53 completed. 53 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 53 | Completed 53 |
Follow Heart Valve Diseases: new trials by email Literature Review of Heart Valve Diseases trials Research Report on Heart Valve Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EMPagliflozin After Aortic Valve Replacement Empagliflozin, Placebo - Aortic Valve Stenosis | Phase 4 | Completed | Copenhagen University Hospital, Rigshospitalet | 206 | 2024-02-14 | 2026-05-22 |
| Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI) Protamine sulfate - Aortic Valve Stenosis | Phase 4 | Completed | St. Antonius Hospital | 1000 | 2023-11-01 | 2026-05-20 |
| Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm Ivabradine, Beta blocker - Mitral Stenosis | Phase 4 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 42 | 2023-02-01 | 2024-04-17 |
| Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery Tranexamic Acid 100 MG/ML, normal saline - Coronary Artery Disease, Valvular Heart Disease | Phase 4 | Completed | Universitas Indonesia | 132 | 2022-10-01 | 2023-02-01 |
| Sugammadex Titration in Cardiac Surgery Patients Sugammadex administration - Coronary Artery Disease, Valvular Heart Disease | Phase 4 | Completed | University of Washington | 100 | 2022-02-01 | 2024-03-21 |
| Postoperative Pain Relief With Transversus Thoracis Muscle Plane Block After Cardiac Surgery Placebo, Ropivacaine - Pain, Postoperative, Anesthesia, Local | Phase 4 | Completed | Turku University Hospital | 120 | 2021-10-15 | 2025-04-13 |
| Buspirone Treatment of Anxiety in Williams Syndrome Buspirone - Williams Syndrome, Anxiety | Phase 4 | Completed | Massachusetts General Hospital | 20 | 2021-08-01 | 2024-12-03 |
| Dapagliflozin After Transcatheter Aortic Valve Implantation Dapagliflozin 10 MG - Aortic Stenosis, Transcatether Aortic Valve Implantation | Phase 4 | Completed | Spanish Society of Cardiology | 1257 | 2021-01-27 | 2025-01-10 |
| Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI) Continuation of oral anticoagulants, Interruption of oral anticoagulants - Aortic Valve Disease, Aortic Valve Stenosis | Phase 4 | Completed | St. Antonius Hospital | 858 | 2020-11-25 | 2024-05-31 |
| Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy Metoprolol - Hypertrophic Cardiomyopathy | Phase 4 | Completed | University Hospital, Motol | 22 | 2020-03-05 | 2023-05-10 |
| Effects of Microplegia on Transfusion Rates After Cardiac Surgery Cardioplegia Solution, Microplegic Solution No. 1 - Aortic Valve Disease, Mitral Valve Disease | Phase 4 | Completed | Washington University School of Medicine | 314 | 2019-03-25 | 2024-08-06 |
| Anticoagulation for Aortic Bioprosthesis (ANTIPRO) Warfarin, Aspirin - Aortic Valve Stenosis, Aortic Valve Disease | Phase 4 | Completed | Instituto Nacional de Cirugia Cardiaca, Uruguay | 140 | 2019-01-01 | 2022-03-08 |
| Study to Evaluate the Effect on Improvement of LVH by the Control of BP in Hypertension Patients With AV Disease Amlodipine 5mg, Losartan, Losartan and Amlodipine - Aortic Stenosis, Aortic Regurgitation | Phase 4 | Completed | Hanmi Pharmaceutical Company Limited | 128 | 2018-10-18 | 2022-09-15 |
| Anticoagulant Versus Dual Antiplatelet Therapy for Preventing Leaflet Thrombosis and Cerebral Embolization After Transcatheter Aortic Valve Replacement NOAC, DAPT - Aortic Valve Stenosis | Phase 4 | Completed | Duk-Woo Park, MD | 235 | 2018-03-15 | 2021-11-08 |
| Hypertonic Saline for Fluid Resuscitation After Cardiac Surgery Hypertonic saline, 0.9% saline - Cardiovascular Diseases, Valvular Heart Disease | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 165 | 2018-02-27 | 2020-03-24 |
| Protamine Sulfate During Transcatheter Aortic Valve Implantation Protamine sulfate, 0.9% NaCl - Aortic Valve Stenosis | Phase 4 | Completed | Medical University of Warsaw | 100 | 2016-12-01 | 2020-10-22 |
| Dabigatran Versus Conventional Treatment for Prevention of Silent Cerebral Infarct in Atrial Fibrillation Associated With Valvular Disease Dabigatran, Acetylsalicylic acid, Warfarin - Atrial Fibrillation, Valve Heart Disease | Phase 4 | Completed | Asan Medical Center | 120 | 2016-12-01 | 2021-01-13 |
| Comparative Effects of Dexmedetomidine and Ketofol for Sedation in Patients Undergoing Trans-esophageal Echocardiography Dexmedetomidine, Ketofol(ketamine+propofol) - Heart Valve Disease, Heart Septal Defects, Atrial | Phase 4 | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 50 | 2016-06-01 | 2017-11-06 |
| Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation LCZ696, Valsartan - Mitral Valve Insufficiency, Left Ventricular Dysfunction | Phase 4 | Completed | Asan Medical Center | 118 | 2016-03-01 | 2018-01-09 |
| Platelet Reactivity After TAVI: A Multicenter Pilot Study Ticagrelor 90 mg twice per day during three months following TAVI, Aspirin 100 mg plus Clopidogrel 75 mg daily during three months following TAVI - Severe Aortic Valve Stenosis, Transcatheter Aortic Valve Implantation | Phase 4 | Completed | Hospital de Meixoeiro | 65 | 2016-01-01 | 2018-08-03 |
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Aortic Valve Stenosis (18) · Coronary Artery Disease (10) · Aortic Valve Disease (7) · Mitral Valve Insufficiency (6) · Stroke (5) · Hemorrhage (4) · Myocardial Infarction (4) · Aortic Valve Insufficiency (3) · Cardiomyopathy, Hypertrophic (3) · Ischemic Stroke (3) · Aortic Diseases (2) · Cardiovascular Diseases (2) · Embolism and Thrombosis (2) · Heart Defects, Congenital (2)
Cardiovascular Diseases (51) · Heart Diseases (51) · Vascular Diseases (21) · Aortic Valve Disease (20) · Ventricular Outflow Obstruction (19) · Myocardial Ischemia (13) · Pathological Conditions, Signs and Symptoms (13) · Arterial Occlusive Diseases (10) · Arteriosclerosis (10) · Coronary Disease (10) · Pathologic Processes (10) · Nervous System Diseases (7) · Brain Diseases (6) · Central Nervous System Diseases (6)
Aspirin (7) · Clopidogrel (6) · Metoprolol (4) · Propofol (4) · Saline Solution (3) · Etomidate (2) · Protamines (2) · Sildenafil Citrate (2) · Ticagrelor (2) · Warfarin (2) · Acenocoumarol (1) · Adrenergic beta-Antagonists (1) · Amlodipine (1) · Buspirone (1) · Cardioplegic Solutions (1)
Insel Gruppe AG, University Hospital Bern (3) · Mayo Clinic (3) · St. Antonius Hospital (3) · Asan Medical Center (2) · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec (2) · Konkuk University Medical Center (2) · Medical University of Vienna (2) · Washington University School of Medicine (2) · Yonsei University (2) · Aarhus University Hospital (1) · Abbott Medical Devices (1) · Andres Iñiguez Romo, MD, PhD (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Copenhagen University Hospital, Rigshospitalet (1) · Duk-Woo Park, MD (1)
United States (12) · South Korea (7) · Spain (5) · Belgium (4) · Canada (4) · Denmark (3) · Netherlands (3) · Switzerland (3) · Austria (2) · Chile (2) · Czechia (2) · Finland (2) · Germany (2) · Luxembourg (2) · Poland (2)
Duk-Hyun Kang, M.D. (2) · Alan Moody, MD (1) · Andres Iniguez Romo, MD;PHD (1) · Benjamin Chow, MD (1) · Brian R. Lindman, MD (1) · Carl-Johan Jakobsen, MD (1) · D C Iliopoulos, Prof (1) · Diego Freire, MD (1) · Duk-Hyun Kang (1) · Esko Ruokonen, MD,PhD (1) · Eva M Base, MD (1)
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