7 completed, 3 unknown, 2 recruiting, 2 withdrawn. 15 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 15 | Completed 7, Unknown 3, Recruiting 2, Withdrawn 2, Terminated 1 |
Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF Dexamethasone, Normal saline - Spinal Stenosis Lumbar, Disc Degeneration | Phase 4 | Recruiting | Potsawat Surabotsopon | 60 | 2024-05-01 | 2025-09-08 |
| Eplerenone as a Supplement to Epidural Steroid Injections Eplerenone 50 Mg Tab, Placebo Oral Tablet - Degenerative Intervertebral Discs, Sciatic Radiculopathy | Phase 4 | Withdrawn | University of Cincinnati | 2023-06-01 | 2023-03-17 | |
| Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine, normal saline - Lumbar Spinal Stenosis, Lumbar Disc Herniation | Phase 4 | Recruiting | John O'Toole | 125 | 2022-02-01 | 2026-02-17 |
| Orthokine Therapy in Lumbar Degenerative Disease Orthokine periradicular injection, Orthokine epidural injection - Degenerative Disc Disease, Lumbar Region | Phase 4 | Unknown | Sutherland Medical Center | 100 | 2021-02-01 | 2021-02-02 |
| NanoFUSE® PL Gutter PMCF NanoFUSE® Bioactive Matrix (75%) w/autograft (25%) - Degenerative Disc Disease | Phase 4 | Unknown | NanoFUSE Biologics, LLC | 50 | 2019-01-01 | 2018-11-23 |
| Efficacy of Using Solum IV and BMC With GFC in TLIF Solum IV, Bone Marrow Concentrate with general fluid concentrate (GFC) in Transforaminal Lumbar Interbody Fusion - Degenerative Disc Disease, Isthmic-lytic Spondylolisthesis | Phase 4 | Withdrawn | Seton Healthcare Family | 2017-09-30 | 2018-04-18 | |
| BIO4 Clinical Case Study: Cervical Spine 1 or 2-Level ACDF utilizing BIO4 with Bio AVS Cervical Allograft (with graft window)., Aviator Anterior Cervical Plating System - Degenerative Disc Disease, Trauma (Including Fractures) | Phase 4 | Completed | Seton Healthcare Family | 20 | 2017-04-06 | 2022-01-14 |
| A Prospective Study to Compare Bupivacaine and Exparel Versus Bupivacaine or Exparel Alone for Postoperative Pain Relief Exparel, Bupivacaine - Low Back Pain, Lumbosacral Radiculopathy | Phase 4 | Terminated | Virtua Health, Inc. | 19 | 2016-12-01 | 2021-01-06 |
| A Prospective Study of the InterFuse T(tm), InterFuse T, Standard of Care TLIF (Stryker AVS Unilif) - Low Back Pain | Phase 4 | Unknown | Vertebral Technologies, Inc. | 60 | 2015-01-01 | 2016-11-02 |
| Post-Market Surveillance Study of the TM Ardis Interbody Fusion System TM-Ardis Interbody - Degenerative Disc Disease | Phase 4 | Completed | Zimmer Biomet | 80 | 2014-03-01 | 2019-03-15 |
| Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Duloxetine, Placebo - Intervertebral Disc Degeneration | Phase 4 | Completed | Serviço de Anestesiologia de Joinville | 60 | 2014-01-01 | 2020-10-09 |
| Evaluation of Fusion Rate of Anterior Cervical Discectomy and Fusion (ACDF) Using Cervios ChronOs™ and Bonion™ Cervios ChronOs, Bonion - Intervertebral Disk Degeneration, Intervertebral Disk Displacement | Phase 4 | Completed | Seoul National University Hospital | 85 | 2011-11-01 | 2014-07-23 |
| Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Oxycodone, Morphine, Placebo - Chronic Low Back Pain, Degenerative Disc Disease | Phase 4 | Completed | Brigham and Women's Hospital | 81 | 2009-02-01 | 2017-07-11 |
| Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain functional anesthetic discography, provocative discography - Low Back Pain | Phase 4 | Completed | Medtronic Spine LLC | 62 | 2007-03-01 | 2021-01-05 |
| Comparison of IDD Therapy and Non-surgical Treatment for Low Back Pain Caused by Degenerative Disc Disease Accu-Spina Device/IDD therapy, Physical Therapy - Degenerative Disc Disease | Phase 4 | Completed | Emory University | 50 | 2004-09-01 | 2013-12-24 |
Low Back Pain (6) · Intervertebral Disc Displacement (3) · Spinal Stenosis (3) · Spondylolisthesis (3) · Anxiety Disorders (1) · Bone Diseases (1) · Congenital Abnormalities (1) · Constriction, Pathologic (1) · Depression (1) · Musculoskeletal Diseases (1) · Neoplasms (1) · Ossification of Posterior Longitudinal Ligament (1) · Pseudarthrosis (1) · Radiculopathy (1)
Bone Diseases (14) · Musculoskeletal Diseases (14) · Spinal Diseases (14) · Pathological Conditions, Signs and Symptoms (8) · Back Pain (6) · Neurologic Manifestations (6) · Pain (6) · Signs and Symptoms (6) · Hernia (3) · Pathological Conditions, Anatomical (3) · Spondylolysis (2) · Spondylosis (2) · Behavior (1) · Behavioral Symptoms (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Saline Solution (2) · Bupivacaine (1) · Clonidine (1) · Dexamethasone (1) · Duloxetine Hydrochloride (1) · Eplerenone (1) · Morphine (1) · Oxycodone (1) · Physical Therapy Modalities (1)
Seton Healthcare Family (2) · Brigham and Women's Hospital (1) · Emory University (1) · John O'Toole (1) · Medtronic Spine LLC (1) · NanoFUSE Biologics, LLC (1) · Potsawat Surabotsopon (1) · Seoul National University Hospital (1) · Serviço de Anestesiologia de Joinville (1) · Sutherland Medical Center (1) · University of Cincinnati (1) · Vertebral Technologies, Inc. (1) · Virtua Health, Inc. (1) · Zimmer Biomet (1)
United States (8) · Belgium (1) · Canada (1) · France (1) · Germany (1) · Poland (1) · South Korea (1) · Spain (1) · Sweden (1) · Thailand (1)
Eeric Truumees, MD (2) · Ajay D Wasan, MD, MSc (1) · Jin Sup Yeom, MD, PhD (1) · Joel Batts (1) · John O'Toole, MD (1) · Michael K Schaufele, M.D. (1) · Piotr Godek, PhD (1) · Ray M Baker, MD (1) · Rick D Guyer, MD (1) · Robert Greenleaf, MD (1) · Shuchita Garg, MD (1) · Stephen P Kallhorn, MD (1)
PMID 15995108, PMID 16757774, PMID 21799397, PMID 24464507, PMID 25932600, PMID 26213843, PMID 27683674, PMID 28002096, PMID 29337717, PMID 31587982
K23DA020681 (1)