43 completed, 6 recruiting, 6 terminated, 3 active not recruiting. 26 Phase 2, 14 Phase 4, 12 Phase 1, 9 Phase 3, 7 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Buspirone for Anxiety in Autistic Youth buspirone, Placebo - Anxiety, Autism Spectrum Disorder | Phase 4 | Recruiting | Massachusetts General Hospital | 20 | 2026-09-01 | 2026-09-17 |
| A Pilot Study of Buspirone for the Treatment of Anxiety in Youth with Autism Spectrum Disorders Buspirone - Autism Spectrum Disorder, Anxiety | Phase 2 | Withdrawn | Massachusetts General Hospital | 2024-12-01 | 2024-09-26 | |
| Measurement of the Hippocampal Theta Rhythm From the Outer Ear Canal Buspirone 10 Mg Oral Tablet, Triazolam 0.25 MG Oral Tablet, Placebo oral tablet - Anxiety | Not applicable | Recruiting | University of Manitoba | 42 | 2023-10-16 | 2026-02-18 |
| Phase Ⅲ Clinical Trial of Buagafuran Capsules in the Treatment of GAD Buagafuran capsules, 15mg/ capsule, Buspirone tablets, 5mg/ tablet, Buagafuran capsules mimic, 0mg/ capsule - Generalized Anxiety Disorder | Phase 3 | Recruiting | Beijing Union Pharmaceutical Factory Ltd | 410 | 2023-07-24 | 2024-02-06 |
| Evaluating Buspirone to Treat Opioid Withdrawal Buspirone, Lofexidine, Placebo - Opioid Use Disorder, Opioid Withdrawal | Phase 2 | Recruiting | University of Maryland, Baltimore | 100 | 2022-12-15 | 2026-08-24 |
| Serotonin-receptor Agonism in Reward Processing Buspirone 20mg, Placebo comparator - Anhedonia | Phase 2 | Completed | University of Oxford | 63 | 2022-05-13 | 2023-05-11 |
| Efficacy and Safety of Buspirone, Sustained-release Tablets, 15 mg in Patients With Autonomic Dysfunction Syndrome Accompanied by Vertigo Buspirone, Placebo - Vertigo, Autonomic Dysfunction | Phase 3 | Completed | Valenta Pharm JSC | 268 | 2022-01-28 | 2022-06-24 |
| Preventing Gastric Glitch With Prucalopride and Buspirone: N-of-1 Clinical Trial Prucalopride, Buspirone, Placebo - Dyspepsia | Phase 1 / Phase 2 | Completed | Universidade de Passo Fundo | 1 | 2022-01-06 | 2022-05-17 |
| Buspirone Treatment of Anxiety in Williams Syndrome Buspirone - Williams Syndrome, Anxiety | Phase 4 | Completed | Massachusetts General Hospital | 20 | 2021-08-01 | 2024-12-03 |
| Buspirone for Weak or Absent Esophageal Peristalsis Buspirone Hydrochloride 10 MG, Placebo - Dysphagia, Esophageal | Phase 4 | Unknown | Universitaire Ziekenhuizen KU Leuven | 25 | 2021-07-06 | 2024-07-03 |
| Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment Acetazolamide + supplemental oxygen + PAP therapy, Zolpidem + PAP therapy, Buspirone + PAP therapy - Sleep Disordered Breathing, Able Bodied | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2021-01-07 | 2026-07-20 |
| Hybrid Functional Electrical Stimulation Exercise to Prevent Cardiopulmonary Declines in High-level Spinal Cord Injury Buspirone Hydrochloride, Buspirone placebo, Noninvasive Ventilation (NIV) - Spinal Cord Injuries | Phase 2 | Active not recruiting | Spaulding Rehabilitation Hospital | 70 | 2020-12-22 | 2026-10-16 |
| Improving Ventilatory Capacity in Those With Chronic High Level SCI Buspirone, Placebo - Spinal Cord Injuries | Phase 2 | Completed | Spaulding Rehabilitation Hospital | 13 | 2020-11-29 | 2025-09-18 |
| Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EES Buspirone, Levodopa-Carbidopa, Buspirone + Levodopa-Carbidopa - Spinal Cord Injuries, Drug Effect | Phase 1 | Completed | Centre Hospitalier Universitaire Vaudois | 3 | 2020-09-11 | 2023-10-05 |
| Buspirone and Melatonin for Depression Following Traumatic Brain Injury Buspirone, Mealatonin - Depression, Brain Injuries, Traumatic | Phase 4 | Recruiting | Massachusetts General Hospital | 10 | 2020-08-01 | 2026-05-06 |
| Transformation of Paralysis to Stepping Buspirone, Non-invasive Spinal Cord Stimulation, Overground stepping - Spinal Cord Injuries | Early Phase 1 | Active not recruiting | University of Louisville | 15 | 2019-09-30 | 2026-03-13 |
| Buspirone for Early Satiety and Symptoms of Gastroparesis Buspirone, Placebo - Gastroparesis | Phase 2 | Completed | Johns Hopkins Bloomberg School of Public Health | 96 | 2019-08-27 | 2023-06-15 |
| Improving Driving in Young People With Autism Spectrum Disorders Buspirone - Autism Spectrum Disorder | Phase 4 | Completed | Massachusetts General Hospital | 26 | 2018-10-31 | 2021-03-18 |
| Buspirone for Opioid Tapering Buspirone oral capsule, Placebo oral capsule - Opioid-Related Disorders, Dependency (Psychology) | Phase 1 | Completed | Johns Hopkins University | 18 | 2018-05-30 | 2020-07-23 |
| Buspirone in Parkinson's Disease Buspirone, Placebo - Parkinson Disease, Anxiety | Phase 2 | Completed | University of Rochester | 21 | 2016-10-01 | 2020-01-02 |
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Anxiety Disorders (13) · Spinal Cord Injuries (6) · Autism Spectrum Disorder (5) · Depression (5) · Marijuana Abuse (4) · Autistic Disorder (3) · Child Development Disorders, Pervasive (3) · Depressive Disorder, Major (3) · Parkinson Disease (3) · Brain Injuries, Traumatic (2) · Cocaine-Related Disorders (2) · Dyspepsia (2) · Hypothermia (2) · Opioid-Related Disorders (2) · Quadriplegia (2)
Massachusetts General Hospital (8) · Medical University of South Carolina (3) · VA Office of Research and Development (3) · Chugani, Diane C. (2) · Emotional Brain NY Inc. (2) · Par Pharmaceutical, Inc. (2) · Spaulding Rehabilitation Hospital (2) · Teva Pharmaceuticals USA (2) · The Cleveland Clinic (2) · The University of Texas Health Science Center, Houston (2) · Universitaire Ziekenhuizen KU Leuven (2) · University of Rochester (2) · Assistance Publique - Hôpitaux de Paris (1) · Beijing Union Pharmaceutical Factory Ltd (1) · Centre Hospitalier Universitaire Vaudois (1)
United States (40) · Canada (5) · China (3) · Germany (2) · Belgium (1) · Brazil (1) · France (1) · Greece (1) · Russia (1) · South Korea (1) · Switzerland (1) · United Kingdom (1)
James D. Carlson, Pharm.D. (2) · A. John Rush, MD (1) · Abdulghani Sankari, MD PhD (1) · Aimee L McRae, PharmD (1) · Aimee McRae-Clark, Pharm.D. (1) · Aimee Mcrae, Pharm.D. (1) · Alexander V Ovechkin, PhD (1) · Andrew A Nierenberg, MD (1) · Atilla Ceranoglu, MD (1) · Bernard Le Foll, MD, PhD (1) · Catherine Harmer, DPhil (1) · Cecilia Bergeria, Ph.D. (1) · Daniel C Lu, MD PhD (1) · Diane C Chugani, PhD (1) · Fernando Fornari (1)
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