6 completed, 4 recruiting, 3 not yet recruiting, 1 active not recruiting. 6 Phase 2, 5 Phase 3, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Completed 3, Recruiting 2, Not yet recruiting 1 |
| Phase 3 | 5 | Completed 2, Not yet recruiting 2, Recruiting 1 |
| Phase 4 | 2 | Active not recruiting 1, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multicentric, Randomized Study to Assess Safety and Efficacy of Centhaquine in Patients With ARDS Normal Saline, Centhaquine - Acute Respiratory Distress Syndrome (ARDS) | Phase 2 | Not yet recruiting | Pharmazz, Inc. | 80 | 2027-05-01 | 2026-09-17 |
| A Study to Assess Safety and Efficacy of Centhaquine as a Resuscitative Agent Normal Saline, Centhaquine - Hypovolemic Shock | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 430 | 2027-02-01 | 2026-09-17 |
| Sovateltide for the Treatment of Acute Traumatic Brain Injury Placebo, Sovateltide - Traumatic Brain Injury | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 214 | 2026-12-01 | 2026-10-13 |
| Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke Drug: Normal Saline, Sovateltide - Acute Ischemic Stroke, Cerebral Stroke | Phase 3 | Recruiting | Pharmazz, Inc. | 514 | 2025-07-24 | 2026-09-15 |
| Study to Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke Sovateltide, Normal Saline - Acute Cerebral Ischemia | Phase 4 | Active not recruiting | Pharmazz, Inc. | 160 | 2024-01-08 | 2026-09-29 |
| Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy Normal Saline along with standard treatment, Sovateltide along with standard treatment - Hypoxic-Ischemic Encephalopathy, Neonatal Asphyxia | Phase 2 | Recruiting | Pharmazz, Inc. | 40 | 2023-09-06 | 2025-12-31 |
| A Study to Assess the Safety and Efficacy of Centhaquine in Hypovolemic Shock Patients Centhaquine - Hypovolemic Shock | Phase 4 | Recruiting | Pharmazz, Inc. | 400 | 2021-08-13 | 2026-09-17 |
| Efficacy of Sovateltide (PMZ-1620) in Patients of Acute Ischemic Stroke Normal Saline along with standard treatment, PMZ-1620 (sovateltide) along with standard treatment - Cerebral Ischemia, Cerebral Infarction | Phase 3 | Completed | Pharmazz, Inc. | 158 | 2019-11-10 | 2023-10-18 |
| Efficacy of PMZ-2010 (Centhaquine) a Resuscitative Agent for Hypovolemic Shock Normal saline + Standard Treatment, Centhaquine + Standard Treatment - Hypovolemic Shock | Phase 3 | Completed | Pharmazz, Inc. | 105 | 2019-01-31 | 2019-10-04 |
| PMZ-1620 (Sovateltide) in Patients of Acute Spinal Cord Injury Normal Saline along with standard treatment, PMZ-1620 along with standard treatment - Acute Spinal Cord Injury | Phase 2 | Recruiting | Pharmazz, Inc. | 40 | 2019-01-10 | 2025-07-04 |
| PMZ-1620 (Sovateltide) in Mild to Moderate Alzheimer's Disease Normal Saline along with standard treatment, PMZ-1620 (sovateltide) along with standard treatment - Alzheimer Disease, Dementia | Phase 2 | Completed | Pharmazz, Inc. | 80 | 2018-03-23 | 2023-01-12 |
| PMZ-1620 (Sovateltide) in Acute Ischemic Stroke Patients Normal Saline along with standard treatment, PMZ-1620 along with standard treatment - Acute Stroke, Cerebral Ischemia | Phase 2 | Completed | Pharmazz, Inc. | 40 | 2018-01-19 | 2025-05-12 |
| PMZ-2010 (Centhaquine) as a Resuscitative Agent for Hypovolemic Shock Normal Saline, Centhaquine - Hypovolemic Shock, Blood Loss | Phase 2 | Completed | Pharmazz, Inc. | 50 | 2017-05-29 | 2019-08-14 |
| A Study to Determine the Safety, Tolerability and Pharmacokinetics of PMZ-2010 (Centhaquin) in Healthy Volunteers PMZ-2010 (Centhaquin) - Healthy | Phase 1 | Completed | Pharmazz, Inc. | 24 | 2014-10-01 | 2015-04-28 |
Shock (4) · Stroke (4) · Brain Ischemia (2) · Hemorrhage (2) · Alzheimer Disease (1) · Asphyxia Neonatorum (1) · Brain Injuries, Traumatic (1) · Cerebral Infarction (1) · Dementia (1) · Hypovolemia (1) · Hypoxia (1) · Hypoxia-Ischemia, Brain (1) · Ischemia (1) · Ischemic Stroke (1) · Respiratory Distress Syndrome (1)
Saline Solution (7) · sovateltide (7) · centhaquine (6)
India (10) · Germany (1) · Spain (1) · United Kingdom (1) · United States (1)
Anil Gulati (5) · Anil Gulati, MD, PhD (3) · Manish Lavhale, Ph.D. (2) · Ashish O Goyal, MD (1)
PMID 33428177, PMID 33173916, PMID 33970455, PMID 34061314, PMID 38999331, PMID 39542995