Liver Diseases: Clinical Trials

6492 completed, 2715 unknown, 1405 recruiting, 913 terminated. 2926 Phase 2, 2835 Not applicable, 1907 Phase 1, 1428 Phase 3, 1105 Phase 4.

By phase and status

Phase	Trials	Status
Phase 2	2926	Completed 1448, Unknown 454, Terminated 335, Recruiting 305, Withdrawn 131, Not yet recruiting 130, Active not recruiting 113, Suspended 6, Enrolling by invitation 4
Not applicable	2835	Completed 1261, Unknown 711, Recruiting 331, Not yet recruiting 163, Terminated 149, Active not recruiting 95, Withdrawn 94, Enrolling by invitation 25, Suspended 6
Phase 1	1907	Completed 1128, Unknown 216, Recruiting 187, Terminated 180, Withdrawn 70, Active not recruiting 64, Not yet recruiting 54, Suspended 7, Enrolling by invitation 1
Phase 3	1428	Completed 833, Unknown 231, Terminated 113, Recruiting 92, Active not recruiting 53, Withdrawn 51, Not yet recruiting 46, Enrolling by invitation 5, Suspended 4
Phase 4	1105	Completed 587, Unknown 300, Terminated 74, Recruiting 47, Withdrawn 47, Not yet recruiting 26, Active not recruiting 18, Enrolling by invitation 5, Suspended 1
Early Phase 1	129	Completed 49, Unknown 29, Recruiting 14, Not yet recruiting 13, Active not recruiting 9, Terminated 7, Withdrawn 7, Suspended 1

Follow Liver Diseases: new trials by email Literature Review of Liver Diseases trials Research Report on Liver Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Integrated Care Versus Usual Care for Opioid Use Disorder and Infectious Diseases in Veterans Integrated care - Opioid Use Disorder, HIV	Not applicable	Not yet recruiting	VA Office of Research and Development	60	2028-04-03	2026-04-24
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment - Acute-On-Chronic Liver Failure	Phase 3	Not yet recruiting	Institute of Liver and Biliary Sciences, India	100	2028-01-01	2025-08-17
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction Caloric Restriction, Hyperglycemic clamp - Type2diabetes	Phase 2	Not yet recruiting	Adrian Vella	20	2027-12-15	2026-10-28
Liver Steatosis in Pediatric CD Patients Gluten-free diet - Celiac Disease in Children, Non-Alcoholic Fatty Liver Disease		Recruiting	University of Palermo	91	2027-11-01	2026-05-01
Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome Shuganhuazhuo Formula, Targeted therapy, Immunotherapy - HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine	Phase 2	Not yet recruiting	Xiang-Qian	120	2027-09-01	2026-08-27
Phase III Clinical Trial of Hepalatide in Patients With Chronic Hepatitis D Hepalatide 2.1mg, Placebo of Hepalatide - Hepatitis D, Chronic	Phase 3	Not yet recruiting	Shanghai HEP Pharmaceutical Co., Ltd.	150	2027-06-01	2026-10-28
SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease Empagliflozin 10 MG, Placebo Oral Tablet - Non-Alcoholic Fatty Liver Disease, NAFLD	Phase 2	Not yet recruiting	Justin Ryder	40	2027-05-01	2026-01-20
Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options Liver transplantation - Colorectal Neoplasms, Liver Neoplasms	Not applicable	Not yet recruiting	Charite University, Berlin, Germany	260	2027-04-01	2026-09-10
Estimating The Rate Of Complete Ablation (A0) With The Use Of Biomechanical Deformable Image Registration RayAblation - Liver Tumors	Not applicable	Not yet recruiting	M.D. Anderson Cancer Center	200	2027-04-01	2026-10-16
Adipose-Derived Mesenchymal Stem Cell for Preventing Biliary Complications Autologous adipose derived mesenchymal stromal cells (AMSC) - Liver Transplant; Complications, Liver Diseases	Phase 1	Not yet recruiting	Mayo Clinic	20	2027-02-01	2026-04-06
Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus	Phase 4	Not yet recruiting	Eunice Dube	2140	2027-01-30	2026-07-30
Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014) Ulonivirine - Hepatic Insufficiency	Phase 1	Not yet recruiting	Merck Sharp & Dohme LLC	22	2027-01-22	2026-07-16
Combating Related Epidemics in HCV Cepheid GeneXpert HCV Test, Abbott Determine HIV - 1/2 Ag/Ab, Abbott Determine HbsAg 2 - HIV - Human Immunodeficiency Virus, Hepatitis B Virus (HBV)	Phase 4	Not yet recruiting	Duke University	1280	2027-01-20	2026-10-15
A Phase 1 Clinical Trial of Adjuvanted Protein-based HCV Vaccine Candidates (HCV Vaccine Trial) AVIHepC1, Normal Saline - Hepatitis C	Phase 1	Not yet recruiting	University of Alberta	27	2027-01-15	2026-09-25
Liver Micro Flow - MRI Novel MRI Software, Ensure Plus Nutrition Shake - Liver Diseases		Not yet recruiting	University of Wisconsin, Madison	110	2027-01-15	2026-09-29
Within-Session Repeatability of EUS-Guided Portal Pressure Gradient Measurement Repeated EUS-Guided Portal Pressure Gradient Measurement - Portal Hypertension, Chronic Liver Disease		Not yet recruiting	University Hospital Muenster	150	2027-01-01	2026-10-26
Human Models of Selective Insulin Resistance: Pancreatic Clamp Insulin human, Octreotide Acetate, Glucagon - Insulin Resistance, Hyperinsulinemia	Phase 1	Not yet recruiting	Columbia University	36	2027-01-01	2026-02-06
NK521 in the Treatment of Advanced Solid Tumors NK521 Cell Injection - Hepatocellular Carcinoma (HCC), Ovarian Cancer	Early Phase 1	Not yet recruiting	Base Therapeutics (Shanghai) Co., Ltd.	18	2027-01-01	2026-09-30
TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) Music-assisted relaxation and imagery (MARI) - Surgery, Stomach Cancer	Not applicable	Not yet recruiting	Case Comprehensive Cancer Center	20	2027-01-01	2026-08-05
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem Cell Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patient- Phase-II Trial ucMSC and Standard medical treatment, Standard medical treatment - Acute-On-Chronic Liver Failure	Phase 2	Not yet recruiting	Institute of Liver and Biliary Sciences, India	100	2027-01-01	2025-08-20

Showing 20 of 13174. Sign in to see all of them.

Narrower conditions

Carcinoma, Hepatocellular (3375)  ·  Hepatitis C (1721)  ·  Non-alcoholic Fatty Liver Disease (1598)  ·  Liver Neoplasms (1288)  ·  Liver Cirrhosis (1265)  ·  Hepatitis B (1003)  ·  Hepatitis C, Chronic (907)  ·  Hepatitis B, Chronic (862)  ·  Fibrosis (677)  ·  Fatty Liver (594)  ·  Hypertension, Portal (363)  ·  Obesity (322)  ·  Hepatitis (318)  ·  Pancreatic Neoplasms (283)

Broader conditions

Digestive System Diseases (13098)  ·  Pathological Conditions, Signs and Symptoms (5022)  ·  Pathologic Processes (4540)  ·  Infections (4288)  ·  Neoplasms by Site (4191)  ·  Virus Diseases (4156)  ·  Digestive System Neoplasms (4146)  ·  Hepatitis (4113)  ·  Neoplasms (4028)  ·  Hepatitis, Viral, Human (4015)  ·  Blood-Borne Infections (3963)  ·  Communicable Diseases (3950)  ·  Neoplasms by Histologic Type (3588)  ·  Neoplasms, Glandular and Epithelial (3500)

Interventions

Ribavirin (673)  ·  peginterferon alfa-2a (426)  ·  Sorafenib (243)  ·  entecavir (206)  ·  Tenofovir (195)  ·  Sofosbuvir (183)  ·  peginterferon alfa-2b (182)  ·  lenvatinib (160)  ·  Bevacizumab (155)  ·  Blood Specimen Collection (106)  ·  Nivolumab (101)  ·  daclatasvir (101)  ·  atezolizumab (89)  ·  Radiosurgery (84)  ·  pembrolizumab (84)

Sponsors

GlaxoSmithKline (222)  ·  Merck Sharp & Dohme LLC (213)  ·  Gilead Sciences (201)  ·  Sun Yat-sen University (199)  ·  Bristol-Myers Squibb (164)  ·  Hoffmann-La Roche (164)  ·  Institute of Liver and Biliary Sciences, India (148)  ·  Assiut University (135)  ·  National Taiwan University Hospital (123)  ·  National Cancer Institute (NCI) (102)  ·  AbbVie (101)  ·  Shanghai Zhongshan Hospital (100)  ·  Assistance Publique - Hôpitaux de Paris (97)  ·  Seoul National University Hospital (93)  ·  National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (84)

Countries

United States (3778)  ·  China (2522)  ·  France (1025)  ·  Germany (777)  ·  United Kingdom (735)  ·  Canada (728)  ·  South Korea (728)  ·  Italy (690)  ·  Spain (684)  ·  Taiwan (633)  ·  Australia (451)  ·  Belgium (449)  ·  India (349)  ·  Egypt (337)  ·  Hong Kong (313)

Top investigators

Ming Shi, MD (21)

Results publications

PMID 37467180, PMID 30739368, PMID 30977945, PMID 12049862, PMID 30012435, PMID 30923816, PMID 28193518, PMID 29461687, PMID 31568620, PMID 11981766, PMID 19192962, PMID 28427875, PMID 30529905, PMID 36318027, PMID 12540794, PMID 18650514, PMID 29377566, PMID 29404492, PMID 29628281, PMID 40434633, PMID 19052126, PMID 19095497, PMID 23607594, PMID 25445400, PMID 26047908, PMID 28404091, PMID 28404092, PMID 30868245, PMID 32402160, PMID 32710245, PMID 34143971, PMID 34256305, PMID 36852452, PMID 37183883, PMID 37786277, PMID 41586499, PMID 12091661, PMID 21374666, PMID 24209977, PMID 24915612, PMID 25040192, PMID 25543678, PMID 25583164, PMID 26575258, PMID 26683763, PMID 26707365, PMID 27847279, PMID 27932229, PMID 29405329, PMID 29433850

NIH funding

2016 (63), 2014 (58), 2015 (56), 2019 (52), 2023 (43), 2009 (38), 2017 (36), 2018 (31), 2025 (26), 2008 (20), 2004 (13), P30CA016672 (12), 2005 (11), P30CA060553 (10), P30CA015083 (8)