66 completed, 16 recruiting, 14 terminated, 13 unknown. 127 Phase 2, 43 Phase 1, 10 Phase 3.
Follow Hypoxia: new trials by email Literature Review of Hypoxia trials Research Report on Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS Normal Saline, Centhaquine - Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Not yet recruiting | Pharmazz, Inc. | 80 | 2027-05-01 | 2026-09-17 |
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| The PROTECT-HIE Pilot Trial Dobutamine, TnECHO - Hypoxic-ischemic Encephalopathy (HIE) | Phase 2 | Recruiting | University of Alberta | 40 | 2026-10-13 | 2026-11-05 |
| Sildenafil Plus Hypothermia to Treat Neonatal Encephalopathy Sildenafil Citrate (IV) - Hypoxic-Ischemic Encephalopathy | Phase 2 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 24 | 2026-10-01 | 2026-03-31 |
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| Levetiracetam Extended-Release Plus Stupp Protocol for Hypoxic IDH-Wildtype Glioblastoma Levetiracetam Extended-Release Granules, Temozolomide (TMZ), Radiotherapy - Glioblastoma | Phase 2 | Not yet recruiting | Tianjin Medical University General Hospital | 140 | 2026-09-01 | 2026-08-11 |
| Study of Preoperative RAdiation Therapy With Concomitant Liposomal Transcrocetin (L-TC) in Soft tISsue Sarcomas Administration of L-TC, HFRT alone - Sarcoma | Phase 2 | Not yet recruiting | Centre Paul Strauss | 42 | 2026-07-01 | 2026-06-04 |
| EFFICACY OF MELATONIN IN MANAGEMENT OF HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE) IN NEONATES Melatonin, intravenous (IV) fluids, intensive monitoring, broad-spectrum antibiotic cover - Hypoxic Ischaemic Encephalopathy (HIE) | Phase 2 | Active not recruiting | University of Child Health Sciences and Children's Hospital, Lahore | 110 | 2025-12-10 | 2025-12-26 |
| Inhaled Treprostinil (Tyvaso Nebulizer) For COPD Patients With Hypoxemia Inhaled Treprostinil (Tyvaso Nebulizer) - COPD (Chronic Obstructive Pulmonary Disease), Hypoxemia | Phase 2 | Recruiting | Bastiaan Driehuys | 10 | 2025-09-29 | 2026-08-27 |
| Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates Dexmedetomidine Infusion, Morphine Infusion - Hypoxic Ischemic Brain Injury, Neonatal Encephalopathy | Phase 2 | Not yet recruiting | Ipsita Goswami | 50 | 2025-07-01 | 2025-05-22 |
| COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial the COMBO Endoscopy Oropharyngeal Airway - Pulmonary Infection, Pulmonary Nodule | Phase 2 | Completed | Zhejiang University | 104 | 2025-06-23 | 2026-02-24 |
| COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients The COMBO Endoscopy Oropharyngeal Airway - Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice | Phase 2 | Recruiting | Zhejiang University | 50 | 2025-06-12 | 2025-06-24 |
| Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two-Stage Phase II Clinical Study Supraglottic Oxygen Delivery via an Endotracheal Tube - Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice | Phase 2 | Recruiting | Zhejiang University | 50 | 2025-06-12 | 2025-07-17 |
| The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy Roxadustat, Darbepoietin Alfa - Diabetes Complications, Diabetes; Nephropathy (Manifestation) | Phase 2 | Not yet recruiting | Region Stockholm | 30 | 2025-06-01 | 2024-11-19 |
| CD73/AXL Targeted HypoSti.CAR-T Cells in CD73/AXL Positive Advanced/Metastatic Solid Tumors CD73/AXL.HypoSti.CAR-T cells, Albumin-Bound Paclitaxel, Cyclophosphamide - Solid Tumor | Phase 1 / Phase 2 | Not yet recruiting | Chinese PLA General Hospital | 30 | 2025-05-01 | 2025-04-22 |
| To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU. Placebo drug ( normal saline ), neostigmine (reversal agent) - Tachycardia, Hypertension | Phase 1 / Phase 2 | Completed | Ziauddin University | 100 | 2025-03-12 | 2025-07-31 |
| Hypertonic Lactate After Cardiac Arrest Sodium Lactate Solution - Cardiac Arrest, Ischemia Reperfusion Injury | Phase 2 | Recruiting | Erasme University Hospital | 125 | 2025-02-19 | 2025-02-21 |
| COMBO Endoscopy Oropharyngeal Airway in Sedated Gastrointestinal Endoscopy for Obese Patients the COMBO Endoscopy Oropharyngeal Airway - Hypoxia, Esophageal Cancer | Phase 2 | Completed | Zhejiang University | 107 | 2025-02-04 | 2025-05-21 |
| Combination COMBO Endoscopy Oropharyngeal Airway With High-Flow Nasal Cannula Oxygenation in Sedated Gastrointestinal Endoscopy for Obese Patients the COMBO Endoscopy Oropharyngeal Airway with High-Flow Nasal Cannula Oxygenation - Hypoxia, Esophageal Cancer | Phase 2 | Completed | Zhejiang University | 50 | 2025-02-04 | 2025-06-25 |
| Prevention of Chronic Kidney Disease(CDK) Progression in Type 1 Diabetes With Long Term Use of Sodium-Glucose-coTransporter Inhibitors Avoiding Kidney hypOxia Sotagliflozin, Placebo - Nephropathy, Diabetic Nephropathies | Phase 2 | Not yet recruiting | Steno Diabetes Center Copenhagen | 69 | 2025-02-01 | 2025-01-27 |
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Hypoxia-Ischemia, Brain (37) · COVID-19 (11) · Asphyxia Neonatorum (6) · Hypoxia, Brain (6) · Carcinoma, Non-Small-Cell Lung (5) · Hypothermia (5) · Lung Neoplasms (5) · Respiratory Distress Syndrome (5) · Stroke (5) · Brain Injuries (4) · Brain Injuries, Traumatic (4) · Esophageal Neoplasms (4) · Head and Neck Neoplasms (4) · Heart Arrest (4)
Pathological Conditions, Signs and Symptoms (127) · Signs and Symptoms (127) · Signs and Symptoms, Respiratory (127) · Nervous System Diseases (51) · Central Nervous System Diseases (50) · Brain Diseases (49) · Respiratory Tract Diseases (48) · Cardiovascular Diseases (47) · Vascular Diseases (47) · Cerebrovascular Disorders (41) · Brain Ischemia (38) · Hypoxia, Brain (36) · Lung Diseases (36) · Neoplasms (27)
Saline Solution (9) · Sodium Chloride (5) · Injections (4) · 3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol (3) · Hypothermia, Induced (3) · Oxygen (3) · Sildenafil Citrate (3) · Darbepoetin alfa (2) · Endothelium-Dependent Relaxing Factors (2) · Hyperbaric Oxygenation (2) · Insemination, Artificial, Homologous (2) · Lasers, Gas (2) · Nitric Oxide (2) · Radiotherapy (2) · TH 302 (2)
Zhejiang University (5) · Maastricht Radiation Oncology (3) · Radboud University Medical Center (3) · University of Alberta (3) · University of Utah (3) · Colorado State University (2) · Global Blood Therapeutics (2) · Great Ormond Street Hospital for Children NHS Foundation Trust (2) · Pharmazz, Inc. (2) · Rain Oncology Inc (2) · Siemens Molecular Imaging (2) · Sohag University (2) · Threshold Pharmaceuticals (2) · University Hospital, Bordeaux (2) · University Hospitals Bristol and Weston NHS Foundation Trust (2)
United States (41) · China (15) · Netherlands (9) · United Kingdom (9) · France (8) · Canada (7) · Australia (4) · Egypt (4) · Denmark (3) · Sweden (3) · Switzerland (3) · Belgium (2) · Germany (2) · India (2) · Israel (2)
Changlian Zhu, MD, PhD (2) · Christopher Bell, PhD (2) · Elsayed Abdelkreem, MD, PhD (2) · Mariana Baserga, MD (2) · Marianne Thoresen, Professor (2) · Stephen Liu (2) · Adrian Streinu Cercel, MD (1) · Agung Putra, Assoc.Prof (1) · Alan C Perkins, PhD (1) · Alan Waxman, MD (1) · Alexander V Averyanov, MD, PhD (1) · Anil Gulati (1) · Ashley Bjorklund, MD (1) · Asma Abdus Salam, Consultant anaesthesiology (1) · Ayca Yildiz-Pekoz, PhD (1)
PMID 24524452, PMID 10492412, PMID 10793602, PMID 12717123, PMID 1356374, PMID 15199405, PMID 15607598, PMID 15607599, PMID 15683820, PMID 17122578, PMID 17893459, PMID 18708248, PMID 19172693, PMID 19183804, PMID 19834012, PMID 19854090, PMID 19883750, PMID 20385632, PMID 20576632, PMID 20631189, PMID 21195036, PMID 21852153, PMID 22091288, PMID 22805873, PMID 22950861, PMID 23133515, PMID 23372884, PMID 23682548, PMID 23897243, PMID 24473179, PMID 24815497, PMID 25512461, PMID 25765333, PMID 25794112, PMID 26156116, PMID 26338178, PMID 26680684, PMID 27126393, PMID 27535166, PMID 27614933, PMID 27632779, PMID 27756258, PMID 28329240, PMID 28606907, PMID 28949952, PMID 29016557, PMID 29028696, PMID 29261883, PMID 29769612, PMID 29800014
2014 (1), 2017 (1), 2018 (1), 2023 (1), 2025 (1), R01HD038600 (1), R01HD081274 (1), R01NS038062 (1), R01NS061860 (1), U24HL135691 (1)