1475 completed, 985 unknown, 670 recruiting, 342 terminated. 1270 Phase 2, 850 Not applicable, 773 Phase 1, 356 Phase 3, 128 Phase 4.
Follow this condition Literature Review of Liver Neoplasms trials Research Report on Liver Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Shuganhuazhuo Formula for Advanced Hepatocellular Carcinoma With Damp-Heat Syndrome Shuganhuazhuo Formula, Targeted therapy, Immunotherapy - HCC - Hepatocellular Carcinoma, Chinese Herbal Medicine | Phase 2 | Not yet recruiting | Xiang-Qian | 120 | 2027-09-01 | 2026-08-27 |
| Liver Transplantation for Non-Resectable Colorectal Liver Metastases Without Local Treatment Options Liver transplantation - Colorectal Neoplasms, Liver Neoplasms | Not applicable | Not yet recruiting | Charite University, Berlin, Germany | 260 | 2027-04-01 | 2026-09-10 |
| Estimating The Rate Of Complete Ablation (A0) With The Use Of Biomechanical Deformable Image Registration RayAblation - Liver Tumors | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 200 | 2027-04-01 | 2026-10-16 |
| Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health. Gardasil 9 vaccine, Hepatitis B Virus Vaccine(HBV), Cognitive Behavioral Therapy - Hepatitis B, Human Papilloma Virus | Phase 4 | Not yet recruiting | Eunice Dube | 2140 | 2027-01-30 | 2026-07-30 |
| A Post Approval Study to Evaluate Safety and Effectiveness of Multicompartmental Dosimetry Planning. TheraSphere - Hepatocellular Carcinoma (HCC) | Not yet recruiting | Boston Scientific Corporation | 140 | 2027-01-01 | 2026-10-01 | |
| NK521 in the Treatment of Advanced Solid Tumors NK521 Cell Injection - Hepatocellular Carcinoma (HCC), Ovarian Cancer | Early Phase 1 | Not yet recruiting | Base Therapeutics (Shanghai) Co., Ltd. | 18 | 2027-01-01 | 2026-09-30 |
| TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) Music-assisted relaxation and imagery (MARI) - Surgery, Stomach Cancer | Not applicable | Not yet recruiting | Case Comprehensive Cancer Center | 20 | 2027-01-01 | 2026-08-05 |
| Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in Patients With Hepatocellular Carcinoma Based on TCM Constitutional Types: A Prospective Cohort Study Liver Cancer | Not yet recruiting | Affiliated Hospital of Chengde Medical University | 500 | 2027-01-01 | 2026-08-03 | |
| Utilize Imaging to Assess Changes in Hepatocellular Carcinoma Perfusion as Potentiated by Intra-Arterial Nitroglycerin Parenchymal Blood Volume (PBV) Imaging, Nitroglycerin, Medical Record Review - Hepatocellular Carcinoma (HCC), Liver Cancer, Adult | Phase 2 | Not yet recruiting | University of California, San Francisco | 50 | 2026-12-15 | 2026-10-13 |
| Study of Tegavivint Plus Zanzalintinib in Patients With Advanced Hepatocellular Carcinoma Zanzalintinib, Tegavivint - Hepatocellular Carcinoma (HCC) | Phase 1 / Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 36 | 2026-12-01 | 2026-10-16 |
| Erlotinib for Hepatocellular Carcinoma Chemoprevention erlotinib hydrochloride, Placebo - Cirrhosis, Liver, Advanced Liver Fibrosis | Phase 2 | Not yet recruiting | University of Texas Southwestern Medical Center | 60 | 2026-12-01 | 2026-06-24 |
| Surgery vs. Watch-and-Wait Strategy in Complete Responders for Hepatocellular Carcinoma Curative-Intent Liver Resection, Immunotherapy-Based Systemic Maintenance Therapy - Hepatocellular Carcinoma | Not applicable | Not yet recruiting | West China Hospital | 60 | 2026-12-01 | 2026-10-08 |
| Autologous CAR T Cells Targeting GPC3 (RPCAR01) for the Treatment of Advanced or Metastatic GPC3 Expressing Hepatocellular Carcinoma Anti-GPC3-CAR Autologous T Lymphocytes, Biospecimen Collection, Computed Tomography - Advanced Hepatocellular Carcinoma, Metastatic Hepatocellular Carcinoma | Phase 1 | Suspended | Roswell Park Cancer Institute | 24 | 2026-11-15 | 2026-09-15 |
| Multiple Adjunct Therapies to Improve Immunotherapy Treatment in Patients With Locally Advanced or Metastatic Melanoma or Advanced Hepatocellular Cancer Biospecimen Collection, Cholecalciferol, Computed Tomography - Advanced Hepatocellular Carcinoma, Advanced Melanoma | Phase 2 | Not yet recruiting | University of Southern California | 46 | 2026-11-01 | 2026-09-23 |
| Lenvatinib Plus Tislelizumab With or Without Gefitinib for Advanced Liver Cancer Lenvatinib, Tislelizumab, Gefitinib - Hepatocellular Carcinoma (HCC) | Phase 2 | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 120 | 2026-11-01 | 2026-09-21 |
| Phase 2 Study of Daraxonrasib in Recurrent KRAS-Mutant Biliary Tract Cancer Daraxonrasib - Biliary Tract Cancers, Intrahepatic Cholangiocarcinoma (Icc) | Phase 2 | Not yet recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 55 | 2026-11-01 | 2026-08-28 |
| Phase 1 Trial of ACE723, A Dual-Payload Antibody Drug Conjugate, in Patients With Advanced HCC Who Have Failed or Progressed on Standard Systemic Therapy Containing ICIs ACE723 - Hepatocellular Carcinoma (HCC), Hepatocellular Carcinoma Metastatic | Phase 1 | Not yet recruiting | Acepodia Biotech, Inc. | 70 | 2026-11-01 | 2026-10-06 |
| STRATHEP: AI-Driven Treatment Stratification for Advanced Hepatocellular Carcinoma Hepatocellular Carcinoma (HCC) | Recruiting | Universitaire Ziekenhuizen KU Leuven | 280 | 2026-10-15 | 2026-10-07 | |
| PULSAR Radiotherapy Combined With Immunotherapy for High-Risk Advanced Liver Cancer PULSAR (Personalized Ultrafractionated Stereotactic Adaptive Radiotherapy), Immune checkpoint inhibitor-based therapy - Hepatocellular Carcinoma (HCC), Radiotherapy-Induced Immune Priming | Phase 2 | Recruiting | Samsung Medical Center | 38 | 2026-10-15 | 2026-10-21 |
| SBRT Combined With Iparomlimab and Tuvonralimab (QL1706) and Bevacizumab for Hepatocellular Carcinoma Stereotactic Body Radiotherapy, Bevacizumab, Iparomlimab and Tuvonralimab - Hepatocellular Carcinoma (HCC) | Phase 2 | Not yet recruiting | Peking University Cancer Hospital & Institute | 33 | 2026-10-15 | 2026-10-20 |
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Carcinoma, Hepatocellular (3371) · Pancreatic Neoplasms (278) · Stomach Neoplasms (270) · Colorectal Neoplasms (243) · Neoplasms (226) · Breast Neoplasms (178) · Carcinoma, Non-Small-Cell Lung (177) · Esophageal Neoplasms (171) · Lung Neoplasms (169) · Cholangiocarcinoma (161) · Neoplasm Metastasis (161) · Carcinoma, Renal Cell (158) · Melanoma (155) · Ovarian Neoplasms (139)
Neoplasms by Site (4128) · Digestive System Diseases (4124) · Digestive System Neoplasms (4115) · Liver Diseases (4056) · Neoplasms (3912) · Neoplasms by Histologic Type (3531) · Neoplasms, Glandular and Epithelial (3484) · Adenocarcinoma (3426) · Carcinoma (3407) · Pathological Conditions, Signs and Symptoms (650) · Pathologic Processes (576) · Gastrointestinal Diseases (506) · Gastrointestinal Neoplasms (446) · Urogenital Diseases (385)
Sorafenib (239) · lenvatinib (159) · Bevacizumab (154) · Nivolumab (96) · atezolizumab (88) · Radiosurgery (84) · pembrolizumab (83) · Oxaliplatin (79) · Fluorouracil (69) · durvalumab (69) · sintilimab (68) · Doxorubicin (53) · Hepatectomy (51) · Leucovorin (50) · Radiofrequency Ablation (50)
Sun Yat-sen University (170) · National Cancer Institute (NCI) (93) · Seoul National University Hospital (65) · Shanghai Zhongshan Hospital (65) · Fudan University (51) · National Taiwan University Hospital (49) · M.D. Anderson Cancer Center (48) · Eastern Hepatobiliary Surgery Hospital (47) · Assistance Publique - Hôpitaux de Paris (42) · Guangxi Medical University (38) · Bayer (36) · Second Affiliated Hospital of Guangzhou Medical University (32) · Tianjin Medical University Cancer Institute and Hospital (32) · Zhejiang University (30) · Tongji Hospital (28)
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Ming Shi, MD (21) · Jeong Min Lee, MD (15) · Tim F Greten, M.D. (12) · Zhenfeng Zhang, MD, PhD (9) · David Hsieh, MD (7)
PMID 12049862, PMID 11981766, PMID 19192962, PMID 12540794, PMID 18650514, PMID 19095497, PMID 29628281, PMID 32402160, PMID 34143971, PMID 36852452, PMID 12091661, PMID 21374666, PMID 27932229, PMID 29433850, PMID 29471013, PMID 29875066, PMID 32557715, PMID 32716739, PMID 33538338, PMID 34905388, PMID 14667750, PMID 14762851, PMID 19766639, PMID 23547075, PMID 26361969, PMID 28434648, PMID 30207593, PMID 31070690, PMID 31401903, PMID 35421228, PMID 36529152, PMID 38319892, PMID 39437804, PMID 40772525, PMID 10207464, PMID 15273542, PMID 16250051, PMID 16495695, PMID 16557381, PMID 16908937, PMID 18054553, PMID 18477802, PMID 19212170, PMID 19300227, PMID 19908093, PMID 19949018, PMID 20130466, PMID 20175033, PMID 20199501, PMID 20203173
2023 (17), 2016 (12), 2017 (12), 2019 (12), 2018 (11), P30CA016672 (10), P30CA060553 (10), 2009 (8), 2015 (8), 2025 (8), P30CA015083 (8), P30CA033572 (8), 2014 (7), P30CA014089 (7), N01CM62201 (5)