46 completed, 16 unknown, 7 not yet recruiting, 7 terminated. 36 Not applicable, 20 Phase 2, 10 Phase 3, 10 Phase 4, 7 Phase 1.
Follow Epistaxis: new trials by email Literature Review of Epistaxis trials Research Report on Epistaxis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| Topical TOR-582 Treatment of Epistaxis in HHT Topical sirolimus ointment - Hereditary Hemorrhagic Telangiectasia (HHT), Epistaxis | Phase 1 | Not yet recruiting | Columbia University | 27 | 2026-10-01 | 2026-08-21 |
| The Efficacy of Local Application of B-sitosterol Versus Vasline in Cases of Idiopathic Epistaxis vasline, B-sitosterol - Epistaxis | Phase 4 | Not yet recruiting | Assiut University | 162 | 2026-05-01 | 2026-04-15 |
| Outcome of Hyaluronic Acid Gel Versus Petroleum Jelly in Treatment of Epistaxis Hyaluronic Acid Gel, Petroleum jelly - Epistaxis | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-05-01 | 2026-04-22 |
| Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease Optimized management, Standard of care management - Von Willebrand Disease (VWD) | Not applicable | Recruiting | University Hospital, Lille | 66 | 2026-03-10 | 2026-05-18 |
| Management of Epistaxis Comparing Nasal Packing Versus Greater Palatine Foramen Block Greater Palatine Foramen Block with 2% xylocaine with adrenaline, Anterior Nasal Packing - Epistaxis Nosebleed, Greater Palatine Foramen | Not applicable | Not yet recruiting | Sheikh Zayed Federal Postgraduate Medical Institute | 40 | 2026-03-01 | 2026-02-24 |
| A Trial of TER-1754 in Patients With Hereditary Hemorrhagic Telangiectasia TER-1754, Placebo - Hereditary Hemorrhagic Telangiectasia (HHT) | Phase 1 | Withdrawn | Terremoto Biosciences Inc. | 2025-12-15 | 2026-04-13 | |
| Comparison of Nasal Endotracheal Tube and Spiral Tube for Nasotracheal Intubation in Pediatric Patients nazotracheal intubation - Epistaxis | Not applicable | Completed | Dicle University | 98 | 2025-05-02 | 2026-02-10 |
| Usage of Orange Peel Extract in Management of Epistaxis Orange - Epistaxis | Not applicable | Not yet recruiting | Minia University | 60 | 2025-02-01 | 2025-02-20 |
| Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation 0.1% xylometazoline nasal drops, Adrenaline nasal pack - Nasal Bleeding, Nasotracheal Intubation | Phase 2 / Phase 3 | Recruiting | Shaheed Mohtarma Benazir Bhutto Institue of Trauma | 70 | 2024-12-01 | 2025-01-30 |
| A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT) ALN-6400, Placebo - Hereditary Hemorrhagic Telangiectasia | Phase 1 / Phase 2 | Active not recruiting | Alnylam Pharmaceuticals | 89 | 2024-11-07 | 2026-10-15 |
| Risk Factors of Epistaxis Recurrence in Adults Epistaxis | Not yet recruiting | University Hospital, Grenoble | 145 | 2024-11-02 | 2024-10-24 | |
| Tranexamic Acid Versus Blood Stopper Treatments in Epistaxis Management Blood Stopper (Ankaferd) - Epistaxis Nosebleed | Phase 4 | Unknown | Ankara Ataturk Sanatorium Training and Research Hospital | 186 | 2024-10-01 | 2024-07-08 |
| Comparison Between Nasal and Oropharyngeal Bleeding in Video Laryngoscopy and Direct Laryngoscopy for Nasal Intubation Combined Video Laryngoscopy (VL) and Bougie, Combined Direct Laryngoscopy (DL) and Bougie - Maxillofacial Injuries, Nasal Bleeding | Not applicable | Unknown | Aswan University | 64 | 2024-06-01 | 2025-02-21 |
| Atmospheric Pressure and Epistaxis Relationship Atmospheric Pressure; Adverse Effect, Epistaxis Nosebleed | Unknown | Saglik Bilimleri Universitesi | 600 | 2024-04-01 | 2024-08-01 | |
| NOVAPAK Nasal Packing in Shellfish Allergic Patients NOVAPAK nasal packing applied to forearm, NOVAPAK nasal packing applied to nasal cavity - Shellfish Hypersensitivity, Epistaxis | Phase 4 | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2024-03-15 | 2023-09-11 |
| Comprehensive HHT Outcomes Registry of the United States (CHORUS) Hereditary Hemorrhagic Telangiectasia, Arteriovenous Malformations | Recruiting | Cure HHT | 10000 | 2023-11-13 | 2026-07-17 | |
| Epistaxis in Patients Receiving Oral Anticoagulants and Antiplatelet: Prevalence Risk Factors at a Tertiary Care Hospital in Nepal Epistaxis | Completed | Institute of medicine, Maharagjung medical campus | 284 | 2023-11-01 | 2025-04-02 | |
| Pazopanib for the Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia Pazopanib - Hereditary Hemorrhagic Telangiectasia, Epistaxis | Phase 1 / Phase 2 | Unknown | Cure HHT | 30 | 2023-07-01 | 2022-09-08 |
| Effects of Pazopanib on Hereditary Hemorrhagic Telangiectasia Related Epistaxis and Anemia (Paz) Pazopanib, Placebo oral capsule - Hereditary Hemorrhagic Telangiectasia, Epistaxis | Phase 2 / Phase 3 | Active not recruiting | Cure HHT | 70 | 2023-05-08 | 2026-03-19 |
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Telangiectasia, Hereditary Hemorrhagic (30) · Anemia (3) · Nasal Obstruction (3) · Airway Obstruction (2) · Arteriovenous Malformations (2) · Bronchial Spasm (2) · Gastrointestinal Hemorrhage (2) · Hemorrhage (2) · Pain (2) · Vascular Malformations (2) · Agnosia (1) · Angiodysplasia (1) · Atherosclerosis (1) · Blood Loss, Surgical (1)
Nose Diseases (88) · Otorhinolaryngologic Diseases (88) · Pathologic Processes (88) · Pathological Conditions, Signs and Symptoms (88) · Respiratory Tract Diseases (88) · Signs and Symptoms (88) · Signs and Symptoms, Respiratory (88) · Hemorrhage (86) · Cardiovascular Diseases (33) · Vascular Diseases (33) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (31) · Hematologic Diseases (31) · Hemic and Lymphatic Diseases (31) · Hemorrhagic Disorders (31) · Cardiovascular Abnormalities (30)
Tranexamic Acid (6) · Bevacizumab (5) · Saline Solution (3) · Sodium Chloride (3) · Drug Packaging (2) · Epinephrine (2) · FloSeal Matrix (2) · Lidocaine (2) · pazopanib (2) · Albumins (1) · Ascorbic Acid (1) · Atrial Natriuretic Factor (1) · Blood Cell Count (1) · Cellulose (1) · Doxycycline (1)
Assiut University (5) · Bezmialem Vakif University (3) · Cure HHT (3) · University of Zurich (3) · Ajou University School of Medicine (2) · Hospices Civils de Lyon (2) · Imperial College London (2) · Unity Health Toronto (2) · University of California, San Diego (2) · Ain Shams University (1) · Alnylam Pharmaceuticals (1) · Ankara Ataturk Sanatorium Training and Research Hospital (1) · Aswan University (1) · Buddhist Tzu Chi General Hospital (1) · Church & Dwight Company, Inc. (1)
United States (21) · France (13) · Canada (9) · Turkey (Türkiye) (7) · South Korea (4) · Switzerland (4) · United Kingdom (4) · Egypt (3) · Germany (2) · Israel (2) · Pakistan (2) · Spain (2) · Argentina (1) · Australia (1) · Austria (1)
Claire L Shovlin, PhD FRCP (2) · Ahmed AbdelAleem AbdelWahab, Prof (1) · Ahmed Khan, MBBS, FCPS (1) · Aimee Moulin, MD (1) · Alan H. Shikani, MD, FACS (1) · Ayman M Eldemrdash, MD (1) · Carlo Balduini, M.D. (1) · Cassi Friday, PhD (1) · Chi-Tan Hu (1) · Christian Debry, Pr (1) · David Cote, MD, FRCS(C) (1) · Eitan Yaniv, MD (1) · Fikret Salik, specialist (1)
PMID 28078544, PMID 23754469, PMID 24146883, PMID 24595923, PMID 24686867, PMID 25005464, PMID 25040799, PMID 26686256, PMID 27195194, PMID 27599328, PMID 27599329, PMID 28347346, PMID 28652319, PMID 29310703, PMID 29349350, PMID 30191360, PMID 30549051, PMID 30787962, PMID 31080025, PMID 31615556, PMID 31910860, PMID 32934988, PMID 32940653, PMID 33009189, PMID 34592949, PMID 37876056, PMID 39292928, PMID 39510938, PMID 40642178, PMID 41719457, PMID 41843464
2009 (1), 2016 (1), 2025 (1), UL1TR000135 (1)