6 completed, 4 unknown, 2 terminated, 1 not yet recruiting. 15 Phase 1, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 15 | Completed 6, Unknown 4, Terminated 2, Not yet recruiting 1, Recruiting 1, Withdrawn 1 |
| Phase 2 | 7 | Completed 4, Terminated 1, Unknown 1, Withdrawn 1 |
Follow Knee Injuries: new trials by email Literature Review of Knee Injuries trials Research Report on Knee Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Genicular Nerve Block After Open Reduction Internal Fixation of Tibial Plateau Bupivacain - Tibial Plateau Fractures | Phase 1 | Recruiting | University of Chicago | 38 | 2024-11-01 | 2026-02-05 |
| Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP - Osteoarthritis of the Knee, Degenerative Osteoarthritis | Phase 1 / Phase 2 | Withdrawn | QC Kinetix LLC | 2023-11-01 | 2024-10-09 | |
| Exparel vs. ACB With Bupivacaine for ACL Reconstruction Exparel - ACL Tear, Opioid Misuse | Phase 1 | Unknown | Children's Hospital of Orange County | 96 | 2023-10-12 | 2024-02-23 |
| Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury Zoledronic Acid Injection, Placebo - Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture | Phase 1 | Terminated | University of Calgary | 4 | 2023-05-16 | 2025-12-02 |
| Synovial Tissue and Fat Pad Stromal Vascular Fraction Bioengineering in Patients With Knee Articular Cartilage Injury Synovial Tissue and Fat Pad Stromal Vascular Fraction - Cell- and Tissue-Based Therapy, Cartilage Injury | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2022-04-01 | 2021-11-15 |
| BioACL Reconstruction With Amnion Collagen Matrix Wrap and Stem Cells Case Series Bio-ACL, amnion wrap and BMAC - ACL - Anterior Cruciate Ligament Rupture | Phase 1 | Completed | Andrews Research & Education Foundation | 10 | 2018-01-08 | 2023-02-01 |
| Clinical Study of Platelet-rich Plasma Promoting Tendon-bone Healing in Anterior Cruciate Ligament Reconstruction Platelet-Rich Plasma - Sports Injury | Phase 1 | Unknown | Beijing Tsinghua Chang Gung Hospital | 60 | 2016-07-01 | 2020-12-09 |
| Functional Outcome Comparison of Implant-Free Bone-Patellar Tendon Autograft in Arthroscopic ACL Reconstruction Patella tendon & bone block autograft + press-fit femoral technique, Arthroscopic ACL reconstruction, Hamstring tendon autograft + implant fixation - Anterior Cruciate Ligament Injuries, Ligament; Rupture, Knee, Spontaneous | Phase 1 / Phase 2 | Completed | Universitas Indonesia | 32 | 2013-03-01 | 2019-10-11 |
| Internet Enhanced, Patient-Centered Orthopedic Care: A Prospective, Randomized, Controlled Pilot Trial eRehab, Formal Physical Therapy - Knee Injuries, Shoulder Injuries | Phase 1 | Completed | Charlotte Sports Medicine Institute, PA | 24 | 2012-07-01 | 2014-01-01 |
| Adult Stem Cell Therapy for Repairing Articular Cartilage in Gonarthrosis Autologous MSC knee implantation - Osteoarthritis, Knee, Knee Injuries | Phase 1 / Phase 2 | Completed | Banc de Sang i Teixits | 15 | 2010-10-01 | 2015-12-11 |
| Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction MSB-CAR001 Combined With Hyaluronan, Hyaluronan - Anterior Cruciate Ligament Injury, Osteoarthritis | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 17 | 2009-03-01 | 2018-08-15 |
| SeriACL™ Device Trial for Anterior Cruciate Ligament (ACL) Reconstruction ACL Reconstruction (SeriACL™ Device) - Anterior Cruciate Ligament, Knee Injuries | Phase 1 | Unknown | Serica Technologies, Inc. | 30 | 2007-06-01 | 2008-10-20 |
| Study to Prevent Cartilage Damage Following Acute Knee Injury. Anakinra - Knee Injury | Phase 1 / Phase 2 | Completed | Duke University | 10 | 2006-03-01 | 2013-05-30 |
| The Efficacy and Safety of Electronic Stimulation in Patients Who Underwent Reconstruction of the Anterior Cruciate Ligament stimulation of the quadriceps muscle with Myospare - Knee Injuries | Phase 1 / Phase 2 | Terminated | Hadassah Medical Organization | 60 | 2009-06-23 |
Anterior Cruciate Ligament Injuries (8) · Osteoarthritis (3) · Joint Diseases (2) · Osteoarthritis, Knee (2) · Tibial Plateau Fractures (2) · Ankle Fractures (1) · Anxiety Disorders (1) · Athletic Injuries (1) · Cartilage Diseases (1) · Opioid-Related Disorders (1) · Pain (1) · Patellofemoral Pain Syndrome (1) · Rheumatic Diseases (1) · Rupture (1)
Leg Injuries (15) · Wounds and Injuries (15) · Musculoskeletal Diseases (4) · Arthritis (3) · Fractures, Bone (2) · Joint Diseases (2) · Knee Fractures (2) · Pathological Conditions, Signs and Symptoms (2) · Rheumatic Diseases (2) · Tibial Fractures (2) · Ankle Injuries (1) · Chemically-Induced Disorders (1) · Connective Tissue Diseases (1) · Infections (1)
Acetaminophen (1) · Anterior Cruciate Ligament Reconstruction (1) · Bupivacaine (1) · Hyaluronic Acid (1) · Ibuprofen (1) · Interleukin 1 Receptor Antagonist Protein (1) · Sodium Chloride (1) · Zoledronic Acid (1)
Andrews Research & Education Foundation (1) · Banc de Sang i Teixits (1) · Beijing Tsinghua Chang Gung Hospital (1) · Charlotte Sports Medicine Institute, PA (1) · Children's Hospital of Orange County (1) · Duke University (1) · Hadassah Medical Organization (1) · Johns Hopkins University (1) · Mesoblast, Ltd. (1) · QC Kinetix LLC (1) · Serica Technologies, Inc. (1) · Universitas Indonesia (1) · University of Calgary (1) · University of Chicago (1) · University of Sao Paulo General Hospital (1)
United States (7) · Australia (1) · Canada (1) · Germany (1) · Israel (1) · Norway (1) · Spain (1)
Adam Anz, MD (1) · Adi Fridman, Dr. (1) · Andri MT Lubis, MD, PhD (1) · Anthony Christiano, MD (1) · Babar Shafi, MD, MSPT (1) · Donna Skerrett, MD (1) · Gabi Agar, Dr. (1) · Gideon Man, Dr. (1) · Gregory Kline, MD (1) · Hans Paessler, MD (1) · Henry T Shu, MD (1) · Holger Schmitt, MD (1) · Joseph Lowe, Dr. (1) · Kenneth P Barnes, MD, MSc. (1) · Lars Engebretsen, MD (1)
PMID 10037543, PMID 15123925, PMID 15527668, PMID 16002493, PMID 16305269, PMID 16885475, PMID 17767899, PMID 18586222, PMID 18835532, PMID 19515102, PMID 21194441, PMID 21248209, PMID 21252603, PMID 22004181, PMID 22273632, PMID 22776554, PMID 22813920, PMID 23209265, PMID 24196464, PMID 25769789, PMID 28768528, PMID 35103026, PMID 8773720, PMID 9362595, PMID 9699158