54 completed, 15 terminated, 13 unknown, 6 withdrawn. 51 Phase 2, 21 Phase 1, 16 Phase 3, 10 Not applicable, 7 Early Phase 1.
Follow Nitric Oxide: new trials by email Literature Review of Nitric Oxide trials Research Report on Nitric Oxide
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Inhaled Nitric Oxide in Severe Obesity Nitric oxide - Obesity, Respiratory Insufficiency | Not applicable | Not yet recruiting | Massachusetts General Hospital | 60 | 2026-10-01 | 2026-05-20 |
| Vascular ARDS Recruitment After Inhaled Nitric Oxide Nitric Oxide - Acute Respiratory Distress Syndrome, Ventilation Perfusion Mismatch | Not applicable | Recruiting | Massachusetts General Hospital | 70 | 2026-07-10 | 2026-10-02 |
| Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients Nitric Oxide, Placebo - Acute Kidney Injury, Nitrous Oxide | Phase 4 | Completed | Beijing Anzhen Hospital | 106 | 2024-11-30 | 2026-02-05 |
| The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease. Nitric Oxide, Placebo - Dyspnea | Phase 1 / Phase 2 | Withdrawn | University of Alberta | 2024-09-01 | 2024-09-19 | |
| High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB Sham treatment, 200-ppm NO - Nosocomial Pneumonia | Not applicable | Completed | Tomsk National Research Medical Center of the Russian Academy of Sciences | 160 | 2024-02-20 | 2026-06-24 |
| Inhaled Nitric Oxide for ARDS-related Pulmonary Hypertension Nitric Oxide - Acute Respiratory Distress Syndrome, Pulmonary Hypertension | Early Phase 1 | Unknown | Yuri Matusov | 20 | 2024-02-01 | 2024-02-08 |
| Nitric Oxide Releasing Mouthwash (NORM) for the Management of Oropharyngeal Candidiasis Nitric Oxide - Candidiasis, Oral | Phase 1 | Completed | Sanotize Research and Development corp. | 6 | 2024-01-20 | 2024-07-10 |
| Mechanism of Nitric Oxide on Ventilator-induced Diaphragm Dysfunction with Extracorporeal Membrane Lung Assistance Nitric Oxide - Tracheal Intubation, Extracorporeal Membrane Oxygenation | Unknown | Zhongnan Hospital | 80 | 2024-01-16 | 2024-10-28 | |
| High-dose Inhalations of Nitric Oxide in the Treatment of Pneumonia 200 ppm Nitric Oxide, Sham treatment - Nosocomial Pneumonia, Community-acquired Pneumonia | Not applicable | Active not recruiting | Tomsk National Research Medical Center of the Russian Academy of Sciences | 200 | 2024-01-15 | 2026-07-30 |
| The Effects of a Nitrate Supplementation on Erectile Function Nitric Oxide, Tadalafil, Placebo - Erectile Dysfunction | Not applicable | Unknown | RHA Investments Ltd | 20 | 2023-12-12 | 2024-01-19 |
| Aqueous Humor Dynamics of NCX 470 Ophthalmic Solution NCX 470, Placebo - Open Angle Glaucoma | Phase 2 / Phase 3 | Completed | Nicox Ophthalmics, Inc. | 18 | 2023-12-12 | 2025-09-08 |
| Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function Alveolar recruitment maneuver, Nitric Oxide - Collapsed Lung, Hemodynamic Stability | Not applicable | Unknown | Fernando Suarez Sipmann | 54 | 2023-11-22 | 2024-02-28 |
| High-dose Inhaled NO Therapy for the Prevention of Nosocomial Pneumonia After Cardiac Surgery With CPB Sham treatment, 200- ppm NO - Nosocomial Pneumonia | Not applicable | Completed | Tomsk National Research Medical Center of the Russian Academy of Sciences | 74 | 2023-11-17 | 2026-06-26 |
| Methemoglobin Concentration in High Dose Inhaled Nitric Oxide Inhaled Nitric Oxide - Healthy Subjects | Early Phase 1 | Active not recruiting | Massachusetts General Hospital | 10 | 2023-10-16 | 2025-12-02 |
| Nitric Oxide Releasing Solution (NORS) For The Treatment Of Human Papillomavirus(HPV) Verrucae Plantaris (Plantar Warts) Sterile water foot bath, Nitric Oxide - Verruca Plantaris | Phase 2 | Completed | Sanotize Research and Development corp. | 20 | 2023-08-02 | 2024-04-17 |
| Perioperative Nitric Oxide Prevents Acute Kidney Injury in Cardiac Surgery Patients With Chronic Kidney Disease Sham treatment, 80-ppm NO - Acute Kidney Disease, Chronic Kidney Disease | Phase 1 / Phase 2 | Completed | Tomsk National Research Medical Center of the Russian Academy of Sciences | 136 | 2023-02-25 | 2026-10-23 |
| NO During CPB in Neonates to Reduce Risk of AKI Nitric Oxide, Oxygen - AKI, CHD - Congenital Heart Disease | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 40 | 2023-01-10 | 2026-08-05 |
| Prone Positioning vs. Prone Positioning and NO Inhalation in COVID-19 ARDS. Nitric oxide, prone positioning - Respiratory Distress Syndrome | Unknown | Shanghai Zhongshan Hospital | 30 | 2022-12-21 | 2023-02-08 | |
| Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass Nitric Oxide (NO) 20 part per million (ppm), Standard of care cardiopulmonary bypass - Congenital Heart Disease, Congenital Heart Defect | Phase 2 / Phase 3 | Enrolling by invitation | Vanderbilt University Medical Center | 50 | 2022-04-25 | 2025-10-08 |
| Inhaled Nitric Oxide (iNO) in Idiopathic Pulmonary Fibrosis (IPF). Nitric Oxide, Medical air - Idiopathic Pulmonary Fibrosis | Early Phase 1 | Unknown | Dr. Denis O'Donnell | 40 | 2022-04-21 | 2024-04-03 |
Showing 20 of 95. Sign in to see all of them.
Hypertension, Pulmonary (8) · COVID-19 (7) · Heart Defects, Congenital (6) · Anemia, Sickle Cell (5) · Dyspnea (5) · Respiratory Distress Syndrome (5) · Hypoxia (4) · Respiratory Insufficiency (4) · Acute Kidney Injury (3) · Acute Lung Injury (3) · Coronary Artery Disease (3) · Coronavirus Infections (3) · Cystic Fibrosis (3) · Healthcare-Associated Pneumonia (3) · Lung Diseases (3)
Mallinckrodt (9) · Massachusetts General Hospital (8) · Sanotize Research and Development corp. (6) · Beyond Air Inc. (5) · Tomsk National Research Medical Center of the Russian Academy of Sciences (5) · Dr. Denis O'Donnell (3) · Nitric BioTherapeutics, Inc (3) · University of Alberta (3) · China Medical University Hospital (2) · National Heart, Lung, and Blood Institute (NHLBI) (2) · The Cleveland Clinic (2) · University Health Network, Toronto (2) · Wake Forest University Health Sciences (2) · Air Liquide Santé International (1) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (1)
United States (39) · Canada (17) · France (6) · Israel (6) · United Kingdom (6) · Russia (5) · Belgium (4) · China (4) · Spain (4) · Germany (3) · Netherlands (2) · Taiwan (2) · Uganda (2) · Australia (1) · Czechia (1)
Lorenzo Berra, MD (6) · Denis E O'Donnell, MD (3) · James Baldassarre, MD (3) · Asher Tal, M.D (2) · Keith Moore, PHARMD (2) · Keith Moore, PHARMMD (2) · Nikolay O. Kamenshchikov (2) · Amin Javer, MD (1) · Andrew Boyle, MD (1) · Andrew J Powers, MD (1) · Aviv Goldbart (1) · Bo Sun, Ph.D (1) · Cameron Dezfulian, MD (1) · Chiu-Shong Liu, M.D. (1)
PMID 23228403, PMID 10190913, PMID 10501745, PMID 12663340, PMID 15069048, PMID 1682593, PMID 19183804, PMID 20405117, PMID 20655106, PMID 21364138, PMID 21745716, PMID 21752262, PMID 23269119, PMID 23830159, PMID 23940237, PMID 24006858, PMID 24916507, PMID 26431718, PMID 26510464, PMID 26589907, PMID 27686343, PMID 27814710, PMID 28046032, PMID 28366306, PMID 29341967, PMID 29370261, PMID 29448936, PMID 29800130, PMID 31278097, PMID 32541773, PMID 32718702, PMID 32859359, PMID 32876469, PMID 33196303, PMID 33769417, PMID 36169967, PMID 39037709, PMID 40790609, PMID 41270263, PMID 41493215, PMID 41784492, PMID 41844498, PMID 41895703, PMID 9036320, PMID 9428538, PMID 9480993, PMID 9603111, PMID 9603127
2004 (2), 2014 (1), K23HL128882 (1)