14 completed, 5 unknown, 2 not yet recruiting, 2 recruiting. 11 Not applicable, 6 Phase 2, 6 Phase 3, 4 Phase 4.
Follow Intraoperative Bleeding: new trials by email Literature Review of Intraoperative Bleeding trials Research Report on Intraoperative Bleeding
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| DDAVP Effect by TEG6 in Cardiac Surgery Desmopressin after protamine reversal - Intraoperative Bleeding | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2026-08-01 | 2026-09-21 | |
| Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project Hepatectomy, Transfusion Requirements | Not yet recruiting | Dr. Glenio Mizubuti (MD, PhD, FRCPC) | 60 | 2026-06-01 | 2026-06-05 | |
| Ostene in Thoracolumbar Decompression and Fusion Evaluated With VIBE Ostene - Intraoperative Complications, Intraoperative Bleeding | Enrolling by invitation | University of Maryland, Baltimore | 173 | 2025-01-17 | 2026-09-04 | |
| Study of Collagen-Based Thrombin Hemostat for the Control of Bleeding in Spinal Surgery CollaStat®, Floseal® - Spinal Tumor, Spinal Injury | Not applicable | Completed | DALIM TISSEN Co., Ltd. | 130 | 2024-10-22 | 2026-01-21 |
| Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery Epinephrine, Normal Saline irrigation fluid - Intraoperative Bleeding | Phase 3 | Withdrawn | The Guthrie Clinic | 2024-08-01 | 2024-10-15 | |
| Lidocaine and Dexmedetomidine Infusions for Intraoperative Bleeding in Functional Endoscopic Sinus Surgery Lidocaine, Dexmedetomidine - Lidocaine, Dexmedetomidine | Not applicable | Completed | Ain Shams University | 40 | 2024-07-01 | 2026-07-21 |
| The Effect of Adding Either Propofol or Ketamine to Magnesium and Lidocaine Infusions in Nasal Surgeries. Intravenous Infusion of propofol, lidocaine, Magnesium sulfate, Intravenous infusion of ketamine, lidocaine, Magnesium sulfate, Intravenous infusion of dexmedetomidine, lidocaine, Magnesium sulfate - Intraoperative Bleeding | Phase 2 / Phase 3 | Recruiting | Ain Shams University | 90 | 2024-06-15 | 2024-10-09 |
| Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle Relaxants conventional cold tonsillectomy and curettage adenoidectomy, Rocuronium Bromide - Anesthesia, Neuromuscular Blockade | Phase 4 | Unknown | University Hospital of Split | 60 | 2024-04-18 | 2024-05-03 |
| GATT-Patch Versus SURGICEL® Original in Minimally Invasive Liver and Gallbladder Surgery GATT-Patch, SURGICEL® Original - Intraoperative Bleeding, Liver Diseases | Not applicable | Completed | GATT Technologies BV | 53 | 2023-10-02 | 2026-02-12 |
| Comparison Between Atenolol,Propnalol and Ivabradine Atenolol 50 MG, Propranolol Pill, Ivabradine - Intraoperative Bleeding | Not applicable | Completed | Menoufia University | 120 | 2023-09-01 | 2024-11-01 |
| Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation Topical Phenylephrine Solution, intravenous tranexamic acid - Intraoperative Bleeding, Coblation Turbinoplasty | Not applicable | Unknown | Assiut University | 80 | 2023-05-01 | 2023-05-03 |
| Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries controlled hypotension using dexmedetomidine, controlled hypotension hypotension using nitroglycerin - Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries | Not applicable | Completed | Zagazig University | 66 | 2022-09-01 | 2026-05-13 |
| GATT-Patch Versus TachoSil in Liver Surgery GATT-Patch (currently named ETHIZIA), TachoSil - Intraoperative Bleeding, Hemorrhage, Surgical | Not applicable | Completed | GATT Technologies BV | 132 | 2022-08-04 | 2026-03-04 |
| Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations Bilateral bi-level Erector spine plane block, General anaesthesia - Scoliosis, Spinal Deformity | Not applicable | Unknown | Lviv National Medical University | 150 | 2020-12-16 | 2023-10-05 |
| Bleeding in Laparoscopic Liver Surgery Neuromuscular blockade - Neuromuscular Blockade, Intraoperative Bleeding | Not applicable | Terminated | Università Vita-Salute San Raffaele | 48 | 2020-10-30 | 2025-08-07 |
| Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy Tranexamic Acid, Epinephrine - Intraoperative Bleeding | Not applicable | Completed | Assiut University | 60 | 2019-12-04 | 2020-04-21 |
| The Value of Tranxemic Acid to Reduce Intraoperative Blood Loss During Elective Cesarean Sections in High Risk Women Tranexamic Acid, Cesarean section - Intraoperative Bleeding | Not applicable | Completed | Cairo University | 160 | 2019-01-31 | 2020-01-06 |
| Effects of Adrenaline Infiltration on Surgical Field of View in Endoscopic Sinus Surgery Epinephrin, 1% lidocaine with epinephrin 1:100,000, Saline - Intraoperative Bleeding | Phase 4 | Completed | Stanford University | 40 | 2017-05-12 | 2023-07-10 |
| Effect of Topical and Systemic Tranexemic Acid on Bleeding During Ear Exploration Surgery Tranexamic Acid, Adrenalin - Intraoperative Bleeding | Phase 2 | Unknown | Assiut University | 90 | 2017-04-01 | 2017-04-13 |
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Blood Loss, Surgical (27) · Hemorrhage (3) · Intraoperative Complications (2) · Liver Diseases (2) · Osteoarthritis (2) · Postoperative Hemorrhage (2) · Acute Pain (1) · Chronic Pain (1) · Epistaxis (1) · Gallbladder Diseases (1) · Hemostatic Disorders (1) · Hyperalgesia (1) · Hypotension (1) · Liver Neoplasms (1) · Neuralgia (1)
Pathologic Processes (27) · Pathological Conditions, Signs and Symptoms (27) · Intraoperative Complications (25) · Hemorrhage (24) · Musculoskeletal Diseases (4) · Cardiovascular Diseases (3) · Digestive System Diseases (3) · Vascular Diseases (3) · Arthritis (2) · Bone Diseases (2) · Joint Diseases (2) · Neoplasms (2) · Neoplasms by Site (2) · Nervous System Diseases (2) · Postoperative Complications (2)
Tranexamic Acid (5) · Epinephrine (4) · Lidocaine (4) · Sodium Chloride (3) · Dexmedetomidine (2) · Anesthesia, General (1) · Ascorbic Acid (1) · Atenolol (1) · Cesarean Section (1) · Fibrinogen (1) · FloSeal Matrix (1) · Gelatin Sponge, Absorbable (1) · Ivabradine (1) · Long-Term Synaptic Depression (1) · Magnesium Sulfate (1)
Assiut University (5) · Ain Shams University (2) · GATT Technologies BV (2) · Rush University Medical Center (2) · Cairo University (1) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (1) · CryoLife, Inc. (1) · DALIM TISSEN Co., Ltd. (1) · Dr. Glenio Mizubuti (MD, PhD, FRCPC) (1) · Esbjerg Hospital - University Hospital of Southern Denmark (1) · Hospital Universitari de Bellvitge (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Lviv National Medical University (1) · Menoufia University (1) · Stanford University (1)
Egypt (8) · United States (8) · Canada (3) · Croatia (1) · Denmark (1) · Germany (1) · Italy (1) · Netherlands (1) · South Korea (1) · Spain (1) · Ukraine (1)
Ahmed Maged, MD (1) · Alberto Zangrillo, Prof. (1) · Antoni Sabate, MD (1) · Benjamin Benzon (1) · Brett R Levine, MD (1) · Glenio Mizubuti, MD, PhD, FRCPC (1) · Hans de Wilt (1) · Ivan Vukovic (1) · James Guarrera (1) · Jesper J Olsen, DDS (1) · Julio C Fernandes, MDMScMBAPhD (1) · Luigi Beretta, Prof. (1) · Maksym Barsa (1) · Mark Belkin, BS (1)
PMID 10565650, PMID 11679600, PMID 20003061, PMID 26880105, PMID 28990201, PMID 31573678, PMID 31671251, PMID 35287618, PMID 37919695, PMID 39152310, PMID 39667380, PMID 42177141, PMID 42615297