21 completed, 4 recruiting, 4 unknown, 3 withdrawn. 37 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 37 | Completed 21, Recruiting 4, Unknown 4, Withdrawn 3, Not yet recruiting 2, Terminated 2, Active not recruiting 1 |
Follow Heart Failure: new trials by email Literature Review of Heart Failure trials Research Report on Heart Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A First-in-Human Study to Evaluate the Safety and Efficacy of Left Ventricular Assist Device Combined With Exosome Therapy for Patients With Heart Failure（RESTORATION） Exosome Preparation, Placebo - Heart Failure | Early Phase 1 | Not yet recruiting | Yining Yang | 24 | 2027-01-15 | 2026-10-20 |
| Visualization of the Effects of Guideline-directed Medical Therapy (GDMT) on Improving Adherence and Quality of Life in Heart Failure With Reduced Ejection Fraction (HFrEF) Intervention: Visual Adherence Support (VISUALIZE-Pro) - Adherence, Medication, Adherence, Treatment | Early Phase 1 | Not yet recruiting | University of Giessen | 100 | 2026-03-01 | 2026-04-01 |
| Oral Carnitine in Heart Failure Patients Levocarnitine - Heart Failure, Carnitine Deficiency | Early Phase 1 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2025-11-12 | 2026-04-20 |
| The Effect of Providing Genetic Risk Information on Lifestyle Behaviors in African Americans Color Genomics Genetic Testing Panels - Diabetes, Hypercholesterolaemia | Early Phase 1 | Completed | Pennington Biomedical Research Center | 60 | 2025-09-22 | 2026-09-24 |
| First-in-Human Pilot Study of Epicardial Circular RNA-HM2002 Injection in CABG for Ischemic Heart Failure HM2002 injection - Ischaemic Heart Disease, Heart Failure | Early Phase 1 | Completed | Ruijin Hospital | 3 | 2024-09-18 | 2026-05-08 |
| Safety and Preliminary Efficacy Study of EE001 in Health/Patients Adults with Mild, Moderate, or Severe (NYHA II-IV) Cardiac Insufficiency EE001，70-105ml per day by IV - Cardiac Insufficiency | Early Phase 1 | Completed | Anhui HygeianCells BioMedical Co., Ltd. | 6 | 2024-06-05 | 2025-03-19 |
| Influence of Neurohormonal Blockade on Natriuresis in Heart Failure Patients Neurohormonal blockade intensification - Heart Failure | Early Phase 1 | Completed | Wroclaw Medical University | 80 | 2024-03-01 | 2026-08-24 |
| Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes Ketone Monoester (KE) - Type 2 Diabetes, Heart Failure, Reduced Ejection Fraction | Early Phase 1 | Recruiting | The University of Texas Health Science Center at San Antonio | 10 | 2024-01-16 | 2026-01-21 |
| Cardiac Power Output in Cardiogenic Shock Patients 1:1 Randomization to receive milrinone - Heart Failure, Cardiogenic Shock | Early Phase 1 | Recruiting | University of Chicago | 5 | 2023-07-06 | 2026-08-06 |
| Myocardial Telomere Recapping Study for Dilated Cardiomyopathy JV001 - Heart Failure, Dilated Cardiomyopathy | Early Phase 1 | Unknown | Shanghai East Hospital | 12 | 2023-03-30 | 2024-07-16 |
| Effects of Different Forms of a Natural Heart Hormone on Blood Pressure and Fluid Balance in Healthy Volunteers Infusion of two different cardiac peptides plus vehicle - Heart Failure, Hypertension | Early Phase 1 | Completed | Peter Fruergaard Andersen | 17 | 2022-05-01 | 2026-05-26 |
| Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure Nicotinamide riboside, Placebo - Heart Failure, Systolic, Heart Failure NYHA Class IV | Early Phase 1 | Active not recruiting | University of Washington | 32 | 2020-09-26 | 2025-03-25 |
| Study to Explore the Safety and Feasibility of Allogeneic Young Plasma Infusion in Older Adults Allogeneic Young Plasma - Frailty Syndrome, Heart Failure | Early Phase 1 | Withdrawn | Wake Forest University Health Sciences | 2020-05-01 | 2020-05-22 | |
| Non Invasive Assessment of Heart Failure Aldosterone Antagonists - Heart Failure | Early Phase 1 | Unknown | Assiut University | 100 | 2020-03-01 | 2020-01-09 |
| Observation on the Effect of Sacubitril/Valsartan in Advanced Chronic Kidney Disease（CKD）Patients With Heart Failure LCZ 696 - CKD | Early Phase 1 | Unknown | The Second Affiliated Hospital of Harbin Medical University | 30 | 2018-12-30 | 2018-12-11 |
| Pumps for Kids, Infants, and Neonates Surgical placement of the Jarvik 2015 VAD, Surgical Placement of Jarvik 2015 VAD - Pediatric Heart Failure | Early Phase 1 | Unknown | Carelon Research | 7 | 2018-10-22 | 2023-09-21 |
| Nicotinamide Riboside in LVAD Recipients Nicotinamide riboside - Heart Failure，Congestive, Heart Failure New York Heart Association Class IV | Early Phase 1 | Completed | University of Washington | 5 | 2018-09-26 | 2024-09-20 |
| Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure Lysine Chloride, Placebo - Heart Failure | Early Phase 1 | Completed | Yale University | 50 | 2018-07-12 | 2026-07-31 |
| Transthyretin Cardiac Amyloidosis in HFpEF 99mTc-PYP - Heart Failure With Preserved Ejection Fraction | Early Phase 1 | Completed | Mayo Clinic | 287 | 2017-12-01 | 2021-03-19 |
| Diffusion MRI in Heart Failure Diffusion Tensor MRI (DTI), Gadolinium DOTA Meglumine - Heart Failure, Myocardial Infarction | Early Phase 1 | Recruiting | Massachusetts General Hospital | 160 | 2017-06-30 | 2025-12-24 |
Showing 20 of 37. Sign in to see all of them.
Coronary Artery Disease (2) · Diabetes Mellitus, Type 2 (2) · Heart Failure, Diastolic (2) · Heart Failure, Systolic (2) · Hypertension (2) · Obesity (2) · Acute Coronary Syndrome (1) · Amyloidosis (1) · Atrial Fibrillation, Familial, 6 (1) · Cardiomyopathy, Dilated (1) · Diabetes Mellitus (1) · Frailty (1) · Heart Defects, Congenital (1) · Hypercholesterolemia (1)
Cardiovascular Diseases (37) · Heart Diseases (37) · Vascular Diseases (6) · Myocardial Ischemia (5) · Pathological Conditions, Signs and Symptoms (5) · Metabolic Diseases (4) · Nutritional and Metabolic Diseases (4) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (3) · Pathologic Processes (3) · Arterial Occlusive Diseases (2) · Arteriosclerosis (2) · Body Weight (2) · Cardiomegaly (2)
nicotinamide-beta-riboside (2) · Cardiac Resynchronization Therapy (1) · Carnitine (1) · Diffusion Tensor Imaging (1) · Exercise (1) · Istaroxime (1) · Milrinone (1) · Mineralocorticoid Receptor Antagonists (1) · Simvastatin (1) · Sitagliptin Phosphate (1) · Sodium Chloride (1) · Technetium Tc 99m Pyrophosphate (1) · Waiting Lists (1) · cyclo(Trp-Asp-Pro-Val-Leu) (1) · gadolinium DOTA meglumine (1)
University of Washington (2) · VA Office of Research and Development (2) · Abbott Medical Devices (1) · Anhui HygeianCells BioMedical Co., Ltd. (1) · Assiut University (1) · Benjamin Levine (1) · Carelon Research (1) · Copenhagen University Hospital, Rigshospitalet (1) · CorAssist Cadiovascular Ltd. (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · MaineHealth (1) · Massachusetts General Hospital (1) · Mayo Clinic (1) · Medtronic Cardiac Rhythm and Heart Failure (1) · Patrick Moriarty, MD, FACP, FACC (1)
United States (21) · China (3) · Denmark (3) · Canada (2) · Poland (1)
Adam A Ghotbi, MD (1) · Benjamin D Levine, MD (1) · Brett Atwater, MD (1) · Carolina Solis-Herrera, MD (1) · Chris McIntyre, MBBS DM (1) · Christian Sticherling, M.D. (1) · Christopher C Erickson, MD (1) · David E. Sosnovik, MD (1) · David G Benditt, MD (1) · David W. Wray, PhD (1) · Eric E Johnson, MD (1) · Jan Biegus, MD, PhD (1) · Jennifer L. Caldwell, PhD, MPH, MS (1) · John F Beshai, MD (1)
PMID 15261929, PMID 24075463, PMID 25458423, PMID 26382243, PMID 26386110, PMID 26418560, PMID 26987597, PMID 27392715, PMID 27440242, PMID 27681278, PMID 30327354, PMID 32161953, PMID 32790648, PMID 34464780, PMID 37086245, PMID 37102974
1UM1TR004538-01 (1), P50MD017338 (1), R01AG017479 (1), R01HL139629 (1), R01HL144937 (1)