PMID 15077099, PMID 15238590, PMID 15321804, PMID 15480537, PMID 15498829, PMID 15534844, PMID 15861319, PMID 15910853, PMID 16168297, PMID 16183441, PMID 16304073, PMID 16337036, PMID 16537663, PMID 16537665, PMID 16537725, PMID 16543037, PMID 16613998, PMID 16644654, PMID 16651474, PMID 16750696, PMID 16757723, PMID 16801465
2019 (5), 2025 (4), 2009 (3), 2005 (2), 2018 (2), 1RC2HL101458-01 (1), 1UG3NS133209-01A1 (1), 2015 (1), 2016 (1), 2017 (1), 2023 (1), M01RR000048 (1), M01RR000645 (1), M01RR007122 (1), P20RR011104 (1)