28 completed, 14 unknown, 4 recruiting, 4 terminated. 55 Phase 3, 9 Phase 2.
Follow Hypoxia: new trials by email Literature Review of Hypoxia trials Research Report on Hypoxia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| Caffeine for Hypoxic Ischemic Encephalopathy Caffeine citrate oral solution, Oral placebo solution - Hypoxic Ischemic Encephalopathy (HIE) | Phase 3 | Recruiting | NICHD Global Network for Women's and Children's Health | 830 | 2026-04-08 | 2026-06-24 |
| Safeguarding the Brain of Our Smallest Children-IIIv (SafeBoosC-IIIv) Cerebral oximetry monitoring device, Usual care - Hypoxia, Infant, Newborn, Diseases | Phase 3 | Recruiting | Copenhagen Trial Unit, Center for Clinical Intervention Research | 1610 | 2025-04-11 | 2025-04-25 |
| Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated Radiation ThErapy and TEmozolomide in Newly Diagnosed GLioblastoma (GBM) Patients Administration of L-TC, Radiotherapy plus Temozolomide - Glioblastoma | Phase 3 | Not yet recruiting | Institut de cancérologie Strasbourg Europe | 554 | 2025-01-01 | 2024-06-27 |
| Oxygen Targets in Acute Heart Failure With Pulmonary Congestion Oxygen - Acute Heart Failure, Pulmonary Congestion | Phase 2 / Phase 3 | Completed | Copenhagen University Hospital, Hvidovre | 135 | 2024-02-01 | 2026-10-26 |
| Effects of Walking Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function Voluntary apnoea - Pain, Hypoxia | Phase 3 | Unknown | Centro Universitario La Salle | 60 | 2023-12-01 | 2024-01-05 |
| Effects of Walking Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function Voluntary apnoea - Pain, Hypoxia | Phase 3 | Unknown | Centro Universitario La Salle | 60 | 2023-12-01 | 2024-01-05 |
| Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function Voluntary apnoea - Pain, Hypoxia | Phase 3 | Unknown | Centro Universitario La Salle | 60 | 2023-12-01 | 2024-01-05 |
| Effects of Static Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function Voluntary apnoea - Pain, Hypoxia | Phase 3 | Unknown | Centro Universitario La Salle | 60 | 2023-12-01 | 2024-01-05 |
| UC-MSCs in the Treatment of Severe and Critical COVID-19 Patients With Refractory Hypoxia UC-MSCs treatment - Mesenchymal Stem Cell, COVID-19 Pneumonia | Phase 3 | Unknown | Shanghai East Hospital | 60 | 2023-01-10 | 2023-01-18 |
| Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior Single Arm, Neonatal Neurobehavioral Scale - Congenital Heart Disease in Children, Hypoxia | Phase 2 / Phase 3 | Completed | University of Utah | 104 | 2021-12-17 | 2026-07-14 |
| Nitric Oxide During Cardiopulmonary Bypass in Adult Surgery Nitric Oxide, standard of care treatment - Hypoxia | Phase 3 | Unknown | Rabin Medical Center | 300 | 2021-08-14 | 2021-10-08 |
| Acetazolamide to Prevent Impending Altitude-illness in Patients With COPD Acetazolamide, Placebo - Chronic Obstructive Pulmonary Disease, Altitude Sickness | Phase 3 | Unknown | University of Zurich | 100 | 2021-06-01 | 2023-03-03 |
| EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19 BEVA+SOC, SOC - Corona Virus Infection, SARS (Severe Acute Respiratory Syndrome) | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 96 | 2021-04-17 | 2022-12-28 |
| Strategy to Avoid Excessive Oxygen in Major Burn Patients Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg) - Critical Illness, Wounds and Injury | Phase 3 | Active not recruiting | University of Colorado, Denver | 2000 | 2021-04-15 | 2025-04-02 |
| Effects of Low Molecular Weight Heparin Therapy With Soft-Mist Inhaler for COVID-19 Induced Hypoxemia Inhaled Low molecular weight heparin, Standard Treatment - COVID-19 Acute Respiratory Distress Syndrome, Hypoxemia | Phase 2 / Phase 3 | Completed | Istanbul University | 80 | 2021-02-03 | 2021-08-05 |
| CEUS Evaluation of Hypoxic Ischemic Injury Sulfur hexafluoride lipid-type A microspheres - Hypoxic-Ischemic Encephalopathy, Brain Ischemia Hypoxia | Phase 3 | Completed | Children's Hospital of Philadelphia | 1 | 2020-12-01 | 2025-05-14 |
| Strategy to Avoid Excessive Oxygen for Critically Ill Trauma Patients Targeting Normoxemia (SpO2 90-96%; PaO2 60-100 mmHg) - Critical Illness, Wounds and Injury | Phase 3 | Active not recruiting | University of Colorado, Denver | 6000 | 2020-10-15 | 2025-04-02 |
| Higher vs. Lower Doses of Dexamethasone for COVID-19 and Severe Hypoxia Dexamethasone - Covid19, Hypoxia | Phase 3 | Completed | Scandinavian Critical Care Trials Group | 1000 | 2020-08-27 | 2022-02-24 |
| DAS181 for STOP COVID-19 DAS181, Placebo - COVID-19 | Phase 2 / Phase 3 | Withdrawn | Ansun Biopharma, Inc. | 2020-07-25 | 2020-08-11 |
Showing 20 of 55. Sign in to see all of them.
Hypoxia-Ischemia, Brain (14) · Apnea (7) · Hypercapnia (5) · COVID-19 (4) · Pain (4) · Heart Defects, Congenital (3) · Hypoxia, Brain (3) · Asphyxia (2) · Burns (2) · Cardiovascular Diseases (2) · Cerebrovascular Disorders (2) · Coronavirus Infections (2) · Critical Illness (2) · Disease Attributes (2)
Pathological Conditions, Signs and Symptoms (55) · Signs and Symptoms (55) · Signs and Symptoms, Respiratory (55) · Respiratory Tract Diseases (21) · Nervous System Diseases (20) · Brain Diseases (19) · Vascular Diseases (19) · Cardiovascular Diseases (18) · Central Nervous System Diseases (18) · Brain Ischemia (15) · Cerebrovascular Disorders (15) · Respiration Disorders (15) · Hypoxia, Brain (14) · Pathologic Processes (10)
Saline Solution (4) · Sodium Chloride (4) · Allopurinol (3) · Mannitol (3) · Hydrocortisone (2) · Radiotherapy (2) · caffeine citrate (2) · hydrocortisone hemisuccinate (2) · Acetazolamide (1) · Budesonide (1) · Capnography (1) · Cardiac Surgical Procedures (1) · Cardiopulmonary Bypass (1) · Cardiopulmonary Resuscitation (1) · Cytidine Diphosphate Choline (1)
Centro Universitario La Salle (4) · Technical University of Munich (4) · Assistance Publique - Hôpitaux de Paris (2) · NICHD Global Network for Women's and Children's Health (2) · Scandinavian Critical Care Trials Group (2) · UMC Utrecht (2) · University of Colorado, Denver (2) · American SIDS Institute (1) · Ansun Biopharma, Inc. (1) · Armed Forces Hospital, Pakistan (1) · Assiut University (1) · Boston Children's Hospital (1) · Burnasyan Federal Medical Biophysical Center (1) · Children's Hospital of Philadelphia (1) · Copenhagen Trial Unit, Center for Clinical Intervention Research (1)
United States (11) · Germany (7) · Spain (6) · Denmark (4) · France (4) · Netherlands (4) · Belgium (3) · China (2) · India (2) · Italy (2) · Pakistan (2) · Russia (2) · Switzerland (2) · Turkey (Türkiye) (2) · United Kingdom (2)
Adit Ginde, MD, MPH (2) · Stefan von Delius, MD (2) · Abbot R. Laptook, MD (1) · Abhik Das, PhD (1) · Aida A. Yakupova, MD, Cand.Med.Sci (1) · Aleksandr Y. Malygin, MD, Dr.Med.Sci (1) · Alina S. Agafina, MD, Cand.Med.Sci (1) · Amanda Peppercorn, MD (1) · Anders Perner, MD, PhD (1) · Andrey M. Alasheev, MD, Dr.Med.Sci (1) · Anne Smits, MD, PhD (1) · Axel Franz, Prof. Dr. (1) · Ayca Yildiz-Pekoz, PhD (1) · Barbara J. Stoll, MD (1) · Bart Lambrecht, MD, PhD (1)
PMID 12165594, PMID 16221780, PMID 17079582, PMID 18534246, PMID 18720323, PMID 18762517, PMID 18829776, PMID 19020525, PMID 19252411, PMID 19564319, PMID 19834012, PMID 19948631, PMID 20921569, PMID 21054515, PMID 21852153, PMID 21875911, PMID 22646631, PMID 24019415, PMID 24352085, PMID 24445955, PMID 25512466, PMID 26387012, PMID 26415090, PMID 27776752, PMID 28249612, PMID 28606907, PMID 29866165, PMID 30138355, PMID 30808770, PMID 31155392, PMID 3124102, PMID 32493441, PMID 32738928, PMID 33038899, PMID 33138837, PMID 33493423, PMID 33583027, PMID 33935163, PMID 34138478, PMID 34673895, PMID 34749762, PMID 34756178, PMID 34757439, PMID 35067914, PMID 35080773, PMID 35349129, PMID 35359168, PMID 35835616, PMID 37316785, PMID 38267942
1UG3HL141722-01A1 (1), 2016 (1), 2017 (1), 2019 (1), 2025 (1), M01RR000030 (1), M01RR000039 (1), M01RR000044 (1), M01RR000070 (1), M01RR000080 (1), M01RR000633 (1), M01RR000750 (1), M01RR006022 (1), M01RR007122 (1), M01RR008084 (1)