7 completed, 2 recruiting, 2 unknown. 4 Not applicable, 4 Phase 4, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 4 | Unknown 2, Completed 1, Recruiting 1 |
| Phase 4 | 4 | Completed 4 |
| Phase 3 | 2 | Completed 1, Recruiting 1 |
Follow Protamines: new trials by email Literature Review of Protamines trials Research Report on Protamines
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Dose for Reversal of Heparin After Cardiopulmonary Bypass Protamine sulfate - Open Heart Surgery | Not applicable | Recruiting | Sohag University | 195 | 2026-03-01 | 2026-05-05 |
| Antagonization of Heparin With Protamine Sulfate After TAVI Antagonization of heparin with protamine sulfate - Aortic Valve Stenosis, Heart Valve Diseases | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 940 | 2025-05-25 | 2025-08-22 |
| Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery Low dose protamine - Protamine Dose, Protamine Adverse Reaction | Not applicable | Unknown | University of Liege | 50 | 2024-03-15 | 2024-02-12 |
| Routine Versus Selective Protamine Administration to Reduce Bleeding Complications After Transcatheter Aortic Valve Implantation (POPular ACE TAVI) Protamine sulfate - Aortic Valve Stenosis | Phase 4 | Completed | St. Antonius Hospital | 1000 | 2023-11-01 | 2026-05-20 |
| Optimal Protamine Dosing for Heparin Reversal Following Cardiopulmonary Bypass Protamine fixed dose, Protamine ratio dose - Coagulation; Intravascular | Phase 4 | Completed | University of Miami | 130 | 2022-06-28 | 2024-08-13 |
| Systematic Evaluation of Protamine Doze in Cardiac Surgery Protamine Sulfate - Cardiac Surgery With Cardiopulmonary Bypass | Not applicable | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 100 | 2018-09-20 | 2018-12-31 |
| Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation Protamine Sulfate - Atrial Fibrillation, Catheter Ablation | Phase 4 | Completed | University of Michigan | 153 | 2017-03-23 | 2018-10-23 |
| Protamine Sulfate During Transcatheter Aortic Valve Implantation Protamine sulfate, 0.9% NaCl - Aortic Valve Stenosis | Phase 4 | Completed | Medical University of Warsaw | 100 | 2016-12-01 | 2020-10-22 |
| Serum Tryptase Levels During Cardiac Surgery, Diagnosis and Treatment Decisions for Allergic Reactions protamine - Protamine Allergy, Protamine Adverse Reaction | Completed | Mustafa Kemal University | 30 | 2016-01-01 | 2017-03-22 | |
| Cardiac Surgery: In Vivo Titration of Protamine Titration protamine, Standard administration of protamine - Bleeding | Not applicable | Completed | Montreal Heart Institute | 138 | 2008-06-01 | 2011-08-25 |
| Comparing Angiomax to Heparin With Protamine Reversal in Patients OPCAB Bivalirudin, Heparin, Protamine - Cardiac Surgery, Coronary Artery Bypass Surgery | Phase 3 | Completed | The Medicines Company | 150 | 2003-08-01 | 2011-11-10 |
Aortic Valve Stenosis (3) · Hemorrhage (2) · Anaphylaxis (1) · Atrial Fibrillation (1) · Heart Valve Diseases (1) · Hypersensitivity (1) · Hypotension (1) · Postoperative Hemorrhage (1) · Thrombosis (1)
Assistance Publique - Hôpitaux de Paris (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Medical University of Warsaw (1) · Montreal Heart Institute (1) · Mustafa Kemal University (1) · Sohag University (1) · St. Antonius Hospital (1) · The Medicines Company (1) · University of Liege (1) · University of Miami (1) · University of Michigan (1)
United States (3) · Canada (2) · Belgium (1) · Egypt (1) · France (1) · Netherlands (1) · Poland (1) · Turkey (Türkiye) (1)
Andrew Sternlicht, MD (1) · Antoine G Rochon (1) · Asmaa S Farghaly, MD (1) · Hakan Oral, MD (1) · Menekse Oksar, M.D. (1) · Michael Fabbro, DO (1)
PMID 12960536, PMID 18005384, PMID 22898522, PMID 23236027, PMID 23583252, PMID 24682842, PMID 25070464, PMID 26139739, PMID 34292562, PMID 36471142, PMID 41177203
2023 (1)