208 completed, 72 unknown, 33 terminated, 28 withdrawn. 78 Phase 2, 66 Phase 3, 52 Not applicable, 33 Phase 1, 10 Phase 4.
Follow Severe Acute Respiratory Syndrome: new trials by email Literature Review of Severe Acute Respiratory Syndrome trials Research Report on Severe Acute Respiratory Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Bio-Manguinhos/Fiocruz COVID-19 (mRNA) Vaccine Booster Grupo 1 - dose 25 μg, Group 2 - 50 μg dose, Group 3 - 100 μg - Severe Acute Respiratory Syndrome (SARS-CoV-2 Virus) | Phase 1 | Not yet recruiting | The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz) | 90 | 2026-07-01 | 2026-06-10 |
| Steroid Treatment for Severe Acute Respiratory Infection (STAR) Trial Corticosteroid - Hypoxemia, Severe Acute Respiratory Syndrome | Phase 4 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 3000 | 2026-03-01 | 2026-02-19 |
| Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome Instilled T3, Placebo Therapy - Covid19, SARS-CoV Infection | Phase 2 | Withdrawn | University of Minnesota | 2026-01-15 | 2026-02-10 | |
| Clinical Multimodal Surveillance of Respiratory Syndrome Pathogens Tiered pathogen testing and multi-omics analysis - Respiratory Tract Infections (RTI), Respiratory Syndrome, Acute, Severe | Recruiting | Huashan Hospital | 2398 | 2025-09-01 | 2026-07-10 | |
| Study of Viral Respiratory Infections Respiratory Infections | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 20000 | 2025-02-03 | 2025-01-08 | |
| A US Study to Look at Loss of Work and Healthcare Costs for People Affected With Mild-to-moderate COVID 19 Who Have High Chances of the Disease Becoming Severe nirmatrelvir-ritonavir - COVID-19 (Coronavirus Disease 2019) | Completed | Pfizer | 131005 | 2024-10-31 | 2026-02-09 | |
| Mitoquinone/Mitoquinol Mesylate as Oral and Safe Postexposure Prophylaxis for Covid-19 Mitoquinone/mitoquinol mesylate, Placebo - SARS-CoV Infection, COVID-19 | Phase 2 | Completed | University of Texas Southwestern Medical Center | 122 | 2024-03-01 | 2026-09-21 |
| Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure intravenous treatment with EVs, intravenous treatment with placebo solution - Severe Acute Respiratory Syndrome (SARS), Acute Respiratory Distress Syndrome (ARDS) | Phase 1 / Phase 2 | Unknown | D'Or Institute for Research and Education | 15 | 2024-02-01 | 2023-08-21 |
| A Trial to Learn if Different Doses of REGN17092 Are Safe in Healthy Adults REGN17092, Matching Placebo - Healthy Volunteers | Phase 1 | Completed | Regeneron Pharmaceuticals | 40 | 2023-11-28 | 2025-03-27 |
| Study of VXCO-100, a SARS-CoV Candidate Vaccine, in Adults in the Republic of South Africa VXCO-100, COVID-19 mRNA vaccine - SARS-CoV, SARS-CoV-2 | Phase 1 | Completed | Vaccine Company, Inc, a wholly owned subsidiary of Eli Lilly and Company | 130 | 2023-08-04 | 2024-12-10 |
| Bioaerosol Sampling Device (BSD) Clinical Study COVID-19 | Unknown | Cantor BioConnect, Inc. | 330 | 2023-07-10 | 2023-09-21 | |
| Study of VXCO-100, a SARS-CoV Candidate Vaccine in Healthy Adults in the United States VXCO-100 - SARS-CoV, SARS-CoV-2 | Phase 1 | Completed | Vaccine Company, Inc, a wholly owned subsidiary of Eli Lilly and Company | 121 | 2023-05-11 | 2024-12-10 |
| Safety, Tolerability, and Immunogenicity of Trivalent Coronavirus Vaccine Candidate VBI-2901e With E6020 Adjuvant VBI-2901e - COVID-19, Coronavirus Infections | Phase 1 | Withdrawn | VBI Vaccines Inc. | 2023-03-01 | 2023-04-04 | |
| Nitric Oxide Gas Inhalation for Severe Acute Respiratory Syndrome in COVID-19. Nitric Oxide Gas, The delivery system will be set up anyway without study gas administration - Coronavirus Covid-19 Infection Variant Omicron, SARS (Severe Acute Respiratory Syndrome) | Phase 2 | Withdrawn | Xijing Hospital | 2023-01-16 | 2023-02-08 | |
| Medicine-induced Cardiac Hemodialysis on COVID-19 Nifedipine 30 MG, Kangzhu BPCB0A-3A, Low Mobility - Severe Acute Respiratory Syndrome-related Coronavirus, Renal Dialysis | Phase 4 | Completed | Yang I. Pachankis | 1 | 2023-01-02 | 2023-02-03 |
| Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen Tozorakimab, Placebo - Viral Lung Infection and Acute Respiratory Failure | Phase 3 | Recruiting | AstraZeneca | 3527 | 2022-12-13 | 2026-10-02 |
| Should Palatine Tonsils be Included in the Oropharyngeal Swab for SARS-CoV-2 Molecular Testing? An Oropharyngeal swab - SARS-CoV Infection, Coronavirus | Not applicable | Unknown | Copenhagen University Hospital, Rigshospitalet | 1000 | 2022-11-10 | 2023-01-11 |
| Safety, Tolerability, and Immunogenicity of Trivalent Coronavirus Vaccine Candidate VBI-2901a VBI-2901a - COVID-19, Coronavirus Infections | Phase 1 | Completed | VBI Vaccines Inc. | 103 | 2022-10-05 | 2026-05-11 |
| Safety, Tolerability and Immunogenicity of Alveavax-v1.2, a BA.2/Omicron-optimized, DNA Vaccine for COVID-19 Prevention Alveavax-v1.2, Janssen Ad26.COV2.S - Sars-CoV-2 Infection | Phase 1 | Completed | Alvea Holdings, LLC | 130 | 2022-06-27 | 2023-05-06 |
| NA-831, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection Drug: NA-831, NA-831 and Atazanavir, NA-831and Dexamethasone - Coronavirus Infection, Severe Acute Respiratory Infection | Phase 2 / Phase 3 | Unknown | Biomed Industries, Inc. | 525 | 2022-06-15 | 2022-02-16 |
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