30 completed, 21 unknown, 6 recruiting, 6 terminated. 29 Phase 4, 20 Phase 3, 7 Not applicable, 5 Phase 2, 3 Phase 1.
Follow bivalirudin: new trials by email Literature Review of bivalirudin trials Research Report on bivalirudin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic Therapy Bivalirudin, Unfractionated heparin - ST-segment Elevation Myocardial Infarction (STEMI) | Not applicable | Not yet recruiting | First Affiliated Hospital Xi'an Jiaotong University | 2400 | 2025-05-01 | 2025-03-06 |
| Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System Cardiohelp device (VA-ECMO), Heparin, Bivalirudin - Heart Failure, Cardiogenic Shock | Phase 2 | Recruiting | Stanford University | 50 | 2025-04-15 | 2026-08-10 |
| Use of Bivalirudin for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation bivalirudin, unfractionated heparin - Extracorporeal Membrane Oxygenation Complication | Not applicable | Recruiting | Xiaotong Hou | 154 | 2024-06-03 | 2026-04-06 |
| BivaLirudin versUS Heparin in Extracorporeal Membrane Oxygenation Unfractionated heparin, Bivalirudin - Extracorporeal Membrane Oxygenation Complication | Phase 2 | Recruiting | Sydney Local Health District | 80 | 2024-05-01 | 2026-05-08 |
| A Study on the Impact of Bivalirudin Usage During PCI for High-risk Plaques on Post-PCI Coronary Microcirculation. Bivalirudin, standard heparin - Coronary Microvascular Dysfunction | Phase 4 | Recruiting | Peking University First Hospital | 70 | 2023-07-01 | 2025-08-12 |
| Bivalirudin Versus Enoxaparin in Critically Ill COVID-19 Patients Enoxaparin Sodium, Bivalirudin - Acute Respiratory Failure, SARS CoV 2 Infection | Not applicable | Completed | University Magna Graecia | 58 | 2022-04-20 | 2022-08-19 |
| Bivalirudin vs Heparin in ECMO Patients Heparin Sodium, Bivalirudin Injection [Angiomax] - Extracorporeal Membrane Oxygenation Complication | Phase 1 | Withdrawn | Johns Hopkins University | 2021-04-01 | 2021-01-19 | |
| Safety and Efficacy of Bivalirudin During Short-term Intervention of Non-infarction Related Artery After PPCI of STEMI Bivalirudin, Heparin - STEMI With Multivessel Coronary Disease | Not applicable | Unknown | First Affiliated Hospital Xi'an Jiaotong University | 100 | 2021-01-12 | 2022-05-02 |
| Efficacy and Safety of Bivalirudin Versus Heparin During Coil Embolization in Patients With Ruptured Intracranial Aneurysms Bivalirudin 250 MG Injection, Heparin - Subarachnoid Hemorrhage, Aneurysmal | Phase 3 | Unknown | Changhai Hospital | 236 | 2020-08-01 | 2020-08-31 |
| Anticoagulation in Patients Suffering From COVID-19 Disease The ANTI-CO Trial Bivalirudin Injection, Standard treatment - Anticoagulation in COVID-19 ARDS | Phase 4 | Unknown | Hamad Medical Corporation | 100 | 2020-06-28 | 2020-06-24 |
| Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care: - Coronavirus Infection (COVID-19), Pulmonary Arterial Hypertension | Recruiting | Duke University | 5000 | 2020-03-05 | 2026-08-21 | |
| Multi-center Application of Bivalirudin in Left Atrial Appendage Occlusion Bivalirudin, Heparin - Evaluate the Safety and Efficacy of Bivalirudin in Decreasing Bleeding Risk | Phase 4 | Unknown | Shanghai Zhongshan Hospital | 100 | 2020-02-01 | 2019-12-12 |
| Bivalirudin in Late PCI for Oatients With STEMI Bivalirudin, Heparin - STEMI - ST Elevation Myocardial Infarction | Phase 4 | Unknown | Second Xiangya Hospital of Central South University | 1200 | 2019-11-30 | 2019-12-10 |
| Reduce Bolus Injection of Bivalirudin Bivalirudin - Acute Coronary Syndrome | Phase 4 | Completed | Han Yaling, MD | 204 | 2019-10-01 | 2021-08-09 |
| Bivalirudin in Elderly Patients Undergoing Elective Percutaneous Coronary Intervention. Bivalirudin, Heparin - Acute Coronary Syndrome, Percutaneous Coronary Intervention | Phase 4 | Unknown | The First Affiliated Hospital of Dalian Medical University | 240 | 2019-07-08 | 2019-08-06 |
| Safety and Efficacy of Bivalirudin Versus Heparin for Systemic Anticoagulation in Extracorporeal Membrane Oxygenation Bivalirudin, Unfractionated heparin - Extracorporeal Membrane Oxygenation Complication, Anticoagulants | Phase 4 | Unknown | Legacy Health System | 34 | 2019-05-23 | 2019-05-28 |
| Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI Bivalirudin, unfractionated Heparin - ST Elevation Myocardial Infarction | Not applicable | Completed | Shenyang Northern Hospital | 6016 | 2019-02-14 | 2025-08-27 |
| Bivalirudin in Elderly Patients With Acute ST-segment Elevation Myocardial Infarction Bivalirudin, Heparin - STEMI, Percutaneous Coronary Intervention | Phase 4 | Unknown | The First Affiliated Hospital of Dalian Medical University | 240 | 2019-01-16 | 2019-03-20 |
| Comparison of Anticoagulation Prolongation vs. no Anticoagulation in STEMI Patients After Primary PCI Bivalirudin, Enoxaparin, Unfractionated heparin - STEMI - ST Elevation Myocardial Infarction | Phase 4 | Completed | Beijing Anzhen Hospital | 2989 | 2019-01-11 | 2023-05-03 |
| Clinical Study of Bivalirudin for Percutaneous Coronary Intervention (PCI) Selective PCI, Bivalirudin - Coronary Heart Disease | Phase 2 | Unknown | Qian Gong | 200 | 2018-09-15 | 2018-08-20 |
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ST Elevation Myocardial Infarction (11) · Coronary Artery Disease (10) · Acute Coronary Syndrome (7) · Myocardial Infarction (6) · Coronary Disease (5) · Hemorrhage (5) · Cardiovascular Diseases (4) · Thrombosis (4) · COVID-19 (3) · Heart Diseases (3) · Heart Failure (3) · Hemostatic Disorders (2) · Myocardial Ischemia (2) · Acute Disease (1) · Adrenal Insufficiency (1)
The Medicines Company (14) · Deutsches Herzzentrum Muenchen (3) · First Affiliated Hospital Xi'an Jiaotong University (2) · NYU Langone Health (2) · Nycomed (2) · Shenyang Northern Hospital (2) · The First Affiliated Hospital of Dalian Medical University (2) · Xijing Hospital (2) · Azienda Ospedaliera San Camillo Forlanini (1) · Beijing Anzhen Hospital (1) · Boston Children's Hospital (1) · CCRF Consulting Co., Ltd. (1) · Cardiovascular Research Foundation, New York (1) · Careggi Hospital (1) · Centre Hospitalier de PAU (1)
United States (25) · China (15) · Italy (9) · Germany (5) · France (4) · Canada (3) · Netherlands (3) · Denmark (2) · United Kingdom (2) · Australia (1) · Austria (1) · Czechia (1) · Israel (1) · Poland (1) · Qatar (1)
Adnan Kastrati, MD (3) · Dongdong Sun, M.D.,Ph.D. (2) · Malcolm Lloyd, MD (2) · Roxana Mehran, MD (2) · Yaling Han, MD (2) · A. Michael Lincoff, MD (1) · Albert Schoemig, MD (1) · Albert Schomig, MD (1) · Ali McMichael, MD (1) · Allen Jeremias, MD (1) · Andrew Sternlicht, MD (1) · Binita Shah, MD, MS (1) · Bo Zheng, Prof (1) · Caroline Ozment, MD (1) · Chi Hornik (1)
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