42 completed, 12 unknown, 7 terminated, 3 withdrawn. 21 Phase 2, 16 Phase 3, 16 Phase 4, 7 Not applicable, 5 Phase 1.
Follow Fibrinogen: new trials by email Literature Review of Fibrinogen trials Research Report on Fibrinogen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pre-hospital Administration of Fibrinogen in Trauma-Induced Coagulopathy Fibrinogen concentrate, Standard trauma care - Trauma Induced Coagulopathy | Not applicable | Unknown | Unidade Local de Saude do Arco Ribeirinho | 52 | 2025-01-01 | 2024-09-19 |
| FIB Grifols Congenital Deficiency for On-demand Treatment and Surgical Prophylaxis FIB Grifols - Congenital Afibrinogenemia, Hypofibrinogenemia | Phase 3 | Withdrawn | Instituto Grifols, S.A. | 2023-12-01 | 2023-10-23 | |
| Effectiveness of Different Fibrinogen Preparations in Restoring Clot Firmness FibCLOT, RiaSTAP - Hypofibrinogenemia, Surgical Blood Loss | Phase 2 | Completed | IRCCS Policlinico S. Donato | 40 | 2023-03-20 | 2024-02-28 |
| Fibrinogen Early In Severe Trauma StudY II Fibrinogen Concentrate, Cryoprecipitate - Trauma, Haemorrhagic Shock | Phase 3 | Completed | Australian and New Zealand Intensive Care Research Centre | 900 | 2022-11-21 | 2026-09-09 |
| Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery Fibrinogen Concentrate Human - Fibrinogen, Spine Deformity | Phase 4 | Completed | Brno University Hospital | 32 | 2022-06-06 | 2026-10-16 |
| Administration of Fibrinogen Concentrate for Refractory Bleeding Fibrinogen Concentrate Human - Hematological Patients, Bleeding | Phase 2 | Terminated | Centre Hospitalier Universitaire de Saint Etienne | 1 | 2022-02-10 | 2025-12-23 |
| Fibrinogen Concentrate and Placenta Acreta Spectrum the group without fibrinogen concentrate (GNF) , the group with fibrinogen concentrate (GF) - Obstetric Anesthesia Problems, Placenta Accreta | Not applicable | Completed | Bakirkoy Dr. Sadi Konuk Research and Training Hospital | 146 | 2022-01-01 | 2023-08-02 |
| Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients Fibrinogen, Cryoprecipitate - Pediatric HD, Bleeding | Phase 4 | Completed | University of Virginia | 31 | 2021-10-26 | 2026-03-06 |
| Factor In the Initial Resuscitation of Severe Trauma 2 Patients Fibrinogen + PCC, Frozen Plasma - Traumatic Hemorrhage, Coagulopathy | Phase 4 | Terminated | University Health Network, Toronto | 142 | 2021-04-01 | 2026-10-21 |
| A Program to Evaluate Riastap® and FIBTEM® for the Early Control and Treatment of Postpartum Hemorrhage (PERFECT PPH) fibrinogen concentrate, Placebo - Postpartum Hemorrhage | Phase 1 / Phase 2 | Withdrawn | Yale University | 2021-01-01 | 2021-03-15 | |
| ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma - Bleeding, Cardiac Defect | Phase 2 | Terminated | IRCCS Policlinico S. Donato | 40 | 2020-02-27 | 2021-11-03 |
| In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB) Fibrinogen Concentrate (FC), Cryoprecipitate - Hemostasis | Phase 3 | Completed | Emory University | 36 | 2019-08-13 | 2024-02-20 |
| Impact of Two Guided Transfusion Strategies on Blood Product Requirements in Liver Transplantation. Fibrinogen Concentrate (Human) 1 MG [RiaSTAP] - Fibrin Blood Clot | Phase 4 | Unknown | Antoni Sabaté Pes | 188 | 2019-06-17 | 2021-11-26 |
| Fibrinogen Concentrate In Children Cardiac Surgery 2 Fibrinogen Concentrate, control - C.Surgical Procedure; Cardiac, Blood Coagulation Disorders | Phase 4 | Unknown | Filomena R B G Galas | 42 | 2019-03-01 | 2019-03-21 |
| Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care. Fibrinogen Concentrate (Human) 1 MG [RiaSTAP], Red blood cells concentrate, Tranexamic Acid - Polytrauma, Traumatic Hemorrhage | Phase 1 / Phase 2 | Completed | Banc de Sang i Teixits | 79 | 2018-11-21 | 2024-01-25 |
| Patient Blood Management for Massive Obstetric Hemorrhage Thromboelastometry, Standard Coagulation Test, Fibrinogen Concentrate Human - Post Partum Hemorrhage, Fibrinogenolysis; Hemorrhage | Not applicable | Completed | Angel Augusto Perez Calatayud | 100 | 2018-11-01 | 2021-06-08 |
| Analyzes of Hemorrhagic Obstetric Patients Whose Were Used Fibrinogen Fibrinogen and blood products - Hemorrhage | Completed | Kanuni Sultan Suleyman Training and Research Hospital | 56 | 2018-10-09 | 2018-10-30 | |
| Changes in Haemostasis After Therapeutic Plasmapheresis With Citrate Anticoagulation Fibrinogen concentrate, Fresh Frozen Plasma - Humoral Rejection, Guillain-Barre Syndrome | Not applicable | Unknown | University Medical Centre Ljubljana | 20 | 2018-10-03 | 2019-01-11 |
| Fibrinogen Early In Severe Trauma studY Junior Fibrinogen Concentrate, Cryoprecipitate - Trauma, Hemorrhage | Phase 2 | Unknown | Gold Coast Hospital and Health Service | 44 | 2018-07-01 | 2020-06-29 |
| Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery Platelet transfusion, Fibrinogen concentrate - Congenital Heart Disease | Phase 2 | Unknown | Sahlgrenska University Hospital | 40 | 2018-03-14 | 2021-03-19 |
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Hemorrhage (20) · Hemostatic Disorders (15) · Afibrinogenemia (10) · Wounds and Injuries (10) · Blood Loss, Surgical (5) · Heart Defects, Congenital (4) · Postpartum Hemorrhage (4) · Blood Coagulation Disorders (3) · Postoperative Hemorrhage (3) · Thrombosis (3) · Coronary Artery Disease (2) · Disseminated Intravascular Coagulation (2) · Heart Diseases (2) · Hemophilia B (2) · Scoliosis (2)
Nycomed (7) · CSL Behring (5) · IRCCS Policlinico S. Donato (3) · Emory University (2) · Gold Coast Hospital and Health Service (2) · Medical University Innsbruck (2) · Sahlgrenska University Hospital (2) · University of Sao Paulo General Hospital (2) · Angel Augusto Perez Calatayud (1) · Antoni Sabaté Pes (1) · Asan Medical Center (1) · Australian and New Zealand Intensive Care Research Centre (1) · Bakirkoy Dr. Sadi Konuk Research and Training Hospital (1) · Banc de Sang i Teixits (1) · Brno University Hospital (1)
Denmark (14) · United States (10) · Brazil (5) · Canada (5) · Italy (5) · Australia (3) · Austria (3) · Czechia (3) · Germany (3) · Spain (3) · Sweden (3) · China (2) · France (2) · Turkey (Türkiye) (2) · United Kingdom (2)
Marco Ranucci, MD (3) · Jakob Stensballe, MD, PhD (2) · Laura Downey, MD (2) · Alastair Nimmo, MBChB (1) · Anders Jeppsson, MD, PhD (1) · Angel Augusto Perez Calatayud, M.D. (1) · Anne J. Wikkelsoe, MD (1) · Antoni Sabate, MD (1) · Arash Afshari, MD (1) · Arno P Nierich, MD, PhD. (1) · Ayca Sultan Sahin, MD (1) · Barto Nascimento, MD MSc (1)
PMID 19545437, PMID 19804533, PMID 20624109, PMID 22805300, PMID 23249928, PMID 23410777, PMID 23718572, PMID 24951020, PMID 25586727, PMID 26037084, PMID 26577034, PMID 26591047, PMID 26880105, PMID 27317703, PMID 27430210, PMID 28241354, PMID 28457980, PMID 28549445, PMID 28990201, PMID 30025661, PMID 30462259, PMID 31502003, PMID 32500569, PMID 33109923, PMID 34129409, PMID 34479938, PMID 34755760, PMID 35305111, PMID 35508351, PMID 36163263, PMID 36408876, PMID 37236666, PMID 37919695, PMID 39116012, PMID 39152310, PMID 39383100, PMID 39768590, PMID 40271704, PMID 40420619, PMID 40982282, PMID 41062134, PMID 41321850
2004 (2), 2009 (2), 2018 (2), 2014 (1)