186 completed, 56 terminated, 51 unknown, 42 recruiting. 95 Phase 4, 94 Phase 2, 85 Phase 3, 55 Not applicable, 38 Phase 1.
Follow Vancomycin: new trials by email Literature Review of Vancomycin trials Research Report on Vancomycin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease Fecal Microbiota Transplant - Parkinson Disease | Phase 1 | Not yet recruiting | ProgenaBiome | 10 | 2027-07-01 | 2026-10-09 |
| Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Vancomycin (local, via calcium sulfate beads), Morphine (local, via calcium sulfate beads), Bupivacaine (local, via calcium sulfate beads) - Spine Surgery, Postoperative Pain Management | Phase 2 | Not yet recruiting | Ganesh M. Shankar | 100 | 2027-01-01 | 2026-04-16 |
| Primary Prophylaxis of Clostridioides Difficile Infection With Oral Vancomycin Vancomycin (POC) - Clostridioides Difficile, Vancomycin Resistance Enterococcus Faecium | Phase 2 / Phase 3 | Withdrawn | University of Maryland, Baltimore | 2027-01-01 | 2026-07-29 | |
| A Phase 2b Study to Evaluate the Efficacy, Safety, and PK Profiles of TNP-2092 Administered Via IA Injection in PJI Participants TNP-2092 for injection, Vancomycin Hydrochloride for Injection, Oral antibiotics - Prosthetic Joint Infection (PJI) | Phase 2 | Recruiting | TenNor Therapeutics (Zhongshan) Limited | 40 | 2026-10-21 | 2026-10-28 |
| Vancomycin Efficacy in Response to Dysbiosis in Atypical Colitis Oral Vancomycin - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Not yet recruiting | Tampere University Hospital | 140 | 2026-10-01 | 2026-09-10 |
| Use of Fidaxomicin Compared to Vancomycin for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease Vancomycin (POC), Fidaxomicin - Inflammatory Bowel Disease (IBD), Clostridioides Difficile Infection | Phase 4 | Not yet recruiting | Brigham and Women's Hospital | 60 | 2026-09-01 | 2025-11-03 |
| A Clinical Trial Evaluating Fecal Microbiota Transplantation (FMT) in Adolescents With ADHD Fecal Microbiota Transplant (FMT), Nitazoxanide 500mg BID, Vancomycin 250mg BID - ADHD, ADHD - Attention Deficit Disorder With Hyperactivity | Phase 2 | Not yet recruiting | University of Calgary | 64 | 2026-08-31 | 2026-09-10 |
| Investigation of Vancomycin Efficacy in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Placebo (blinded), Vancomycin (blinded), Vancomycin (open-label extension) - Ulcerative Colitis (UC), Primary Sclerosing Cholangitis (PSC) | Phase 2 | Recruiting | McMaster University | 14 | 2026-06-17 | 2026-10-09 |
| Implementation of Vancomycin Powder Application in the Emergency Department for Open Fractures Vancomycin (VAN) treatment, Standard Open Fracture Care - Open Fracture | Phase 3 | Not yet recruiting | Atlantic Health System | 100 | 2026-06-10 | 2026-06-22 |
| Early Discontinuation of Antibiotics in Paediatric High-risk Febrile Neutropenia Early Discontinuation of Antibiotics, Standard Antibiotic Continuation Strategy - Febrile Neutropenia (FN), Pediatric Cancer | Phase 4 | Not yet recruiting | Hospital Universitari Vall d'Hebron Research Institute | 136 | 2026-06-01 | 2026-05-15 |
| Radiation, Oral Vancomycin, and CAR-T for B-Cell Lymphomas Vancomycin 125mg, Radiation Therapy, CAR-T - Large B Cell Lymphoma, Non Hodgkin Lymphoma (NHL) | Phase 1 | Recruiting | Abramson Cancer Center at Penn Medicine | 14 | 2026-05-29 | 2026-07-01 |
| Novel Biomarkers of Non-IgE Immediate Hypersensitivity Drug Reactions Vancomycin (IV) - Healthy Volunteer, Hypersensitivity Reactions | Phase 1 / Phase 2 | Active not recruiting | Johns Hopkins University | 25 | 2026-05-21 | 2026-10-27 |
| Prospective, Randomized, Multicenter Clinical Trial of Bisphosphonates Combined With Vancomycin for the Treatment of Cierny-Mader Type I and III Osteomyelitis Bisphosphonates Combined with Vancomycin, Vancomycin - Osteomyelitis (Refractory) | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 280 | 2026-05-01 | 2026-02-27 |
| Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies Topical Vancomycin Powder, Standard Perioperative Care - Hydrocephalus, Ventriculoperitoneal Shunt Infection | Phase 4 | Not yet recruiting | Assiut University | 164 | 2026-05-01 | 2026-04-23 |
| Vancomycin Taper to Prevent Recurrent Clostridioides Difficile Fidaxomicin, Vancomycin capsule - Clostridia Difficile Colitis | Phase 3 | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 500 | 2026-04-24 | 2026-09-23 |
| Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial Cefazolin, Vancomycin - Infection, Surgical Site | Phase 4 | Not yet recruiting | Hamilton Health Sciences Corporation | 38000 | 2026-03-01 | 2026-03-12 |
| A Pragmatic Clinical Trial Comparing the Risk of Acute Kidney Injury During Treatment With Vancomycin and Piperacillin-Tazobactam vs. Vancomycin and Cefepime in Hospitalized Patients Vancomycin, Piperacillin-tazobactam, Cefepime - Acute Kidney Injury | Phase 4 | Recruiting | University of Pennsylvania | 750 | 2026-01-28 | 2026-02-13 |
| Impact Of The Gut Microbiota On Host Cells Energy Metabolism in Health And In Inflammatory Bowel Disease Vancomycin /Amphotericin B (Fungizone®) /Gentamicine 80 mg, Inulin/Inulin C13 - IBD, Crohn Disease | Phase 2 | Recruiting | Assistance Publique - Hôpitaux de Paris | 45 | 2026-01-02 | 2026-03-12 |
| Topical Vancomycin for Infection Prophylaxis in TJA Vancomycin Powder - Infection of Total Hip Joint Prosthesis, Infection of Total Knee Joint Prosthesis | Phase 2 | Not yet recruiting | Alberta Hip and Knee Clinic | 100 | 2025-12-30 | 2024-07-31 |
| A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement Tissue Expander (TE), Vancomycin and Gentamicin, Stimulan Rapid Cure - Breast Cancer | Phase 4 | Recruiting | Memorial Sloan Kettering Cancer Center | 392 | 2025-10-21 | 2026-07-10 |
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Clostridium Infections (51) · Infections (41) · Surgical Wound Infection (28) · Cellulitis (19) · Staphylococcal Infections (19) · Bacteremia (14) · Diarrhea (14) · Bacterial Infections (13) · Cholangitis, Sclerosing (13) · Sepsis (13) · Wound Infection (11) · Soft Tissue Infections (10) · Staphylococcal Skin Infections (10) · Colitis, Ulcerative (9) · Endocarditis (9)
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (12) · Pfizer (11) · Cumberland Pharmaceuticals (8) · Mayo Clinic (6) · Assiut University (5) · Forest Laboratories (5) · Melinta Therapeutics, Inc. (5) · Actelion (4) · Arizona State University (4) · Hamilton Health Sciences Corporation (4) · University of Minnesota (4) · Basilea Pharmaceutica (3) · Duke University (3) · Leiden University Medical Center (3) · M.D. Anderson Cancer Center (3)
United States (191) · Canada (37) · Spain (25) · Italy (23) · Germany (21) · United Kingdom (19) · France (18) · Poland (17) · Russia (15) · Israel (14) · Argentina (13) · Belgium (13) · Brazil (12) · China (12) · Romania (12)
G. Ralph Corey, MD (9) · James B Adams, PhD (3) · Anne Claire Marrast, MD (2) · Bryan Springer, MD (2) · David Melnick, MSD (2) · Dominik Mertz, MD, MSc (2) · Donald Poretz, MD (2) · Lindsey Albenberg, DO (2) · Lori Styles, MD (2) · Michael Dunne, MD (2) · Nadine Rouphael, MD (2)
PMID 30597021, PMID 30716446, PMID 34741280, PMID 34922058, PMID 18444791, PMID 19095213, PMID 20695801, PMID 21115456, PMID 22416054, PMID 22752857, PMID 22752865, PMID 23054338, PMID 23715579, PMID 24011955, PMID 24599770, PMID 24708675, PMID 24897082, PMID 27370913, PMID 27585969, PMID 27718118, PMID 28630189, PMID 29358292, PMID 29454592, PMID 29680101, PMID 29783024, PMID 30349845, PMID 30709665, PMID 32633158, PMID 32747931, PMID 34905144, PMID 10440607, PMID 11171619, PMID 11751780, PMID 15276398, PMID 15327406, PMID 15509186, PMID 15840453, PMID 18225981, PMID 18662172, PMID 18702902, PMID 18719064, PMID 19036671, PMID 19128645, PMID 19133801, PMID 19222623, PMID 19376733, PMID 19588358, PMID 20309522, PMID 20350927, PMID 20458318
2014 (2), 2019 (2), 2023 (2), 2025 (2), 2005 (1), 2009 (1), 2015 (1), 2018 (1), 5UM1AI104681-12 (1), K23DK109136 (1), P50CA221707 (1), R21AI176298 (1), R21AI182531 (1), RC2AR058986 (1), U01AI125053 (1)