77 completed. 77 Phase 2, 15 Phase 1, 9 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 77 | Completed 77 |
| Phase 1 | 15 | Completed 15 |
| Phase 3 | 9 | Completed 9 |
Follow Lung Injury: new trials by email Literature Review of Lung Injury trials Research Report on Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of Sildenafil in Premature Infants With Severe Bronchopulmonary Dysplasia Sildenafil, Placebo - Bronchopulmonary Dysplasia of Newborn | Phase 2 | Completed | Christoph Hornik | 125 | 2021-05-27 | 2026-01-26 |
| The Safety and Preliminary Tolerability of Lyophilized Lucinactant in Adults With Coronavirus Disease 2019 (COVID-19) Lucinactant - COVID-19, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Completed | Windtree Therapeutics | 20 | 2021-01-05 | 2023-06-23 |
| Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury Nebulised heparin - Covid19, ARDS, Human | Phase 1 / Phase 2 | Completed | University College Hospital Galway | 40 | 2020-12-23 | 2024-07-24 |
| SAFEty Study of Early Infusion of Vitamin C for Treatment of Novel Coronavirus Acute Lung Injury (SAFE EVICT CORONA-ALI) L-ascorbic acid, Placebo - COVID-19, Lung Injury, Acute | Phase 2 | Completed | Virginia Commonwealth University | 47 | 2020-12-18 | 2024-04-04 |
| FX06 to Rescue Acute Respiratory Distress Syndrome During Covid-19 Pneumonia FX06, Placebo of FX06 - Ards, Covid19 | Phase 2 | Completed | Assistance Publique - Hôpitaux de Paris | 50 | 2020-11-13 | 2021-06-22 |
| Examination of Pirfenidone (Esbriet®) Therapy in Coal Workers' Pneumoconiosis With Pulmonary Fibrosis Pirfenidone - Coal Workers' Pneumoconiosis (Complicated) | Phase 2 | Completed | Pulmonary Research of Abingdon, LLC | 50 | 2020-08-31 | 2024-07-16 |
| Clinical Trial to Evaluate CERC-002 in Adults With COVID-19 Pneumonia and Acute Lung Injury CERC-002, Placebo - COVID-19 Pneumonia, Acute Lung Injury | Phase 2 | Completed | Aevi Genomic Medicine, LLC, a Cerecor company | 88 | 2020-07-17 | 2022-03-24 |
| TD-0903 for ALI Associated With COVID-19 TD-0903, Placebo - Acute Lung Injury (ALI) Associated With COVID-19, Lung Inflammation Associated With COVID-19 | Phase 2 | Completed | Theravance Biopharma | 235 | 2020-06-24 | 2022-03-17 |
| Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury Ibrutinib, Placebo - CoronaVirus Induced Disease-2019 (COVID-19) | Phase 2 | Completed | AbbVie | 46 | 2020-06-06 | 2022-06-01 |
| A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19 APL-9, Vehicle Control - COVID, Covid-19 | Phase 1 / Phase 2 | Completed | Apellis Pharmaceuticals, Inc. | 72 | 2020-05-28 | 2022-03-23 |
| Zilucoplan® in Improving Oxygenation, Short-, Longterm Outcome of COVID19 Patients With Acute Hypoxic Respiratory Failure Zilucoplan®, Placebo - COVID-19 | Phase 2 | Completed | University Hospital, Ghent | 81 | 2020-05-22 | 2023-09-14 |
| Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure Aviptadil by intravenous infusion + standard of care, Normal Saline Infusion + standard of care - Critical COVID-19 With Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS) | Phase 2 / Phase 3 | Completed | APR Applied Pharma Research s.a. | 203 | 2020-05-15 | 2023-07-24 |
| Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation L-ascorbic acid - COVID-19, Hypoxia | Phase 1 / Phase 2 | Completed | Hunter Holmes Mcguire Veteran Affairs Medical Center | 20 | 2020-04-16 | 2022-02-25 |
| A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE) Gimsilumab, Placebo - COVID-19 | Phase 2 | Completed | Kinevant Sciences GmbH | 227 | 2020-04-15 | 2021-12-14 |
| Clinical Study to Assess the Safety and Preliminary Efficacy of HCR040 in Acute Respiratory Distress Syndrome HCR040 (Phase 1), Placebo (Phase 2), HCR040 (Phase 2) - Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Completed | Histocell, S.L. | 26 | 2019-12-10 | 2024-02-28 |
| Role of Ascorbic Acid Infusion in Critically Ill Patients With Transfusion Related Acute Lung Injury Ascorbic Acid Injectable Product, Placebo - Acute Lung Injury, Transfusion Related | Phase 2 | Completed | Damanhour University | 40 | 2019-11-30 | 2023-07-19 |
| Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population Artichoke WPC - Asbestos Exposure | Phase 2 | Completed | Ontario Clinical Oncology Group (OCOG) | 3 | 2019-11-05 | 2021-07-13 |
| Clinical Study of Endostatin in Improving Radiation Pneumonia and Fibrosis Endostar, standard SRILI treatment - Radiation Pneumonitis, Endostatin | Phase 2 | Completed | Xinqiao Hospital of Chongqing | 126 | 2018-09-01 | 2024-02-23 |
| PNEUMOSTEM for the Prevention and Treatment of Severe BPD in Premature Infants PNEUMOSTEM, Placebo - Severe Bronchopulmonary Dysplasia | Phase 2 | Completed | Medipost Co Ltd. | 60 | 2018-08-13 | 2025-01-24 |
| Autologous Cord Blood Cells for Prevention of BPD in Preterm Autologous Umbilical Cord Blood Mononuclear Cells infusion Therapy, 0.9% Sodiun Chloride - Safety Issues, BPD - Bronchopulmonary Dysplasia | Phase 2 | Completed | yangjie | 62 | 2018-07-01 | 2020-06-02 |
Showing 20 of 77. Sign in to see all of them.
Acute Lung Injury (38) · Bronchopulmonary Dysplasia (29) · Respiratory Distress Syndrome (27) · Premature Birth (16) · COVID-19 (11) · Sepsis (7) · Pneumonia (4) · Severe Acute Respiratory Syndrome (4) · Coronavirus Infections (3) · Radiation Pneumonitis (3) · Respiratory Insufficiency (3) · Retinopathy of Prematurity (3) · Hypoxia (2) · Infections (2)
Respiratory Tract Diseases (76) · Lung Diseases (75) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (30) · Respiration Disorders (30) · Infant, Premature, Diseases (29) · Infant, Newborn, Diseases (28) · Ventilator-Induced Lung Injury (28) · Infections (21) · Female Urogenital Diseases and Pregnancy Complications (17) · Pregnancy Complications (17) · Urogenital Diseases (17) · Obstetric Labor Complications (16) · Obstetric Labor, Premature (16) · Pathological Conditions, Signs and Symptoms (15)
Saline Solution (6) · Ascorbic Acid (5) · Aspirin (2) · Azithromycin (2) · Furosemide (2) · Glucose (2) · Hydrocortisone (2) · Nitric Oxide (2) · Sildenafil Citrate (2) · Sodium Chloride (2) · ALT-836 (1) · Acetylcysteine (1) · Albumins (1) · Ampicillin (1) · Anti-Bacterial Agents (1)
NICHD Neonatal Research Network (5) · Virginia Commonwealth University (3) · Assistance Publique - Hôpitaux de Paris (2) · GlaxoSmithKline (2) · Mayo Clinic (2) · Medipost Co Ltd. (2) · University of Alabama at Birmingham (2) · University of North Carolina, Chapel Hill (2) · APR Applied Pharma Research s.a. (1) · AbbVie (1) · Abbott (1) · Aevi Genomic Medicine, LLC, a Cerecor company (1) · Ajou University School of Medicine (1) · Albert Einstein College of Medicine (1) · Altor BioScience (1)
United States (48) · Canada (6) · South Korea (5) · United Kingdom (5) · China (4) · France (3) · Belgium (2) · Brazil (2) · Italy (2) · Spain (2) · Argentina (1) · Australia (1) · Austria (1) · Egypt (1) · Finland (1)
Barbara J. Stoll, MD (4) · Charles R. Bauer, MD (3) · Edward F. Donovan, MD (3) · Richard A. Ehrenkranz, MD (3) · Seetha Shankaran, MD (3) · Waldemar A. Carlo, MD (3) · Abbot R. Laptook, MD (2) · Abhik Das, PhD (2) · Avroy A. Fanaroff, MD (2) · Brenda B. Poindexter, MD MS (2) · Dale L. Phelps, MD (2) · Daryl Kor, MD (2) · David K. Stevenson, MD (2) · James A. Lemons, MD (2)
PMID 33876883, PMID 10379020, PMID 15342835, PMID 15713907, PMID 15774846, PMID 20963840, PMID 22155140, PMID 22291116, PMID 22300564, PMID 22340260, PMID 22943074, PMID 23095978, PMID 23140612, PMID 24069180, PMID 24484547, PMID 24503265, PMID 25063725, PMID 25486575, PMID 25981908, PMID 26102252, PMID 26376074, PMID 26400297, PMID 26431718, PMID 26494395, PMID 26503312, PMID 27074126, PMID 27079965, PMID 27179988, PMID 27870826, PMID 28082531, PMID 28489488, PMID 28750677, PMID 28821525, PMID 28829877, PMID 28877748, PMID 28934640, PMID 29782179, PMID 30471715, PMID 30992220, PMID 31573637, PMID 31756675, PMID 32170033, PMID 32539121, PMID 32817460, PMID 33213529, PMID 33305842, PMID 33317479, PMID 33479274, PMID 34004189, PMID 34337553
U10HD021364 (5), U10HD027853 (5), U10HD021373 (4), U10HD021385 (4), U10HD027851 (4), U10HD027856 (4), U10HD027871 (4), U10HD027880 (4), U10HD034216 (4), M01RR008084 (3), U10HD021397 (3), U10HD027904 (3), U10HD036790 (3), U01HD019897 (2), U10HD021415 (2)