461 completed, 216 unknown, 198 recruiting, 62 not yet recruiting. 406 Not applicable, 47 Phase 2, 46 Phase 4, 32 Phase 3, 17 Phase 1.
Follow Aortic Diseases: new trials by email Literature Review of Aortic Diseases trials Research Report on Aortic Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AI-assisted Subtyping-directed Precision Treatment in Acute Aortic Dissection Ulinastatin and Thymalfasin, Ulinastatin - Aortic Aneurysm and Dissection | Not applicable | Not yet recruiting | Nanjing Medical University | 300 | 2027-12-31 | 2026-02-02 |
| Clinical Health Outcomes Evaluation of Terumo Aortic Hybrid Devices Thoraflex Hybrid - Aortic Aneurysm and Dissection | Not yet recruiting | Vascutek Ltd. | 150 | 2027-05-01 | 2026-11-02 | |
| Pilot Study on the Effectiveness and Safety of OPTILENE® SILVER MESH ELASTIC in Prevention of Surgical Site Infection (SSI) and Incisional Hernia (IH) Prophylactic mesh - Abdominal Aortic Aneurysm, Morbid Obesity | Not yet recruiting | Aesculap AG | 110 | 2027-02-01 | 2026-11-06 | |
| Safety and Effectiveness Assessment of AneuFix Injectable Polymer Sac Filling to Assure Long-term Durability of EVAR. AneuFix Injectable Polymer, Endovascular AneuRysm Repair (EVAR) - Endoleak After Endovascular Aneurysm Repair, Aortic Aneurysm Abdominal | Not applicable | Not yet recruiting | TripleMed B.V. | 150 | 2027-01-15 | 2026-11-10 |
| Real-World Data Collection of GORE Devices Used In the Endovascular Treatment of Aortic Aneurysms Which Incorporate Visceral Arteries. Complex Aortic Aneurysms, Thoracoabdominal Aneurysm | Not yet recruiting | W.L.Gore & Associates | 400 | 2026-12-01 | 2026-10-23 | |
| Mechanistic Clinical Trial of PCSK9 Inhibition for AAA Evolocumab, Placebo - Abdominal Aortic Aneurysm | Early Phase 1 | Not yet recruiting | University of Pennsylvania | 44 | 2026-12-01 | 2026-04-20 |
| Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study. [18F]FDG Long-Axial Field of View (LAFOV)-PET/CT, CT Angiogram, MR Angiogram - Large Vessel Vasculitis, Takayasu Arteritis | Not applicable | Not yet recruiting | Imperial College London | 18 | 2026-12-01 | 2026-10-16 |
| Aortic Size and Height Indices in Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm, Ruptured | Not yet recruiting | Tecnologico de Monterrey | 2000 | 2026-11-01 | 2026-10-26 | |
| A Novel Wire-Reinforced Fenestration of a Hybrid Frozen Elephant Trunk Device for Supra-Aortic Branch Vessel Stenting During Aortic Arch Replacement Modified Supra-Aortic Frozen Elephant Trunk (SA-FET) Device - Aortic Aneurysm, Aortic Dissection | Not applicable | Not yet recruiting | University of Maryland, Baltimore | 100 | 2026-11-01 | 2026-10-21 |
| Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery Remimazolam Besylate, propofol - Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch | Phase 4 | Not yet recruiting | Seoul National University Hospital | 80 | 2026-11-01 | 2026-10-29 |
| Prospective Multicenter Study Evaluating Myval TAVR Safety and Effectiveness in High-risk Severe AR Myval THV series - Aortic Regurgitation, Aortic Disease | Not applicable | Not yet recruiting | Ceric Sàrl | 164 | 2026-10-30 | 2026-08-07 |
| Deep-learning Predictors of Abdominal Aortic Aneurysm Enlargement in Type II Endoleaks After Endovascular Aortic Repair: The RADAR Study Artificial intelligence model analyzing preoperative CT angiography - Type II Endoleak, Abdominal Aortic Aneurysm Enlargement | Not yet recruiting | Ente Ospedaliero Cantonale, Bellinzona | 1250 | 2026-10-01 | 2026-09-11 | |
| Cardiovascular Rehabilitation After Infrarenal Aortic Aneurysm Repair Structured cardiovascular rehabilitation - Abdominal Aortic Aneurysm | Not applicable | Recruiting | Medical University Innsbruck | 40 | 2026-10-01 | 2026-10-15 |
| AAR/AAR+HAR vs AAR+TAR+FET for Type A Aortic Intramural Hematoma Ascending Aorta Replacement / Ascending Aorta Plus Hemiarch Replacement, Ascending Aorta Replacement With Total Arch Replacement and Frozen Elephant Trunk - Aortic Intramural Hematoma | Not applicable | Not yet recruiting | Second Hospital of Jilin University | 400 | 2026-10-01 | 2026-08-13 |
| Outcomes of Left Subclavian Artery Revascularization Strategies During Zone 2 Thoracic Endovascular Aortic Repair Bypass graft - Aortic Aneurysm and Dissection | Not applicable | Not yet recruiting | Assiut University | 50 | 2026-10-01 | 2026-07-13 |
| False Lumen Treatment for Prevention of Aortic Growth Using Shape Memory Polymer - First-in-Human Study (FLAGSHIP_FRA) False Lumen Embolization System, IMPEDE-FX RapidFill - Aortic Dissection | Not applicable | Not yet recruiting | Shape Memory Medical, Inc. | 15 | 2026-10-01 | 2026-01-29 |
| Effect of Remimazolam Versus Propofol Total Intravenous Anesthesia on Intraoperative Hemodynamic Stability in Patients Undergoing Thoracic or Abdominal Endovascular Aortic Repair Remimazolam Besylate, propofol - Aortic Aneurysm, Thoracoabdominal, Aortic Aneurysm, Abdominal | Phase 4 | Recruiting | Seoul National University Hospital | 44 | 2026-10-01 | 2026-10-29 |
| Selective Antegrade Cerebral Perfusion and Perioperative Optic Nerve Sheath Diameter in Ascending Aortic Surgery Optic nerve sheath and optic nerve diameter ultrasonography, Transcranial Doppler ultrasonography - Aortic Diseases, Cardiac Surgical Procedures | Not applicable | Not yet recruiting | Koşuyolu Kartal Heart Training and Research Hospital | 134 | 2026-09-30 | 2026-09-02 |
| A Clinical Investigational Study of Ankura™ II AAA, IE and AE Stent Graft System for Endovascular Treatment of Abdominal Aortic Aneurysm Ankura™ II Abdominal Aortic Stent Graft System - Abdominal Aortic Aneurysms (AAA) | Not applicable | Recruiting | Lifetech Scientific (Shenzhen) Co., Ltd. | 45 | 2026-09-30 | 2026-08-18 |
| Multimodal Physiologic State Intelligence Study OMNIPHYS Multimodal Ultrasound Imaging System - Heart Failure, Cardiomyopathies | Enrolling by invitation | Truway Health, Inc. | 25000 | 2026-09-02 | 2026-09-10 |
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Aortic Aneurysm, Abdominal (443) · Aortic Aneurysm (210) · Aortic Dissection (205) · Aortic Aneurysm, Thoracic (131) · Aneurysm (84) · Takayasu Arteritis (76) · Aortic Aneurysm, Thoracoabdominal (63) · Cardiovascular Diseases (39) · Vascular Diseases (32) · Peripheral Arterial Disease (31) · Dissection, Thoracic Aorta (30) · Aneurysm, Aortic Arch (27) · Giant Cell Arteritis (24) · Penetrating Atherosclerotic Ulcer (24)
Vascular Diseases (1075) · Cardiovascular Diseases (1068) · Aneurysm (874) · Aortic Aneurysm (597) · Acute Aortic Syndrome (246) · Dissection, Blood Vessel (238) · Pathological Conditions, Signs and Symptoms (157) · Pathologic Processes (130) · Heart Diseases (116) · Skin and Connective Tissue Diseases (102) · Arterial Occlusive Diseases (91) · Nervous System Diseases (91) · Skin Diseases (91) · Aortic Arch Syndromes (78)
Endovascular Aneurysm Repair (54) · Surgical Procedures, Operative (10) · tocilizumab (8) · Saline Solution (7) · Transcatheter Aortic Valve Replacement (7) · Propofol (6) · Adalimumab (5) · Conversion to Open Surgery (5) · Infliximab (5) · Magnetic Resonance Imaging (5) · Magnetic Resonance Spectroscopy (5) · Prednisone (5) · Preoperative Exercise (5) · Tomography, X-Ray Computed (5) · Ultrasonography (5)
W.L.Gore & Associates (32) · Medtronic Cardiovascular (29) · Assistance Publique - Hôpitaux de Paris (17) · Cook Group Incorporated (15) · Endologix (15) · Rijnstate Hospital (15) · Cook Research Incorporated (13) · Vascutek Ltd. (13) · Bolton Medical (12) · IRCCS San Raffaele (12) · Lifetech Scientific (Shenzhen) Co., Ltd. (12) · Shanghai Zhongshan Hospital (12) · University of Pennsylvania (12) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (10) · Nanjing Medical University (10)
United States (277) · China (128) · France (127) · Italy (115) · United Kingdom (102) · Germany (91) · Netherlands (90) · Canada (57) · Spain (56) · Sweden (45) · Denmark (38) · Switzerland (34) · Belgium (29) · Austria (28) · New Zealand (24)
Peter A. Merkel, MD, MPH (6) · Peter A Merkel, MD, MPH (5) · Christopher Kwolek, MD (4) · Lindi Jiang, PhD (4) · Ronald Fairman, MD (4) · Sean Lyden, MD (4) · Wei Guo, Professor (4) · Yang Yan (4) · Amanda M. Terry, MA (3) · Edward B Diethrich, M.D. (3) · Eric Roselli, MD (3) · Hence Verhagen, MD, PhD (3) · Hong Liu (3) · Joseph Lombardi, MD (3) · Marc Schermerhorn, MD (3)
PMID 37059239, PMID 37330702, PMID 39963789, PMID 38989575, PMID 36645250, PMID 23978572, PMID 26088302, PMID 30401530, PMID 32599034, PMID 34468733, PMID 36001309, PMID 36912033, PMID 42729155, PMID 17980540, PMID 21917992, PMID 23171095, PMID 23809203, PMID 24188715, PMID 25173340, PMID 26205591, PMID 26637837, PMID 26943336, PMID 27565586, PMID 27866781, PMID 27986479, PMID 28216359, PMID 29030346, PMID 29268916, PMID 30714570, PMID 31126765, PMID 31220387, PMID 31455986, PMID 31611106, PMID 31980247, PMID 32144014, PMID 32197996, PMID 32861863, PMID 32864718, PMID 33002587, PMID 33227467, PMID 33262091, PMID 33417331, PMID 33548434, PMID 33775747, PMID 33892122, PMID 34132698, PMID 34297930, PMID 34708266, PMID 34954272, PMID 35181519
U54AR057319 (5), 2016 (2), 2023 (2), 2009 (1), 2014 (1), 2019 (1), 268200700036C-5-0-1 (1), 268201000048C-5-0-1 (1), 5KL2RR025006 (1), I50HX002263 (1), N01HV681997 (1), P50HL083800 (1), R01HL044682 (1), R01HL151704 (1), R01HL166991 (1)