Constriction, Pathologic: Clinical Trials

108 completed, 40 unknown, 28 recruiting, 22 terminated. 110 Not applicable, 15 Phase 2, 15 Phase 3, 13 Phase 4, 10 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	110	Completed 53, Unknown 21, Recruiting 12, Terminated 10, Not yet recruiting 6, Active not recruiting 4, Withdrawn 2, Enrolling by invitation 1, Suspended 1
Phase 2	15	Completed 5, Unknown 4, Not yet recruiting 3, Terminated 2, Recruiting 1
Phase 3	15	Completed 5, Terminated 3, Unknown 3, Recruiting 2, Not yet recruiting 1, Withdrawn 1
Phase 4	13	Completed 6, Active not recruiting 2, Unknown 2, Enrolling by invitation 1, Terminated 1, Withdrawn 1
Phase 1	10	Completed 4, Not yet recruiting 1, Recruiting 1, Suspended 1, Terminated 1, Unknown 1, Withdrawn 1
Early Phase 1	1	Terminated 1

Follow Constriction, Pathologic: new trials by email Literature Review of Constriction, Pathologic trials Research Report on Constriction, Pathologic

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
FGF-1 for Intramuscular Injection for the Treatment of Peripheral Arterial Disease FGF-1, Placebo - Peripheral Arterial Disease, Stenosis	Phase 1 / Phase 2	Not yet recruiting	Venturis Therapeutics, Inc.	24	2028-10-15	2026-08-19
Endoscopic Treatment Informed consent, Eligibility criteria check, Randomisation - Stenoses, Dyspnea	Not applicable	Not yet recruiting	University Hospital, Toulouse	96	2027-01-01	2026-07-27
Aortic Valve Replacement for Moderate Aortic Stenosis With Left Ventricular Decompensation Early Feasibility Study Ross procedure - Moderate Aortic Valve Stenosis	Not applicable	Withdrawn	Dermed Diagnostics, Inc.		2027-01-01	2025-07-11
Pain After Microsurgical Decompression LUMBAR STENOSIS		Enrolling by invitation	Aalborg University	200	2026-11-01	2026-10-20
Medical Treatment Versus Surgery in Stricturing Small Bowel Crohn's Disease Azathioprine + infliximab, Intestinal resection - Crohn Disease	Not applicable	Not yet recruiting	Nantes University Hospital	150	2026-10-01	2026-06-23
A Phase 2, Placebo-Controlled Study of Oral RXC008 for Crohn's Strictures High Dose, Low Dose, Placebo - Strictures Due to Crohn's Disease	Phase 2	Not yet recruiting	Redx Pharma Ltd	180	2026-10-01	2026-09-22
Adjuvant Steroid Outcomes in Idiopathic Subglottic Stenosis Triamcinolone 0.1%, Placebo - Idiopathic Subglottic Stenosis	Phase 3	Recruiting	Johns Hopkins University	226	2026-05-20	2026-10-22
A Study Comparing the MAGICTouch™ Sirolimus-coated Balloon With a Paclitaxel-coated Balloon for Treating Severe Narrowing or Blockage in the Femoropopliteal Arteries. Sirolimus (RAPAMUNE) drug-coated balloon angioplasty catheter, Paclitaxel drug-coated balloon angioplasty - Popliteal Artery Disease, Superficial Femoral Artery Disease	Phase 2 / Phase 3	Not yet recruiting	Concept Medical Inc.	478	2026-04-01	2026-04-17
Comparison of the Therapeutic Effects of Balloon Assisted Enteroscopy Assisted Narrow Incision and Balloon Dilation in the Treatment of Crohn's Disease Small Intestinal Stenosis stricture incision, balloon dilation, No Interventions - CD - Crohn's Disease	Not applicable	Not yet recruiting	Second Affiliated Hospital, Zhejiang University, School of Medicine	100	2026-03-01	2026-02-13
Guselkumab Vs Ustekinumab in Stricturing Crohn's Disease Guselkumab (GUS), Ustekinumab (UST) - CD - Crohn's Disease, Stricture; Bowel		Recruiting	Second Affiliated Hospital, Zhejiang University, School of Medicine	100	2026-03-01	2026-03-02
Targeting Real World Usage In Stroke Treatment Aneurysm Treatment with a Neurovascular Flow Diverter, Dissection Treatment with a Neurovascular Flow Diverter, Perforation Treatment with a Neurovascular Flow Diverter - Saccular and Fusiform Aneurysms, Pseudoaneurysm		Recruiting	Phenox GmbH	5000	2026-01-29	2026-03-16
A Comparative Analysis of the Effectiveness of Nepafenac Combined With a Lubricant Versus a Lubricant Alone in the Treatment of Epiphora Associated With Lacrimal Punctum Stenosis Nepafenac and lubricant, Placebo - Epiphora, Punctal Stenosis	Phase 4	Active not recruiting	Instituto de Oftalmología Fundación Conde de Valenciana	68	2026-01-12	2026-01-28
Intra-arterial Thrombolysis for Acute Ischemic Stroke With Medium Vessel Occlusion Intra-arterial Thrombolysis, Best Medical Treatment - Stroke, Cerebrovascular Disorders	Not applicable	Recruiting	The Second Hospital of Anhui Medical University	282	2026-01-06	2026-04-16
Ultrasound and Proteomics for Guselkumab Response Assessment in Crohn's Disease (UPGRADE). Guselkumab Subcutaneous - Crohn's Disease of Both Small and Large Intestine		Recruiting	University of Calgary	90	2025-10-31	2025-11-24
Spontaneous Correction of Sagittal Imbalance After Isolated Lumbar Decompression Isolated lumbar decomression - LUMBAR STENOSIS, Sagittal Imbalance	Not applicable	Recruiting	N.N. Priorov National Medical Research Center of Traumatology and Orthopedics	165	2025-10-06	2026-07-02
EvaluatioN of Optilume Drug-Coated Balloon for the Endoscopic Treatment of UREteric Strictures Optilume - Ureteral Stricture	Not applicable	Recruiting	Urotronic Inc.	60	2025-10-01	2026-03-09
Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity Cardiopulmonary Exercise Testing (CPET), Shear Wave Elastography Scan - Single-ventricle, Stenosis		Recruiting	Children's Hospital Los Angeles	20	2025-08-01	2025-07-18
The Prevalence of Directional Preference in the Lumbar Stenosis Population Lumbar Stenosis		Recruiting	NYU Langone Health	67	2025-06-09	2026-05-04
Non-invasive Detection of Coronary Artery Stenosis Coronary Arterial Disease (CAD)		Not yet recruiting	Nilocas	20	2025-05-01	2024-12-27
Beacon Tip Sizing Catheter and Slip-Cath Beacon Tip Catheter Study Beacon Tip Catheters - Stenosis, Bleed Intracranial		Completed	Cook Research Incorporated	816	2025-04-20	2026-07-06

Showing 20 of 228. Sign in to see all of them.

Narrower conditions

Crohn Disease (17)  ·  Coronary Artery Disease (16)  ·  Carotid Stenosis (13)  ·  Stroke (13)  ·  Bites and Stings (12)  ·  Peripheral Arterial Disease (11)  ·  Spondylolisthesis (11)  ·  Vascular Diseases (11)  ·  Aortic Valve Stenosis (10)  ·  Atherosclerosis (10)  ·  Arteriovenous Fistula (9)  ·  Kidney Failure, Chronic (8)  ·  Coronary Stenosis (7)  ·  Ischemia (7)

Broader conditions

Pathological Conditions, Signs and Symptoms (228)  ·  Pathological Conditions, Anatomical (225)  ·  Cardiovascular Diseases (93)  ·  Vascular Diseases (71)  ·  Arterial Occlusive Diseases (47)  ·  Pathologic Processes (41)  ·  Digestive System Diseases (37)  ·  Arteriosclerosis (36)  ·  Heart Diseases (36)  ·  Nervous System Diseases (36)  ·  Central Nervous System Diseases (33)  ·  Gastrointestinal Diseases (33)  ·  Brain Diseases (31)  ·  Cerebrovascular Disorders (28)  ·  Musculoskeletal Diseases (26)

Interventions

Angioplasty (3)  ·  Clopidogrel (3)  ·  Sirolimus (3)  ·  Stents (3)  ·  Angioplasty, Balloon (2)  ·  Aspirin (2)  ·  Atorvastatin (2)  ·  Blood Specimen Collection (2)  ·  Methylprednisolone (2)  ·  Paclitaxel (2)  ·  Transcatheter Aortic Valve Replacement (2)  ·  Ustekinumab (2)  ·  cholesterol-binding protein (2)  ·  2-mercaptopurine (1)  ·  5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide (1)

Sponsors

C. R. Bard (7)  ·  Mayo Clinic (5)  ·  Second Affiliated Hospital, Zhejiang University, School of Medicine (5)  ·  Singapore General Hospital (5)  ·  SeaSpine, Inc. (4)  ·  W.L.Gore & Associates (4)  ·  Boston Scientific Corporation (3)  ·  Cardiawave SA (3)  ·  St Vincent's Hospital Melbourne (3)  ·  Al-Azhar University (2)  ·  Assistance Publique - Hôpitaux de Paris (2)  ·  Biotronik AG (2)  ·  Centre Hospitalier Universitaire de Nice (2)  ·  Centre Hospitalier Universitaire de Nīmes (2)  ·  Cook Group Incorporated (2)

Countries

United States (77)  ·  Germany (24)  ·  China (21)  ·  France (17)  ·  Belgium (12)  ·  Italy (12)  ·  United Kingdom (12)  ·  Canada (9)  ·  Spain (8)  ·  Australia (7)  ·  Israel (7)  ·  Singapore (7)  ·  Austria (6)  ·  Netherlands (6)  ·  Brazil (5)

Top investigators

Bronte Holt, MBBS PhD (3)  ·  Emily Wright, MBBS PhD (3)  ·  Michael Kamm, MBBS PhD (3)  ·  Bart Dolmatch, M.D. (2)  ·  Chris Metzger, MD (2)  ·  Emmanuel Messas, MD (2)  ·  Gregory A Cote, MD, MS (2)  ·  Gunnar Tepe, MD (2)  ·  Peter Schneider, MD (2)  ·  Abid Assali, Prof. MD (1)  ·  Adnan Siddiqui, MD (1)  ·  Adriaan Moelker, dr (1)  ·  Adrien Guenego, MD (1)  ·  Ajay Kirtane, MD (1)  ·  Albert Miralles (1)

Results publications

PMID 42573020, PMID 11320025, PMID 11320034, PMID 11820911, PMID 14452301, PMID 14644218, PMID 16160130, PMID 18222352, PMID 18609466, PMID 18806663, PMID 18829240, PMID 20129555, PMID 20142967, PMID 20147715, PMID 20194880, PMID 20505173, PMID 20876500, PMID 21205942, PMID 21307169, PMID 21386741, PMID 21550314, PMID 21606394, PMID 21799173, PMID 21899409, PMID 21958882, PMID 21980205, PMID 21982102, PMID 21982309, PMID 22241928, PMID 2243969, PMID 22496083, PMID 22539545, PMID 22581488, PMID 22821614, PMID 22848141, PMID 22857850, PMID 22910894, PMID 22941123, PMID 23159552, PMID 23265585, PMID 23670746, PMID 24055515, PMID 24315720, PMID 24345529, PMID 24661748, PMID 24864182, PMID 24929484, PMID 24935281, PMID 24957314, PMID 25213339

NIH funding

1UG3HL173394-01A1 (1), K23DK095148 (1), R01CA263776 (1), R01NS038384 (1), R21DK090708 (1), R21DK119740 (1), U01HL128606 (1), U19AI095261 (1)