71 completed, 29 unknown, 23 terminated, 18 recruiting. 176 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 176 | Completed 71, Unknown 29, Terminated 23, Recruiting 18, Withdrawn 16, Active not recruiting 9, Not yet recruiting 7, Enrolling by invitation 3 |
Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF) Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC) - Degenerative Disc Disease, Spinal Stenosis Lumbar | Not applicable | Not yet recruiting | Isto Biologics | 280 | 2026-12-01 | 2026-08-20 |
| Kore Fiber PLF Study Kore Fiber, Autologous bone graft - Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease | Not applicable | Not yet recruiting | Kolosis Bio, LLC | 75 | 2026-11-01 | 2026-10-22 |
| Lumbar Fusion With Nanotube Versus Titanium Cage Adaptix nanoPEEK Cage, Capstone PTC Cage - Degenerative Disc Disease, Lumbar Fusion | Not applicable | Not yet recruiting | Francis Farhadi | 108 | 2026-10-01 | 2026-10-16 |
| Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease Cervical Fusion (ZetaFuse™ Bone Graft) - Radiculopathy, Cervical, Myelopathy Cervical | Not applicable | Recruiting | Zetagen Therapeutics, Inc | 10 | 2026-09-01 | 2025-04-24 |
| Biologic Injection For Adults With Lumbar Disc Herniation Bone Marrow Aspirate Concentrate (BMAC) - Degenerative Disc Disease, DDD | Not applicable | Recruiting | Weill Medical College of Cornell University | 90 | 2026-08-30 | 2026-07-29 |
| Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion - Degenerative Disc Disease(DDD) | Not applicable | Not yet recruiting | Providence Medical Technology, Inc. | 225 | 2026-06-30 | 2026-07-23 |
| Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings Standard Physical Therapy Program - Low Back Pain, Physical Therapy | Not applicable | Not yet recruiting | Bahçeşehir University | 120 | 2026-06-10 | 2026-06-16 |
| Proprio Spine Measurement Tool Intraoperative spinal measurement system - Intervertebral Disc Degeneration, Intervertebral Disc Displacement | Not applicable | Withdrawn | Duke University | 2026-04-20 | 2026-04-23 | |
| Long-term Assessment of BDyn Dynamic Stabilization Device in Patients With Lumbar Degenerative Disc Disease Dynamic Lumbar Stabilization Device - Degenerative Disc Disease | Not applicable | Not yet recruiting | Cousin Biotech | 150 | 2026-04-01 | 2026-05-12 |
| Physiotherapy and Osteopathic Treatment for Pain in the Cervical and Lumbar Spine and Temporomandibular Joints General Osteopathic Treatment, Visceral Therapy, Magnetic field therapy - Disc Degenerative Disease, Spine Degeneration | Not applicable | Enrolling by invitation | Poznan University of Physical Education | 300 | 2026-02-01 | 2026-09-21 |
| Comparaison of Interbody Bone Fusion Between Two Osteoinductive Bioactive Bone Substitutes After Anterior Lumbar Interbody Arthrodesis in Degenerative Lumbar Disc Surgery in Adults Use of bone substitute during intervertebral fusion surgery - Disc Degeneration | Not applicable | Recruiting | University Hospital, Montpellier | 100 | 2026-01-28 | 2026-03-11 |
| Examining the Impact of a Digital Health Program and TENS Device for Patients With Chronic Low Back Pain Digital Musculoskeletal (MSK) Program, Transcutaneous Electrical Nerve Stimulation (TENS), Standard of Care (SOC) - Back Pain Lower Back Chronic, Chronic Pain | Not applicable | Enrolling by invitation | Hinge Health, Inc | 196 | 2026-01-16 | 2026-01-23 |
| Assessing Microbiome in Primary Anterior Cervical Fusion Patients Primary Anterior Cervical Discectomy Procedures - Cervical Stenosis, Myelopathy | Not applicable | Enrolling by invitation | Hospital for Special Surgery, New York | 76 | 2025-10-14 | 2026-10-16 |
| Stem Cells vs. Steroids for Discogenic Back Pain Autologous stem cells, Corticosteroid, Local anesthetic - Chronic Low Back Pain, Degenerative Disc Disease | Not applicable | Withdrawn | Johns Hopkins University | 2025-09-30 | 2025-10-07 | |
| Investigation of miRNA Expression Profiles in Human Degenerated Intervertebral Disc Tissues surgery (any volume) and / or pharmaceuticals treatment initiated or planned or only dynamic observation, in accordance with current clinical guidelines, excised, Diagnostic work up - Degeneration Disc Intervertebral, miRNA | Not applicable | Active not recruiting | Çanakkale Onsekiz Mart University | 50 | 2025-04-11 | 2025-08-11 |
| Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease VIA Disc NP, Sham - Degenerative Disc Disease, Disc Degeneration | Not applicable | Recruiting | VIVEX Biologics, Inc. | 325 | 2025-02-17 | 2026-09-14 |
| The Role of Disc Nutrition in the Etiology and Clinical Treatment of Disc Degeneration Physical Therapy - Back Pain, Intervertebral Disc Degeneration | Not applicable | Withdrawn | VA Office of Research and Development | 2025-02-03 | 2026-02-27 | |
| Fusion or Not - a Study on Low Back Pain Fusion surgery, Non-fusion surgery - Low Back Pain, Mechanical, Degenerative Disc Disease Lumbar | Not applicable | Recruiting | Uppsala University | 90 | 2025-02-01 | 2026-09-08 |
| Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain Midline Lumbar Interbody Fusion (MIDLIF), Minimally Invasive Transforaminal Lumbar Interbody Fusion (mini-TLIF) - Lower Back Pain Chronic, Lumbar Degenerative Disease | Not applicable | Recruiting | Copernicus Memorial Hospital | 100 | 2025-01-19 | 2026-04-15 |
| HYDRAFIL-D: HYDRogel Augmentation For Intervertebral Lumbar Discs The ReGelTec HYDRAFIL™ System, Conservative Care Management - Degenerative Disc Disease (DDD) | Not applicable | Recruiting | ReGelTec, Inc. | 225 | 2025-01-13 | 2026-09-18 |
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Spondylolisthesis (35) · Low Back Pain (27) · Spinal Stenosis (26) · Intervertebral Disc Displacement (15) · Spondylosis (14) · Radiculopathy (10) · Back Pain (8) · Intervertebral disc disease (6) · Klippel-Feil Syndrome (4) · Osteoarthritis (4) · Spinal Curvatures (4) · Lymphoma, Follicular (3) · Spinal Cord Diseases (3) · Spinal Diseases (3)
Bone Diseases (175) · Musculoskeletal Diseases (175) · Spinal Diseases (173) · Pathological Conditions, Signs and Symptoms (46) · Neurologic Manifestations (36) · Signs and Symptoms (36) · Pain (34) · Spondylolysis (34) · Spondylosis (25) · Back Pain (23) · Pathological Conditions, Anatomical (17) · Hernia (15) · Nervous System Diseases (12) · Neuromuscular Diseases (10) · Peripheral Nervous System Diseases (10)
Transplantation, Autologous (11) · Total Disc Replacement (5) · Gene Fusion (3) · Exercise (2) · Pedicle Screws (2) · Spinal Fusion (2) · Standard of Care (2) · Transcutaneous Electric Nerve Stimulation (2) · Adrenal Cortex Hormones (1) · Analgesics, Opioid (1) · Anesthesia, Epidural (1) · Anesthetics, Local (1) · Anti-Inflammatory Agents, Non-Steroidal (1) · Arthrodesis (1) · Arthroplasty (1)
Medtronic Spinal and Biologics (15) · Kuros Biosurgery AG (4) · Pioneer Surgical Technology, Inc. (4) · VIVEX Biologics, Inc. (4) · CeraPedics, Inc (3) · Duke University (3) · Ohio State University (3) · Olympus Biotech Corporation (3) · Rush University Medical Center (3) · Spinal Stabilization Technologies (3) · Synthes USA HQ, Inc. (3) · AxioMed Spine Corporation (2) · Baxter Healthcare Corporation (2) · Bioventus LLC (2) · CarboFix Orthopedics Ltd. (2)
United States (85) · Germany (7) · Canada (5) · China (5) · Switzerland (5) · Australia (4) · Belgium (4) · France (4) · Poland (4) · Sweden (4) · Turkey (Türkiye) (4) · Israel (3) · Italy (3) · Netherlands (3) · Russia (3)
Kern Singh, MD (3) · Michael Hess, MD (3) · Christopher Centeno, MD (2) · Douglas Beall, MD (2) · Fred Geisler, MD (2) · Jad G Khalil, MD (2) · Jadwiga Kuciel-Lewandowska, MD (2) · Matt Jenkins (2) · Aleksandr V Krutko, PhD, MD (1) · Alphonse Lubansu, M.D. (1) · Amir Fayyazi, MD (1) · Andrew Dailey, M.D. (1) · Antonio Castellvi, M.D. (1) · Benjamin C Mayo, BA (1)
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