515 completed, 144 unknown, 108 terminated, 93 recruiting. 989 Phase 2, 169 Phase 1, 151 Phase 3.
Follow Inflammation: new trials by email Literature Review of Inflammation trials Research Report on Inflammation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase IIb Multicenter Randomized Controlled Trial Evaluating the Efficacy of Sivelestat in Patients With Septic Coagulopathy • Sivelestat intravenous infusion, NaCl intravenous infusion - Septic Shock, Coagulopathy | Phase 2 | Not yet recruiting | University Hospital, Strasbourg, France | 120 | 2027-08-01 | 2026-08-20 |
| Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses Methylene Blue, Lipid Emulsion, Insertion of optical fiber - Abscess | Phase 2 | Not yet recruiting | University of Rochester | 120 | 2027-07-15 | 2026-11-06 |
| Efficacy of Para-Tyrosine Supplementation on the Survival and Clinical Outcome in Patients With Sepsis Para-Tyrosine supplementation, Placebo solution - Sepsis | Phase 2 | Suspended | University of Pecs | 296 | 2027-01-01 | 2025-03-30 |
| Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults Pentadecanoic Acid, Placebo - Red Blood Cell Health, Biological Aging | Phase 2 | Not yet recruiting | ReCellience15, Inc | 93 | 2027-01-01 | 2026-10-05 |
| Mild-Intensity Whole Body Hyperthermia (WBH) for Major Depressive Disorder Tocilizumab, Placebo, Whole-Body Hyperthermia - Major Depressive Disorder | Phase 2 | Suspended | Massachusetts General Hospital | 35 | 2026-12-01 | 2025-11-13 |
| THiamine for Recovery In Vulnerable Early-life Infections thiamine hydrochloride 100 mg, Placebo - Meningitis, Bacteremia | Phase 2 | Not yet recruiting | Milton S. Hershey Medical Center | 240 | 2026-12-01 | 2026-10-09 |
| IGOB131 As A GLP-1 Modulator For Metabolic Disorders In Adults With Obesity IGOB131, Dextrin - Obesity & Overweight | Phase 2 | Not yet recruiting | University of Yaounde 1 | 80 | 2026-12-01 | 2026-10-20 |
| A Pivotal Safety and Immunogenicity GBS-NN/NN2 Vaccine Maternal Immunisation Trial GBS-NN/NN2 vaccine, Placebo - Streptococcus Agalactiae Infection, Neonatal Sepsis | Phase 2 / Phase 3 | Not yet recruiting | Minervax ApS | 6600 | 2026-11-30 | 2026-11-06 |
| Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction Colchicine, Placebo - Heart Failure With Preserved Ejection Fraction, Microvascular Coronary Artery Disease | Phase 2 | Recruiting | Montreal Heart Institute | 64 | 2026-11-06 | 2026-11-10 |
| Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis inulin, Maltodextrin (Placebo) - Knee Osteoarthritis | Phase 2 | Not yet recruiting | Yale University | 84 | 2026-11-01 | 2026-07-07 |
| Low Dose Dexamethasone for the Prevention of Cytokine Release Syndrome Associated With Tebentafusp Dexamethasone - Uveal Melanoma, Metastatic | Phase 2 | Withdrawn | University of California, San Diego | 2026-11-01 | 2026-11-06 | |
| Butyric Acid Supplementation for Gut Improvement After Cardiac Surgery in Kids 2 mL SunButyrate-TG, Placebo, 4 mL SunButyrate-TG - Congenital Heart Disease (CHD) | Phase 1 / Phase 2 | Recruiting | University of Nebraska | 105 | 2026-11-01 | 2026-10-30 |
| Ticagrelor for Inflammation and Cardiovascular Risk in Patients With Chronic Kidney Disease Ticagrelor: an oral, direct-acting, reversibly binding P2Y12 receptor antagonist, Placebo - Chronic Kidney Disease (CKD) | Phase 2 | Recruiting | University of Arkansas | 230 | 2026-11-01 | 2026-11-10 |
| Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans 2-hydroxybenzylamine, Placebo - Salt Sensitivity of Blood Pressure, High Blood Pressure | Phase 2 | Recruiting | Vanderbilt University Medical Center | 20 | 2026-10-30 | 2026-11-04 |
| Efficacy and Safety of Olatorepatide Versus Placebo in Adults With Moderate to Severe Hidradenitis Suppurativa Living With Overweight or Obesity Olatorepatide, Placebo - Hidradenitis Suppurativa | Phase 2 | Recruiting | Regeneron Pharmaceuticals | 300 | 2026-10-29 | 2026-11-10 |
| NAI Plus Standard of Care Compared With Placebo Plus Standard of Care in Critically Ill Adults With Sepsis Nogapendekin alfa inbakicept (NAI), Placebo - Sepsis | Phase 2 | Not yet recruiting | ImmunityBio, Inc. | 50 | 2026-10-15 | 2026-09-25 |
| "IL-1β Blockade to Prevent Immunothrombosis in Recipients of a Pancreatic Organ" Anakinra 100Mg/0.67Ml Inj Syringe - Pancreatic Transplant | Phase 1 / Phase 2 | Recruiting | Nantes University Hospital | 15 | 2026-10-07 | 2026-10-13 |
| Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults Fish Oil, Corn oil control - Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance) | Phase 2 | Recruiting | May Faraj, PDt, PhD | 84 | 2026-10-05 | 2026-10-08 |
| Pre-emptive Anakinra for Cytokine Event Reduction Anakinra (Kineret®) - B-Acute Lymphoblastic Leukemia, CAR-T Cell Therapy | Phase 1 / Phase 2 | Withdrawn | Kevin McNerney | 2026-10-01 | 2026-08-13 | |
| CORTISHOCK-P: Trial of Corticosteroids in Inflammation-Enriched Heart Failure Cardiogenic Shock Methylprednisone, Standard of Care (SOC) - Cardiogenic Shock, Heart Failure | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 30 | 2026-10-01 | 2026-08-13 |
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Sepsis (227) · Shock, Septic (147) · Cytokine Release Syndrome (64) · COVID-19 (52) · Neuroinflammatory Diseases (32) · Respiratory Distress Syndrome (28) · Bacteremia (27) · Atherosclerosis (24) · Infections (24) · Systemic Inflammatory Response Syndrome (24) · Pain (23) · Cellulitis (22) · Alzheimer Disease (21) · Heart Failure (21)
Pathological Conditions, Signs and Symptoms (989) · Pathologic Processes (984) · Infections (450) · Systemic Inflammatory Response Syndrome (399) · Shock (224) · Respiratory Tract Diseases (137) · Cardiovascular Diseases (131) · Sepsis (120) · Lung Diseases (119) · Vascular Diseases (112) · Nervous System Diseases (111) · Signs and Symptoms (110) · Immune System Diseases (107) · Nutritional and Metabolic Diseases (93)
Saline Solution (34) · Sodium Chloride (29) · Standard of Care (21) · Ascorbic Acid (20) · Interleukin 1 Receptor Antagonist Protein (20) · Colchicine (14) · tocilizumab (12) · salicylsalicylic acid (11) · Daptomycin (10) · Hydrocortisone (10) · Thiamine (10) · Meropenem (9) · Vancomycin (9) · esmolol (9) · Aspirin (8)
Ain Shams University (16) · Novo Nordisk A/S (10) · AstraZeneca (9) · Beth Israel Deaconess Medical Center (9) · National Institute of Allergy and Infectious Diseases (NIAID) (9) · University of Florida (9) · Novartis Pharmaceuticals (8) · GlaxoSmithKline (7) · Massachusetts General Hospital (7) · Radboud University Medical Center (7) · Virginia Commonwealth University (7) · Mansoura University (6) · Mayo Clinic (6) · University of Colorado, Denver (6) · University of Roma La Sapienza (6)
United States (421) · Canada (78) · Germany (57) · France (56) · Spain (50) · Italy (46) · United Kingdom (45) · Netherlands (43) · Brazil (38) · Belgium (37) · China (37) · Denmark (33) · Egypt (33) · Australia (28) · Poland (28)
Andrea Morelli, MD (5) · Allison B. Goldfine, MD (4) · Antonio Abbate, MD, PhD (3) · Benjamin Van Tassell, PharmD (3) · Eric Bellissant, MD, PhD (3) · Issam Raad, MD (3) · Joaquin Espinosa, PhD (3) · Michael W Donnino, MD (3) · Ritankar Das, MSc (3)
PMID 26903338, PMID 23001587, PMID 24484547, PMID 24794878, PMID 28159728, PMID 36915146, PMID 37916745, PMID 38321529, PMID 39230271, PMID 10379020, PMID 10415784, PMID 10722036, PMID 11230313, PMID 1138591, PMID 11402097, PMID 11502226, PMID 11588440, PMID 12147930, PMID 12454520, PMID 12500513, PMID 12519925, PMID 12545007, PMID 12563677, PMID 12628952, PMID 12700374, PMID 1342820, PMID 14719037, PMID 14759425, PMID 14987884, PMID 15030944, PMID 15231405, PMID 15234492, PMID 15663512, PMID 15713907, PMID 16003060, PMID 1607900, PMID 16134000, PMID 16134766, PMID 16164444, PMID 16319269, PMID 16505648, PMID 16507156, PMID 16570523, PMID 16636217, PMID 16980879, PMID 17076839, PMID 17181919, PMID 17206944, PMID 17429083, PMID 17551901
2015 (5), 2014 (4), 2017 (4), 2018 (4), 2019 (4), 2023 (4), 2016 (3), 2008 (2), 2009 (2), 2025 (2), K23AG052633 (2), P30AG028740 (2), R01HL095149 (2), U01DK074556 (2), U01HD019897 (2)