1642 completed, 539 unknown, 291 recruiting, 166 terminated. 1020 Not applicable, 319 Phase 2, 264 Phase 4, 239 Phase 3, 180 Phase 1.
Follow Atherosclerosis: new trials by email Literature Review of Atherosclerosis trials Research Report on Atherosclerosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease FGF-1, Placebo - Peripheral Arterial Disease, Stenosis | Phase 1 / Phase 2 | Not yet recruiting | Venturis Therapeutics, Inc. | 24 | 2028-10-15 | 2026-08-19 |
| Vitamin B6 on Exercise Pressor Reflex on Leg Ischemia-reperfusion Vitamin B6 25 MG, Vitamin B6 50 MG, Vitamin B6 100 MG - Ischemia Reperfusion Injury, Peripheral Artery Disease | Early Phase 1 | Not yet recruiting | Milton S. Hershey Medical Center | 30 | 2027-12-01 | 2026-03-17 |
| PAtient Similarity for Decision-Making in Prevention of Cardiovascular Toxicity (PACT): A Feasibility Study Clinical Decision Aid, Standard Care - Heart Failure, Coronary Artery Disease | Not yet recruiting | Medical College of Wisconsin | 60 | 2027-12-01 | 2026-11-03 | |
| Study to Image Inflammatory Activity of a Fluorescence Imaging Agent in Excised Human Artery Plaques Pegulicianine, Placebo - Carotid Artery Diseases, Peripheral Arterial Disease | Early Phase 1 | Not yet recruiting | Massachusetts General Hospital | 25 | 2027-06-01 | 2026-11-10 |
| PCSK9 Inhibitors in Hyperlipidemia and Atherosclerosis Hyperlipidemia, Atherosclerotic Cardiovascular Disease (ASCVD) | Not yet recruiting | Fundación Santa Fe de Bogota | 100 | 2027-02-01 | 2026-10-02 | |
| Target-Oriented Strategy of Ultra-Low LDL-C (<1.0 vs. 1.0-1.39 mmol/L) in Extreme-High-Risk ASCVD Patients: Clinical Benefit, Safety and Cost-Effectiveness Assessment Lipid-lowering therapy targeting LDL-C <1.0 mmol/L, Lipid-lowering therapy targeting LDL-C 1.0-1.39 mmol/L - Atherosclerotic Cardiovascular Disease (ASCVD) | Not applicable | Not yet recruiting | Beijing Anzhen Hospital | 6000 | 2027-01-01 | 2026-05-29 |
| wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65 Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care - Cardiovascular Diseases (CVD), Coronary Artery Disease | Not applicable | Not yet recruiting | Women's Heart Austria | 800 | 2027-01-01 | 2026-09-30 |
| EHR Nudges: Optimizing a Clinical Decision Support System for Evidence-Based Statin Medication Prescribing to Reduce the Risk of Cardiovascular Disease EHR Nudge - Atherosclerotic Cardiovascular Disease | Not applicable | Not yet recruiting | NYU Langone Health | 7501 | 2027-01-01 | 2026-11-04 |
| Daily Stretching to Improve Walking in Older Patients With Peripheral Artery Disease: The STRETCH PAD Study Therapeutic calf stretching, Sham calf stretching - Peripheral Artery Disease (PAD), Intermittent Claudication | Not applicable | Not yet recruiting | Penn State University | 300 | 2027-01-01 | 2026-11-05 |
| Drug-coated Balloons Versus Drug-eluting Stents for the Treatment of Femoropopliteal In-Stent Restenosis Drug-Coated Balloon-First Strategy, Eluvia Drug-Eluting Stent-First Strategy - Femoropopliteal In-Stent Restenosis (ISR) | Not yet recruiting | Chunshui He | 600 | 2027-01-01 | 2026-11-02 | |
| FRAME, External Support for Lower Limb Autologous Grafts FRAME - Peripheral Arterial Disease, Peripheral Artery Disease | Not applicable | Suspended | Vascular Graft Solutions Ltd. | 30 | 2026-12-31 | 2025-02-04 |
| Qatar Cardiometabolic Cohort Cardiometabolic Diseases | Not yet recruiting | Weill Cornell Medical College in Qatar | 3000 | 2026-12-01 | 2026-10-26 | |
| Spectroscopic Assessment of Tissue Oxygenation Changes During Vascular Surgery Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia | Not yet recruiting | Spectrocor | 30 | 2026-12-01 | 2026-08-26 | |
| DCB Outcomes After Non-Compliant Balloon Vessel Preparation With or Without Scoring in Patients With Femoropopliteal Arterial Disease Non-compliant Plain Balloon angioplasty (PBA), Non-compliant Scoring Balloon Angioplasty (SB) - Femoropopliteal Disease, Drug Coated Balloon | Not applicable | Not yet recruiting | Marc Sirvent | 142 | 2026-12-01 | 2026-10-07 |
| The NICE-PAD II Trial Nicotinamide Riboside (NR), Placebo - Peripheral Artery Disease (PAD) | Phase 3 | Not yet recruiting | Northwestern University | 250 | 2026-12-01 | 2026-08-24 |
| XPAD European Feasibility Study XPAD conduit - Peripheral Arterial Disease | Not applicable | Not yet recruiting | Xeltis | 15 | 2026-12-01 | 2026-07-21 |
| IV-X Medical Peripheral Intravascular Lithotripsy Study for PAD IV-X Medical IVL System - Peripheral Artery Disease (PAD) | Not applicable | Not yet recruiting | IVX Medical | 140 | 2026-12-01 | 2026-10-21 |
| Hs-CRP-Guided Colchicine Treatment Targets in Very-High-Risk Patients With Coronary Artery Disease After PCI (TARGET-CHD) Colchicine (Colcrys®) - Coronary Artery Disease, Atherosclerotic Cardiovascular Disease (ASCVD) | Not applicable | Not yet recruiting | Sir Run Run Shaw Hospital | 1768 | 2026-12-01 | 2026-11-05 |
| PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With 64Cu-NODAGA-CANF (Multisite) 64Cu-NODAGA-CANF, Optimal Medical Therapy (OMT), Carotid Endarterectomy (CEA) surgery - Carotid Atherosclerosis, Carotid Artery Stenosis Asymptomatic | Not yet recruiting | Washington University School of Medicine | 30 | 2026-11-18 | 2026-11-12 | |
| Perioperative Limb Oxygenation Monitoring in Patients With CLTI Near-infrared spectroscopy (NIRS, Medtronic, INVOS) tissue oxygenation monitoring - Chronic Limb Threatening Ischemia, CLTI | Not applicable | Recruiting | Belarusian State Medical University | 120 | 2026-11-02 | 2026-11-12 |
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Peripheral Arterial Disease (1362) · Cardiovascular Diseases (416) · Chronic Limb-Threatening Ischemia (354) · Coronary Artery Disease (317) · Intermittent Claudication (222) · Peripheral Vascular Diseases (203) · Diabetes Mellitus (161) · Heart Diseases (142) · Inflammation (136) · Coronary Disease (133) · Stroke (112) · Myocardial Infarction (107) · Diabetes Mellitus, Type 2 (101) · Hypertension (94)
Arteriosclerosis (2932) · Arterial Occlusive Diseases (2901) · Vascular Diseases (2881) · Cardiovascular Diseases (2553) · Peripheral Vascular Diseases (1405) · Pathological Conditions, Signs and Symptoms (1083) · Pathologic Processes (752) · Nutritional and Metabolic Diseases (491) · Heart Diseases (480) · Myocardial Ischemia (477) · Ischemia (451) · Metabolic Diseases (451) · Disease Attributes (434) · Chronic Disease (412)
Aspirin (66) · Atorvastatin (47) · Clopidogrel (47) · Exercise (47) · Angioplasty (40) · Ezetimibe (37) · Rosuvastatin Calcium (37) · Simvastatin (35) · Standard of Care (23) · Stents (23) · ALN-PCS (21) · Cilostazol (21) · Rivaroxaban (20) · darapladib (20) · Colchicine (18)
National Heart, Lung, and Blood Institute (NHLBI) (96) · GlaxoSmithKline (32) · Northwestern University (28) · University Hospital, Angers (28) · Boston Scientific Corporation (26) · Massachusetts General Hospital (25) · Novartis Pharmaceuticals (25) · Abbott Medical Devices (22) · Medtronic Endovascular (22) · AstraZeneca (21) · VA Office of Research and Development (21) · C. R. Bard (18) · Xuanwu Hospital, Beijing (17) · Brigham and Women's Hospital (16) · Flanders Medical Research Program (16)
United States (958) · Germany (247) · China (201) · France (196) · United Kingdom (174) · Italy (167) · Netherlands (146) · Canada (134) · Belgium (129) · Austria (123) · South Korea (115) · Spain (106) · Brazil (84) · Japan (78) · Denmark (75)
Marc Bosiers, MD (13) · Koen Deloose, MD (12) · Mary McDermott, MD (10) · Thomas Zeller, MD (10) · Marianne Brodmann, MD (9) · Dierk Scheinert, MD (8) · Jihad Mustapha, MD (8) · Gunnar Tepe, MD (7) · Howard N. Hodis, MD (7) · Andrew Holden, MD (6)
PMID 42573020, PMID 42035974, PMID 31567024, PMID 23636237, PMID 30690141, PMID 31543165, PMID 33025243, PMID 35802393, PMID 36588397, PMID 26354543, PMID 32609313, PMID 35916348, PMID 36137674, PMID 37565307, PMID 39329200, PMID 17223489, PMID 23583245, PMID 23915883, PMID 26062950, PMID 26708287, PMID 29098321, PMID 31926836, PMID 34134520, PMID 34167675, PMID 35224730, PMID 35526057, PMID 36645250, PMID 38415744, PMID 40875095, PMID 16449620, PMID 16672699, PMID 17140820, PMID 17848483, PMID 20208057, PMID 20484101, PMID 21123095, PMID 21146749, PMID 21262997, PMID 21873417, PMID 21953370, PMID 22169682, PMID 23050152, PMID 23797811, PMID 24475026, PMID 24529158, PMID 25084698, PMID 25119856, PMID 25216871, PMID 25237048, PMID 25245415
2025 (9), 2009 (6), 2017 (5), 2016 (4), 2023 (4), 2014 (2), 2015 (2), 2018 (2), 2019 (2), K23HL169929 (2), P01AT002034 (2), P50HL083762 (2), R01HL095149 (2), R01HL098909 (2), R01HL159803 (2)