204 completed, 68 unknown, 34 recruiting, 19 terminated. 127 Not applicable, 49 Phase 4, 42 Phase 3, 23 Phase 2, 8 Early Phase 1.
Follow Intraoperative Complications: new trials by email Literature Review of Intraoperative Complications trials Research Report on Intraoperative Complications
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Quantra QPlus in Pediatric Cardiovascular Procedures Quantra System - Blood Loss, Surgical | Not yet recruiting | HemoSonics LLC | 160 | 2027-06-25 | 2026-09-17 | |
| TEG Use in Children Undergoing Procedures With High Anticipated Blood Loss Thromboelastography (TEG), Anesthesia Provider Survey - Surgical Blood Loss, Surgical Hemorrhage | Not applicable | Not yet recruiting | Boston Children's Hospital | 60 | 2027-01-01 | 2026-08-14 |
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy Tranexamic Acid (IV), Placebo - Cerebral Palsy, Hip Surgery Corrective | Phase 3 | Not yet recruiting | Murdoch Childrens Research Institute | 52 | 2026-11-01 | 2026-10-14 |
| Study of the Hemorai Vysio Wearable Device for Monitoring Changes Related to Blood Loss in Patients During and After Surgery. Wearable optical hemodynamic monitoring device - Blood Loss, Surgical, Postoperative Hemorrhage | Not applicable | Not yet recruiting | Hemorai Inc | 80 | 2026-10-15 | 2026-09-22 |
| Evaluation of Consciousness Depth (qCON) and Analgesia Depth (qNOX) Indices in General Anesthesia Cesarean Section (MeSH: D002585), Anesthesia | Not yet recruiting | Kudret Dogru | 140 | 2026-10-15 | 2026-10-22 | |
| Hemocoll, Avitene, or Bone Wax for Cancellous Bone Bleeding After Single-Ray Amputation Hemocoll® Fibrillar type-I collagen haemostat, Bone wax, Avitene™ Microfibrillar Collagen Hemostat - Hemostasis, Surgical Blood Loss | Not applicable | Recruiting | Adichunchanagiri Institute of Medical Sciences, B G Nagara | 135 | 2026-09-05 | 2026-10-27 |
| Video-Based Grading of Intraoperative Adverse Events in Pediatric Laparoscopic Appendectomy Laparoscopic appendectomy - Appendicitis, Acute, Appendectomy | Recruiting | Ahmet Burak Doğan, MD | 80 | 2026-09-01 | 2026-09-04 | |
| Phase 3 Trial of Reltodecacog Alfa (VMX-C001) vs Usual Pharmacological Care in Patients Taking a FXa Direct Oral Anticoagulant Who Require Urgent Surgery With or Without Heparin. Reltodecacog alfa, Usual Pharmacological Care - Blood Loss, Surgical, Coagulation Disorder | Phase 3 | Recruiting | VarmX B.V. | 800 | 2026-08-18 | 2026-10-14 |
| The Efficacy of Carbitocin in Reduction of Blood Loss During Myomectomy Carbetocin - Blood Loss, Surgical | Early Phase 1 | Not yet recruiting | Alex Ekwueme Federal University Teaching Hospital | 900 | 2026-08-15 | 2026-07-23 |
| Opioid-Free Anesthesia in FESS: A Prospective ERAS Study Dexmedetomidine, Remifentanil - Chronic Sinusitis, Postoperative Pain | Recruiting | Filiz Kaya | 104 | 2026-08-15 | 2026-09-10 | |
| Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial Carbetocin, Oxytocin, Placebo Saline Infusion - Postpartum Hemorrhage, Uterine Atony | Phase 4 | Recruiting | Mansoura University | 332 | 2026-08-08 | 2026-10-09 |
| DDAVP Effect by TEG6 in Cardiac Surgery Desmopressin after protamine reversal - Intraoperative Bleeding | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2026-08-01 | 2026-09-21 | |
| TEAPOT Study Multisite Tranexamic Acid Injectable Product, Normal Saline - Hemorrhage, Surgical, Tonsillar Bleeding | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 30 | 2026-07-14 | 2026-07-17 |
| Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery Tranexamic Acid (Topical), Normal Saline (Placebo) - Cesarean Delivery, Postpartum Hemorrhage (PPH) | Early Phase 1 | Recruiting | Wolfson Medical Center | 112 | 2026-07-01 | 2026-07-02 |
| Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without Tourniquet Simultaneous Bilateral Total Knee Replacement with Tourniquet, Simultaneous Bilateral Total Knee Replacement without Tourniquet - Arthroplasty, Replacement, Knee, Blood Loss, Surgical | Not applicable | Enrolling by invitation | Shifa International Hospital | 84 | 2026-07-01 | 2026-10-29 |
| Hemodynamic Changes and Trigeminocardiac Reflex During Bimaxillary Orthognathic Surgery Orthognathic Surgery, Trigeminocardiac Reflex | Recruiting | Kırıkkale University | 18 | 2026-06-20 | 2026-07-28 | |
| Reducing Red Blood Cell Transfusion Requirements for Adults Undergoing Surgical Resection of the Liver - A Quality Improvement Project Hepatectomy, Transfusion Requirements | Not yet recruiting | Dr. Glenio Mizubuti (MD, PhD, FRCPC) | 60 | 2026-06-01 | 2026-06-05 | |
| Deep Learning Framework for Continuous Depth of Anesthesia Forecasting BIS, BIS-EEG | Not yet recruiting | Universitair Ziekenhuis Brussel | 115 | 2026-06-01 | 2026-04-17 | |
| Prospective Cohort Study of Pheochromocytoma/Paraganglioma Pheochromocytoma, Paraganglioma | Not yet recruiting | Peking Union Medical College Hospital | 200 | 2026-04-01 | 2026-04-07 |
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Blood Loss, Surgical (213) · Intraoperative Awareness (55) · Hemorrhage (54) · Postoperative Complications (33) · Postoperative Hemorrhage (31) · Pain, Postoperative (19) · Malignant Hyperthermia (12) · Hemostatic Disorders (9) · Pain (7) · Thrombosis (7) · Postpartum Hemorrhage (6) · Anemia (5) · Burns (5) · Agnosia (4)
Pathological Conditions, Signs and Symptoms (366) · Pathologic Processes (365) · Hemorrhage (160) · Signs and Symptoms (63) · Postoperative Complications (55) · Neurologic Manifestations (35) · Cardiovascular Diseases (32) · Vascular Diseases (27) · Neoplasms (25) · Nervous System Diseases (23) · Urogenital Diseases (22) · Wounds and Injuries (22) · Female Urogenital Diseases and Pregnancy Complications (20) · Digestive System Diseases (19)
Tranexamic Acid (44) · Saline Solution (22) · Sodium Chloride (14) · Misoprostol (9) · Oxytocin (8) · Dexmedetomidine (6) · Fibrinogen (6) · Epinephrine (5) · Sevoflurane (5) · Thrombin (5) · Anesthesia, General (4) · Aprotinin (4) · Bupivacaine (4) · Control Groups (4) · Lidocaine (4)
Assiut University (11) · Ain Shams University (7) · HemoSonics LLC (6) · Bayer (4) · Cairo University (4) · CytoSorbents, Inc (3) · Egymedicalpedia (3) · GATT Technologies BV (3) · Hospital Clinic of Barcelona (3) · National and Kapodistrian University of Athens (3) · Nycomed (3) · Seoul National University Hospital (3) · The University of Texas Health Science Center at San Antonio (3) · University Hospital, Basel, Switzerland (3) · Università Vita-Salute San Raffaele (3)
United States (80) · Turkey (Türkiye) (34) · Egypt (28) · Canada (23) · Germany (18) · Italy (18) · China (17) · Spain (15) · Netherlands (12) · Switzerland (12) · United Kingdom (11) · Denmark (10) · France (10) · Belgium (9) · Brazil (9)
Akiyoshi Namiki, MD, PhD (2) · Andre Lamy, MD (2) · Andrew D Meyer, MD, MS (2) · Benjamin Benzon (2) · C. M Gibson, MD (2) · De Cosmo Germano, PhD (2) · Emine Ozcan, MD (2) · Francesco Egro (2) · Giovanni Landoni, MD (2) · Giuseppe Crescenzi, MD (2) · Hala S Abdelghaffar, MD (2) · Ivan Vukovic (2) · Joaquim E Vieira, MD, PhD (2)
PMID 21062463, PMID 30908754, PMID 35657375, PMID 39667380, PMID 10334155, PMID 10536541, PMID 10553858, PMID 10565650, PMID 10598599, PMID 10598642, PMID 10839257, PMID 10903015, PMID 10960408, PMID 11307125, PMID 11411248, PMID 11472278, PMID 11679600, PMID 12145033, PMID 12225610, PMID 1284606, PMID 1389813, PMID 14581667, PMID 15155337, PMID 15454134, PMID 15545569, PMID 16078916, PMID 16438759, PMID 16525984, PMID 17218108, PMID 17264717, PMID 17276271, PMID 17295411, PMID 17646507, PMID 17671004, PMID 17714574, PMID 17884710, PMID 18019945, PMID 18029344, PMID 18043061, PMID 18331175, PMID 18333937, PMID 18480196, PMID 19007970, PMID 19112059, PMID 19247742, PMID 19397502, PMID 19545437, PMID 19698857, PMID 19713260, PMID 19795951
2005 (2), 2004 (1), 2016 (1), 2017 (1), 2023 (1), R34HL177446 (1), U54HL143541 (1)