100 completed, 28 unknown, 23 recruiting, 21 terminated. 77 Not applicable, 26 Phase 2, 24 Phase 4, 13 Phase 3, 9 Phase 1.
Follow Heart Failure, Diastolic: new trials by email Literature Review of Heart Failure, Diastolic trials Research Report on Heart Failure, Diastolic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| GLP-1/GIP Receptor Agonists in Obesity-Related HFpEF: The GLIDE-HF Registry GLP-1 / GIP receptor agonist - Heart Failure With Preserved Ejection Fraction, Obesity | Not yet recruiting | Miedziowe Centrum Zdrowia SA | 150 | 2027-01-01 | 2026-08-26 | |
| Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction Heart Failure, Heart Failure, Diastolic | Not yet recruiting | Instituto Politécnico de Leiria | 200 | 2026-12-01 | 2026-02-24 | |
| Exercise, Mediterranean Diet and Inflammation in Heart Failure Structured exercise training program, Mediterranean diet counseling, Standard heart failure management - Heart Failure, Heart Failure Preserved Ejection Fraction | Not applicable | Not yet recruiting | Hospital Severo Ochoa | 214 | 2026-11-01 | 2026-10-21 |
| Finerenone's Impact on Cardiac Electrical Stability in HFpEF Finerenone, Placebo - Heart Failure and Preserved Ejection Fraction, Atrial Fibrillation (AF) | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-08 | |
| PrEcision Pacing in HFpEF: the PEP-HFpEF Trial Individualized myPACE pacemaker programming - Heart Failure and Preserved Ejection Fraction, Heart Failure New York Heart Association Class III | Not applicable | Recruiting | Tufts Medical Center | 36 | 2026-10-01 | 2026-10-20 |
| Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis Lupus Nephritis, Diastolic Dysfunction | Not yet recruiting | Assiut University | 90 | 2026-09-20 | 2026-09-24 | |
| eHealth Lifestyle Intervention To Enhance Outcomes in HFpEF Digital lifestyle education program, Usual Care - Heart Failure and Preserved Ejection Fraction, Obesity & Overweight | Not applicable | Not yet recruiting | Maimónides Biomedical Research Institute of Córdoba | 52 | 2026-09-01 | 2026-06-22 |
| A Study of LY3971297 in Participants With Heart Failure LY3971297, Placebo - Heart Failure, Heart Failure, Diastolic | Phase 1 | Recruiting | Eli Lilly and Company | 90 | 2026-08-11 | 2026-09-22 |
| Incretin Therapies in Obesity-related HFpEF Tirzepatide - Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction | Phase 4 | Recruiting | Columbia University | 50 | 2026-08-07 | 2026-08-24 |
| Heart Failure and Postoperative Outcome in Surgery - a National Registry Study Heart Failure, Diastolic Heart Failure | Not yet recruiting | Umeå University | 2200000 | 2026-08-01 | 2026-06-09 | |
| Dancing as an Alternative to the Traditional Exercising in Older Adults With Cardiac Diseases Dancing Intervention, Exercising - Heart Failure and Preserved Ejection Fraction | Not applicable | Active not recruiting | University College, London | 120 | 2026-08-01 | 2026-09-11 |
| Randomized Double-blind Controlled Clinical Study of SGLT-2i Combined With Probiotic Preparations in Elderly Patients With HFpEF Henggliflozin Combined with Probiotics, Henggliflozin, double placebo - Heart Failure, Preserved Ejection Fraction | Phase 1 / Phase 2 | Not yet recruiting | The First Affiliated Hospital of Air Force Medicial University | 162 | 2026-07-01 | 2026-07-07 |
| Investigation on the Impact of Finerenone on Myocardial Remodeling in Patients With Diabetic Kidney Disease and Heart Failure Finerenone - Heart Failure and Preserved Ejection Fraction, Heart Failure | Phase 4 | Enrolling by invitation | Cathay General Hospital | 40 | 2026-04-01 | 2026-03-02 |
| Selenium Intervention Registry Randomized Trial in Heart Failure Selenium Supplement, Placebo - Heart Failure, Heart Failure and Reduced Ejection Fraction | Phase 3 | Recruiting | Skane University Hospital | 4326 | 2026-04-01 | 2026-04-22 |
| DICE Study- Diastolic Improvement With Carvedilol & Empagliflozin in Patients With Cirrhosis Empagliflozin + Carvedilol, Carvedilol - Cirrhotic Cardiomyopathy, Empagliflozin | Phase 4 | Recruiting | Post Graduate Institute of Medical Education and Research, Chandigarh | 400 | 2026-04-01 | 2026-05-14 |
| Study of JK07 in Patients With Heart Failure and WHO Group 2 Combined Post- and Pre-Capillary Pulmonary Hypertension JK07 - HFrEF - Heart Failure With Reduced Ejection Fraction, HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 2 | Withdrawn | Salubris Biotherapeutics Inc | 2025-12-15 | 2026-05-15 | |
| Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction GLP-1RA - Heart Failure Preserved Ejection Fraction, Epicardial Adipose Tissue | Phase 4 | Recruiting | University of Virginia | 192 | 2025-11-20 | 2026-08-11 |
| Coronary Sinus Reducer For The Management Of Symptomatic Heart Failure Coronary Sinus Reducer - Heart Failure Preserved Ejection Fraction | Not applicable | Enrolling by invitation | Mayo Clinic | 35 | 2025-10-16 | 2026-08-05 |
| Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure Acetazolamide, Metolazone - Acute Decompensated Heart Failure, Heart Failure, Diastolic | Not applicable | Recruiting | University of Health Sciences Lahore | 320 | 2025-10-11 | 2025-10-03 |
| Chronic Exogenous Ketosis in HFpEF Exogenous Ketone Drink, Placebo - Heart Failure With Preserved Ejection Fraction (HFPEF), Heart Failure With Normal Ejection Fraction | Phase 2 | Enrolling by invitation | Duke University | 20 | 2025-07-28 | 2026-10-14 |
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Heart Failure (87) · Heart Failure, Systolic (34) · Hypertension, Pulmonary (11) · Heart Diseases (10) · Hypertension (10) · Motor Activity (10) · Cardiovascular Diseases (9) · Obesity (9) · Atrial Fibrillation (7) · Ventricular Dysfunction, Left (6) · Diabetes Mellitus (5) · Diabetes Mellitus, Type 2 (5) · Heart Murmurs (5) · Myocardial Ischemia (5)
Cardiovascular Diseases (189) · Heart Diseases (188) · Heart Failure (111) · Pathological Conditions, Signs and Symptoms (42) · Vascular Diseases (31) · Pathologic Processes (26) · Nutritional and Metabolic Diseases (20) · Signs and Symptoms (19) · Respiratory Tract Diseases (15) · Metabolic Diseases (14) · Behavior (13) · Lung Diseases (13) · Hypertension (11) · Body Weight (10) · Glucose Metabolism Disorders (9)
Exercise (7) · Echocardiography (6) · High-Intensity Interval Training (5) · Spironolactone (5) · Blood Specimen Collection (4) · Sildenafil Citrate (4) · Adrenergic beta-Antagonists (3) · Carvedilol (3) · Diet (3) · Eplerenone (3) · Metoprolol (3) · Nebivolol (3) · empagliflozin (3) · Acebutolol (2) · Atenolol (2)
Mayo Clinic (9) · University of Michigan (5) · University of Texas Southwestern Medical Center (5) · CorAssist Cadiovascular Ltd. (3) · Duke University (3) · Herlev and Gentofte Hospital (3) · Weill Medical College of Cornell University (3) · Arizona State University (2) · Assiut University (2) · Baylor College of Medicine (2) · Boston Scientific Corporation (2) · Cedars-Sinai Medical Center (2) · Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Hospital de Clinicas de Porto Alegre (2) · Impulse Dynamics (2)
United States (94) · Germany (15) · Canada (10) · Netherlands (9) · Italy (8) · Sweden (7) · United Kingdom (7) · Australia (6) · Belgium (6) · Brazil (6) · China (6) · Denmark (6) · Russia (6) · Poland (5) · Taiwan (5)
Antonio Abbate, MD, PhD (2) · Benjamin D Levine, MD (2) · Dalane W Kitzman, MD (2) · Minjie Lu, PhD (2) · Parag Goyal, MD (2) · Scott L Hummel, MD MS (2) · Ajit Singh, PHARM D, PhD (1) · Alexander Lyon, BCh PhD FRCP (1) · Amit Patel, MD (1) · Andrea Natale, MD (1) · Andreas Schuster, MD, PhD (1) · Anne Catherine Pouleur (1) · Anthony DeMaria, MD (1) · Anton Borisov, MD (1)
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K76AG064428 (2), R01AG018915 (2), 2009 (1), 2014 (1), 2023 (1), I21RX004655 (1), K01HL092585 (1), K23GM112014 (1), R01AG054486 (1), R01HL104018 (1), R03AG064371 (1), R21AG053512 (1), R34HL118348 (1), R37AG018915 (1), R44HL071379 (1)