52 completed, 12 unknown, 8 terminated, 7 withdrawn. 91 Phase 1, 43 Phase 2.
Follow Hypoxia: new trials by email Literature Review of Hypoxia trials Research Report on Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mesenchymal Stem Cells With Cooling Therapy for Infants With Hypoxic-Ischemic Encephalopathy Wharton's jelly-derived mesenchymal stem cells, 0.9 % Normal Saline - Hypoxic-Ischemic Encephalopathy, Neonatal, Brain Injuries, Hypoxic-Ischemic | Phase 1 / Phase 2 | Not yet recruiting | Mahidol University | 40 | 2026-09-15 | 2026-09-02 |
| Dose-Escalation Study of Artesunate Patients With IPF Artesuante, Placebo capsules - Idiopathic Pulmonary Fibrosis | Phase 1 | Recruiting | Joseph C. Wu | 15 | 2026-08-01 | 2026-08-11 |
| Hydrogen In Neonatal Encephalopathy (HIE) Trial Hydrogen Gas (H2) - HIE, Hypoxic-Ischemic Encephalopathy | Phase 1 | Not yet recruiting | Boston Children's Hospital | 54 | 2026-03-01 | 2026-02-17 |
| A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury Metformin - Hypoxic-Ischemic Encephalopathy, HIE | Phase 1 | Enrolling by invitation | Boston Children's Hospital | 30 | 2025-10-01 | 2026-02-17 |
| CD73/AXL Targeted HypoSti.CAR-T Cells in CD73/AXL Positive Advanced/Metastatic Solid Tumors CD73/AXL.HypoSti.CAR-T cells, Albumin-Bound Paclitaxel, Cyclophosphamide - Solid Tumor | Phase 1 / Phase 2 | Not yet recruiting | Chinese PLA General Hospital | 30 | 2025-05-01 | 2025-04-22 |
| To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU. Placebo drug ( normal saline ), neostigmine (reversal agent) - Tachycardia, Hypertension | Phase 1 / Phase 2 | Completed | Ziauddin University | 100 | 2025-03-12 | 2025-07-31 |
| Dose Optimization of Caffeine for HIE Caffeine citrate 20 mg/kg, Caffeine citrate 30 mg/kg - Hypoxic-Ischemic Encephalopathy | Phase 1 | Active not recruiting | University of North Carolina, Chapel Hill | 16 | 2024-07-26 | 2026-08-14 |
| PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia Caffeine citrate - Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy | Phase 1 | Withdrawn | University of Arkansas | 2024-05-08 | 2024-05-10 | |
| Advair HFA in Healthy and HAPE Predisposed Subjects Advair HFA, Placebo - Altitude Edema | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 60 | 2023-12-12 | 2025-09-22 |
| Metformin Treatment in Infants After Perinatal Brain Injury Metformin Hydrochloride - Hypoxic Ischemic Encephalopathy of Newborn, Premature Birth | Phase 1 | Terminated | The Hospital for Sick Children | 1 | 2023-05-02 | 2024-03-07 |
| Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep, Placebo and Normoxia Sleep - Obstructive Sleep Apnea of Adult, Hypoxia, Brain | Phase 1 / Phase 2 | Recruiting | University of Calgary | 12 | 2023-01-01 | 2026-05-01 |
| Adenosine 2A Receptor Antagonism and AIH in ALS Consume 20mg of istradefylline, Low Oxygen therapy, Placebo counterpart to the istradefylline drug - ALS | Phase 1 / Phase 2 | Active not recruiting | University of Florida | 40 | 2022-06-21 | 2026-03-27 |
| Multiple N-of-1 Trials of (Intermittent) Hypoxia Therapy in Parkinson's Disease Hypoxic Gas Mixture - Parkinson Disease, Effect of Drug | Phase 1 / Phase 2 | Completed | Radboud University Medical Center | 29 | 2022-02-22 | 2023-07-21 |
| A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma Oral NKT2152 - ccRCC, Clear Cell Renal Cell Carcinoma | Phase 1 / Phase 2 | Terminated | NiKang Therapeutics, Inc. | 120 | 2021-10-26 | 2025-11-12 |
| Reducing Hypoxia in Patients With Coronavirus Disease (COVID-19) Using Topotecan With Standard of Care Topotecan - COVID-19 Respiratory Infection | Phase 1 | Unknown | National University Hospital, Singapore | 24 | 2021-08-16 | 2021-11-04 |
| Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn Magnesium sulfate, Sildenafil Citrate, Isotonic saline - Persistent Pulmonary Hypertension of Newborn | Phase 1 / Phase 2 | Recruiting | Sohag University | 40 | 2021-06-02 | 2024-11-27 |
| Tolerability and Efficacy of RJX in Patients With COVID-19 Rejuveinix (RJX) Active Comparator, Placebo Comparator - COVID-19, Acute Respiratory Distress Syndrome | Phase 1 / Phase 2 | Unknown | Reven Pharmaceuticals, Inc. | 237 | 2021-03-25 | 2022-03-15 |
| Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation L-NMMA, Ketorolac, Ascorbic Acid - Hypoxia, Hypercapnia | Phase 1 | Withdrawn | University of Wisconsin, Madison | 2020-12-01 | 2019-01-10 | |
| Safety and Efficacy of Trans Sodium Crocetinate (TSC) in SARS-CoV-2 (COVID-19) Infected Subjects Trans Sodium Crocetinate, Normal saline - SARS-CoV-2 (Covid19) | Phase 1 / Phase 2 | Completed | Diffusion Pharmaceuticals Inc | 25 | 2020-09-10 | 2022-04-14 |
| Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness Methylphenidate - Brain Injury Traumatic Severe (Diagnosis), Coma | Phase 1 | Active not recruiting | Massachusetts General Hospital | 10 | 2020-08-24 | 2025-10-29 |
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Hypoxia-Ischemia, Brain (34) · Asphyxia Neonatorum (5) · COVID-19 (5) · Pancreatic Neoplasms (5) · Neoplasms (4) · Respiratory Distress Syndrome (4) · Altitude Sickness (3) · Brain Injuries (3) · Head and Neck Neoplasms (3) · Hypothermia (3) · Lung Neoplasms (3) · Motor Activity (3) · Necrosis (3) · Neoplasm Metastasis (3)
Pathological Conditions, Signs and Symptoms (91) · Signs and Symptoms (91) · Signs and Symptoms, Respiratory (91) · Vascular Diseases (44) · Cardiovascular Diseases (42) · Central Nervous System Diseases (38) · Nervous System Diseases (38) · Brain Diseases (37) · Cerebrovascular Disorders (36) · Brain Ischemia (34) · Hypoxia, Brain (34) · Respiratory Tract Diseases (29) · Pathologic Processes (21) · Lung Diseases (20)
Saline Solution (7) · TH 302 (4) · Sodium Chloride (3) · caffeine citrate (3) · Ascorbic Acid (2) · Bacterial Load (2) · Bumetanide (2) · Endothelium-Dependent Relaxing Factors (2) · Epoetin Alfa (2) · Erythropoietin (2) · Injections (2) · Insemination, Artificial, Homologous (2) · Metformin (2) · Nitric Oxide (2) · Oxygen (2)
Threshold Pharmaceuticals (4) · Radboud University Medical Center (3) · University of California, San Francisco (3) · BioMed Valley Discoveries, Inc (2) · Boston Children's Hospital (2) · Colorado State University (2) · National University Hospital, Singapore (2) · Sohag University (2) · University of Calgary (2) · University of East Anglia (2) · University of North Carolina, Chapel Hill (2) · Zhengzhou University (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Assistance Publique - Hôpitaux de Paris (1) · Bayside Health (1)
United States (43) · Canada (7) · China (6) · Netherlands (5) · United Kingdom (5) · Egypt (3) · France (2) · India (2) · Japan (2) · Russia (2) · Sweden (2) · Australia (1) · Austria (1) · Germany (1) · Hong Kong (1)
Brian Kalish, MD (2) · Changlian Zhu, MD, PhD (2) · Christopher Bell, PhD (2) · Elsayed Abdelkreem, MD, PhD (2) · Katja Ruh, MD (2) · Wesley M Jackson, MD, MPH (2) · Yvonne W Wu, MD, MPH (2) · Adrian Streinu Cercel, MD (1) · Alexander V Averyanov, MD, PhD (1) · Anees Sindi, FRCPC (1) · Asma Abdus Salam, Consultant anaesthesiology (1) · Balraj Guhan, MD (1) · Baoyong Yan, Doctor (1) · Barbara Smith (1)
PMID 24524452, PMID 10492412, PMID 10793602, PMID 12717123, PMID 1356374, PMID 15199405, PMID 17122578, PMID 17893459, PMID 18668653, PMID 18977464, PMID 19172693, PMID 19183804, PMID 19883750, PMID 20385632, PMID 20576632, PMID 20631189, PMID 21195036, PMID 22091288, PMID 23008465, PMID 23133515, PMID 23372884, PMID 24388332, PMID 24815497, PMID 25439577, PMID 25512461, PMID 25765333, PMID 25794112, PMID 26680684, PMID 27535166, PMID 27632779, PMID 27756258, PMID 28729473, PMID 28890439, PMID 28949952, PMID 29016557, PMID 29261883, PMID 29769612, PMID 30573962, PMID 30661082, PMID 31261373, PMID 32813884, PMID 33046513, PMID 33362471, PMID 33415555, PMID 33626457, PMID 34155211, PMID 34482377, PMID 34667360, PMID 35473726, PMID 35836147
DP2HD101400 (1), K23HD111623 (1), R01HD081274 (1), R01NS066929 (1), R03DK065958 (1)