3278 completed, 1548 unknown, 1445 recruiting, 735 terminated. 2917 Phase 2, 1823 Not applicable, 1531 Phase 1, 727 Phase 3, 119 Early Phase 1.
Follow Head and Neck Neoplasms: new trials by email Literature Review of Head and Neck Neoplasms trials Research Report on Head and Neck Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 9-ING-41 Plus Carboplatin in Patients With Advanced, Metastatic Salivary Gland Carcinoma 9-ING-41, Carboplatin - Salivary Gland Carcinoma, Adenoid Cystic Carcinoma | Phase 2 | Withdrawn | Actuate Therapeutics Inc. | 2030-12-18 | 2022-02-22 | |
| Mapping Patient Decision-making in Thyroid Cancer Decision navigation tool - Thyroid Cancer | Not applicable | Not yet recruiting | University of California, Los Angeles | 50 | 2028-04-01 | 2026-07-24 |
| Adaptive Neoadjuvant Therapy for Esophageal Cancer Neoadjuvant concurrent chemoradiotherapy - Esophageal Carcinoma, Neoadjuvant Therapy | Not applicable | Enrolling by invitation | Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center | 43 | 2028-03-01 | 2025-05-25 |
| Symptom Management to Improve Completion of Patient-reported Outcome Measures Monitoring of PROMIS symptoms and physical function, Monitoring of additional symptoms and symptom self-management - Malignant Solid Neoplasm, Malignant Head and Neck Neoplasm | Not applicable | Not yet recruiting | Henry Ford Health System | 78 | 2027-10-01 | 2026-07-29 |
| Pre-Clinic Visit Online Education for Thyroid Cancer THRIVE, ACS "After a Thyroid Cancer Diagnosis" Flyer - Thyroid Cancer | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 60 | 2027-08-01 | 2026-09-01 |
| The FORCE Trial Pilot: Fish Oil-enriched Nutrition for Radiotherapy in Cancer of the hEad and Neck Nutrition counseling, Fresubin Supportan - Head &Amp;Amp; Neck Squamous Cell Carcinoma | Phase 1 / Phase 2 | Not yet recruiting | Anna Arthur, PhD | 15 | 2027-06-01 | 2026-08-07 |
| Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With Pembrolizumab PANDA-VAC, Pembrolizumab - Squamous Cell Lung Cancer, Squamous Non-small Cell Lung Cancer | Phase 1 | Suspended | UNC Lineberger Comprehensive Cancer Center | 6 | 2027-05-20 | 2026-04-23 |
| Chemo-embolization for Head and Neck Cancer Cisplatin - SCCHN, Squamous Cell Carcinoma | Phase 2 | Withdrawn | University of Alabama at Birmingham | 2027-05-01 | 2025-04-27 | |
| A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy Colchicine, Placebo - Head and Neck Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-03-01 | 2026-10-05 |
| Understanding the Role of MyCareGorithm as a Visual Digital Platforms in Cancer Treatment Education and Patient Comprehension of Oncology Treatment Plans Survey - Head and Neck Cancer, Prostate Cancer | Not applicable | Not yet recruiting | M.D. Anderson Cancer Center | 94 | 2027-03-01 | 2026-10-01 |
| Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy Osteoradionecrosis, Radiotherapy | Not yet recruiting | AO Innovation Translation Center | 1000 | 2027-03-01 | 2026-09-23 | |
| Maximizing Quality of Life After Cancer Through Rehabilitation TIMELY REHAB - Head and Neck Cancer, Hearing Loss | Not applicable | Not yet recruiting | VA Office of Research and Development | 74 | 2027-03-01 | 2026-06-03 |
| Proactively Intervening On Early Cranial Nerve Injury As A Delayed Sequela Of Oropharyngeal Cancer: A Randomized Feasibility Clinical Trial For Pro-Habilitation (proNERVE RCT) Prednisone, Ajovy, Manual Therapy - Cranial Nerve Injury, Oropharyngeal Cancer | Phase 1 | Not yet recruiting | M.D. Anderson Cancer Center | 48 | 2027-03-01 | 2026-09-21 |
| Testing the Addition of an Anti-Cancer Drug, Camonsertib, to Radiation Therapy for Recurrent Head and Neck Squamous Cell Carcinoma Biospecimen Collection, Camonsertib, Computed Tomography - Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Recurrent Head and Neck Squamous Cell Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2027-02-13 | 2026-09-03 |
| Speed of Processing Training to Improve Cognitive Functioning and Driving Performance in Head and Neck Cancer Survivors Speed of Processing Training, Home-Based Sham Training - Head and Neck Cancer (H&N) | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 30 | 2027-01-03 | 2026-10-02 |
| Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules Diagnostic DNA Methylation Signature - Thyroid Gland Nodule | Recruiting | City of Hope Medical Center | 22 | 2027-01-01 | 2026-06-02 | |
| RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial FLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab - Gastroesophageal Adenocarcinoma | Phase 2 | Not yet recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 184 | 2027-01-01 | 2026-07-10 |
| Outside the Cage (OTC) Robotic Esophagectomy OTC MIE Esophagectomy - Esophageal Cancer | Phase 1 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 31 | 2027-01-01 | 2026-03-18 |
| Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer Quad Shot Radiotherapy, Split Course Radiotherapy - Head and Neck Neoplasms, Squamous Cell Carcinoma of Head and Neck | Not applicable | Not yet recruiting | Instituto Nacional de Cancerologia, Columbia | 40 | 2027-01-01 | 2026-10-02 |
| Bacterial Decolonization to Prevent Severe Radiation Dermatitis in Head and Neck Squamous Cell Carcinoma Bacterial decolonization, Standard Hygiene Measures - HNSCC | Not applicable | Not yet recruiting | Institut Cancerologie de l'Ouest | 144 | 2027-01-01 | 2026-10-22 |
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Squamous Cell Carcinoma of Head and Neck (1946) · Esophageal Neoplasms (1840) · Thyroid Neoplasms (720) · Stomach Neoplasms (673) · Nasopharyngeal Carcinoma (645) · Esophageal Squamous Cell Carcinoma (622) · Carcinoma, Non-Small-Cell Lung (578) · Neoplasms (480) · Breast Neoplasms (469) · Lung Neoplasms (444) · Mouth Neoplasms (443) · Colorectal Neoplasms (439) · Pancreatic Neoplasms (377) · Melanoma (369)
Neoplasms by Site (8324) · Neoplasms (7871) · Neoplasms by Histologic Type (4079) · Neoplasms, Glandular and Epithelial (3909) · Carcinoma (3705) · Digestive System Diseases (2902) · Gastrointestinal Diseases (2833) · Digestive System Neoplasms (2771) · Gastrointestinal Neoplasms (2622) · Carcinoma, Squamous Cell (2365) · Esophageal Diseases (2357) · Stomatognathic Diseases (1959) · Endocrine System Diseases (1508) · Endocrine Gland Neoplasms (1490)
Cisplatin (862) · Radiotherapy (508) · pembrolizumab (394) · Fluorouracil (354) · Paclitaxel (337) · Cetuximab (308) · Docetaxel (305) · Carboplatin (304) · Radiotherapy, Intensity-Modulated (231) · Nivolumab (171) · Drug Therapy (156) · Radiation (147) · Capecitabine (142) · Gemcitabine (140) · Surgical Procedures, Operative (122)
Sun Yat-sen University (280) · National Cancer Institute (NCI) (216) · M.D. Anderson Cancer Center (172) · Memorial Sloan Kettering Cancer Center (138) · Fudan University (113) · National Taiwan University Hospital (88) · University Health Network, Toronto (71) · Dana-Farber Cancer Institute (70) · Washington University School of Medicine (61) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (59) · Mayo Clinic (55) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (48) · West China Hospital (47) · Tianjin Medical University Cancer Institute and Hospital (46) · Zhejiang Cancer Hospital (46)
United States (3111) · China (1917) · France (618) · Canada (453) · United Kingdom (398) · Taiwan (369) · Italy (360) · Spain (335) · Germany (309) · South Korea (305) · Netherlands (275) · Belgium (240) · Australia (218) · Japan (187) · Denmark (151)
Jun Ma, M.D. (14) · Lillian Siu, MD (14) · Barbara Murphy, MD (13) · Nancy Lee, MD (13) · David H. Ilson, MD, PhD (11)
PMID 25057165, PMID 31150573, PMID 33538338, PMID 30207593, PMID 26808342, PMID 40668552, PMID 22646630, PMID 36990609, PMID 26254683, PMID 27686945, PMID 28837405, PMID 29584545, PMID 30089078, PMID 31679945, PMID 34341578, PMID 37650478, PMID 37934000, PMID 10071296, PMID 12361079, PMID 12988177, PMID 15128893, PMID 15172646, PMID 15459926, PMID 15979480, PMID 16467544, PMID 17960012, PMID 18309943, PMID 18457329, PMID 19097774, PMID 19260131, PMID 19564532, PMID 20014446, PMID 20299249, PMID 20623305, PMID 21541945, PMID 21684205, PMID 22108231, PMID 22422558, PMID 22864015, PMID 23720248, PMID 24817237, PMID 25081901, PMID 26313683, PMID 26884585, PMID 27718784, PMID 28434660, PMID 30213452, PMID 30350310, PMID 31178151, PMID 31420360
2023 (59), 2019 (35), 2017 (31), 2016 (28), 2014 (22), P30CA068485 (22), 2015 (21), 2025 (21), U10CA032102 (21), 2018 (19), P30CA016672 (17), U10CA180868 (16), P30CA012197 (15), U10CA021115 (15), P30CA006516 (13)