42 completed, 20 unknown, 10 terminated, 9 recruiting. 92 Phase 1, 39 Phase 2.
Follow Lung Injury: new trials by email Literature Review of Lung Injury trials Research Report on Lung Injury
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy Study of GKL-006RTU in Moderate to Severe Acute Respiratory Distress Syndrome (ARDS) GKL-006RTU injection, Placebo - ARDS (Acute Respiratory Distress Syndrome) | Phase 1 / Phase 2 | Not yet recruiting | Beijing Gene Key Life Technology Co., Ltd | 52 | 2026-11-10 | 2026-09-30 |
| High-energy Human Milk Diets in the First Two Weeks After Birth to Reduce BPD in Extremely Preterm Infants High-energy group, Standard-energy group - Extreme Prematurity, Enteral Nutrition | Phase 1 / Phase 2 | Recruiting | University of Alabama at Birmingham | 150 | 2026-09-21 | 2026-09-24 |
| 129Xe MRI in Pediatric Population With BPD MagniXene, hyperpolarized 129Xe MRI - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | Xemed LLC | 2026-08-01 | 2026-02-05 | |
| Pharmacokinetics and Placental Transfer of Caffeine Caffeine citrate - Preterm Labor With Preterm Delivery, Premature Birth | Phase 1 | Recruiting | Indiana University | 30 | 2026-06-01 | 2026-06-04 |
| Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of HT31-1 for Treating ARDS HT31-1, Saline (0.9%, sterile, for infusion) - ARDS (Acute Respiratory Distress Syndrome) | Phase 1 | Recruiting | HTIC, Inc | 24 | 2026-05-28 | 2026-09-16 |
| PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia montelukast 4 mg granule, Placebo - Bronchopulmonary Dysplasia (BPD), Premature Births | Phase 1 / Phase 2 | Recruiting | Duke University | 28 | 2026-02-23 | 2026-07-14 |
| Inhaled Ciclesonide Study in Preterm Infants Alvesco Inhalant Product - Bronchopulmonary Dysplasia | Phase 1 | Recruiting | Venkatesh Sampath | 30 | 2025-09-16 | 2026-09-09 |
| Inhaled Treatment for Bronchopulmonary Dysplasia GSNO - Bronchopulmonary Dysplasia | Phase 1 | Withdrawn | University Hospitals Cleveland Medical Center | 2025-08-01 | 2025-08-22 | |
| Safety and Efficacy of Umbilical Cord-derived Mesenchymal Stem Cell(MSC) Transplantation in the Treatment of Bronchopulmonary Dysplasia(BPD) in Premature Infants MSC - BPD - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Recruiting | The Children's Hospital of Zhejiang University School of Medicine | 10 | 2024-08-09 | 2025-01-23 |
| Different Levels of BiPAP BiPAP setting - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Unknown | King's College Hospital NHS Trust | 21 | 2024-05-23 | 2024-06-11 |
| Recombinant Surfactant Protein D (rfhSP-D) to Prevent Neonatal Chronic Lung Disease Recombinant fragment of human surfactant protein D (rfhSP-D) - Chronic Lung Disease of Prematurity, Respiratory Distress Syndrome in Premature Infant | Phase 1 | Completed | University College, London | 18 | 2024-04-06 | 2026-04-07 |
| Safety and Efficacy of MSC-EVs in the Prevention of BPD in Extremely Preterm Infants Endotracheopulmonary Instillation, Suspension - Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Recruiting | EXO Biologics S.A. | 265 | 2023-12-28 | 2024-09-19 |
| Single-cell Sequencing of BLF to Guide the Treatment of Radiation Pneumonitis or Immune Checkpoint Inhibitor Pneumonitis single-cell sequencing - Pneumonitis | Phase 1 / Phase 2 | Recruiting | Xinqiao Hospital of Chongqing | 40 | 2023-08-01 | 2025-07-14 |
| Stem Cell Treatment for Lung Injury Caused by Major Infectious Diseases mesenchymal stem cells, saline - Lung Injury | Phase 1 / Phase 2 | Unknown | Cell Energy Life Sciences Group Co. LTD | 80 | 2023-05-10 | 2024-05-16 |
| The Formulation of Compound Phellinus Igniarius Decoction on Radiation Pneumonitis The formulation of Compound Phellinus igniarius decoction - Radiation Pneumonitis | Phase 1 | Completed | Zhejiang Cancer Hospital | 40 | 2023-03-22 | 2025-03-11 |
| Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia Allogeneic Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells - Bronchopulmonary Dysplasia | Phase 1 | Active not recruiting | Ottawa Hospital Research Institute | 9 | 2022-10-17 | 2025-07-16 |
| Pulmonary and Inflammatory Responses Following Exposure to a Low Concentration of Ozone or Clean Air 0.070 ppm ozone concentration, Clean air (0.0 ppm ozone) - Lung Injury, Acute, Symptoms and Signs | Phase 1 | Unknown | Martin W. Case | 60 | 2022-10-13 | 2023-01-11 |
| Inhaled Tobramycin in BPD Tobramycin solution for inhalation 78mg dose, Tobramycin solution for inhalation 150mg dose, Tobramycin solution for inhalation 216mg dose - Bronchopulmonary Dysplasia | Phase 1 | Completed | Erik Allen Jensen | 27 | 2022-03-22 | 2025-01-31 |
| Anakinra for Preterm Infants Pilot Anakinra - Prematurity; Extreme, Inflammation | Phase 1 / Phase 2 | Unknown | Monash Medical Centre | 25 | 2022-02-15 | 2024-09-19 |
| TD-0903 Pharmacokinetics Study in Healthy Participants With Supplemental Oxygenation Nezulcitinib (TD-0903) Dose A, Nezulcitinib (TD-0903) Dose B - Acute Lung Injury (ALI) Due to Coronavirus Disease-2019 (COVID-19) | Phase 1 | Completed | Theravance Biopharma | 14 | 2021-10-13 | 2021-12-10 |
Showing 20 of 92. Sign in to see all of them.
Bronchopulmonary Dysplasia (40) · Acute Lung Injury (34) · Respiratory Distress Syndrome (22) · Premature Birth (15) · COVID-19 (11) · Pneumonia (7) · Lung Diseases (6) · Respiratory Insufficiency (6) · Sepsis (5) · Hypertension, Pulmonary (4) · Coronavirus Infections (3) · Inflammation (3) · Respiration Disorders (3) · Berylliosis (2)
Respiratory Tract Diseases (91) · Lung Diseases (86) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (40) · Infant, Newborn, Diseases (39) · Ventilator-Induced Lung Injury (39) · Infant, Premature, Diseases (38) · Respiration Disorders (28) · Infections (21) · Pathological Conditions, Signs and Symptoms (17) · Female Urogenital Diseases and Pregnancy Complications (15) · Obstetric Labor Complications (15) · Pregnancy Complications (15) · Respiratory Tract Infections (15) · Urogenital Diseases (15)
Sodium Chloride (4) · Ascorbic Acid (2) · Budesonide (2) · GSK1995057 (2) · Saline Solution (2) · montelukast (2) · nezulcitinib (2) · ALT-836 (1) · Azithromycin (1) · Bronchoalveolar Lavage (1) · Cell Count (1) · Clinical Trials, Phase I as Topic (1) · Clinical Trials, Phase II as Topic (1) · Continuous Positive Airway Pressure (1) · Heart Rate (1)
GlaxoSmithKline (4) · Children's Hospital of Chongqing Medical University (3) · Children's Hospital of Philadelphia (3) · Affiliated Hospital to Academy of Military Medical Sciences (2) · Mayo Clinic (2) · NICHD Neonatal Research Network (2) · Theravance Biopharma (2) · University of Alabama at Birmingham (2) · AdventHealth (1) · Airway Therapeutics, Inc. (1) · Altor BioScience (1) · Apellis Pharmaceuticals, Inc. (1) · Beijing Chao Yang Hospital (1) · Beijing Gene Key Life Technology Co., Ltd (1) · Cell Energy Life Sciences Group Co. LTD (1)
United States (44) · China (16) · United Kingdom (9) · Canada (6) · Spain (4) · Australia (3) · Belgium (2) · Brazil (2) · New Zealand (2) · Taiwan (2) · Ireland (1) · Italy (1) · Poland (1) · Russia (1) · Saudi Arabia (1)
Zhou Fu (3) · Bing Liu, M.D. (2) · Charles R. Bauer, MD (2) · Edward F. Donovan, MD (2) · Alan Davidson, MD (1) · Alexander Binning, MD (1) · Alpha Fowler, MD (1) · Andy Ghio, M.D. (1) · Anna Thomas, MD (1) · Ariel A. Salas, MD, MSPH (1) · Avroy A. Fanaroff, MD (1) · Bai-Horng Su, MD, PhD (1)
PMID 24508444, PMID 10379020, PMID 15342835, PMID 15713907, PMID 15774846, PMID 22340260, PMID 22974830, PMID 23364976, PMID 23370599, PMID 24484547, PMID 24503265, PMID 24690891, PMID 24891325, PMID 25529339, PMID 25593740, PMID 26059242, PMID 26178412, PMID 26400297, PMID 26544934, PMID 26547399, PMID 26643677, PMID 28821525, PMID 29021519, PMID 29382797, PMID 30175268, PMID 30992220, PMID 32006953, PMID 34004189, PMID 34473343, PMID 36038890, PMID 36104785, PMID 36389766, PMID 37223507, PMID 37549675, PMID 37640809, PMID 39153779, PMID 39643111, PMID 41018057, PMID 9179535
M01RR008084 (2), U10HD021364 (2), U10HD021397 (2), U10HD027853 (2), U10HD034216 (2), 1UL1RR025780 (1), 2017 (1), 2019 (1), M01RR000070 (1), M01RR000080 (1), M01RR000750 (1), M01RR000997 (1), M01RR006022 (1), M01RR016587 (1), R01HD113201 (1)