1905 completed, 360 unknown, 239 terminated, 178 recruiting. 2934 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 2934 | Completed 1905, Unknown 360, Terminated 239, Recruiting 178, Withdrawn 125, Not yet recruiting 78, Active not recruiting 34, Enrolling by invitation 11, Suspended 4 |
Follow Mental Disorders: new trials by email Literature Review of Mental Disorders trials Research Report on Mental Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Smoking Cessation Medication And Rewards Using a Teamlet to Treat Tobacco Use Disorder (SMARTTT 2.0) Among Persons With HIV: A Multi-site Hybrid Type 2 Effectiveness-implementation Trial nicotine patch, nicotine gum, nicotine lozenge, varenicline, bupropion, Multi-target Contingency Management, Teamlet booster - Tobacco Use Disorder/Cigarette Smoking, HIV | Phase 4 | Not yet recruiting | Yale University | 794 | 2027-09-30 | 2026-09-23 |
| Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 246 | 2027-07-01 | 2026-09-29 |
| Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder | Phase 4 | Not yet recruiting | Stony Brook University | 42 | 2027-06-01 | 2026-04-23 |
| Evaluating an Innovative Tobacco Treatment Approach for Veterans in Substance Use Treatment Healthy Changes Nicotine Replacement Therapy (NRT), Cessation Treatment Nicotine Replacement Therapy (NRT), Cessation Treatment Counseling - Cigarette Smoking, Veterans | Phase 4 | Not yet recruiting | VA Office of Research and Development | 112 | 2027-04-01 | 2026-09-14 |
| Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome | Phase 4 | Not yet recruiting | VA Office of Research and Development | 70 | 2027-03-01 | 2026-10-15 |
| Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 282 | 2027-03-01 | 2026-10-28 |
| Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis Metformin - Psychosis, Cannabis Use | Phase 4 | Not yet recruiting | Nova Scotia Health Authority | 24 | 2027-02-01 | 2026-11-10 |
| Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus | Phase 4 | Not yet recruiting | Eunice Dube | 2140 | 2027-01-30 | 2026-07-30 |
| Effect of Midazolam Given at Induction on Recall of Propofol Injection Pain Midazolam, Lidocaine Hydrochloride 2%, Propofol 1% - Propofol Injection Pain, Postoperative Recall of Pain | Phase 4 | Not yet recruiting | Atlas University | 150 | 2026-12-01 | 2026-11-03 |
| NOTRE: Optimizing Long-Acting Pre-Exposure Prophylaxis and Medications for Opioid Use Disorder Interventions in Carceral Settings Cabotegravir Injection, Cabotegravir Pill, Buprenorphine injection - HIV Infections, Opioid Use Disorder | Phase 4 | Not yet recruiting | Duke University | 450 | 2026-12-01 | 2026-11-06 |
| Higher-Dose Maintenance With ERZOFRI 351 mg in Adults With Schizophrenia Paliperidone Palmitate - SCHIZOPHRENIA 1 (Disorder) | Phase 4 | Not yet recruiting | Alejandro Alva | 40 | 2026-12-01 | 2026-11-10 |
| Remimazolam Versus Dexmedetomidine for Sedation During Neuraxial Remimazolam, Dexmedetomidine - Pregnant People, Anxiety | Phase 4 | Not yet recruiting | Icahn School of Medicine at Mount Sinai | 150 | 2026-11-25 | 2026-09-09 |
| Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder Lurasidone (Latuda) - Bipolar Disorder Depression | Phase 4 | Not yet recruiting | Martin Lan | 60 | 2026-11-01 | 2026-09-08 |
| Delayed-Release, Extended-Release Methylphenidate (Jornay PM) for Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder and Cannabis Use Disorder Delayed-release, extended-release methylphenidate, Placebo - ADHD, Cannabis Use Disorder | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 66 | 2026-11-01 | 2026-09-28 |
| IPP Placement & Intracavernosal Block Exparel/bupivacaine mixture - Erectile Dysfunction (ED) | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 100 | 2026-11-01 | 2026-09-24 |
| A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease Donanemab - Alzheimer Disease | Phase 4 | Not yet recruiting | Eli Lilly and Company | 50 | 2026-11-01 | 2026-10-15 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-11-01 | 2026-10-29 |
| Comparing Outpatient Treatment Retention Among Individuals Using Fentanyl Randomized to Low-dose and Direct-to-inject Buprenorphine Initiation Injectable buprenorphine, Sublingual Buprenorphine (SUBOXONE, Zubsolv, or generic tablets) - Opioid Use Disorder, Fentanyl | Phase 4 | Not yet recruiting | University of California, San Francisco | 50 | 2026-11-01 | 2026-11-10 |
| Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Sphenopalatine Ganglion Block for Functional Endoscopic Sinus Surgery Bupivacaine & normal saline, Dexmedetomidine & Bupivacaine., Dexamethasone & Bupivacaine. - Post Operative Pain, Emergence Agitation | Phase 4 | Not yet recruiting | Sohag University | 60 | 2026-11-01 | 2026-11-10 |
Showing 20 of 2934. Sign in to see all of them.
Schizophrenia (449) · Depressive Disorder, Major (333) · Depression (268) · Bipolar Disorder (232) · Attention Deficit Disorder with Hyperactivity (225) · Psychotic Disorders (212) · Anxiety Disorders (172) · Alzheimer Disease (137) · Sleep Initiation and Maintenance Disorders (137) · Cognitive Dysfunction (127) · Alcoholism (125) · Opioid-Related Disorders (109) · Stress Disorders, Post-Traumatic (105) · Erectile Dysfunction (104) · Tobacco Use Disorder (95)
Nervous System Diseases (813) · Pathological Conditions, Signs and Symptoms (620) · Mood Disorders (619) · Signs and Symptoms (523) · Behavior (506) · Neurocognitive Disorders (498) · Schizophrenia Spectrum and Other Psychotic Disorders (481) · Chemically-Induced Disorders (450) · Neurologic Manifestations (445) · Depressive Disorder (369) · Substance-Related Disorders (364) · Behavioral Symptoms (334) · Central Nervous System Diseases (312) · Brain Diseases (294)
Risperidone (138) · Escitalopram (115) · Aripiprazole (107) · Methylphenidate (103) · Olanzapine (97) · Quetiapine Fumarate (97) · Dexmedetomidine (90) · Ketamine (68) · Sertraline (63) · Bupropion (60) · Saline Solution (59) · Sugars (56) · Atomoxetine Hydrochloride (55) · Naltrexone (54) · Paliperidone Palmitate (50)
Massachusetts General Hospital (115) · Eli Lilly and Company (76) · New York State Psychiatric Institute (65) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (36) · University of California, Los Angeles (33) · University of Pennsylvania (33) · VA Office of Research and Development (29) · NYU Langone Health (28) · Peking University First Hospital (25) · University of Pittsburgh (25) · University of California, San Francisco (23) · Emory University (22) · Centre for Addiction and Mental Health (21) · Shanghai Mental Health Center (21) · University of Texas Southwestern Medical Center (21)
United States (1502) · China (200) · Canada (163) · South Korea (101) · Germany (96) · Spain (76) · France (69) · Brazil (65) · United Kingdom (59) · Italy (57) · Taiwan (51) · Denmark (50) · Israel (48) · Netherlands (48) · Australia (47)
Dong-Xin Wang, MD, PhD (16) · Joseph Biederman, MD (12) · Amit Anand, MD (8) · Janet Wozniak, MD (8)
PMID 25019647, PMID 37142273, PMID 37230961, PMID 37335995, PMID 37811711, PMID 33189083, PMID 38958149, PMID 28892218, PMID 34231914, PMID 35141873, PMID 38767196, PMID 28832750, PMID 33884617, PMID 36063082, PMID 39428602, PMID 39868569, PMID 12760985, PMID 15114210, PMID 17074942, PMID 19578654, PMID 19617584, PMID 20840778, PMID 21095016, PMID 21256799, PMID 21569378, PMID 21586165, PMID 21975110, PMID 23380715, PMID 24290461, PMID 25441015, PMID 25758058, PMID 25980552, PMID 26107752, PMID 26709542, PMID 26745211, PMID 26803397, PMID 27733282, PMID 28980198, PMID 29608461, PMID 29856773, PMID 30097769, PMID 31415936, PMID 34183490, PMID 34582562, PMID 34611902, PMID 35201607, PMID 35592490, PMID 35833913, PMID 36375174, PMID 36413436
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